LOCUS       NM_006782               1382 bp    mRNA    linear   PRI 17-FEB-2025
DEFINITION  Homo sapiens zinc finger protein like 1 (ZFPL1), mRNA.
ACCESSION   NM_006782
VERSION     NM_006782.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1382)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1382)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1382)
  AUTHORS   Cai,M.J., Zhan,F.X., Kong,X.N., Zhu,S.Z., Cui,Y. and Wang,Q.
  TITLE     RING domain of zinc finger protein like 1 is essential for cell
            proliferation in endometrial cancer cell line RL95-2
  JOURNAL   Gene 677, 17-23 (2018)
   PUBMED   30036656
  REMARK    GeneRIF: The RING domain was essential for the function of ZFPL1.
REFERENCE   4  (bases 1 to 1382)
  AUTHORS   Xie,Y.Z., Ma,W.L., Meng,J.M. and Ren,X.Q.
  TITLE     Knockdown of ZFPL1 results in increased autophagy and
            autophagy-related cell death in NCI-N87 and BGC-823 human gastric
            carcinoma cell lines
  JOURNAL   Mol Med Rep 15 (5), 2633-2642 (2017)
   PUBMED   28447717
  REMARK    GeneRIF: These results suggest that ZFPL1 may serve an important
            role in regulating autophagy in NCIN87 and BGC823 cells.
REFERENCE   5  (bases 1 to 1382)
  AUTHORS   Chiu,C.F., Ghanekar,Y., Frost,L., Diao,A., Morrison,D., McKenzie,E.
            and Lowe,M.
  TITLE     ZFPL1, a novel ring finger protein required for cis-Golgi integrity
            and efficient ER-to-Golgi transport
  JOURNAL   EMBO J 27 (7), 934-947 (2008)
   PUBMED   18323775
  REMARK    GeneRIF: These data suggest that ZFPL1 has an important function in
            maintaining the integrity of the cis-Golgi and that it does so
            through interactions with GM130.
REFERENCE   6  (bases 1 to 1382)
  AUTHORS   Clark,A.G., Glanowski,S., Nielsen,R., Thomas,P.D., Kejariwal,A.,
            Todd,M.A., Tanenbaum,D.M., Civello,D., Lu,F., Murphy,B.,
            Ferriera,S., Wang,G., Zheng,X., White,T.J., Sninsky,J.J.,
            Adams,M.D. and Cargill,M.
  TITLE     Inferring nonneutral evolution from human-chimp-mouse orthologous
            gene trios
  JOURNAL   Science 302 (5652), 1960-1963 (2003)
   PUBMED   14671302
REFERENCE   7  (bases 1 to 1382)
  AUTHORS   Imabayashi,H., Mori,T., Gojo,S., Kiyono,T., Sugiyama,T., Irie,R.,
            Isogai,T., Hata,J., Toyama,Y. and Umezawa,A.
  TITLE     Redifferentiation of dedifferentiated chondrocytes and
            chondrogenesis of human bone marrow stromal cells via chondrosphere
            formation with expression profiling by large-scale cDNA analysis
  JOURNAL   Exp Cell Res 288 (1), 35-50 (2003)
   PUBMED   12878157
REFERENCE   8  (bases 1 to 1382)
  AUTHORS   Hoppener,J.W., De Wit,M.J., Simarro-Doorten,A.Y., Roijers,J.F., van
            Herrewaarden,H.M., Lips,C.J., Parente,F., Quincey,D., Gaudray,P.,
            Khodaei,S., Weber,G., Teh,B., Farnebo,F., Larsson,C., Zhang,C.X.,
            Calender,A., Pannett,A.A., Forbes,S.A., Bassett,J.H., Thakker,R.V.,
            Lemmens,I., Van de Ven,W.J. and Kas,K.
  TITLE     A putative human zinc-finger gene (ZFPL1) on 11q13, highly
            conserved in the mouse and expressed in exocrine pancreas. The
            European Consortium on MEN 1
  JOURNAL   Genomics 50 (2), 251-259 (1998)
   PUBMED   9653652
REFERENCE   9  (bases 1 to 1382)
  AUTHORS   Guru,S.C., Agarwal,S.K., Manickam,P., Olufemi,S.E., Crabtree,J.S.,
            Weisemann,J.M., Kester,M.B., Kim,Y.S., Wang,Y., Emmert-Buck,M.R.,
            Liotta,L.A., Spiegel,A.M., Boguski,M.S., Roe,B.A., Collins,F.S.,
            Marx,S.J., Burns,L. and Chandrasekharappa,S.C.
  TITLE     A transcript map for the 2.8-Mb region containing the multiple
            endocrine neoplasia type 1 locus
  JOURNAL   Genome Res 7 (7), 725-735 (1997)
   PUBMED   9253601
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AU279924.1, AF030291.1 and AI207587.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006782.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.61145.1,
                                           SRR3476690.744810.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294258.8/ ENSP00000294258.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AU279924.1         1-13
            14-1377             AF030291.1         1-1364
            1378-1382           AI207587.1         23-27               c
FEATURES             Location/Qualifiers
     source          1..1382
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..1382
                     /gene="ZFPL1"
                     /gene_synonym="D11S750; MCG4"
                     /note="zinc finger protein like 1"
                     /db_xref="GeneID:7542"
                     /db_xref="HGNC:HGNC:12868"
                     /db_xref="MIM:619397"
     exon            1..157
                     /gene="ZFPL1"
                     /gene_synonym="D11S750; MCG4"
                     /inference="alignment:Splign:2.1.0"
     exon            158..267
                     /gene="ZFPL1"
                     /gene_synonym="D11S750; MCG4"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1098
                     /gene="ZFPL1"
                     /gene_synonym="D11S750; MCG4"
                     /note="zinc-finger protein in MEN1 region; zinc finger
                     protein MCG4"
                     /codon_start=1
                     /product="zinc finger protein-like 1"
                     /protein_id="NP_006773.2"
                     /db_xref="CCDS:CCDS8092.1"
                     /db_xref="GeneID:7542"
                     /db_xref="HGNC:HGNC:12868"
                     /db_xref="MIM:619397"
                     /translation="MGLCKCPKRKVTNLFCFEHRVNVCEHCLVANHAKCIVQSYLQWL
                     QDSDYNPNCRLCNIPLASRETTRLVCYDLFHWACLNERAAQLPRNTAPAGYQCPSCNG
                     PIFPPTNLAGPVASALREKLATVNWARAGLGLPLIDEVVSPEPEPLNTSDFSDWSSFN
                     ASSTPGPEEVDSASAAPAFYSQAPRPPASPGRPEQHTVIHMGNPEPLTHAPRKVYDTR
                     DDDRTPGLHGDCDDDKYRRRPALGWLARLLRSRAGSRKRPLTLLQRAGLLLLLGLLGF
                     LALLALMSRLGRAAADSDPNLDPLMNPHIRVGPS"
     exon            268..379
                     /gene="ZFPL1"
                     /gene_synonym="D11S750; MCG4"
                     /inference="alignment:Splign:2.1.0"
     exon            380..573
                     /gene="ZFPL1"
                     /gene_synonym="D11S750; MCG4"
                     /inference="alignment:Splign:2.1.0"
     exon            574..646
                     /gene="ZFPL1"
                     /gene_synonym="D11S750; MCG4"
                     /inference="alignment:Splign:2.1.0"
     exon            647..793
                     /gene="ZFPL1"
                     /gene_synonym="D11S750; MCG4"
                     /inference="alignment:Splign:2.1.0"
     exon            794..911
                     /gene="ZFPL1"
                     /gene_synonym="D11S750; MCG4"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1382
                     /gene="ZFPL1"
                     /gene_synonym="D11S750; MCG4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1360..1365
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFPL1"
                     /gene_synonym="D11S750; MCG4"
                     /note="hexamer: AATAAA"
     polyA_site      1382
                     /gene="ZFPL1"
                     /gene_synonym="D11S750; MCG4"
                     /note="major polyA site"
ORIGIN      
        1 agagacgtgg cagcggaggg ataatcgggg cggccggggc tgaagggaga ggcgcaggag
       61 ccctggggag agtggtccct gcccttccgc gcctcgagcc atcgctaccg cccttcggaa
      121 ccagtgcagc ggccgatcag taaacacaga gactggggat cgatcatggg gctttgtaag
      181 tgccccaaga gaaaggtgac caacctgttc tgcttcgaac atcgggtcaa cgtctgcgag
      241 cactgcctgg tagccaatca cgccaagtgc atcgtccagt cctacctgca atggctccaa
      301 gatagcgact acaaccccaa ttgccgcctg tgcaacatac ccctggccag ccgagagacg
      361 acccgccttg tctgctatga tctctttcac tgggcctgcc tcaatgaacg tgctgcccag
      421 ctaccccgaa acacggcacc tgccggctat cagtgcccca gctgcaatgg ccccatcttc
      481 cccccaacca acctggctgg ccccgtggcc tccgcactga gagagaagct ggccacagtc
      541 aactgggccc gggcaggact gggcctccct ctgatcgatg aggtggtgag cccagagccc
      601 gagcccctca acacgtctga cttctctgac tggtctagtt ttaatgccag cagtacccct
      661 ggaccagagg aggtagacag cgcctctgct gccccagcct tctacagcca ggccccccgg
      721 cccccagctt ccccaggccg gcccgagcag cacacagtga tccacatggg caatcctgag
      781 cccttgactc acgcccctag gaaggtgtat gatacgcggg atgatgaccg gacaccaggc
      841 ctccatggag actgtgacga tgacaagtac cgacgtcggc cggccttggg ttggctggcc
      901 cggctgctaa ggagccgggc tgggtctcgg aagcggccgc tgaccctgct ccagcgggcg
      961 gggctgctgc tactcttggg actgctgggc ttcctggccc tccttgccct catgtctcgc
     1021 ctaggccggg ccgcagctga cagcgatccc aacctggacc cactcatgaa ccctcacatc
     1081 cgcgtgggcc cctcctgagc ccccttgctt gtggctaggc cagcctagga tgtgggttct
     1141 gtggaggaga ggcggggtaa tggggaggct gagggcacct cttcactgcc cctctccctc
     1201 aagcctaaga cactaagacc ccagacccaa agccaagtcc accagagtgg ctgcaggcca
     1261 ggcctggagt ccccgtgggt caagcatttg tcttgacttg ctttcctccc gggtctccag
     1321 cctccgaccc ctcgccccat gaaggagctg gcaggtggaa ataaacaaca actttattaa
     1381 aa
//
