LOCUS       NM_053023               5776 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens ZFP91 zinc finger protein, atypical E3 ubiquitin
            ligase (ZFP91), transcript variant 1, mRNA.
ACCESSION   NM_053023
VERSION     NM_053023.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5776)
  AUTHORS   Liu,T.T., Yang,H., Zhuo,F.F., Yang,Z., Zhao,M.M., Guo,Q., Liu,Y.,
            Liu,D., Zeng,K.W. and Tu,P.F.
  TITLE     Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2
            transcription factor degradation for cancer therapy
  JOURNAL   EBioMedicine 86, 104353 (2022)
   PUBMED   36375317
  REMARK    GeneRIF: Atypical E3 ligase ZFP91 promotes small-molecule-induced
            E2F2 transcription factor degradation for cancer therapy.
REFERENCE   2  (bases 1 to 5776)
  AUTHORS   Wu,W., Nelson,G.M., Koch,R., Donovan,K.A., Nowak,R.P.,
            Heavican-Foral,T.B., Nirmal,A.J., Liu,H., Yang,L., Duffy,J.,
            Powers,F., Stevenson,K.E., Jones,M.K., Ng,S.Y., Wu,G., Jain,S.,
            Xu,R., Amaka,S., Trevisani,C., Donaldson,N.L., Hagner,P.R., de
            Leval,L., Gaulard,P., Iqbal,J., Thakurta,A., Fischer,E.S.,
            Adelman,K. and Weinstock,D.M.
  TITLE     Overcoming IMiD resistance in T-cell lymphomas through potent
            degradation of ZFP91 and IKZF1
  JOURNAL   Blood 139 (13), 2024-2037 (2022)
   PUBMED   34936696
  REMARK    GeneRIF: Overcoming IMiD resistance in T-cell lymphomas through
            potent degradation of ZFP91 and IKZF1.
REFERENCE   3  (bases 1 to 5776)
  AUTHORS   Zhong,Y., Zhang,Z.H., Wang,J.Y., Xing,Y., Ri,M.H., Jin,H.L.,
            Zuo,H.X., Li,M.Y., Ma,J. and Jin,X.
  TITLE     Zinc finger protein 91 mediates necroptosis by initiating
            RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1
            ligation
  JOURNAL   Toxicol Lett 356, 75-88 (2022)
   PUBMED   34942311
  REMARK    GeneRIF: Zinc finger protein 91 mediates necroptosis by initiating
            RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1
            ligation.
REFERENCE   4  (bases 1 to 5776)
  AUTHORS   Wang,F., Zhang,Y., Yu,X., Teng,X.L., Ding,R., Hu,Z., Wang,A.,
            Wang,Z., Ye,Y. and Zou,Q.
  TITLE     ZFP91 disturbs metabolic fitness and antitumor activity of
            tumor-infiltrating T cells
  JOURNAL   J Clin Invest 131 (19) (2021)
   PUBMED   34403361
  REMARK    GeneRIF: ZFP91 disturbs metabolic fitness and antitumor activity of
            tumor-infiltrating T cells.
REFERENCE   5  (bases 1 to 5776)
  AUTHORS   Tang,N., Xu,S., Song,T., Qiu,Y., He,J. and Fu,X.
  TITLE     Zinc finger protein 91 accelerates tumour progression by activating
            beta-catenin signalling in pancreatic cancer
  JOURNAL   Cell Prolif 54 (5), e13031 (2021)
   PUBMED   33755268
  REMARK    GeneRIF: Zinc finger protein 91 accelerates tumour progression by
            activating beta-catenin signalling in pancreatic cancer.
REFERENCE   6  (bases 1 to 5776)
  AUTHORS   Obuse,C., Yang,H., Nozaki,N., Goto,S., Okazaki,T. and Yoda,K.
  TITLE     Proteomics analysis of the centromere complex from HeLa interphase
            cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of
            the CEN-complex, while BMI-1 is transiently co-localized with the
            centromeric region in interphase
  JOURNAL   Genes Cells 9 (2), 105-120 (2004)
   PUBMED   15009096
REFERENCE   7  (bases 1 to 5776)
  AUTHORS   Unoki,M., Okutsu,J. and Nakamura,Y.
  TITLE     Identification of a novel human gene, ZFP91, involved in acute
            myelogenous leukemia
  JOURNAL   Int J Oncol 22 (6), 1217-1223 (2003)
   PUBMED   12738986
  REMARK    GeneRIF: likely to play an important role in cell proliferation
            and/or anti-apoptosis, and may serve as a molecular marker for AML
REFERENCE   8  (bases 1 to 5776)
  AUTHORS   Iuchi,S.
  TITLE     Three classes of C2H2 zinc finger proteins
  JOURNAL   Cell Mol Life Sci 58 (4), 625-635 (2001)
   PUBMED   11361095
  REMARK    Review article
REFERENCE   9  (bases 1 to 5776)
  AUTHORS   Grottke,C., Mantwill,K., Dietel,M., Schadendorf,D. and Lage,H.
  TITLE     Identification of differentially expressed genes in human melanoma
            cells with acquired resistance to various antineoplastic drugs
  JOURNAL   Int J Cancer 88 (4), 535-546 (2000)
   PUBMED   11058868
REFERENCE   10 (bases 1 to 5776)
  AUTHORS   Saotome,Y., Winter,C.G. and Hirsh,D.
  TITLE     A widely expressed novel C2H2 zinc-finger protein with multiple
            consensus phosphorylation sites is conserved in mouse and man
  JOURNAL   Gene 152 (2), 233-238 (1995)
   PUBMED   7835706
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001350.4, BC051743.1,
            AB056107.1, BP219969.1 and AI687439.1.
            
            On Nov 22, 2018 this sequence version replaced NM_053023.4.
            
            Summary: The protein encoded by this gene is a member of the zinc
            finger family of proteins. The gene product contains C2H2-type
            domains, which are the classical zinc finger domains found in
            numerous nucleic acid-binding proteins. This protein functions as a
            regulator of the non-canonical NF-kappaB pathway in
            lymphotoxin-beta receptor signaling. Alternative splicing results
            in multiple transcript variants. A read-through transcript variant
            composed of ZFP91 and the downstream CNTF gene sequence has been
            identified, but it is thought to be non-coding. Read-through
            transcription of ZFP91 and CNTF has also been observed in mouse. A
            ZFP91-related pseudogene has also been identified on chromosome 2.
            [provided by RefSeq, Oct 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB056107.1, SRR1660807.98663.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316059.7/ ENSP00000339030.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AP001350.4         14733-14783
            52-327              BC051743.1         4-279
            328-3402            AB056107.1         223-3297
            3403-5268           AB056107.1         3299-5164
            5269-5489           BP219969.1         232-452
            5490-5776           AI687439.1         11-297              c
FEATURES             Location/Qualifiers
     source          1..5776
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..5776
                     /gene="ZFP91"
                     /gene_synonym="DMS-8; DSM-8; DSM8; FKSG11; PZF; ZFP-91;
                     ZNF757"
                     /note="ZFP91 zinc finger protein, atypical E3 ubiquitin
                     ligase"
                     /db_xref="GeneID:80829"
                     /db_xref="HGNC:HGNC:14983"
                     /db_xref="MIM:619289"
     exon            1..560
                     /gene="ZFP91"
                     /gene_synonym="DMS-8; DSM-8; DSM8; FKSG11; PZF; ZFP-91;
                     ZNF757"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..1932
                     /gene="ZFP91"
                     /gene_synonym="DMS-8; DSM-8; DSM8; FKSG11; PZF; ZFP-91;
                     ZNF757"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein homologous to Zfp91 in mouse; penta zinc
                     finger protein; E3 ubiquitin-protein ligase ZFP91; drug
                     resistance-associated sequence in melanoma 8; zinc finger
                     protein 757; zinc finger protein 91 homolog; RING-type E3
                     ubiquitin transferase ZFP91"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase ZFP91 isoform 1"
                     /protein_id="NP_444251.1"
                     /db_xref="CCDS:CCDS31553.1"
                     /db_xref="GeneID:80829"
                     /db_xref="HGNC:HGNC:14983"
                     /db_xref="MIM:619289"
                     /translation="MPGETEEPRPPEQQDQEGGEAAKAAPEEPQQRPPEAVAAAPAGT
                     TSSRVLRGGRDRGRAAAAAAAAAVSRRRKAEYPRRRRSSPSARPPDVPGQQPQAAKSP
                     SPVQGKKSPRLLCIEKVTTDKDPKEEKEEEDDSALPQEVSIAASRPSRGWRSSRTSVS
                     RHRDTENTRSSRSKTGSLQLICKSEPNTDQLDYDVGEEHQSPGGISSEEEEEEEEEML
                     ISEEEIPFKDDPRDETYKPHLERETPKPRRKSGKVKEEKEKKEIKVEVEVEVKEEENE
                     IREDEEPPRKRGRRRKDDKSPRLPKRRKKPPIQYVRCEMEGCGTVLAHPRYLQHHIKY
                     QHLLKKKYVCPHPSCGRLFRLQKQLLRHAKHHTDQRDYICEYCARAFKSSHNLAVHRM
                     IHTGEKPLQCEICGFTCRQKASLNWHMKKHDADSFYQFSCNICGKKFEKKDSVVAHKA
                     KSHPEVLIAEALAANAGALITSTDILGTNPESLTQPSDGQGLPLLPEPLGNSTSGECL
                     LLEAEGMSKSYCSGTERVSLMADGKIFVGSGSSGGTEGLVMNSDILGATTEVLIEDSD
                     SAGP"
     exon            561..589
                     /gene="ZFP91"
                     /gene_synonym="DMS-8; DSM-8; DSM8; FKSG11; PZF; ZFP-91;
                     ZNF757"
                     /inference="alignment:Splign:2.1.0"
     exon            590..799
                     /gene="ZFP91"
                     /gene_synonym="DMS-8; DSM-8; DSM8; FKSG11; PZF; ZFP-91;
                     ZNF757"
                     /inference="alignment:Splign:2.1.0"
     exon            800..836
                     /gene="ZFP91"
                     /gene_synonym="DMS-8; DSM-8; DSM8; FKSG11; PZF; ZFP-91;
                     ZNF757"
                     /inference="alignment:Splign:2.1.0"
     exon            837..941
                     /gene="ZFP91"
                     /gene_synonym="DMS-8; DSM-8; DSM8; FKSG11; PZF; ZFP-91;
                     ZNF757"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1076
                     /gene="ZFP91"
                     /gene_synonym="DMS-8; DSM-8; DSM8; FKSG11; PZF; ZFP-91;
                     ZNF757"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1127
                     /gene="ZFP91"
                     /gene_synonym="DMS-8; DSM-8; DSM8; FKSG11; PZF; ZFP-91;
                     ZNF757"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1206
                     /gene="ZFP91"
                     /gene_synonym="DMS-8; DSM-8; DSM8; FKSG11; PZF; ZFP-91;
                     ZNF757"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1321
                     /gene="ZFP91"
                     /gene_synonym="DMS-8; DSM-8; DSM8; FKSG11; PZF; ZFP-91;
                     ZNF757"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1421
                     /gene="ZFP91"
                     /gene_synonym="DMS-8; DSM-8; DSM8; FKSG11; PZF; ZFP-91;
                     ZNF757"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..5776
                     /gene="ZFP91"
                     /gene_synonym="DMS-8; DSM-8; DSM8; FKSG11; PZF; ZFP-91;
                     ZNF757"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5162..5167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP91"
                     /gene_synonym="DMS-8; DSM-8; DSM8; FKSG11; PZF; ZFP-91;
                     ZNF757"
                     /note="hexamer: AATAAA"
     polyA_site      5188
                     /gene="ZFP91"
                     /gene_synonym="DMS-8; DSM-8; DSM8; FKSG11; PZF; ZFP-91;
                     ZNF757"
                     /note="major polyA site"
     regulatory      5247..5252
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP91"
                     /gene_synonym="DMS-8; DSM-8; DSM8; FKSG11; PZF; ZFP-91;
                     ZNF757"
                     /note="hexamer: AATAAA"
     polyA_site      5268
                     /gene="ZFP91"
                     /gene_synonym="DMS-8; DSM-8; DSM8; FKSG11; PZF; ZFP-91;
                     ZNF757"
     regulatory      5755..5760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP91"
                     /gene_synonym="DMS-8; DSM-8; DSM8; FKSG11; PZF; ZFP-91;
                     ZNF757"
                     /note="hexamer: TATAAA"
     polyA_site      5776
                     /gene="ZFP91"
                     /gene_synonym="DMS-8; DSM-8; DSM8; FKSG11; PZF; ZFP-91;
                     ZNF757"
ORIGIN      
        1 gtggcgcgcg cgcgcgcgcc gccagcggta gcggaccttg agtggcaggg ggtggggggg
       61 gcgccctcgg agccgggcgg aggggagggg ggaaagagga gcgcagggtg agagtgagcc
      121 gcaggcttcg ggaggcgagg gggcgggggg agcagcgccg aggccgccgc ctccgcctcc
      181 gccgcctagg actagggggt gggggacgga caagccccga tgccggggga gacggaagag
      241 ccgagacccc cggagcagca ggaccaggaa gggggagagg cggccaaggc ggctccggag
      301 gagccccaac aacggccccc tgaggcggtc gcggcggcgc ctgcagggac cactagcagc
      361 cgcgtgctga ggggaggtcg ggaccgaggc cgggccgctg cggccgccgc cgccgcagct
      421 gtgtcccgcc ggaggaaggc cgagtatccc cgccggcgga ggagcagccc cagcgccagg
      481 cctcccgacg tccccgggca gcagccccag gccgcgaagt ccccgtctcc agttcagggc
      541 aagaagagtc cgcgactcct atgcatagaa aaagtaacaa ctgataaaga tcccaaggaa
      601 gaaaaagagg aagaagacga ttctgccctc cctcaggaag tttccattgc tgcatctaga
      661 cctagccggg gctggcgtag tagtaggaca tctgtttctc gccatcgtga tacagagaac
      721 acccgaagct ctcggtccaa gaccggttca ttgcagctca tttgcaagtc agaaccaaat
      781 acagaccaac ttgattatga tgttggagaa gagcatcagt ctccaggtgg cattagtagt
      841 gaagaggaag aggaggagga agaagagatg ttaatcagtg aagaggagat accattcaaa
      901 gatgatccaa gagatgagac ctacaaaccc cacttagaaa gggaaacccc aaagccacgg
      961 agaaaatcag ggaaggtaaa agaagagaag gagaagaagg aaattaaagt ggaagtagag
     1021 gtggaggtga aagaagagga gaatgaaatt agagaggatg aggaacctcc aaggaagaga
     1081 ggaagaagac gaaaagatga caaaagtcca cgtttaccca aaaggagaaa aaagcctcca
     1141 atccagtatg tccgttgtga gatggaagga tgtggaactg tccttgccca tcctcgctat
     1201 ttgcagcacc acattaaata ccagcatttg ctgaagaaga aatatgtatg tccccatccc
     1261 tcctgtggac gactcttcag gcttcagaag caacttctgc gacatgccaa acatcataca
     1321 gatcaaaggg attatatctg tgaatattgt gctcgggcct tcaagagttc ccacaatctg
     1381 gcagtgcacc ggatgattca cactggcgag aagccattac aatgtgagat ctgtggattt
     1441 acttgtcgac aaaaggcatc tcttaattgg cacatgaaga aacatgatgc agactccttc
     1501 taccagtttt cttgcaatat ctgtggcaaa aaatttgaga agaaggacag cgtagtggca
     1561 cacaaggcaa aaagccaccc tgaggtgctg attgcagaag ctctggctgc caatgcaggc
     1621 gccctcatca ccagcacaga tatcttgggc actaacccag agtccctgac gcagccttca
     1681 gatggtcagg gtcttcctct tcttcctgag cccttgggaa actcaacctc tggagagtgc
     1741 ctactgttag aagctgaagg gatgtcaaag tcatactgca gtgggacgga acgggtgagc
     1801 ctgatggctg atgggaagat ctttgtggga agcggcagca gtggaggcac tgaagggctg
     1861 gttatgaact cagatatact cggtgctacc acagaggttc tgattgaaga ttcagactct
     1921 gccggacctt agtggacagg aagacttggg gcatgggaca gctcagactt tgtatttaaa
     1981 agttaaaaag gacaaaaaaa aaatctaaag catttaaaat ctagtgaaat aactgaaggg
     2041 cctgctcttt ccattgtgga tcacagcaca cacatacata caccctccac ctccccatcc
     2101 cctgttctcc ctctgttgct ccccttataa aattgatgtt gtctttacca gaaaggtaga
     2161 caaaaaagaa gcagcagcag ctcttaaagt gagggttatt ctcatactcg gttccagcca
     2221 tcagcagact tcctgctcat cggcagatcc ccctttccaa cctgtaactc tgatgtgctc
     2281 tggatcagct tttaactttt aatcatatat tactgtcttc taaatccctt ctcctcctct
     2341 actgctgccc tatggttctg gctcctaccc cctgcggcac acttatcttc aaataccata
     2401 gaattctaat ctctggaggc tggcagcttg acttggcact ttagggcccc ttagcagggt
     2461 gagctgttaa aacagcacac atctctcatc ccctcttcct ttattccccc ctgggtttca
     2521 gaaaggaagg atatatgggg accacctccc ccttctttga tcccagcatc tcagtccccc
     2581 tcccaaccct ccatatggct ctcaatggtg ctcacttgct tggaagcagg ctcccaatag
     2641 ggagggggct gccctctaca gtctctttga ctgtaagaca gggctctgta tcagtgagac
     2701 gatgagaaaa gtcccaggct aatggcagaa atttgcactt tgaacatgtg tgtttttgtg
     2761 ttgtggaacc tgagattcct tatttattaa caggaagtct gatttttttt ttttggagtc
     2821 tttgttgcta tattttgtgg ggctgggaga gagagattag attattttga catgggatcc
     2881 cttccataac aggtactttg aaggcaagac atagggttga agaagcacag ccagcctctg
     2941 aaatcatagc tctccagtgg cttttaaaga aagctggtcc tcagcactaa caaaatcact
     3001 acaatagcct agtgcttttt tggaagcctt tttagggaag aatgttaggt tcatggtaac
     3061 tagtatgctc tttgagattt ttacagtgtt gaaacttaag aattttgaga gggtgaggag
     3121 ggttgttcag aatctaaatt acagatagat gattgtttct tgtgaatttg tttcttttcc
     3181 tttttttttg tccctaccat ttccttacat ttcccttggg gcccatctct ggctccttgc
     3241 tttttgtttc ttgctttgct ttatcagttc attccagctc cctgttagtg aaggacactg
     3301 ctgttagtga aggaacaaag tctatgagtc ctaaaatttt aagtcaaaga aaactgctct
     3361 gtttcccctt tagtaacact tctgaagagg aaaaacttca atagccaaag ttaataatcc
     3421 tatataataa ttgctttggc tttcacctaa aattctgggc atcacaattt ccttgggata
     3481 gaggttgtgt tggggaatag attgcttatt gctgttcact ggagagaaaa ggtagtgttt
     3541 ttgtacaagg tcataccgcc agaagcccca aatcctattt tggctcatct tcaggtaaag
     3601 agtaattcct atcctgtgtg cctcagaagc tagaatcgaa ggcttaccct attcattgtt
     3661 tattgtcaga aatgcatgat ggctcttgga aagaatgacg ttttgctgga aaaaaaaaaa
     3721 agaacagttt gtgtttcaca aacatggctt atcaattttt tcaaagaatt cttttttccc
     3781 aaaaagagga gtaacaaaat gtcatttctg aaagaggctt actttatacc aactagtgtc
     3841 agcatttggg atgccaggga acagagagtg agacacctac aatcaccagt ctcaaatgcg
     3901 ctattgtttc ttttcagagt gttgcagatt tgccatttct ccataatatg gggatagaaa
     3961 atggaataaa gatagaaggg atgtagaata tgctttcctg ccaacatggt ttggagtcga
     4021 ctttggtata ttgactagat ttgaaaatac aagattgatt agatgaatct acaaaaaagt
     4081 tgtcctcctc tcaggtccct tttacacttt ttgactaact agcatctata ttccacactt
     4141 agcttttttg tcacacttat cctttgtctc cgtaaatttc atttgcagtg gttagtcatc
     4201 agatatttta gccacctaca caaaagcaaa ctgcattttt aaaaatcttt ctgagatggg
     4261 agaaaatgta ttctcctttc ctataccgct ctcccaacaa aaaaacaact agttagttct
     4321 actaattaga aacttgctgt actttttctt ttcttttagg ggtcaaggac cctctttata
     4381 gctaccattt gcctacaata aattattgca gcagtttgca atactaaaat attttttata
     4441 gactttatat ttttcctttt gataaaggga tgctgcatag tagagttggt gtaattaaac
     4501 tatctcagcc gtttccctgc tttcccttct gctccatatg cctcattgtc cttccaggga
     4561 gctcttttaa tcttaaagtt ctacatttca tgctcttagt caaattctgt taccttttta
     4621 ataactcttc ccactgcata tttccatctt gaattggtgg ttctaaattc tgaaactgta
     4681 gttgagatac agctatttaa tatttctggg agatgtgcat ccctcttctt tgtggttgcc
     4741 caaggttgtt ttgcgtaact gagactcctt gatatgcttc agagaattta ggcaaacact
     4801 ggccatggcc gtgggagtac tgggagtaaa ataaaaatat cgaggtatag actagcatcc
     4861 acatagagca cttgaacctc ctttgtacct gtttggggaa aaagtataat gagtgtacta
     4921 ccaatctaac taagattatt atagtctggt tgtttgaaat accatttttt tctccttttg
     4981 tgtttttccc actttccaat gtactcaaga aaattgaaca aatgtaatgg atcaatttaa
     5041 aatattttat ttcttaaaag ccttttttgc ctgttgtaat gtgcaggacc cttctccttt
     5101 catgggagag acaggtagtt acctgaatat aggttgaaaa ggttatgtaa aaagaaatta
     5161 taataaaagg gatactttgc ttttcaaatc tttgttttct cttattctag gtaaggcata
     5221 ttaaaaataa atatgtaaag aagaaaaata aaagttgtct tcatggaagc aacttgtctt
     5281 ccttggttgt actgagttac agttatccta ggggtgaaac atgtgatgct gctaagcaaa
     5341 ccaaatgccc tcagaacagg tgttatgtgg ggcatactat tgtttgcttt tgttgagaat
     5401 caggtggtta atttttgact gttcttgatt tctaatgctg aaatgacatg attctgttat
     5461 tcagcaaact tggaaatctt gatgttttga caactgcctc ctaggaaaac tggccatatg
     5521 ttaattaacc tagtagatgg aaaattaagg attatgtgag gttaatttta ccctgataat
     5581 gacaaaacct tgatagcatt taatattaat acttcttctc aaaattgaat gtttatatca
     5641 agtactgatt tttattttaa aaaagaaaaa actataatcc ttctgccttc caaaagccat
     5701 gctgtgatag ctgcccaggc tgctctgtta catctcccat ttattgttta cttttataaa
     5761 tttgcttcta agatgg
//
