LOCUS       NM_003411               5336 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein Y-linked (ZFY), transcript variant
            1, mRNA.
ACCESSION   NM_003411
VERSION     NM_003411.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5336)
  AUTHORS   Ni,W., Perez,A.A., Schreiner,S., Nicolet,C.M. and Farnham,P.J.
  TITLE     Characterization of the ZFX family of transcription factors that
            bind downstream of the start site of CpG island promoters
  JOURNAL   Nucleic Acids Res 48 (11), 5986-6000 (2020)
   PUBMED   32406922
  REMARK    GeneRIF: Characterization of the ZFX family of transcription
            factors that bind downstream of the start site of CpG island
            promoters.
REFERENCE   2  (bases 1 to 5336)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5336)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   4  (bases 1 to 5336)
  AUTHORS   Decarpentrie,F., Vernet,N., Mahadevaiah,S.K., Longepied,G.,
            Streichemberger,E., Aknin-Seifer,I., Ojarikre,O.A., Burgoyne,P.S.,
            Metzler-Guillemain,C. and Mitchell,M.J.
  TITLE     Human and mouse ZFY genes produce a conserved testis-specific
            transcript encoding a zinc finger protein with a short acidic
            domain and modified transactivation potential
  JOURNAL   Hum Mol Genet 21 (12), 2631-2645 (2012)
   PUBMED   22407129
  REMARK    GeneRIF: Studies identified a major testis-specific ZFY transcript
            that encodes a protein with the same short acidic domain.
REFERENCE   5  (bases 1 to 5336)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (bases 1 to 5336)
  AUTHORS   Tricoli,J.V. and Bracken,R.B.
  TITLE     ZFY gene expression and retention in human prostate adenocarcinoma
  JOURNAL   Genes Chromosomes Cancer 6 (2), 65-72 (1993)
   PUBMED   7680890
REFERENCE   7  (bases 1 to 5336)
  AUTHORS   Kochoyan,M., Keutmann,H.T. and Weiss,M.A.
  TITLE     Alternating zinc fingers in the human male associated protein ZFY:
            refinement of the NMR structure of an even finger by selective
            deuterium labeling and implications for DNA recognition
  JOURNAL   Biochemistry 30 (29), 7063-7072 (1991)
   PUBMED   1854720
REFERENCE   8  (bases 1 to 5336)
  AUTHORS   North,M., Sargent,C., O'Brien,J., Taylor,K., Wolfe,J., Affara,N.A.
            and Ferguson-Smith,M.A.
  TITLE     Comparison of ZFY and ZFX gene structure and analysis of
            alternative 3' untranslated regions of ZFY
  JOURNAL   Nucleic Acids Res 19 (10), 2579-2586 (1991)
   PUBMED   2041734
REFERENCE   9  (bases 1 to 5336)
  AUTHORS   Kochoyan,M., Havel,T.F., Nguyen,D.T., Dahl,C.E., Keutmann,H.T. and
            Weiss,M.A.
  TITLE     Alternating zinc fingers in the human male associated protein ZFY:
            2D NMR structure of an even finger and implications for
            'jumping-linker' DNA recognition
  JOURNAL   Biochemistry 30 (14), 3371-3386 (1991)
   PUBMED   1849423
REFERENCE   10 (bases 1 to 5336)
  AUTHORS   Palmer,M.S., Berta,P., Sinclair,A.H., Pym,B. and Goodfellow,P.N.
  TITLE     Comparison of human ZFY and ZFX transcripts
  JOURNAL   Proc Natl Acad Sci U S A 87 (5), 1681-1685 (1990)
   PUBMED   2308929
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006157.2, AI763177.1,
            AI469059.1, M30607.1, BC114526.1 and AL137603.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003411.3.
            
            Summary: This gene encodes a zinc finger-containing protein that
            may function as a transcription factor. This gene was once a
            candidate gene for the testis-determining factor (TDF) and was
            erroneously referred to as TDF. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.74946.1, BC114960.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000155093.8/ ENSP00000155093.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AC006157.2         17950-18045
            97-124              AI763177.1         1-28
            125-295             AI469059.1         1-171
            296-296             AC006157.2         18245-18245
            297-417             AI469059.1         173-293
            418-2079            M30607.1           1-1662
            2080-3976           BC114526.1         1568-3464
            3977-4513           AC006157.2         63716-64252
            4514-5336           AL137603.1         1-823
FEATURES             Location/Qualifiers
     source          1..5336
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="Y"
                     /map="Yp11.2"
     gene            1..5336
                     /gene="ZFY"
                     /gene_synonym="ZNF911"
                     /note="zinc finger protein Y-linked"
                     /db_xref="GeneID:7544"
                     /db_xref="HGNC:HGNC:12870"
                     /db_xref="MIM:490000"
     exon            1..389
                     /gene="ZFY"
                     /gene_synonym="ZNF911"
                     /inference="alignment:Splign:2.1.0"
     exon            390..478
                     /gene="ZFY"
                     /gene_synonym="ZNF911"
                     /inference="alignment:Splign:2.1.0"
     CDS             418..2823
                     /gene="ZFY"
                     /gene_synonym="ZNF911"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger Y-chromosomal protein"
                     /codon_start=1
                     /product="zinc finger Y-chromosomal protein isoform 1"
                     /protein_id="NP_003402.2"
                     /db_xref="CCDS:CCDS14774.1"
                     /db_xref="GeneID:7544"
                     /db_xref="HGNC:HGNC:12870"
                     /db_xref="MIM:490000"
                     /translation="MDEDEFELQPQEPNSFFDGIGADATHMDGDQIVVEIQEAVFVSN
                     IVDSDITVHNFVPDDPDSVVIQDVVEDVVIEEDVQCSDILEEADVSENVIIPEQVLDS
                     DVTEEVSLPHCTVPDDVLASDITSTSMSMPEHVLTSESMHVCDIGHVEHMVHDSVVEA
                     EIITDPLTSDIVSEEVLVADCAPEAVIDASGISVDQQDNDKASCEDYLMISLDDAGKI
                     EHDGSTGVTIDAESEMDPCKVDSTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDH
                     GVELLDQNSSIRVPREKMVYMTVNDSQQEDEDLNVAEIADEVYMEVIVGEEDAAVAAA
                     AAAVHEQQIDEDEMKTFVPIAWAAAYGNNSDGIENRNGTASALLHIDESAGLGRLAKQ
                     KPKKKRRPDSRQYQTAIIIGPDGHPLTVYPCMICGKKFKSRGFLKRHMKNHPEHLAKK
                     KYHCTDCDYTTNKKISLHNHLESHKLTSKAEKAIECDECGKHFSHAGALFTHKMVHKE
                     KGANKMHKCKFCEYETAEQGLLNRHLLAVHSKNFPHICVECGKGFRHPSELRKHMRIH
                     TGEKPYQCQYCEYRSADSSNLKTHIKTKHSKEMPFKCDICLLTFSDTKEVQQHTLVHQ
                     ESKTHQCLHCDHKSSNSSDLKRHVISVHTKDYPHKCEMCEKGFHRPSELKKHVAVHKG
                     KKMHQCRHCDFKIADPFVLSRHILSVHTKDLPFRCKRCRKGFRQQNELKKHMKTHSGR
                     KVYQCEYCEYSTTDASGFKRHVISIHTKDYPHRCEYCKKGFRRPSEKNQHIMRHHKEV
                     GLP"
     exon            479..1051
                     /gene="ZFY"
                     /gene_synonym="ZNF911"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1201
                     /gene="ZFY"
                     /gene_synonym="ZNF911"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1345
                     /gene="ZFY"
                     /gene_synonym="ZNF911"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1498
                     /gene="ZFY"
                     /gene_synonym="ZNF911"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1639
                     /gene="ZFY"
                     /gene_synonym="ZNF911"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..5336
                     /gene="ZFY"
                     /gene_synonym="ZNF911"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5297..5302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFY"
                     /gene_synonym="ZNF911"
                     /note="hexamer: AATAAT"
     regulatory      5314..5319
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFY"
                     /gene_synonym="ZNF911"
                     /note="hexamer: AATAAA"
     polyA_site      5315
                     /gene="ZFY"
                     /gene_synonym="ZNF911"
                     /note="major polyA site"
     polyA_site      5336
                     /gene="ZFY"
                     /gene_synonym="ZNF911"
                     /note="major polyA site"
ORIGIN      
        1 agtgctccag agaaaggccg tcctgcagca cccgccgctg tcgccgaccg cccgcacatc
       61 cgtcgggtga gtcccgcgtg cccccgcggc cgcggggcct agtgcgcgcg cagtaacctg
      121 tttgtggcct ggtcggcgtc ccgtagggcg ccctcccgcg ctaggccggc cggcgtggcg
      181 ctcggcgccg aacaggcccc gaggaggccg cagttaggcc tagtgattat ccagttgccc
      241 tgagcggctg cggaggtgcg ctccataagc gggcagggtg ggaaaagttc gcccgtttgt
      301 ccggaaggca gttgatggac ctggggtcga caccactgcg gacgcagggc acggcacggg
      361 ggcgagaagg cgaaggctgc aggcgtgagg agctgtgact aatgagaatt aaaggccatg
      421 gatgaagatg aatttgaatt gcagccacaa gagccaaact cattttttga tggaatagga
      481 gctgatgcta cacacatgga tggtgatcag attgttgtgg aaatacaaga agcagttttt
      541 gtttctaata ttgtggattc tgacataact gtgcataact ttgttcctga tgacccagac
      601 tcagttgtaa tccaagatgt tgttgaagat gttgtcatag aggaggatgt tcagtgctca
      661 gatatcttag aagaggcaga tgtatctgaa aatgtcatca ttcctgagca agtgctggac
      721 tcagatgtaa ctgaagaagt ttctttacca cactgcacag tcccagatga tgttttagct
      781 tctgacatta cttcaacctc aatgtctatg ccagaacatg ttttaacgag tgaatccatg
      841 catgtgtgtg acattggaca tgttgaacat atggtgcatg atagtgtagt ggaagcagaa
      901 atcattactg atcctctgac gagtgacata gtttcagaag aagtattggt agcagactgt
      961 gcccctgaag cagtcataga tgccagcggg atctcagtgg accagcaaga taatgacaaa
     1021 gccagctgtg aggactacct aatgatttcg ttggatgatg ctggcaaaat agaacatgat
     1081 ggttccactg gagtgaccat cgatgcagaa tcagaaatgg atccttgtaa agtggatagc
     1141 acttgtcctg aagtcatcaa ggtgtacatt tttaaagctg accctggaga agatgactta
     1201 ggtggaactg tagacattgt ggagagtgaa cctgaaaatg atcatggagt tgaactactt
     1261 gatcagaaca gcagtattcg tgttcccagg gaaaagatgg tttatatgac tgtcaatgac
     1321 tctcaacaag aagatgaaga tttaaatgtt gctgaaattg ctgatgaagt ttatatggaa
     1381 gtgatcgtag gagaggagga tgctgctgtt gcagcagcag cagctgctgt gcatgagcag
     1441 caaattgatg aggatgaaat gaaaaccttc gtaccaattg catgggcagc agcttatggt
     1501 aataattctg atggaattga aaaccggaat ggcactgcaa gtgccctctt gcacatagat
     1561 gagtctgctg gccttggcag actggctaaa cagaaaccaa agaaaaagag aagacctgat
     1621 tccaggcagt accaaacagc aataattatt ggccctgatg gtcatccttt gactgtctat
     1681 ccttgcatga tttgtgggaa gaagtttaag tcgaggggtt ttttgaaaag acacatgaaa
     1741 aaccatcctg aacaccttgc caagaagaag taccactgta ctgactgtga ttacactacc
     1801 aataagaaga taagtttaca taaccacctg gagagccaca agctgaccag caaggcagag
     1861 aaggccattg aatgtgatga gtgtgggaag catttttctc atgcaggggc tttgtttact
     1921 cacaaaatgg tgcataagga aaaaggggcc aacaaaatgc acaagtgtaa attctgtgaa
     1981 tatgagacag ctgaacaggg gttattgaat cgccacctct tggcagtcca cagcaagaac
     2041 tttcctcata tttgtgtgga gtgtggtaaa ggtttccgac acccgtcgga actgagaaag
     2101 cacatgcgaa tccataccgg cgagaagcca taccaatgcc agtactgtga atataggtct
     2161 gcagactctt ctaacttgaa aacacatata aaaacaaagc atagtaaaga gatgccattc
     2221 aagtgtgaca tttgtcttct gactttctca gataccaaag aagtgcagca acatactctt
     2281 gtccaccaag aaagcaaaac acatcagtgt ttgcattgcg accacaagag ttcaaactca
     2341 agtgatttga aacgacatgt aatttcagtt catacgaaag actatcctca taagtgtgag
     2401 atgtgcgaga aaggctttca caggccttca gaacttaaga aacatgtggc tgtccacaaa
     2461 ggtaaaaaaa tgcaccaatg tagacattgt gactttaaga ttgcagaccc atttgttcta
     2521 agtcgccata ttctctcagt tcacacaaag gatcttccat ttaggtgtaa gagatgtaga
     2581 aagggattta ggcaacaaaa tgagcttaaa aagcatatga agacacacag tggcaggaaa
     2641 gtatatcagt gtgagtactg tgagtatagc actacagatg cctcaggctt taaacggcac
     2701 gttatttcca ttcatacaaa agactatcct catcggtgtg agtactgcaa gaaaggcttc
     2761 cgaagacctt cagaaaagaa ccagcacata atgagacacc ataaagaagt tggtctgccc
     2821 taacagtgtg tctacaagct tgtaaagatg ttggccttga agcagaaaat tcatttttta
     2881 aagccagtct tgttcacatc cattactata cattgaatta tgctgtgtaa aaatagaatt
     2941 attgcttcta gtccactttt ctttacattt tattcaatac gctgtcctga atcctattca
     3001 gtttctttaa tagatgagga aaaatagcaa caagcaagtt gcttataata aaataatttg
     3061 tgattctata ctgaattttc agtcataaaa gctttactat ttatttacat atttattcat
     3121 gttcatggta ctcttctaag acaaaatcag attgataact atgaaagtaa catttttgac
     3181 ccatttcctc ctacacaagt gtttcacatt ggagacatct gctaatataa atgggaggtt
     3241 ttactgtcaa gtccaattag caaaacgtgg taataatttt tttgtcagta ttttcagatt
     3301 acatgataaa attttacatt tgagcttcta gcattgatta atataggata ttgaccacgt
     3361 ttatgtttaa atttcatttt gttcagcaga caaaatgtac ttcccttaac tttcattaat
     3421 agtgtttaca tcttttgtca gcacagcaaa cttttagaaa gtaatagttt tacttatttt
     3481 tatcttctgt tttctctttg tactgctttg tcttgcattg tgttccaaca catgagactt
     3541 actgctcact gaattttgga gtcttttaga ggtaaattgt ggactcagga ttttttgaaa
     3601 cttggtgtgt aactctaaat cttgtatatg catctttgtt gcttattaca tatttacaca
     3661 cacaaccaca aattttaaac ttatgatgaa aatttacaat aacctgaaag atccagagat
     3721 gtatgagagc attttgtaac ttgttattca gttactaaat ttgaggtgaa taattaaaaa
     3781 gaaaaggaca ttaggagagt gaaaatcttc tcttcaaata atctttgata gataaaaatg
     3841 gaaggtaaga tgtttctaga tagaatgttt tcatacaatt tcagcttcat atcataaatt
     3901 tttctggaaa gctatttcag acatagattt catagtattt ttctgagaat cctgtgaagg
     3961 aacgctgtct ctttgcaaag taaggaggac taagggaaaa tgatggtacc atgtaacaga
     4021 atgagagcta attccaaatt agcaacttca tcctgctttc tattttacat tgagtaaagt
     4081 tttaaaaaga caacagtcaa gttgattttg attagaagat aaaagtacat aatgaaaatc
     4141 catggcctta tttggaatat atatcacttt ccaaatttta ttatttattt gagagttaat
     4201 aagttaatgt tattaagcag ttaataattt atatgtatgg atataatata aaatgaattc
     4261 atataattaa aaagaatttg gttaataaga atttggagaa tggaaaatac atttttaggt
     4321 tccttaattt ggctgttggt acctgtgtat ttggaatatt ttaggggatt cgaatttttt
     4381 ttaacccaca ttacagctac cttctagctt tagtatggta gtgcttcatt caacttttgc
     4441 tgtcaggttt ttattttcac ctttttctgt gccaccaatt caaaagttat aggattagga
     4501 aatataaatt tatatttggt gattggcagc ctctgaaatg ttagattaat ttgatctagt
     4561 tctaaagtgc tttagtcata tatgaattta aacctagtac catccaaaac catgtaatgg
     4621 attttaagaa tctgttaggc cttcttagcc tttatacatg tccctacctg atttttactg
     4681 tccttcatga tcctgttctt gaaaacttca gtttgtattt gagaatcctt taaatctcct
     4741 tccaatttgt tttctccctg aagtaatata aaaggaagta tttaagtgaa agtttaagag
     4801 ttttaaaaca ttctttaaaa ttaatacaga tagttagcta tttatctttt aaaaataaac
     4861 taaggtaaaa aacgtgacac tttacatatt tcatattttt catatagtct ggaggtatac
     4921 acagttgttt tgtttttaac cacggtattg aaacctttaa aaggtaatta agcatttggt
     4981 caagtaaata tagaacattt gtataaagaa agaaatgaaa ttgtgcttaa tgttatatac
     5041 tgttattatt tgcaggctgg ttttaattct taatttgatt agcaaagcta aaaaagtgga
     5101 tgttgaagtt gaaagtttta aagaggtaca aaatcttaca aggacataaa ttattatttg
     5161 gttgaaaaat agcctattag atattgtatg tcccttcctc tgtacaaatt gtaaaatact
     5221 taaaataact atgaagaatt catataggaa gtgtgatact attgtaaatg tgtatttgag
     5281 aatatgcaaa aataaaaata atattttact gttaataaat gtttacttgt atatga
//
