LOCUS       NM_001144936            5716 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens zinc finger translocation associated (ZFTA), mRNA.
ACCESSION   NM_001144936 XM_001715390 XM_933539 XM_944529
VERSION     NM_001144936.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5716)
  AUTHORS   Dorwal,P., White,C., Goh,A.F., Kumar,A., McEniery,J., Walker,R. and
            Robertson,T.
  TITLE     Ependymoma-like tumor with mesenchymal differentiation (ELTMD) with
            ZFTA:NCOA1 fusion: A diagnostic challenge
  JOURNAL   Neuropathology 44 (3), 216-221 (2024)
   PUBMED   37931917
REFERENCE   2  (bases 1 to 5716)
  AUTHORS   Tauziede-Espariat,A., Nicaise,Y., Sievers,P., Sahm,F., von
            Deimling,A., Guillemot,D., Pierron,G., Duchesne,M., Edjlali,M.,
            Dangouloff-Ros,V., Boddaert,N., Roux,A., Dezamis,E., Hasty,L.,
            Lhermitte,B., Hirsch,E., Hirsch,M.P.V., Ardellier,F.D.,
            Karnoub,M.A., Csanyi,M., Maurage,C.A., Mokhtari,K., Bielle,F.,
            Rigau,V., Roujeau,T., Abad,M., Klein,S., Bernier,M., Horodyckid,C.,
            Adam,C., Brandal,P., Niehusmann,P., Vannod-Michel,Q., Provost,C.,
            de Champfleur,N.M., Nichelli,L., Metais,A., Mariet,C., Chretien,F.,
            Blauwblomme,T., Beccaria,K., Pallud,J., Puget,S., Uro-Coste,E. and
            Varlet,P.
  CONSRTM   RENOCLIP-LOC
  TITLE     CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic
            spectrum of supratentorial ependymomas
  JOURNAL   Acta Neuropathol Commun 12 (1), 55 (2024)
   PUBMED   38581034
  REMARK    GeneRIF: CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the
            genetic spectrum of supratentorial ependymomas.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5716)
  AUTHORS   Tomomasa,R., Arai,Y., Kawabata-Iwakawa,R., Fukuoka,K., Nakano,Y.,
            Hama,N., Nakata,S., Suzuki,N., Ishi,Y., Tanaka,S., Takahashi,J.A.,
            Yuba,Y., Shiota,M., Natsume,A., Kurimoto,M., Shiba,Y., Aoki,M.,
            Nabeshima,K., Enomoto,T., Inoue,T., Fujimura,J., Kondo,A., Yao,T.,
            Okura,N., Hirose,T., Sasaki,A., Nishiyama,M., Ichimura,K.,
            Shibata,T., Hirato,J., Yokoo,H. and Nobusawa,S.
  TITLE     Ependymoma-like tumor with mesenchymal differentiation harboring
            C11orf95-NCOA1/2 or -RELA fusion: A hitherto unclassified tumor
            related to ependymoma
  JOURNAL   Brain Pathol 31 (3), e12943 (2021)
   PUBMED   33576087
  REMARK    GeneRIF: Ependymoma-like tumor with mesenchymal differentiation
            harboring C11orf95-NCOA1/2 or -RELA fusion: A hitherto unclassified
            tumor related to ependymoma.
REFERENCE   4  (bases 1 to 5716)
  AUTHORS   Ozawa,T., Kaneko,S., Szulzewsky,F., Qiao,Z., Takadera,M.,
            Narita,Y., Kondo,T., Holland,E.C., Hamamoto,R. and Ichimura,K.
  TITLE     C11orf95-RELA fusion drives aberrant gene expression through the
            unique epigenetic regulation for ependymoma formation
  JOURNAL   Acta Neuropathol Commun 9 (1), 36 (2021)
   PUBMED   33685520
  REMARK    GeneRIF: C11orf95-RELA fusion drives aberrant gene expression
            through the unique epigenetic regulation for ependymoma formation.
            Erratum:[Acta Neuropathol Commun. 2021 May 27;9(1):100. doi:
            10.1186/s40478-021-01157-y.. PMID: 34044883]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5716)
  AUTHORS   Tamai,S., Nakano,Y., Kinoshita,M., Sabit,H., Nobusawa,S., Arai,Y.,
            Hama,N., Totoki,Y., Shibata,T., Ichimura,K. and Nakada,M.
  TITLE     Ependymoma with C11orf95-MAML2 fusion: presenting with granular
            cell and ganglion cell features
  JOURNAL   Brain Tumor Pathol 38 (1), 64-70 (2021)
   PUBMED   33221956
  REMARK    GeneRIF: Ependymoma with C11orf95-MAML2 fusion: presenting with
            granular cell and ganglion cell features.
REFERENCE   6  (bases 1 to 5716)
  AUTHORS   Pietsch,T., Wohlers,I., Goschzik,T., Dreschmann,V., Denkhaus,D.,
            Dorner,E., Rahmann,S. and Klein-Hitpass,L.
  TITLE     Supratentorial ependymomas of childhood carry C11orf95-RELA fusions
            leading to pathological activation of the NF-kappaB signaling
            pathway
  JOURNAL   Acta Neuropathol 127 (4), 609-611 (2014)
   PUBMED   24562983
  REMARK    GeneRIF: C11orf95-RELA fusions represent a unique novel mechanism
            leading to pathological activation of NF-kappaB signaling in
            supratentorial ependymomas.
REFERENCE   7  (bases 1 to 5716)
  AUTHORS   Parker,M., Mohankumar,K.M., Punchihewa,C., Weinlich,R.,
            Dalton,J.D., Li,Y., Lee,R., Tatevossian,R.G., Phoenix,T.N.,
            Thiruvenkatam,R., White,E., Tang,B., Orisme,W., Gupta,K., Rusch,M.,
            Chen,X., Li,Y., Nagahawhatte,P., Hedlund,E., Finkelstein,D., Wu,G.,
            Shurtleff,S., Easton,J., Boggs,K., Yergeau,D., Vadodaria,B.,
            Mulder,H.L., Becksfort,J., Gupta,P., Huether,R., Ma,J., Song,G.,
            Gajjar,A., Merchant,T., Boop,F., Smith,A.A., Ding,L., Lu,C.,
            Ochoa,K., Zhao,D., Fulton,R.S., Fulton,L.L., Mardis,E.R.,
            Wilson,R.K., Downing,J.R., Green,D.R., Zhang,J., Ellison,D.W. and
            Gilbertson,R.J.
  TITLE     C11orf95-RELA fusions drive oncogenic NF-kappaB signalling in
            ependymoma
  JOURNAL   Nature 506 (7489), 451-455 (2014)
   PUBMED   24553141
  REMARK    Erratum:[Nature. 2014 Apr 24;508(7497):554. Becksford, Jared
            [corrected to Becksfort, Jared]]
REFERENCE   8  (bases 1 to 5716)
  AUTHORS   Flucke,U., Tops,B.B., de Saint Aubain Somerhausen,N., Bras,J.,
            Creytens,D.H., Kusters,B., Groenen,P.J., Verdijk,M.A.,
            Suurmeijer,A.J. and Mentzel,T.
  TITLE     Presence of C11orf95-MKL2 fusion is a consistent finding in
            chondroid lipomas: a study of eight cases
  JOURNAL   Histopathology 62 (6), 925-930 (2013)
   PUBMED   23672313
  REMARK    GeneRIF: Based on a recurrent translocation t(11;16)(q13;p13), the
            C11orf95-MKL2 fusion gene has been found in eight further cases of
            chondroid lipomas.
REFERENCE   9  (bases 1 to 5716)
  AUTHORS   Nishio,J.
  TITLE     Contributions of cytogenetics and molecular cytogenetics to the
            diagnosis of adipocytic tumors
  JOURNAL   J Biomed Biotechnol 2011, 524067 (2011)
   PUBMED   21274402
  REMARK    Review article
REFERENCE   10 (bases 1 to 5716)
  AUTHORS   Huang,D., Sumegi,J., Dal Cin,P., Reith,J.D., Yasuda,T., Nelson,M.,
            Muirhead,D. and Bridge,J.A.
  TITLE     C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13)
            in chondroid lipoma
  JOURNAL   Genes Chromosomes Cancer 49 (9), 810-818 (2010)
   PUBMED   20607705
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP006289.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001144936.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. There are no full-length human transcripts
            supporting this exon combination; it is predicted based on partial
            transcript alignments and on homologous alignments from mouse
            GeneID:108899.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968540,
                              SAMEA1970526 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000433688.2/ ENSP00000482180.1
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-292               AP006289.2         46686-46977         c
            293-790             AP006289.2         44009-44506         c
            791-1177            AP006289.2         43070-43456         c
            1178-1738           AP006289.2         42240-42800         c
            1739-5716           AP006289.2         38094-42071         c
FEATURES             Location/Qualifiers
     source          1..5716
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..5716
                     /gene="ZFTA"
                     /gene_synonym="C11orf95"
                     /note="zinc finger translocation associated"
                     /db_xref="GeneID:65998"
                     /db_xref="HGNC:HGNC:28449"
                     /db_xref="MIM:615699"
     exon            1..292
                     /gene="ZFTA"
                     /gene_synonym="C11orf95"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..2190
                     /gene="ZFTA"
                     /gene_synonym="C11orf95"
                     /note="uncharacterized protein C11orf95"
                     /codon_start=1
                     /product="zinc finger translocation-associated protein"
                     /protein_id="NP_001138408.1"
                     /db_xref="CCDS:CCDS44636.1"
                     /db_xref="GeneID:65998"
                     /db_xref="HGNC:HGNC:28449"
                     /db_xref="MIM:615699"
                     /translation="MEPGGDHRSRSSGGRGGPGPAVASARGRRLPPAGSSGSAEPEED
                     EGGQDLQLEGGALGSWGSAPLPSSRARGPASSGRKYSDHCEARASRPGKSRIPGRDHR
                     RYYHDHWRLEYLMDFNPARHGMVCMVCGSSLATLKLSTIKRHIRQKHPYSLHWSPREK
                     EVISNSWDAHLGLGACGEAEGLGVQGAEEEEEEEEEEEEEGAGVPACPPKGPGKAPAG
                     GGCRRQRRGGPVAPRARRLRLSASRRAGGSRGLGARRLERRLKESLQNWFRAECLMDY
                     DPRGNRLVCMACGRALPSLHLDDIRAHVLEVHPGSLGLSGPQRSALLQAWGGQPEALS
                     ELTQSPPGDDLAPQDLTGKSRDSASAAGAPSSQDLSPPDVKEEAGWVPERPGPAEEEE
                     ELEEGEGERAGVPGRSPRGRAHRRHPQERWRLEYLMELDGGRRGLVCGVCGGALASLK
                     MSTIERHIRRRHPGSTRLGGPVQALIAREWSEKAAHLLALGPPRPESPQGPIPPGTAA
                     ASDEGGGDEEEEPEEEEEEWGDVPLSPGAPLERPAEEEEDEEDGQEPGGLALPPPPPP
                     PPPPPPRSREQRRNYQPRWRGEYLMDYDGSRRGLVCMVCGGALATLKVSTIKRHILQV
                     HPFSMDFTPEERQTILEAYEEAALRCYGHEGFGPPAPAPRDGGADLKSGAVCRA"
     exon            293..790
                     /gene="ZFTA"
                     /gene_synonym="C11orf95"
                     /inference="alignment:Splign:2.1.0"
     exon            791..1177
                     /gene="ZFTA"
                     /gene_synonym="C11orf95"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1738
                     /gene="ZFTA"
                     /gene_synonym="C11orf95"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..5716
                     /gene="ZFTA"
                     /gene_synonym="C11orf95"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5687..5692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFTA"
                     /gene_synonym="C11orf95"
                     /note="hexamer: AATAAA"
     polyA_site      5716
                     /gene="ZFTA"
                     /gene_synonym="C11orf95"
                     /note="major polyA site"
ORIGIN      
        1 gccgagcgag cagcctgccg tccgtgcggc cggccgcccc gtgcatgcgc cccgcgcccc
       61 ggggccccgc gcagcgagcg ctccgcgcgg gctgccgccg gccccgcggc cccgcgcccc
      121 gccgccccgg ggccccgctc cgcagcgcag cgcatggagc ccggcgggga ccaccggagc
      181 cggagcagcg gcggcagggg cggccccggg ccagcagtgg cctcggcacg gggccgacgg
      241 ctgccgcccg ccggatcgag cggcagcgcg gagccagagg aagacgaagg cgggcaagat
      301 cttcagctgg aagggggtgc cttggggtcc tgggggagtg cccccctgcc ctcctccagg
      361 gccaggggac cagcatcttc aggcaggaaa tattcagacc actgtgaggc ccgggcctcg
      421 aggcctggaa agagccgcat ccctggccgt gaccaccggc gctactacca cgaccactgg
      481 cggctggagt acctgatgga cttcaaccct gcccggcacg gcatggtgtg catggtgtgc
      541 ggcagctccc tggccaccct caagctcagc accatcaagc gccacatccg ccaaaagcac
      601 ccctactcct tgcattggag tccccgggag aaggaagtca tcagcaacag ctgggatgca
      661 cacctggggc tgggggcctg cggagaggcc gagggcctgg gggtccaggg ggctgaggag
      721 gaggaggagg aggaagaaga ggaggaggag gagggggccg gtgtcccagc ttgcccgccc
      781 aagggcccag gcaaagcccc agctggtggg ggctgccggc gccagcggcg agggggccca
      841 gtggcacccc gggctcggcg tctgcgcctc tcagcctccc ggagggccgg gggcagcagg
      901 gggctggggg cccggcgcct ggagaggagg ctgaaggagt ccctgcagaa ctggttccgg
      961 gccgagtgtc tcatggacta tgacccgcgg gggaaccggc tggtgtgcat ggcctgtggc
     1021 cgggcactgc ccagcctgca cctggacgac atccgtgccc acgtgctgga ggtgcaccct
     1081 ggctccctgg ggctcagcgg cccccagcgc agtgccctgc tgcaggcctg ggggggccag
     1141 cccgaggcgc tgtctgagct cacccagtcc ccaccaggcg atgacctcgc cccccaggac
     1201 ctgaccggaa agagccggga ctcggcctcc gctgctggag ccccctcctc tcaggatctc
     1261 agccccccag acgtaaagga agaggctggc tgggtccctg agaggcccgg gcccgcagag
     1321 gaggaggagg agctggagga gggcgagggc gagagggcgg gggtcccggg ccggtcgccg
     1381 cggggccgcg cccaccgccg ccacccccag gagcgctggc ggctggagta cctcatggag
     1441 ttggacggcg gccggcgcgg cctggtgtgc ggggtgtgcg ggggcgcgct ggcctcgctc
     1501 aagatgagca ccatcgagcg ccacatccgc cggcgccacc cgggctccac gcgcctcggc
     1561 gggcctgtcc aggccctcat cgcccgggag tggagcgaga aggccgccca cctgctggcc
     1621 ctggggccgc cccgccccga gtccccccag ggccccatcc cccccggcac tgccgcagcc
     1681 tccgacgagg ggggagggga cgaggaggag gagccagagg aggaggagga ggagtggggc
     1741 gacgttccgc tgtcccctgg agctcccttg gagcggcccg ccgaagaaga ggaggacgaa
     1801 gaggacggcc aggagcctgg gggactcgcc ttgccgccgc cgcctcctcc cccgcctccg
     1861 cccccgcccc gcagccggga gcagcggcgg aactaccagc cgcggtggcg gggcgagtac
     1921 ctgatggact acgacggcag ccggcgcggc ctggtgtgta tggtgtgcgg gggcgcgctg
     1981 gccacgctca aggtgagcac catcaagcgc cacatcctgc aggtgcaccc cttctccatg
     2041 gacttcacgc ctgaggagcg ccagactatc ctggaggcct acgaggaggc ggcgctgcgc
     2101 tgctacggcc acgagggctt cgggccgccc gccccggcgc cgcgtgacgg cggcgcggac
     2161 ctcaagtctg gcgctgtgtg tcgggcgtag cggcctagcg ggcccccggg tcaggtcggg
     2221 tcgggtcgga tcggccccgc cccgccctgt gctcgcccgg cccttcggct gggagaccct
     2281 cgcgtccggt gttagcgctt cccgcggccg cgccccccgc tggccgggcc gggcggagac
     2341 gggggatcgg gtggggccac cggcgtctgc gcggtgccac ttgggtccct gagccagtcg
     2401 gtgcgctgcg ggaagcgcac tctcccatcg gcccggagcc ctgccctccc cgcgcagggc
     2461 ccacgttttc cgagaatcct cagtggcctc cacgtgttag cgccgagcgc tcccggccgc
     2521 accccgcgag ggggttctcc gcaggccggg actgggggcg ccgtcagtca gtattagggc
     2581 cgaagggggg ccgtgcgggc tctggctctg gccctggctg ggggcccagt tccctgcagc
     2641 cttgcacgct ggcaggcacg gctcccggct tgggggctgc tggctgccct tccctaattg
     2701 ggattctcgg cctctcggag gccccggctg cggactgggg cttccagcgg gaggctgggc
     2761 cgcagggctc gggagccttc ccggggtggg aaggcgcgtt ggaccgaggg cggggctacg
     2821 cgcccggggc ccgggctgga ccagctgcgc ttacctcccc ggcaggctca gtgagaaccg
     2881 tgcgcccggc ggccccactc tcctcccagg ccgctgccac gccctccagg aaagctcttg
     2941 taaagggatt agcacttttt tcctttgctc ctcttgcccc gagggtctct gcttacccct
     3001 aaaccaagtc cgtgggagcc cggggcacag gcggtcccgg cagtcagcct tcgattcccg
     3061 ccccatcccc atcccccttt gtccgcggtg gatgcggcgt ccgttctcaa cccgcagggc
     3121 ctggggccgg gcctcggcct cttttccccg tggcagccgc aggccctgtg tggcagggat
     3181 ggggccccgc gatctcccag gcaggtccga gagggatgtg tagattcatt ctcctgtgga
     3241 gaacaggtgg ccccgagatc aggccctttt ttgctctttg tattttattt tgaaactgta
     3301 tttaatgctt ttatatgaaa gggggagggg cggggacaga gctgacccag tcacccttat
     3361 gtgcaaatgt cttatttatt atgcgtgtat cagagataag ctgtgaggtg gtggagggag
     3421 gacctgaagg aaggaggagc gagggcagag gcggggacgg gaggacccca actagctgtg
     3481 ctgatgttaa tcccgctggg agactccggg ccctactgtc tgctcttcac aaagccaggc
     3541 tgctgcagga acagttcccg cggtcctaaa gccggggcgg ggaggctagt gggtggaact
     3601 tgagggttgg gtctggagga agagatgcct gggcagcgtg gtccagcccc tgcctcgggg
     3661 tggaaaggca gagagcaaag aggaggcccc tcttattccg gacccccagg ccagagccca
     3721 ggagtgggaa agcagagggc aaagaggagg cccctcctct catccctgac ccccaggcca
     3781 gagcctaagg ttcaagtgcc tcaggcccag tccccttgac gcttcctgtt tgggagttgg
     3841 attttatacc acggatttta tagcattttt atataattga ggattgtcag aattggaaag
     3901 ggccctggag atcactagta ctaccctcct caccttcaca gataggtaaa ttggagccca
     3961 ggaaccgaga tgatcacaca gccaggtagg gacagtacaa gaactagaat gaaaatccta
     4021 gctcctgact cagtgttctt tgcacgatgc cacactgctt cccaattcgc tggtcagtta
     4081 ttaaaatttg tcaggcctgc cgaaggattg acatgctggg caatgcaggc caccacggtg
     4141 gatctgtgac tcctgaaggt ggcaaagccc tgcacactgc cttgggatga gcacactgag
     4201 ctctgcaggg cctcagctgg aaggcgccat ccaatcgtcc ttcccctccc cagcagaact
     4261 ccagaggtgg ggcggctgcc gcagggccca aggctgcctc ggcagggggc tttgtgcttt
     4321 ttgttgtgga ggccaccagg gattcaggaa gatcctgaat gggttgtcaa ttgactgaaa
     4381 agtaaattcc cagtgagttt gaacctccac ggtttttgag acagtattaa aagcttgaga
     4441 acggagatta tggatggcac caggctgggc actgccattc ttttactttc cttcatgcat
     4501 tttttcggat ccagagtatt aacaccactt tttttactct gcccattcaa aaacagtagg
     4561 caaattgggg gaaccaattt ataatcactc aagcccactg ccaaagttcg gataagccag
     4621 ggcagagggg ttagattccc ccccctccgt aggcagagag aggcctcagg agagtggaca
     4681 tctttactga gacagcccca aacacaccag tggctctcaa agtgtgtccc tgagaccagc
     4741 agcatcacct taggaatctg ctagaaataa aaattcttgg gccatacccc agggttactg
     4801 aatcagaaac ttggttgggg cctagcagtg ttttcatgag ccctccattg atcttgatgc
     4861 agctgaagtg ccgggcacca gtgaaaggga agggctgcgg tagtgattcc attgattcct
     4921 gctttgatgg aagttatggc ctcacaggtt agacgttgca agttgagttg gccctcttgc
     4981 ctaggtgtgc ctccttgcct tgggattctg acatgaacag gtgaagtctc ttcatgattt
     5041 tttttgttgt tgttgttaat ggtatgcttg ctattatggc caatatgtaa atgttactct
     5101 gaatacatat ttatatacca tgttacttag tgacattatt caaacatttg tatgcgtatt
     5161 tgtgaaattg tttgcatcag tcatttaaaa aatatttcag cctaagtttt ctaagaggta
     5221 tgttgaatac atttttaaaa gccagcttaa gggtcacagc agccttagtt taggagaaga
     5281 gctaatcaca ggtgaccact caagttcttt caatgaagac ctgatgatgt atttagttcc
     5341 cattttccac ggtgattgac tcaatttaag tgtattgtgg ctatatgtaa tttacaggct
     5401 gctttgcgtt gcaggtggga aaatctccca ggctggtgtg aggctgaact ggggtaaaag
     5461 accccctgac ccctcctcat tcttctaagg tcaccacctc ttagagggtc tcttattttc
     5521 tttcagagat caaatgcaca gttatgctgt acaactaaat tctgcagtct tgggaatcct
     5581 tacgagtacc aactattagt cactttttaa agtccccaaa gtggagtgag gataggggga
     5641 gtggaagcag tgtttggttc ttactttacc caaactgtgt ataaagaata aagttagcag
     5701 aatgatgcca cagtca
//
