LOCUS       NM_016107               4717 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger RNA binding protein (ZFR), mRNA.
ACCESSION   NM_016107
VERSION     NM_016107.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4717)
  AUTHORS   Zhang,L., He,S., Guan,H., Zhao,Y. and Zhang,D.
  TITLE     Circulating RNA ZFR promotes hepatocellular carcinoma cell
            proliferation and epithelial-mesenchymal transition process through
            miR-624-3p/WEE1 axis
  JOURNAL   Hepatobiliary Pancreat Dis Int 23 (1), 52-63 (2024)
   PUBMED   37516591
  REMARK    GeneRIF: Circulating RNA ZFR promotes hepatocellular carcinoma cell
            proliferation and epithelial-mesenchymal transition process through
            miR-624-3p/WEE1 axis.
REFERENCE   2  (bases 1 to 4717)
  AUTHORS   Xu,R., Yin,S., Zheng,M., Pei,X. and Ji,X.
  TITLE     Circular RNA circZFR Promotes Hepatocellular Carcinoma Progression
            by Regulating miR-375/HMGA2 Axis
  JOURNAL   Dig Dis Sci 66 (12), 4361-4373 (2021)
   PUBMED   33433801
  REMARK    GeneRIF: Circular RNA circZFR Promotes Hepatocellular Carcinoma
            Progression by Regulating miR-375/HMGA2 Axis.
REFERENCE   3  (bases 1 to 4717)
  AUTHORS   Zhou,M., Yang,Z., Wang,D., Chen,P. and Zhang,Y.
  TITLE     The circular RNA circZFR phosphorylates Rb promoting cervical
            cancer progression by regulating the SSBP1/CDK2/cyclin E1 complex
  JOURNAL   J Exp Clin Cancer Res 40 (1), 48 (2021)
   PUBMED   33516252
  REMARK    GeneRIF: The circular RNA circZFR phosphorylates Rb promoting
            cervical cancer progression by regulating the SSBP1/CDK2/cyclin E1
            complex.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4717)
  AUTHORS   Long,Y., Marian,T.A. and Wei,Z.
  TITLE     ZFR promotes cell proliferation and tumor development in colorectal
            and liver cancers
  JOURNAL   Biochem Biophys Res Commun 513 (4), 1027-1034 (2019)
   PUBMED   31010678
  REMARK    GeneRIF: overexpression of ZFR in CRC and liver cancer cells led to
            accelerated tumor development. Consistently, knockdown of ZFR
            resulted in significantly decelerated tumor development.
REFERENCE   5  (bases 1 to 4717)
  AUTHORS   Xing,X., Wang,H., Zhang,Y., Niu,T., Jiang,Y., Shi,X., Wang,C. and
            Liu,K.
  TITLE     O- glycosylation can regulate the proliferation and migration of
            human retinal microvascular endothelial cells through ZFR in high
            glucose condition
  JOURNAL   Biochem Biophys Res Commun 512 (3), 552-557 (2019)
   PUBMED   30914198
  REMARK    GeneRIF: Hyperglycaemia elevates ZFR in vivo and in vitro. ZFR can
            promote the proliferation and migration of human retinal
            microvascular endothelial cells cultured in high glucose condition.
REFERENCE   6  (bases 1 to 4717)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 4717)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   8  (bases 1 to 4717)
  AUTHORS   Miyamoto-Sato,E., Fujimori,S., Ishizaka,M., Hirai,N., Masuoka,K.,
            Saito,R., Ozawa,Y., Hino,K., Washio,T., Tomita,M., Yamashita,T.,
            Oshikubo,T., Akasaka,H., Sugiyama,J., Matsumoto,Y. and Yanagawa,H.
  TITLE     A comprehensive resource of interacting protein regions for
            refining human transcription factor networks
  JOURNAL   PLoS One 5 (2), e9289 (2010)
   PUBMED   20195357
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4717)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   10 (bases 1 to 4717)
  AUTHORS   Kleines,M., Gartner,A., Ritter,K. and Schaade,L.
  TITLE     Cloning and expression of the human single copy homologue of the
            mouse zinc finger protein zfr
  JOURNAL   Gene 275 (1), 157-162 (2001)
   PUBMED   11574164
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA691446.1, BC017879.1,
            BC030540.1, AJ314790.1, BC051893.1 and AL137258.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_016107.4.
            
            Summary: This gene encodes an RNA-binding protein characterized by
            its DZF (domain associated with zinc fingers) domain. The encoded
            protein may play a role in the nucleocytoplasmic shuttling of
            another RNA-binding protein, Staufen homolog 2, in neurons.
            Expression of this gene is regulated through alternative
            polyadenylation that mediates differential microRNA targeting.
            Elevated expression of this gene has been observed in human
            patients with pancreatic cancer and knockdown of this gene may
            result in reduced viability and invasion of pancreatic cancer
            cells. [provided by RefSeq, Sep 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.68649.1,
                                           SRR1660809.166613.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265069.13/ ENSP00000265069.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DA691446.1         22-23
            3-502               BC017879.1         1-500
            503-1462            BC030540.1         473-1432
            1463-2055           AJ314790.1         1414-2006
            2056-3500           BC051893.1         645-2089
            3501-4717           AL137258.1         514-1730
FEATURES             Location/Qualifiers
     source          1..4717
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.3"
     gene            1..4717
                     /gene="ZFR"
                     /gene_synonym="SPG71; ZFR1"
                     /note="zinc finger RNA binding protein"
                     /db_xref="GeneID:51663"
                     /db_xref="HGNC:HGNC:17277"
                     /db_xref="MIM:615635"
     exon            1..119
                     /gene="ZFR"
                     /gene_synonym="SPG71; ZFR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..3307
                     /gene="ZFR"
                     /gene_synonym="SPG71; ZFR1"
                     /note="M-phase phosphoprotein homolog"
                     /codon_start=1
                     /product="zinc finger RNA-binding protein"
                     /protein_id="NP_057191.2"
                     /db_xref="CCDS:CCDS34139.1"
                     /db_xref="GeneID:51663"
                     /db_xref="HGNC:HGNC:17277"
                     /db_xref="MIM:615635"
                     /translation="MIPICPVVSFTYVPSRLGEDAKMATGNYFGFTHSGAAAAAAAAQ
                     YSQQPASGVAYSHPTTVASYTVHQAPVAAHTVTAAYAPAAATVAVARPAPVAVAAAAT
                     AAAYGGYPTAHTATDYGYTQRQQEAPPPPPPATTQNYQDSYSYVRSTAPAVAYDSKQY
                     YQQPTATAAAVAAAAQPQPSVAETYYQTAPKAGYSQGATQYTQAQQTRQVTAIKPATP
                     SPATTTFSIYPVSSTVQPVAAAATVVPSYTQSATYSTTAVTYSGTSYSGYEAAVYSAA
                     SSYYQQQQQQQKQAAAAAAAAAATAAWTGTTFTKKAPFQNKQLKPKQPPKPPQIHYCD
                     VCKISCAGPQTYKEHLEGQKHKKKEAALKASQNTSSSNSSTRGTQNQLRCELCDVSCT
                     GADAYAAHIRGAKHQKVVKLHTKLGKPIPSTEPNVVSQATSSTAVSASKPTASPSSIA
                     ANNCTVNTSSVATSSMKGLTTTGNSSLNSTSNTKVSAVPTNMAAKKTSTPKINFVGGN
                     KLQSTGNKAEDIKGTECVKSTPVTSAVQIPEVKQDTVSEPVTPASLAALQSDVQPVGH
                     DYVEEVRNDEGKVIRFHCKLCECSFNDPNAKEMHLKGRRHRLQYKKKVNPDLQVEVKP
                     SIRARKIQEEKMRKQMQKEEYWRRREEEERWRMEMRRYEEDMYWRRMEEEQHHWDDRR
                     RMPDGGYPHGPPGPLGLLGVRPGMPPQPQGPAPLRRPDSSDDRYVMTKHATIYPTEEE
                     LQAVQKIVSITERALKLVSDSLSEHEKNKNKEGDDKKEGGKDRALKGVLRVGVLAKGL
                     LLRGDRNVNLVLLCSEKPSKTLLSRIAENLPKQLAVISPEKYDIKCAVSEAAIILNSC
                     VEPKMQVTITLTSPIIREENMREGDVTSGMVKDPPDVLDRQKCLDALAALRHAKWFQA
                     RANGLQSCVIIIRILRDLCQRVPTWSDFPSWAMELLVEKAISSASSPQSPGDALRRVF
                     ECISSGIILKGSPGLLDPCEKDPFDTLATMTDQQREDITSSAQFALRLLAFRQIHKVL
                     GMDPLPQMSQRFNIHNNRKRRRDSDGVDGFEAEGKKDKKDYDNF"
     exon            120..219
                     /gene="ZFR"
                     /gene_synonym="SPG71; ZFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            220..502
                     /gene="ZFR"
                     /gene_synonym="SPG71; ZFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..647
                     /gene="ZFR"
                     /gene_synonym="SPG71; ZFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..866
                     /gene="ZFR"
                     /gene_synonym="SPG71; ZFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1114
                     /gene="ZFR"
                     /gene_synonym="SPG71; ZFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1306
                     /gene="ZFR"
                     /gene_synonym="SPG71; ZFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1598
                     /gene="ZFR"
                     /gene_synonym="SPG71; ZFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1795
                     /gene="ZFR"
                     /gene_synonym="SPG71; ZFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1915
                     /gene="ZFR"
                     /gene_synonym="SPG71; ZFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2061
                     /gene="ZFR"
                     /gene_synonym="SPG71; ZFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2224
                     /gene="ZFR"
                     /gene_synonym="SPG71; ZFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2430
                     /gene="ZFR"
                     /gene_synonym="SPG71; ZFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2581
                     /gene="ZFR"
                     /gene_synonym="SPG71; ZFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..2723
                     /gene="ZFR"
                     /gene_synonym="SPG71; ZFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2724..2821
                     /gene="ZFR"
                     /gene_synonym="SPG71; ZFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2822..2917
                     /gene="ZFR"
                     /gene_synonym="SPG71; ZFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3029
                     /gene="ZFR"
                     /gene_synonym="SPG71; ZFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3030..3127
                     /gene="ZFR"
                     /gene_synonym="SPG71; ZFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3128..4717
                     /gene="ZFR"
                     /gene_synonym="SPG71; ZFR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4696..4701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFR"
                     /gene_synonym="SPG71; ZFR1"
                     /note="hexamer: AGTAAA"
     polyA_site      4717
                     /gene="ZFR"
                     /gene_synonym="SPG71; ZFR1"
                     /note="major polyA site"
ORIGIN      
        1 ctgttctccg ctgaggagga gcggggcaga ggagggaggc agcgggtgag agttcagagt
       61 tcagcagcag cagcccgagc ccatgattcc catatgccct gtagtttctt tcacctatgt
      121 gcccagccgg ctgggggaag atgccaaaat ggcgaccggc aactactttg gattcaccca
      181 cagcggggcg gcggcggcgg cggctgcggc ccaatatagc cagcagccag cttcgggtgt
      241 agcctattct catccaacta cagttgctag ctacactgtc catcaggctc cagtagctgc
      301 tcacacagtt actgctgcct atgcaccagc agccgccaca gttgcagttg ccaggcctgc
      361 tccagtagct gttgcagctg ctgcaacagc tgctgcttat ggaggctacc ccactgcaca
      421 cacagcaact gactatggtt atactcagag gcaacaagaa gcaccaccac caccaccccc
      481 agctactaca caaaactacc aggattcata ctcatatgta aggtccacag ctcctgctgt
      541 agcttatgat agtaagcaat actaccaaca accaacagca actgctgctg ctgtagctgc
      601 cgctgcccaa cctcagcctt ctgttgctga aacttactat cagacagccc ccaaagcagg
      661 ttacagccaa ggtgcaactc agtatactca agcccagcaa actcgacaag tgacagccat
      721 aaaaccagcc acaccaagtc cagctaccac tactttctcc atctatcctg tatcctccac
      781 cgtacagcca gtagcagctg cggctactgt ggtgccatcc tatactcaga gtgctactta
      841 cagtaccaca gcagttacat attctggtac gtcttattca ggttatgaag cagcagtgta
      901 ttcagctgca tcttcctact atcaacagca gcagcagcaa cagaagcagg cagcagcagc
      961 agctgctgct gctgctgcaa cagctgcctg gacagggacc acctttacta aaaaagcacc
     1021 attccaaaat aaacaactga aaccaaaaca gcctcccaaa ccaccacaga ttcactattg
     1081 tgatgtttgt aagatcagct gtgctggacc acagacttat aaagaacatt tagaaggaca
     1141 gaaacataaa aaaaaagaag ctgcattgaa agcctcacaa aataccagca gcagcaacag
     1201 ttctactcgt gggactcaaa atcagctacg ttgtgagctc tgcgatgtgt cttgtacagg
     1261 agcagatgcg tatgctgccc acattcgtgg tgctaagcat cagaaagtgg ttaagttaca
     1321 cacaaaactt ggtaaaccca ttccatcaac agaaccaaat gttgttagcc aagctacttc
     1381 ttcaacagct gtatctgctt caaagccgac tgcctctcct tcaagcattg cagcaaacaa
     1441 ttgtactgtg aatacgtcat cagttgcaac gtcttcaatg aagggtctta cgactacagg
     1501 aaactcgtct cttaatagca catctaacac taaagtatca gcagtgccta caaatatggc
     1561 tgccaagaaa acatctaccc ccaaaataaa ttttgttggt ggtaataagc tgcagtcaac
     1621 aggaaataaa gcagaagaca taaaaggaac cgaatgtgtt aaaagtactc ctgtcacttc
     1681 tgctgtgcag attcctgaag taaagcaaga cacagtgtca gaaccagtca cacctgcatc
     1741 tcttgctgct ttacagagtg atgtgcagcc agtgggccat gattatgtgg aagaggtacg
     1801 aaatgatgaa ggaaaagtaa ttcggttcca ttgtaaatta tgcgagtgca gctttaatga
     1861 tcccaatgct aaggagatgc acttaaaagg gcgaagacac agacttcaat ataaaaaaaa
     1921 agtaaatcca gatttgcaag tagaagtaaa gcctagtatt cgagcaagaa agattcaaga
     1981 agagaaaatg aggaagcaaa tgcagaagga ggagtactgg cgaagacgag aagaagagga
     2041 gcgttggaga atggaaatga gacgttatga agaggacatg tactggagga gaatggagga
     2101 agaacaacat cattgggatg atcgccgccg aatgccagat ggaggttatc ctcatggtcc
     2161 tccaggccca ttaggccttc tgggagtccg accaggcatg cctcctcagc ctcaggggcc
     2221 tgcaccctta cgtcgtcctg actcatctga tgaccgttat gtaatgacaa aacatgccac
     2281 catttatcca actgaagagg agttacaggc agttcagaaa attgtttcta ttactgaacg
     2341 tgctttaaaa ctcgtttcag acagtttgtc tgaacatgag aagaacaaga acaaagaggg
     2401 agatgataag aaagagggag gtaaagacag agctttgaaa ggagttttgc gagtgggagt
     2461 attggcaaaa ggattacttc tccgaggaga tagaaatgtc aaccttgttt tgctgtgctc
     2521 agagaaacct tcaaagacat tattaagccg tattgcagaa aacctaccca aacagcttgc
     2581 tgttataagc cctgagaagt atgacataaa atgtgctgta tctgaagcgg caataatttt
     2641 gaattcatgt gtggaaccca aaatgcaagt cactatcaca ctgacatctc caattattcg
     2701 agaagagaac atgagggaag gagatgtaac ctcgggtatg gtgaaagacc caccggacgt
     2761 cttggacagg caaaaatgcc ttgacgctct ggctgctcta cgccacgcta agtggttcca
     2821 ggctagagct aatggtctgc agtcctgtgt gattatcata cgcattcttc gagacctctg
     2881 tcagcgagtt ccaacttggt ctgattttcc aagctgggct atggagttac tagtagagaa
     2941 agcaatcagc agtgcttcta gccctcagag ccctggggat gcactgagaa gagtttttga
     3001 atgcatttct tcagggatta ttcttaaagg tagtcctgga cttctggatc cttgtgaaaa
     3061 ggatcccttt gataccttgg caacaatgac tgaccagcag cgtgaagaca tcacatccag
     3121 tgcacagttt gcattgagac tccttgcatt ccgccagata cacaaagttc taggcatgga
     3181 tccattaccg caaatgagcc aacgttttaa catccacaac aacaggaaac gaagaagaga
     3241 tagtgatgga gttgatggat ttgaagctga ggggaaaaaa gacaaaaaag attatgataa
     3301 cttttaaaaa gtgtctgtaa atcttcagtg ttaaaaaaac agatgcccat ttgttggctg
     3361 tttttcattc ataataatgt ctacattgaa aaatttatca agaatttaaa ggatttcatg
     3421 gaagaaccaa gtttttctat gatattaaaa aatgtacagt gttaggtatt atttgaatgg
     3481 aaagacaccc aaaaaaaaaa atgtgctccg actaggggga aaacagtagt tccgattttt
     3541 tcccattatt tttattttat tttctggttg ccctagcttc cccccctatt tttgtgtctt
     3601 ttattaacta gtgcattgtc ttattaaatc ttcactgtat ttaatgcagg atgtgtgctt
     3661 cagttgctct gtgtattttg atattttaat ttagaggttt tgtttgcttt ttgacactag
     3721 ttgtaagtta ctttgttata gatggtatcc tttacccctt cttaatattt tacagcagta
     3781 cgtttttttg taacgtgaga ctgcagagtt tgtttttcta tatgtgaagg attacaacac
     3841 aaaaagttat cctgccattc gagtgctcag aactgaatgt ttctgcagat cttgtggcat
     3901 ttgtctctag tgtgatatat aaaggtgtaa ttaagacaga gttctgttaa tctaatcaag
     3961 tttgctgtta gttgtgcatt agcagtataa aagctaatat atactatatg gtcttgcaac
     4021 agttttaaag cctctgcata attgataata aaaatgcatg acattcttgt ttttaataga
     4081 cttttaaaat cataatttta ggtttaacac gtagatcttt gtacagttga ctttttgaca
     4141 tagcaaggcc aaaaataact ttctgaatat ttttttcttg tgtataagtg gaaagggcat
     4201 ttttcacata taagtgggct aaccaatatt ttcaaaagaa cttcatcatt gtacaactaa
     4261 caacagtaac tagcccttaa ttatggtgac agttccttat tggtgtgtgt gagattactc
     4321 tagcaactat tacagtataa cacagatgat cttctccaca caccccatca cccagataat
     4381 ttacagttct gttaacagtg aggttgataa agtattactg ataaaaaatt atctaaggaa
     4441 aaaaacagaa aattatttgg tgtggccatc ttacctgctt atgtctccta cacaaagcta
     4501 aatattctag cagtgatgta atgaaaaatt acatcttact gttgatatat gtatgctctg
     4561 gtacacagat gtcattttgt tgtcacagca ctacagtgaa atacacaaaa aatgaaattc
     4621 atataatgac ttaaatgtat tatatgttag aattgacaac ataaactact tttgctttga
     4681 aatgatgtat gcttcagtaa aatcatattc aaattta
//
