LOCUS       NM_153813               5432 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein, FOG family member 1 (ZFPM1),
            mRNA.
ACCESSION   NM_153813
VERSION     NM_153813.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5432)
  AUTHORS   Liu,G., Hou,Y., Jin,X., Zhang,Y., Sun,C., Huang,C., Ren,Y., Gao,J.,
            Wang,X. and Jiang,X.
  TITLE     PI3K/HSCB axis facilitates FOG1 nuclear translocation to promote
            erythropoiesis and megakaryopoiesis
  JOURNAL   Elife 13, 95815 (2024)
   PUBMED   38757931
  REMARK    GeneRIF: PI3K/HSCB axis facilitates FOG1 nuclear translocation to
            promote erythropoiesis and megakaryopoiesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5432)
  AUTHORS   Mansoorabadi,Z. and Kheirandish,M.
  TITLE     The upregulation of Gata transcription factors family and FOG-1 in
            expanded and differentiated cord blood-derived CD34+ hematopoietic
            stem cells to megakaryocyte lineage during co-culture with cord
            blood mesenchymal stem cells
  JOURNAL   Transfus Apher Sci 61 (6), 103481 (2022)
   PUBMED   35690555
  REMARK    GeneRIF: The upregulation of Gata transcription factors family and
            FOG-1 in expanded and differentiated cord blood-derived CD34[+]
            hematopoietic stem cells to megakaryocyte lineage during co-culture
            with cord blood mesenchymal stem cells.
REFERENCE   3  (bases 1 to 5432)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5432)
  AUTHORS   Lyv,X., Wu,F., Zhang,H., Lu,J., Wang,L. and Ma,Y.
  TITLE     Long Noncoding RNA ZFPM2-AS1 Knockdown Restrains the Development of
            Retinoblastoma by Modulating the
            MicroRNA-515/HOXA1/Wnt/beta-Catenin Axis
  JOURNAL   Invest Ophthalmol Vis Sci 61 (6), 41 (2020)
   PUBMED   32561925
  REMARK    GeneRIF: Long Noncoding RNA ZFPM2-AS1 Knockdown Restrains the
            Development of Retinoblastoma by Modulating the
            MicroRNA-515/HOXA1/Wnt/beta-Catenin Axis.
REFERENCE   5  (bases 1 to 5432)
  AUTHORS   Fujiwara,T., Sasaki,K., Saito,K., Hatta,S., Ichikawa,S.,
            Kobayashi,M., Okitsu,Y., Fukuhara,N., Onishi,Y. and Harigae,H.
  TITLE     Forced FOG1 expression in erythroleukemia cells: Induction of
            erythroid genes and repression of myelo-lymphoid transcription
            factor PU.1
  JOURNAL   Biochem Biophys Res Commun 485 (2), 380-387 (2017)
   PUBMED   28216155
  REMARK    GeneRIF: Forced FOG1 protein expression in K562 erythroleukemia
            cells induced the expression of SLC4A1 protein, but repressed that
            of transcription factor PU.1.
REFERENCE   6  (bases 1 to 5432)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   7  (bases 1 to 5432)
  AUTHORS   Freson,K., Thys,C., Wittewrongel,C., Vermylen,J., Hoylaerts,M.F.
            and Van Geet,C.
  TITLE     Molecular cloning and characterization of the GATA1 cofactor human
            FOG1 and assessment of its binding to GATA1 proteins carrying D218
            substitutions
  JOURNAL   Hum Genet 112 (1), 42-49 (2003)
   PUBMED   12483298
  REMARK    GeneRIF: Erythroid and megakaryocytic lineage differentiation and
            maturation are regulated via cooperation between transcription
            factor GATA1 and its essential cofactor FOG1.  It depends on the
            binding of FOG1 to the N-terminalfinger of GATA1.
REFERENCE   8  (bases 1 to 5432)
  AUTHORS   Mehaffey,M.G., Newton,A.L., Gandhi,M.J., Crossley,M. and
            Drachman,J.G.
  TITLE     X-linked thrombocytopenia caused by a novel mutation of GATA-1
  JOURNAL   Blood 98 (9), 2681-2688 (2001)
   PUBMED   11675338
REFERENCE   9  (bases 1 to 5432)
  AUTHORS   Turner,J. and Crossley,M.
  TITLE     Cloning and characterization of mCtBP2, a co-repressor that
            associates with basic Kruppel-like factor and other mammalian
            transcriptional regulators
  JOURNAL   EMBO J 17 (17), 5129-5140 (1998)
   PUBMED   9724649
REFERENCE   10 (bases 1 to 5432)
  AUTHORS   Tsang,A.P., Visvader,J.E., Turner,C.A., Fujiwara,Y., Yu,C.,
            Weiss,M.J., Crossley,M. and Orkin,S.H.
  TITLE     FOG, a multitype zinc finger protein, acts as a cofactor for
            transcription factor GATA-1 in erythroid and megakaryocytic
            differentiation
  JOURNAL   Cell 90 (1), 109-119 (1997)
   PUBMED   9230307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135049.2, BE219988.1, AF488691.1 and AC116552.2.
            
            On Nov 23, 2018 this sequence version replaced NM_153813.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF488691.1, SRR9304718.189005.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319555.8/ ENSP00000326630.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-326               AC135049.2         63991-64316         c
            327-761             BE219988.1         1-435
            762-1689            AF488691.1         725-1652
            1690-3567           AC116552.2         131414-133291       c
            3568-5432           AC116552.2         129549-131413       c
FEATURES             Location/Qualifiers
     source          1..5432
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.2"
     gene            1..5432
                     /gene="ZFPM1"
                     /gene_synonym="FOG; FOG1; ZC2HC11A; ZNF408; ZNF89A"
                     /note="zinc finger protein, FOG family member 1"
                     /db_xref="GeneID:161882"
                     /db_xref="HGNC:HGNC:19762"
                     /db_xref="MIM:601950"
     exon            1..399
                     /gene="ZFPM1"
                     /gene_synonym="FOG; FOG1; ZC2HC11A; ZNF408; ZNF89A"
                     /inference="alignment:Splign:2.1.0"
     CDS             360..3380
                     /gene="ZFPM1"
                     /gene_synonym="FOG; FOG1; ZC2HC11A; ZNF408; ZNF89A"
                     /note="FOG-1; friend of GATA 1; friend of GATA protein 1;
                     zinc finger protein 89A; zinc finger protein, multitype 1"
                     /codon_start=1
                     /product="zinc finger protein ZFPM1"
                     /protein_id="NP_722520.2"
                     /db_xref="CCDS:CCDS32502.1"
                     /db_xref="GeneID:161882"
                     /db_xref="HGNC:HGNC:19762"
                     /db_xref="MIM:601950"
                     /translation="MSRRKQSNPRQIKRSLGDMEAREEVQLVGASHMEQKATAPEAPS
                     PPSADVNSPPPLPPPTSPGGPKELEGQEPEPRPTEEEPGSPWSGPDELEPVVQDGQRR
                     IRARLSLATGLSWGPFHGSVQTRASSPRQAEPSPALTLLLVDEACWLRTLPQALTEAE
                     ANTEIHRKDDALWCRVTKPVPAGGLLSVLLTAEPHSTPGHPVKKEPAEPTCPAPAHDL
                     QLLPQQAGMASILATAVINKDVFPCKDCGIWYRSERNLQAHLLYYCASRQGTGSPAAA
                     ATDEKPKETYPNERVCPFPQCRKSCPSASSLEIHMRSHSGERPFVCLICLSAFTTKAN
                     CERHLKVHTDTLSGVCHSCGFISTTRDILYSHLVTNHMVCQPGSKGEIYSPGAGHPAT
                     KLPPDSLGSFQQQHTALQGPLASADLGLAPTPSPGLDRKALAEATNGEARAEPLAQNG
                     GSSEPPAAPRSIKVEAVEEPEAAPILGPGEPGPQAPSRTPSPRSPAPARVKAELSSPT
                     PGSSPVPGELGLAGALFLPQYVFGPDAAPPASEILAKMSELVHSRLQQGAGAGAGGAQ
                     TGLFPGAPKGATCFECEITFSNVNNYYVHKRLYCSGRRAPEDAPAARRPKAPPGPARA
                     PPGQPAEPDAPRSSPGPGAREEGAGGAATPEDGAGGRGSEGSQSPGSSVDDAEDDPSR
                     TLCEACNIRFSRHETYTVHKRYYCASRHDPPPRRPAAPPGPPGPAAPPAPSPAAPVRT
                     RRRRKLYELHAAGAPPPPPPGHAPAPESPRPGSGSGSGPGLAPARSPGPAADGPIDLS
                     KKPRRPLPGAPAPALADYHECTACRVSFHSLEAYLAHKKYSCPAAPPPGALGLPAAAC
                     PYCPPNGPVRGDLLEHFRLAHGLLLGAPLAGPGVEARTPADRGPSPAPAPAASPQPGS
                     RGPRDGLGPEPQEPPPGPPPSPAAAPEAVPPPPAPPSYSDKGVQTPSKGTPAPLPNGN
                     HRYCRLCNIKFSSLSTFIAHKKYYCSSHAAEHVK"
     exon            400..504
                     /gene="ZFPM1"
                     /gene_synonym="FOG; FOG1; ZC2HC11A; ZNF408; ZNF89A"
                     /inference="alignment:Splign:2.1.0"
     exon            505..627
                     /gene="ZFPM1"
                     /gene_synonym="FOG; FOG1; ZC2HC11A; ZNF408; ZNF89A"
                     /inference="alignment:Splign:2.1.0"
     exon            628..761
                     /gene="ZFPM1"
                     /gene_synonym="FOG; FOG1; ZC2HC11A; ZNF408; ZNF89A"
                     /inference="alignment:Splign:2.1.0"
     exon            762..864
                     /gene="ZFPM1"
                     /gene_synonym="FOG; FOG1; ZC2HC11A; ZNF408; ZNF89A"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1071
                     /gene="ZFPM1"
                     /gene_synonym="FOG; FOG1; ZC2HC11A; ZNF408; ZNF89A"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1305
                     /gene="ZFPM1"
                     /gene_synonym="FOG; FOG1; ZC2HC11A; ZNF408; ZNF89A"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1401
                     /gene="ZFPM1"
                     /gene_synonym="FOG; FOG1; ZC2HC11A; ZNF408; ZNF89A"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1548
                     /gene="ZFPM1"
                     /gene_synonym="FOG; FOG1; ZC2HC11A; ZNF408; ZNF89A"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..5432
                     /gene="ZFPM1"
                     /gene_synonym="FOG; FOG1; ZC2HC11A; ZNF408; ZNF89A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3542..3547
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFPM1"
                     /gene_synonym="FOG; FOG1; ZC2HC11A; ZNF408; ZNF89A"
                     /note="hexamer: AATAAA"
     polyA_site      3565
                     /gene="ZFPM1"
                     /gene_synonym="FOG; FOG1; ZC2HC11A; ZNF408; ZNF89A"
                     /note="major polyA site"
     regulatory      5399..5404
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFPM1"
                     /gene_synonym="FOG; FOG1; ZC2HC11A; ZNF408; ZNF89A"
                     /note="hexamer: AGTAAA"
     polyA_site      5432
                     /gene="ZFPM1"
                     /gene_synonym="FOG; FOG1; ZC2HC11A; ZNF408; ZNF89A"
ORIGIN      
        1 agcccgccag gagcgccctc gcagtggccg cctgctccgc cgctcgccgc ccgcgggttc
       61 cattgagaaa agccgagcgg ccgcggcggc ggcggcgagt gcgcgggagc ggaggagccg
      121 gcacccgccc gtcgggcagt ccgcgcgccc gcaacgcagg accgtggcct ctcgggcctc
      181 cgcggcagct ccagcggctc cggggctggg cgcgcgggct gggggcgcgg gccggggcgg
      241 ccgcggagac cgggggccgg gggcatgagc ggccccgcgg ccccgccgcg cccccgccgc
      301 ccgccgccgc ccgcccgggg ctagaggcgg ccgccgggag ggcgcgcggc gccggagaca
      361 tgtccaggcg gaaacagagc aacccccggc agatcaagcg ttccctcgga gacatggagg
      421 ccagagagga ggtgcagttg gtgggtgcca gccacatgga gcaaaaggcc acggcacctg
      481 aagccccgag ccctcccagc gcagatgtta actcaccccc accgctgccg ccccccacat
      541 ccccaggagg ccccaaggag ctggaaggac aggaaccaga acccaggccc acggaggaag
      601 agccgggcag tccctggagc gggccagacg agctggagcc ggtggtgcag gatgggcaga
      661 ggcgcatacg ggcccgactc agcctcgcca cgggcctgtc ctggggcccg ttccatggga
      721 gtgtccagac cagagcctca tcccccaggc aggcggagcc gagcccagcc ctgaccctgc
      781 tgctggtgga cgaggcctgc tggctgagga cgctgcccca ggccctgact gaggccgagg
      841 ccaacacaga gatccacagg aaggatgacg cactctggtg cagggtcacc aagccggtgc
      901 ctgcgggggg actcctgagc gtgctcctca cggccgagcc ccacagcacc cccggccacc
      961 ctgtgaagaa ggagccagca gagcccacgt gcccggcccc tgcacacgac ctccagctcc
     1021 tgccccagca ggccgggatg gcctccatcc ttgccaccgc agtgatcaac aaagacgtct
     1081 tcccctgcaa ggactgtggc atctggtacc gcagcgagcg caacctgcag gcgcacctgc
     1141 tctactactg cgccagccgc cagggcaccg gctccccggc cgcagccgcc acagacgaga
     1201 agcccaaaga gacctacccc aacgagcgcg tctgcccctt cccccagtgc cgcaagagct
     1261 gccccagcgc cagctccctg gagatccaca tgcgcagcca cagcggagag cggcccttcg
     1321 tgtgcctgat ctgcctgtcg gccttcacca ccaaggccaa ctgcgagcgg cacctcaagg
     1381 tgcacacgga cacgctgagc ggtgtctgcc acagctgtgg cttcatctcc accacaaggg
     1441 acatcctcta cagccacttg gtcaccaacc acatggtctg ccagcctggc tccaagggtg
     1501 agatctactc gccaggggcc ggacacccag caaccaagct gcccccagac agtctgggca
     1561 gcttccagca gcagcacacg gccctgcaag gccccctggc ctccgcggac ctgggcctgg
     1621 cgcccacccc atcgccagga ctggacagaa aggccctggc cgaggccacc aacggagagg
     1681 ccagagcgga gcctctggcc cagaatggag gcagcagcga gcccccggcg gcccccagga
     1741 gcatcaaggt ggaggcggtg gaggagccgg aggcggcccc catcctgggc cccggagagc
     1801 ctgggcccca ggccccgtcg cggacgccgt cgccgcgcag ccccgccccg gccagggtca
     1861 aggccgagct gtccagcccc acgccgggct ccagcccggt gcccggcgag ctgggcctgg
     1921 ccggggccct gttccttccg cagtacgtgt tcgggcccga cgcggcgccc cccgcctcgg
     1981 agatcctggc caagatgtcc gagctggtgc acagccggct gcagcagggc gcgggcgcgg
     2041 gcgccggcgg cgcgcagacc gggctcttcc ccggggcccc caagggcgct acgtgcttcg
     2101 agtgcgagat caccttcagc aacgtcaaca actactacgt gcacaagcgc ctctactgtt
     2161 caggccgccg tgcgcccgag gacgcgcctg ccgcgcgcag gcccaaggcg ccccccggcc
     2221 cggcccgcgc gccccccggc cagcccgccg aacccgacgc gccgcgctcg tccccgggcc
     2281 ccggagcgcg cgaggagggg gctgggggcg cggccacgcc cgaggacggc gcgggcggcc
     2341 ggggcagcga gggcagccag agcccgggta gctccgtgga cgacgcggag gacgacccca
     2401 gccgcacgct gtgcgaggcc tgcaacatcc gcttcagccg ccacgagacc tacaccgtgc
     2461 acaagcggta ctactgcgcc tcgcgccacg acccgccgcc gcgccgaccg gccgcgcccc
     2521 cgggaccccc tgggccggcc gcgcccccgg ccccctctcc cgccgcgcct gtgcgcacgc
     2581 gcagacgccg caagctctac gagctgcacg cggccggcgc cccgcccccc ccgccgcccg
     2641 gccacgcccc cgcgcccgag tcgccgcggc ccggaagcgg aagcggaagc ggccccggcc
     2701 tcgcccctgc gcgctcgccc ggccccgcgg ccgacggccc catcgacctg agcaagaagc
     2761 cgcggcgccc gctccccgga gccccggcac cggcgctggc cgactaccac gagtgcacgg
     2821 cctgccgcgt gagcttccac agcctcgagg cctacctggc gcacaagaag tactcgtgcc
     2881 ccgctgcgcc accgcccggc gcgctcggcc tgcccgccgc cgcctgcccc tactgccccc
     2941 cgaacggccc ggtgcgcggg gacctgctgg agcatttccg cctggcgcac ggcctgctgc
     3001 tcggcgcgcc cctggccggc ccgggggtcg aggcccggac gccggccgac cgcggcccct
     3061 cgcccgctcc cgcccccgcc gcctccccgc agcccgggtc ccgtggcccc cgggacggcc
     3121 tcggcccgga gccccaggag ccgccgcccg gcccgccccc gtccccggcc gccgcgcccg
     3181 aggccgtgcc gcccccgccg gcgcccccct cctactcgga caagggcgtc cagactccca
     3241 gcaagggcac gccggcgccg ctgcccaacg gcaaccaccg gtactgccgt ctttgcaaca
     3301 tcaagttcag cagcctgtcc accttcatcg cccacaagaa gtattactgc tcctcgcacg
     3361 ccgccgagca cgtgaagtga gcgcccacac tacagccgca gacgctttgc acgccccgct
     3421 gcgatgcggg gagggggccg cccccaggcc gcacggactg ccgctcctgg gaaccccgcc
     3481 acgcacaggc ctcggcggag ggggccgcag ggggcagcgc ccgcctggac ccttggcact
     3541 taataaagaa gttcagtttg atgagcatgg tggtgggcca gcctagttct ctgagccagc
     3601 aggcacacgc agccagtgtc acatccagcc ctgctgtgta cacaggccac tgcggcccgg
     3661 agtggctggg cccctgccgg agttacacca ctgggtgcta agagctagac cgagcgtcag
     3721 gtcggaggcc acagcacaca ctgaaccact gcagggccag ccgctctggg cctaccccac
     3781 cccagccctg tccatacccc cctagggaga gcagcctcca cactgctgac cctctccacg
     3841 gtctacttgg ccgccagaca cggaagagag gggcactgac ctggctggcc atcccccaac
     3901 cctgcatggt cctgggggtc cgatgtcccc catccagtca cagaccacca gggatggcag
     3961 gggtgggggc gccctgggga ggatgaagcc ctgtggtggc caaggctggg ggaagaacag
     4021 gcgagtaggt ggacaggaga gggagaccga ggccgaagca ttccctggcc tcgagggggt
     4081 cctgatgctc actggtgggt gcatctctcc ctcagagcca gggctgagga caaccgtgtg
     4141 gtggagtcac ctgtggtggc tgagtcggtg caagggtcag ggcaccccca ccccccgtct
     4201 tccctgccct gctgggctgt atgggccggc cacactgagg gagtacttgg ctgaccgcgt
     4261 tcagccacgg tgtcaccgtg ccgtttgcag ctgggtggct gtgggcagcc tccagcgtgc
     4321 tttctcactg gagaacaaaa acactcttct attcccaacg tcactttatt tttttatttt
     4381 tgggtctcac tctcttgccc aggctggagt ccctgggata ctcacggctc attgcagcct
     4441 tgacctcgtg agctcaagtg atcttcccac ctcagtttcc tcagtagctg gggctacagg
     4501 tgtacaccac catgcccagc tagtttttgt gttttttgta gaaatggtgt ctccctatgt
     4561 tgcccaggct gggcaaccct atatttttta gagctaaggt cttgttcggt tccccaggct
     4621 gaagttcagt ggcacgatca taagtcactg cagcctcaaa ctcctgagct gaaaccatct
     4681 tcctgcctca gcctcccaag tagctgggac tacaggcttg acccaccaca cctggctaac
     4741 ttttaaaaca tttttataga gacagggtct tcctgtgttg cccaagatgg tctcaaactc
     4801 ctgacctcca gtgctcctgc agcctcagcc tcccagaaca ttaggatgac aggcgcgagc
     4861 taccattccc agcccatttc caactctact tgaactagct gcattttttt cagctttgcc
     4921 cagcagccct ggtgagtgca ggcaaagaag gcagcggcct cttgcctcag aagcccgagg
     4981 cacttcccag ccagtccagg gctcgctctc ctgcccgcag ctcgtgggcc tgggtctgca
     5041 gcgctttcag tggtctctga tgtctttgtc cacctgccca ctagggtctg gccagatggg
     5101 gcccgtagcc aaggccaatg gacagacatg gcttccaccc cctcccaggg acctgagctc
     5161 cagggaaggc aagcagcctt ttcctcacag acaccccttc tgttgaagac caggtgatag
     5221 cggggacggg aggcacggac ccctcaagtc tgctcatcat ttgcattgtt gtgcatgaat
     5281 ttgcgtggag ggttcaggag gctctgcccc caagtcctcc ccaggtgcgg gcgcagggta
     5341 caagatgttc taaaaaatag aaacctggtg gggggttgtc actgtgtgta catttaaaag
     5401 taaactgttt aaaggtgtct agaaactacg aa
//
