LOCUS       NM_001305204             752 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens ZFP90 zinc finger protein (ZFP90), transcript variant
            3, mRNA.
ACCESSION   NM_001305204 XM_005255805
VERSION     NM_001305204.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 752)
  AUTHORS   Zhu,T., Huang,Y., Qian,D., Sheng,Y., Zhang,C., Chen,S., Zhang,H.,
            Wang,H., Zhang,X., Liu,J., Ding,C. and Liu,L.
  TITLE     Assessing the Function of the ZFP90 Variant rs1170426 in SLE and
            the Association Between SLE Drug Target and Susceptibility Genes
  JOURNAL   Front Immunol 12, 611515 (2021)
   PUBMED   33796098
  REMARK    GeneRIF: Assessing the Function of the ZFP90 Variant rs1170426 in
            SLE and the Association Between SLE Drug Target and Susceptibility
            Genes.
            Erratum:[Front Immunol. 2022 Feb 18;13:840847. doi:
            10.3389/fimmu.2022.840847.. PMID: 35251037]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 752)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 752)
  AUTHORS   Yu,C.Y., Han,J.X., Zhang,J., Jiang,P., Shen,C., Guo,F., Tang,J.,
            Yan,T., Tian,X., Zhu,X., Ma,D., Hu,Y., Xie,Y., Du,W., Zhong,M.,
            Chen,J., Liu,Q., Sun,D., Chen,Y., Zou,W., Hong,J., Chen,H. and
            Fang,J.Y.
  TITLE     A 16q22.1 variant confers susceptibility to colorectal cancer as a
            distal regulator of ZFP90
  JOURNAL   Oncogene 39 (6), 1347-1360 (2020)
   PUBMED   31641208
  REMARK    GeneRIF: A 16q22.1 variant confers susceptibility to colorectal
            cancer as a distal regulator of ZFP90.
REFERENCE   4  (bases 1 to 752)
  AUTHORS   Huang,C., Martin,S., Pfleger,C., Du,J., Buckner,J.H.,
            Bluestone,J.A., Riley,J.L. and Ziegler,S.F.
  TITLE     Cutting Edge: a novel, human-specific interacting protein couples
            FOXP3 to a chromatin-remodeling complex that contains KAP1/TRIM28
  JOURNAL   J Immunol 190 (9), 4470-4473 (2013)
   PUBMED   23543754
REFERENCE   5  (bases 1 to 752)
  AUTHORS   Hata,L., Murakami,M., Kuwahara,K., Nakagawa,Y., Kinoshita,H.,
            Usami,S., Yasuno,S., Fujiwara,M., Kuwabara,Y., Minami,T.,
            Yamada,Y., Yamada,C., Nakao,K., Ueshima,K., Nishikimi,T. and
            Nakao,K.
  TITLE     Zinc-finger protein 90 negatively regulates neuron-restrictive
            silencer factor-mediated transcriptional repression of fetal
            cardiac genes
  JOURNAL   J Mol Cell Cardiol 50 (6), 972-981 (2011)
   PUBMED   21284946
REFERENCE   6  (bases 1 to 752)
  AUTHORS   Anderson,C.A., Boucher,G., Lees,C.W., Franke,A., D'Amato,M.,
            Taylor,K.D., Lee,J.C., Goyette,P., Imielinski,M., Latiano,A.,
            Lagace,C., Scott,R., Amininejad,L., Bumpstead,S., Baidoo,L.,
            Baldassano,R.N., Barclay,M., Bayless,T.M., Brand,S., Buning,C.,
            Colombel,J.F., Denson,L.A., De Vos,M., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Fehrmann,R.S., Floyd,J.A., Florin,T.,
            Franchimont,D., Franke,L., Georges,M., Glas,J., Glazer,N.L.,
            Guthery,S.L., Haritunians,T., Hayward,N.K., Hugot,J.P., Jobin,G.,
            Laukens,D., Lawrance,I., Lemann,M., Levine,A., Libioulle,C.,
            Louis,E., McGovern,D.P., Milla,M., Montgomery,G.W., Morley,K.I.,
            Mowat,C., Ng,A., Newman,W., Ophoff,R.A., Papi,L., Palmieri,O.,
            Peyrin-Biroulet,L., Panes,J., Phillips,A., Prescott,N.J.,
            Proctor,D.D., Roberts,R., Russell,R., Rutgeerts,P., Sanderson,J.,
            Sans,M., Schumm,P., Seibold,F., Sharma,Y., Simms,L.A.,
            Seielstad,M., Steinhart,A.H., Targan,S.R., van den Berg,L.H.,
            Vatn,M., Verspaget,H., Walters,T., Wijmenga,C., Wilson,D.C.,
            Westra,H.J., Xavier,R.J., Zhao,Z.Z., Ponsioen,C.Y., Andersen,V.,
            Torkvist,L., Gazouli,M., Anagnou,N.P., Karlsen,T.H., Kupcinskas,L.,
            Sventoraityte,J., Mansfield,J.C., Kugathasan,S., Silverberg,M.S.,
            Halfvarson,J., Rotter,J.I., Mathew,C.G., Griffiths,A.M., Gearry,R.,
            Ahmad,T., Brant,S.R., Chamaillard,M., Satsangi,J., Cho,J.H.,
            Schreiber,S., Daly,M.J., Barrett,J.C., Parkes,M., Annese,V.,
            Hakonarson,H., Radford-Smith,G., Duerr,R.H., Vermeire,S.,
            Weersma,R.K. and Rioux,J.D.
  TITLE     Meta-analysis identifies 29 additional ulcerative colitis risk
            loci, increasing the number of confirmed associations to 47
  JOURNAL   Nat Genet 43 (3), 246-252 (2011)
   PUBMED   21297633
  REMARK    Erratum:[Nat Genet. 2011 Sep;43(9):919]
REFERENCE   7  (bases 1 to 752)
  AUTHORS   McClay,J.L., Adkins,D.E., Aberg,K., Bukszar,J., Khachane,A.N.,
            Keefe,R.S., Perkins,D.O., McEvoy,J.P., Stroup,T.S., Vann,R.E.,
            Beardsley,P.M., Lieberman,J.A., Sullivan,P.F. and van den Oord,E.J.
  TITLE     Genome-wide pharmacogenomic study of neurocognition as an indicator
            of antipsychotic treatment response in schizophrenia
  JOURNAL   Neuropsychopharmacology 36 (3), 616-626 (2011)
   PUBMED   21107309
REFERENCE   8  (bases 1 to 752)
  AUTHORS   Barrett,J.C., Lee,J.C., Lees,C.W., Prescott,N.J., Anderson,C.A.,
            Phillips,A., Wesley,E., Parnell,K., Zhang,H., Drummond,H.,
            Nimmo,E.R., Massey,D., Blaszczyk,K., Elliott,T., Cotterill,L.,
            Dallal,H., Lobo,A.J., Mowat,C., Sanderson,J.D., Jewell,D.P.,
            Newman,W.G., Edwards,C., Ahmad,T., Mansfield,J.C., Satsangi,J.,
            Parkes,M., Mathew,C.G., Donnelly,P., Peltonen,L., Blackwell,J.M.,
            Bramon,E., Brown,M.A., Casas,J.P., Corvin,A., Craddock,N.,
            Deloukas,P., Duncanson,A., Jankowski,J., Markus,H.S., Mathew,C.G.,
            McCarthy,M.I., Palmer,C.N., Plomin,R., Rautanen,A., Sawcer,S.J.,
            Samani,N., Trembath,R.C., Viswanathan,A.C., Wood,N., Spencer,C.C.,
            Barrett,J.C., Bellenguez,C., Davison,D., Freeman,C., Strange,A.,
            Donnelly,P., Langford,C., Hunt,S.E., Edkins,S., Gwilliam,R.,
            Blackburn,H., Bumpstead,S.J., Dronov,S., Gillman,M., Gray,E.,
            Hammond,N., Jayakumar,A., McCann,O.T., Liddle,J., Perez,M.L.,
            Potter,S.C., Ravindrarajah,R., Ricketts,M., Waller,M., Weston,P.,
            Widaa,S., Whittaker,P., Deloukas,P., Peltonen,L., Mathew,C.G.,
            Blackwell,J.M., Brown,M.A., Corvin,A., McCarthy,M.I., Spencer,C.C.,
            Attwood,A.P., Stephens,J., Sambrook,J., Ouwehand,W.H.,
            McArdle,W.L., Ring,S.M. and Strachan,D.P.
  CONSRTM   UK IBD Genetics Consortium; Wellcome Trust Case Control Consortium
            2
  TITLE     Genome-wide association study of ulcerative colitis identifies
            three new susceptibility loci, including the HNF4A region
  JOURNAL   Nat Genet 41 (12), 1330-1334 (2009)
   PUBMED   19915572
REFERENCE   9  (bases 1 to 752)
  AUTHORS   Macedo-Souza,L.I., Kok,F., Santos,S., Amorim,S.C., Starling,A.,
            Nishimura,A., Lezirovitz,K., Lino,A.M. and Zatz,M.
  TITLE     Spastic paraplegia, optic atrophy, and neuropathy is linked to
            chromosome 11q13
  JOURNAL   Ann Neurol 57 (5), 730-737 (2005)
   PUBMED   15852396
REFERENCE   10 (bases 1 to 752)
  AUTHORS   Lange,R., Christoph,A., Thiesen,H.J., Vopper,G., Johnson,K.R.,
            Lemaire,L., Plomann,M., Cremer,H., Barthels,D. and Heinlein,U.A.
  TITLE     Developmentally regulated mouse gene NK10 encodes a zinc finger
            repressor protein with differential DNA-binding domains
  JOURNAL   DNA Cell Biol 14 (11), 971-981 (1995)
   PUBMED   7576184
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009162.11, AC126773.3 and
            AW135652.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001305204.1.
            
            Summary: This gene encodes a member of the zinc finger protein
            family that modulates gene expression. The encoded protein
            derepresses the transcription of certain fetal cardiac genes and
            may contribute to the genetic reprogramming that occurs during the
            development of heart failure. Genome wide association studies have
            identified this gene among ulcerative colitis risk loci.
            Alternative splicing of this gene results in multiple transcript
            variants. [provided by RefSeq, Mar 2015].
            
            Transcript Variant: This variant (3) contains an alternate 3'
            terminal exon, compared to variant 1. It encodes isoform 2 which is
            shorter and has a distinct C-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KC249978.1, AV722381.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               AC009162.11        3474-3652           c
            180-247             AC009162.11        3118-3185           c
            248-374             AC126773.3         51679-51805
            375-470             AC126773.3         52154-52249
            471-737             AC126773.3         69472-69738
            738-752             AW135652.1         16-30               c
FEATURES             Location/Qualifiers
     source          1..752
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..752
                     /gene="ZFP90"
                     /gene_synonym="FIK; NK10; zfp-90; ZNF756"
                     /note="ZFP90 zinc finger protein"
                     /db_xref="GeneID:146198"
                     /db_xref="HGNC:HGNC:23329"
                     /db_xref="MIM:609451"
     exon            1..179
                     /gene="ZFP90"
                     /gene_synonym="FIK; NK10; zfp-90; ZNF756"
                     /inference="alignment:Splign:2.1.0"
     exon            180..247
                     /gene="ZFP90"
                     /gene_synonym="FIK; NK10; zfp-90; ZNF756"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..556
                     /gene="ZFP90"
                     /gene_synonym="FIK; NK10; zfp-90; ZNF756"
                     /note="isoform 2 is encoded by transcript variant 3; zinc
                     finger protein 476; zinc finger protein 756; zinc finger
                     protein 90 homolog; FOXP3-interacting KRAB
                     domain-containing protein"
                     /codon_start=1
                     /product="zinc finger protein 90 homolog isoform 2"
                     /protein_id="NP_001292133.1"
                     /db_xref="CCDS:CCDS76892.1"
                     /db_xref="GeneID:146198"
                     /db_xref="HGNC:HGNC:23329"
                     /db_xref="MIM:609451"
                     /translation="MAPRPPTAAPQESVTFKDVSVDFTQEEWYHVDPAQRSLYRDVML
                     ENYSHLVSLGYQVSKPEVIFKLEQGEEPWISEGEIQRPFYPGFVCLLPLSLPSGSKGE
                     RRQKLPRKNPE"
     exon            248..374
                     /gene="ZFP90"
                     /gene_synonym="FIK; NK10; zfp-90; ZNF756"
                     /inference="alignment:Splign:2.1.0"
     exon            375..470
                     /gene="ZFP90"
                     /gene_synonym="FIK; NK10; zfp-90; ZNF756"
                     /inference="alignment:Splign:2.1.0"
     exon            471..752
                     /gene="ZFP90"
                     /gene_synonym="FIK; NK10; zfp-90; ZNF756"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      752
                     /gene="ZFP90"
                     /gene_synonym="FIK; NK10; zfp-90; ZNF756"
                     /note="major polyA site"
ORIGIN      
        1 acttccagtt ctgccccacc gctgcggcca ttgtccgacc ccggtgcggc tgaggcccct
       61 ttgggcagcc cctccgcaga tcagaattgg agataaccga ggcttcggcg ggggcgggag
      121 gagctgcccg aggctctggg tgggccggag gtcgcgaaat ccggagcccc ccagaggcgc
      181 tcctgccccg gagccgggcc ctggcgaggc aggaatggcc ccgaggcctc cgaccgccgc
      241 gccccaggaa tcagtgacat tcaaagatgt gtctgtggac ttcacccagg aagaatggta
      301 ccatgtcgac cctgctcaga ggagcttata cagggatgtg atgctggaga actatagcca
      361 cctggtttct cttggatatc aagtttccaa gccagaggtg atcttcaaat tggagcaagg
      421 agaagagcca tggatatcag agggagaaat ccaacgacct ttctatccag gatttgtctg
      481 cctcctgccg ctgtcgctac catctgggag taagggcgaa agaagacaga aacttccaag
      541 aaagaatcct gagtgatgtc agcaagaatg gctaagtaag gacctccaga agttctctgc
      601 cccgtacaag ccatgcaaat actgacaaaa ctgtgagaat cagatttttc acaactctgg
      661 aacatttatt ccagcaagca gcaaatgttc cccttgcagc aagctaggaa acatttattt
      721 aaaaaaaaaa aaaaaaagca tttcattaac aa
//
