LOCUS       NM_012082               4961 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens zinc finger protein, FOG family member 2 (ZFPM2),
            transcript variant 1, mRNA.
ACCESSION   NM_012082
VERSION     NM_012082.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4961)
  AUTHORS   Broman,M.T., Nadadur,R.D., Perez-Cervantes,C., Burnicka-Turek,O.,
            Lazarevic,S., Gams,A., Laforest,B., Steimle,J.D., Iddir,S.,
            Wang,Z., Smith,L., Mazurek,S.R., Olivey,H.E., Zhou,P., Gadek,M.,
            Shen,K.M., Khan,Z., Theisen,J.W.M., Yang,X.H., Ikegami,K.,
            Efimov,I.R., Pu,W.T., Weber,C.R., McNally,E.M., Svensson,E.C. and
            Moskowitz,I.P.
  TITLE     A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2
            Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network
  JOURNAL   Circulation 149 (15), 1205-1230 (2024)
   PUBMED   38189150
  REMARK    GeneRIF: A Genomic Link From Heart Failure to Atrial Fibrillation
            Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory
            Network.
REFERENCE   2  (bases 1 to 4961)
  AUTHORS   Hirano,T., Tsuruda,T., Tanaka,Y., Harada,H., Yamazaki,T. and
            Ishida,A.
  TITLE     Long noncoding RNA CCDC26 as a modulator of transcriptional
            switching between fetal and embryonic globins
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (3), 118931 (2021)
   PUBMED   33340546
  REMARK    GeneRIF: Long noncoding RNA CCDC26 as a modulator of
            transcriptional switching between fetal and embryonic globins.
REFERENCE   3  (bases 1 to 4961)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4961)
  AUTHORS   Song,Z., Gao,S., Liu,Y.M., Wang,Y., Sun,Z.X., Bao,D. and Liu,C.
  TITLE     EphA3 promotes the proliferation of NPC cells through negatively
            regulating the ability of FOG2
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (12), 6735-6743 (2020)
   PUBMED   32633364
  REMARK    GeneRIF: EphA3 promotes the proliferation of NPC cells through
            negatively regulating the ability of FOG2.
REFERENCE   5  (bases 1 to 4961)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4961)
  AUTHORS   Crispino,J.D., Lodish,M.B., Thurberg,B.L., Litovsky,S.H.,
            Collins,T., Molkentin,J.D. and Orkin,S.H.
  TITLE     Proper coronary vascular development and heart morphogenesis depend
            on interaction of GATA-4 with FOG cofactors
  JOURNAL   Genes Dev 15 (7), 839-844 (2001)
   PUBMED   11297508
REFERENCE   7  (bases 1 to 4961)
  AUTHORS   Holmes,M., Turner,J., Fox,A., Chisholm,O., Crossley,M. and Chong,B.
  TITLE     hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2
            and modulates GATA-mediated activation
  JOURNAL   J Biol Chem 274 (33), 23491-23498 (1999)
   PUBMED   10438528
REFERENCE   8  (bases 1 to 4961)
  AUTHORS   Fox,A.H., Liew,C., Holmes,M., Kowalski,K., Mackay,J. and
            Crossley,M.
  TITLE     Transcriptional cofactors of the FOG family interact with GATA
            proteins by means of multiple zinc fingers
  JOURNAL   EMBO J 18 (10), 2812-2822 (1999)
   PUBMED   10329627
REFERENCE   9  (bases 1 to 4961)
  AUTHORS   Svensson,E.C., Tufts,R.L., Polk,C.E. and Leiden,J.M.
  TITLE     Molecular cloning of FOG-2: a modulator of transcription factor
            GATA-4 in cardiomyocytes
  JOURNAL   Proc Natl Acad Sci U S A 96 (3), 956-961 (1999)
   PUBMED   9927675
REFERENCE   10 (bases 1 to 4961)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC041039.8, BC109222.1,
            BC020928.1 and AL389988.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_012082.3.
            
            Summary: The zinc finger protein encoded by this gene is a widely
            expressed member of the FOG family of transcription factors. The
            family members modulate the activity of GATA family proteins, which
            are important regulators of hematopoiesis and cardiogenesis in
            mammals. It has been demonstrated that the protein can both
            activate and down-regulate expression of GATA-target genes,
            suggesting different modulation in different promoter contexts. A
            related mRNA suggests an alternatively spliced product but this
            information is not yet fully supported by the sequence. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.102410.1,
                                           SRR1660805.58011.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000407775.7/ ENSP00000384179.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-481               AC041039.8         69691-70171         c
            482-4010            BC109222.1         2-3530
            4011-4958           BC020928.1         1468-2415
            4959-4961           AL389988.1         1234-1236
FEATURES             Location/Qualifiers
     source          1..4961
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q23.1"
     gene            1..4961
                     /gene="ZFPM2"
                     /gene_synonym="DIH3; FOG2; hFOG-2; SRXY9; ZC2HC11B;
                     ZNF89B"
                     /note="zinc finger protein, FOG family member 2"
                     /db_xref="GeneID:23414"
                     /db_xref="HGNC:HGNC:16700"
                     /db_xref="MIM:603693"
     exon            1..544
                     /gene="ZFPM2"
                     /gene_synonym="DIH3; FOG2; hFOG-2; SRXY9; ZC2HC11B;
                     ZNF89B"
                     /inference="alignment:Splign:2.1.0"
     CDS             505..3960
                     /gene="ZFPM2"
                     /gene_synonym="DIH3; FOG2; hFOG-2; SRXY9; ZC2HC11B;
                     ZNF89B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor GATA4, modulator of; Friend of GATA2;
                     zinc finger protein ZFPM2; FOG-2; friend of GATA 2; friend
                     of GATA protein 2; zinc finger protein 89B; zinc finger
                     protein, multitype 2"
                     /codon_start=1
                     /product="zinc finger protein ZFPM2 isoform 1"
                     /protein_id="NP_036214.2"
                     /db_xref="CCDS:CCDS47908.1"
                     /db_xref="GeneID:23414"
                     /db_xref="HGNC:HGNC:16700"
                     /db_xref="MIM:603693"
                     /translation="MSRRKQSKPRQIKRPLEDAIEDEEEECPSEETDIISKGDFPLEE
                     SFSTEFGPENLSCEEVEYFCNKGDDEGIQETAESDGDTQSEKPGQPGVETDDWDGPGE
                     LEVFQKDGERKIQSRQQLPVGTTWGPFPGKMDLNNNSLKTKAQVPMVLTAGPKWLLDV
                     TWQGVEDNKNNCIVYSKGGQLWCTTTKAISEGEELIAFVVDFDSRLQAASQMTLTEGM
                     YPARLLDSIQLLPQQAAMASILPTAIVNKDIFPCKSCGIWYRSERNLQAHLMYYCSGR
                     QREAAPVSEENEDSAHQISSLCPFPQCTKSFSNARALEMHLNSHSGVKMEEFLPPGAS
                     LKCTVCSYTADSVINFHQHLFSHLTQAAFRCNHCHFGFQTQRELLQHQELHVPSGKLP
                     RESDMEHSPSATEDSLQPATDLLTRSELPQSQKAMQTKDASSDTELDKCEKKTQLFLT
                     NQRPEIQPTTNKQSFSYTKIKSEPSSPRLASSPVQPNIGPSFPVGPFLSQFSFPQDIT
                     MVPQASEILAKMSELVHRRLRHGSSSYPPVIYSPLMPKGATCFECNITFNNLDNYLVH
                     KKHYCSSRWQQMAKSPEFPSVSEKMPEALSPNTGQTSINLLNPAAHSADPENPLLQTS
                     CINSSTVLDLIGPNGKGHDKDFSTQTKKLSTSSNNDDKINGKPVDVKNPSVPLVDGES
                     DPNKTTCEACNITFSRHETYMVHKQYYCATRHDPPLKRSASNKVPAMQRTMRTRKRRK
                     MYEMCLPEQEQRPPLVQQRFLDVANLNNPCTSTQEPTEGLGECYHPRCDIFPGIVSKH
                     LETSLTINKCVPVSKCDTTHSSVSCLEMDVPIDLSKKCLSQSERTTTSPKRLLDYHEC
                     TVCKISFNKVENYLAHKQNFCPVTAHQRNDLGQLDGKVFPNPESERNSPDVSYERSII
                     KCEKNGNLKQPSPNGNLFSSHLATLQGLKVFSEAAQLIATKEENRHLFLPQCLYPGAI
                     KKAKGADQLSPYYGIKPSDYISGSLVIHNTDIEQSRNAENESPKGQASSNGCAALKKD
                     SLPLLPKNRGMVIVNGGLKQDERPAANPQQENISQNPQHEDDHKSPSWISENPLAANE
                     NVSPGIPSAEEQLSSIAKGVNGSSQAPTSGKYCRLCDIQFNNLSNFITHKKFYCSSHA
                     AEHVK"
     exon            545..703
                     /gene="ZFPM2"
                     /gene_synonym="DIH3; FOG2; hFOG-2; SRXY9; ZC2HC11B;
                     ZNF89B"
                     /inference="alignment:Splign:2.1.0"
     exon            704..805
                     /gene="ZFPM2"
                     /gene_synonym="DIH3; FOG2; hFOG-2; SRXY9; ZC2HC11B;
                     ZNF89B"
                     /inference="alignment:Splign:2.1.0"
     exon            806..924
                     /gene="ZFPM2"
                     /gene_synonym="DIH3; FOG2; hFOG-2; SRXY9; ZC2HC11B;
                     ZNF89B"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1036
                     /gene="ZFPM2"
                     /gene_synonym="DIH3; FOG2; hFOG-2; SRXY9; ZC2HC11B;
                     ZNF89B"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1243
                     /gene="ZFPM2"
                     /gene_synonym="DIH3; FOG2; hFOG-2; SRXY9; ZC2HC11B;
                     ZNF89B"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1468
                     /gene="ZFPM2"
                     /gene_synonym="DIH3; FOG2; hFOG-2; SRXY9; ZC2HC11B;
                     ZNF89B"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..4961
                     /gene="ZFPM2"
                     /gene_synonym="DIH3; FOG2; hFOG-2; SRXY9; ZC2HC11B;
                     ZNF89B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4937..4942
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFPM2"
                     /gene_synonym="DIH3; FOG2; hFOG-2; SRXY9; ZC2HC11B;
                     ZNF89B"
                     /note="hexamer: AATAAA"
     polyA_site      4961
                     /gene="ZFPM2"
                     /gene_synonym="DIH3; FOG2; hFOG-2; SRXY9; ZC2HC11B;
                     ZNF89B"
                     /note="major polyA site"
ORIGIN      
        1 agaacaggag ctgcgcggcc cggagcggcg gcggcggcgc cggagtatcc gtcccgcacg
       61 ccggggcgag gggcgagcga gcgcgctcct cctcccgcgc cctgcgcccc cgcgctcccc
      121 ctctcctcgc tgctcgctct cccgtccctc cctccttctc ttccttcttt ccgtgttatt
      181 tttctcttct ctttcccctt ttctctctcc ctgaccgttc gcttgtacat tcccattctc
      241 cccccgtcgc tctcctctcc ccctcccctc ctcactgtca cactctctgt gcccccgtct
      301 ctcttctctc atttgcttgc tcatctccga acgtgaatcc gcggctcccg gaggagccca
      361 gcgcccggag cacctggagt ccggccggcg gcgggccgag cctggccagc ggcggcggcg
      421 gcggcggcgg cggcgggagc cgagggagcg gcagccgcga ccgcgggcac cgcgggagcc
      481 ccagcggcag cagccgccgc cgagatgtcc cggcgaaagc aaagcaaacc ccggcagatc
      541 aaacggccgc ttgaagatgc cattgaagat gaggaagaag aatgtccatc agaggaaaca
      601 gacatcatct ccaaaggaga ctttccattg gaggaaagct tttccacaga atttgggcct
      661 gaaaatctga gctgcgaaga agtggaatac ttttgtaaca aaggtgatga tgaaggaatc
      721 caggagacag cagaatcaga tggggacaca cagtcagaga aaccggggca acctggagtt
      781 gagacagacg actgggatgg accaggagag ctggaggtgt ttcagaaaga tggggaacga
      841 aaaattcaga gtcgacagca acttccagtg ggaacaacct gggggccgtt tcctgggaag
      901 atggacttga ataataattc tttgaagaca aaggctcagg tcccaatggt gctgactgct
      961 ggtcccaagt ggttgctgga tgtgacttgg caaggagtgg aagacaacaa aaacaactgc
     1021 attgtgtaca gcaaaggggg tcagctttgg tgtacaacta cgaaggccat ctctgagggt
     1081 gaagagctaa ttgcctttgt ggtggatttt gactcaaggc tacaagctgc cagtcagatg
     1141 actctcacag aagggatgta ccctgcacgc ctgctggact caattcagct gcttcctcag
     1201 caagctgcca tggcttctat tttgcccaca gctattgtca ataaggatat attcccttgc
     1261 aagtcctgtg gcatctggta tcggagtgag cggaatctgc aggcccattt gatgtactac
     1321 tgcagtggga ggcaaagaga agctgctccg gtgtcagagg aaaatgaaga cagtgcccat
     1381 cagatttcca gcctgtgccc cttcccacag tgcaccaaga gcttttcaaa tgctcgagct
     1441 ctagaaatgc acctgaattc acacagtgga gtgaaaatgg aagaattcct gccccctggt
     1501 gctagtctaa aatgcaccgt ctgtagctac actgctgatt ccgtgatcaa ctttcaccaa
     1561 cacctgttct cccatctcac tcaagctgcc ttccgatgta atcactgcca tttcggcttc
     1621 cagactcaga gggagttatt gcagcaccag gagctccatg tccctagcgg caaacttccc
     1681 agagaaagtg acatggaaca ctctccaagt gcaactgaag acagcttaca gccagccaca
     1741 gacttattga ccagaagcga acttccccag agccaaaagg ccatgcagac taaagatgcg
     1801 agctctgaca cagagctgga caagtgtgag aaaaagactc agctctttct cacgaaccag
     1861 agaccagaga tacagcctac aacaaataaa caaagctttt cttacacaaa aataaagtct
     1921 gagccctcta gcccaagact tgcctcatct ccagttcagc ctaatattgg gccttctttc
     1981 cctgtgggcc ctttcctatc tcagttttct ttcccccaag atatcaccat ggtccctcaa
     2041 gcttcagaga tcttagctaa gatgtctgaa ctggtgcatc ggcgactgag gcatggcagt
     2101 agtagctacc ctcccgtcat ttacagccct ttgatgccca agggggctac ttgttttgag
     2161 tgtaacataa cattcaataa tttggataat tatctagtgc acaaaaagca ttattgcagc
     2221 agccgatggc agcagatggc taagtcccca gagttcccta gtgtgtcaga aaagatgcct
     2281 gaagctttga gtcccaacac tggccaaacc tccataaacc ttctcaaccc agctgctcat
     2341 tctgctgatc ctgagaatcc acttcttcaa acatcttgca tcaattcttc cactgtctta
     2401 gatttaattg ggccaaatgg gaagggccat gacaaggact tttccactca aactaagaag
     2461 ctctccacct ccagtaacaa tgatgacaaa attaatggaa aacctgttga tgtgaaaaat
     2521 cccagtgtcc ccttagtgga tggggaaagt gacccaaata agactacctg tgaagcttgc
     2581 aacattacct tcagccggca cgaaacatac atggtccaca aacagtatta ctgtgctaca
     2641 cgccacgacc ctccactgaa gaggtctgct tccaacaaag tgcctgccat gcagagaacc
     2701 atgcgcacac gcaagcgcag aaagatgtat gagatgtgcc tacctgagca ggaacaaagg
     2761 cctccactgg ttcagcagag atttcttgac gtagccaacc tcaataatcc ttgtacctcc
     2821 actcaagaac ccacagaagg gctaggagag tgctaccacc caagatgtga tatctttcca
     2881 ggaattgtct ctaaacactt ggaaacttct ctgacgatca acaagtgtgt tccagtttcc
     2941 aaatgtgata ctactcattc cagtgtttcc tgcctagaga tggacgtgcc catagatctc
     3001 agcaaaaagt gtttatctca gtctgagcgg acgaccacgt ctcccaaaag gctgctggac
     3061 tatcacgagt gcactgtgtg caagatcagt ttcaataagg tagaaaacta tctggcccac
     3121 aagcagaatt tctgcccggt tactgcacat cagcgtaatg acctgggtca actggacggc
     3181 aaagtgtttc cgaatccaga aagcgaacga aacagccctg atgtcagcta cgaaagaagc
     3241 ataataaaat gtgagaaaaa tgggaatttg aagcagcctt cccccaatgg aaacttattt
     3301 tcatcccacc tagcaaccct gcaaggcttg aaggtcttta gtgaagctgc tcagctcatt
     3361 gctacaaaag aagaaaacag acatttgttt cttccacaat gcctttaccc tggagcaata
     3421 aagaaagcaa aaggagccga ccagctttct ccatattatg gaatcaagcc aagtgattat
     3481 atttctggtt ctcttgtcat ccataacact gacatcgagc aaagcagaaa tgcagaaaat
     3541 gaatctccta aaggccaggc ttcctcaaat gggtgtgctg cgctgaagaa agattctctg
     3601 ccattgttgc ccaaaaatcg aggaatggta atagtgaatg gtggactgaa acaagatgag
     3661 agacctgctg ccaacccaca gcaagagaac atttcccaga atcctcagca cgaagacgac
     3721 cacaaatctc cctcgtggat ctctgagaac ccattagctg ccaatgagaa tgtctcacca
     3781 ggaattccct cagcagagga acagttgtct agtatagcaa aaggtgtgaa tggttccagc
     3841 caggctccaa ccagtgggaa atattgccgg ctatgtgata tccagttcaa caacctttca
     3901 aactttataa ctcacaagaa gttttattgc tcatcacatg cagcagaaca tgtcaaatga
     3961 actaactaaa catcagtcac ctttggtatc agtgtttagt atgttgttct aaccagtcca
     4021 gaaaaaaaaa taagctgttt gaattacatc tgggcaatca ggagataatt cattatggct
     4081 gagttgaaga cttaaggtgt aatttcatta cagtccatta gtaaagtgta ttattggtgc
     4141 cattttcaaa aaaattaatt tattttacca gcagtattca tagctgtggt tatgttattt
     4201 tttatttaaa aactttatat taaagtcatt tgtaatgtta ttgtatagtt attgtgtagc
     4261 acatatggtt tgcactgtat agtagctttt aaagaaaata gtcacaatac agaaaagcat
     4321 tttagaaata gcttcaaaag cacttgtgta tcttgatttt ttcttatatg ctgttgcaga
     4381 tatatgtata tgctaaaata taacttgcaa agatgttcta aatacacatg ctataagttc
     4441 gccttaagat ttcaattctt ggataatcag gctctgtttg cactttatat tttagcagat
     4501 acagtctctt agtcactagg ctttgcattt gtatgtagct gtatgtttcc gtccattttc
     4561 ttaatcctga acctgtatgt taaatgaaga tggcaatttt tttcttgtat agtacttgta
     4621 ttttctttcg ctgatgcagc tctgtctcaa tttttaaacc tttgctgtta aatgcaatac
     4681 tttataaaga atgaacaaaa ttactggaag cagtattgta agtaatgagg tagtattaat
     4741 cagttttatc ttttgaaagg cacagtctaa atcgaaaccc taaactcaat gctgcaagta
     4801 tgaatttaat tcatatataa gatctattta aatataagag tagcaatact gcacctggtg
     4861 atcacaaaga taatgttcta cttctgatag aaataatttc tcaacaaatg ttgttactat
     4921 gcatgtatat ggatggaata aaattccaga ttgttggaga a
//
