LOCUS       NM_133466               5941 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens ZFP82 zinc finger protein (ZFP82), transcript variant
            1, mRNA.
ACCESSION   NM_133466
VERSION     NM_133466.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5941)
  AUTHORS   Deng,S., Xiang,J.J., Ge,H.P., Hu,Z.P., Shen,J.P., Lin,S.Y. and
            Zeng,Y.Q.
  TITLE     The role of MIR-186 and ZNF545 in inhibiting the proliferation of
            multiple myeloma cells
  JOURNAL   J Biol Regul Homeost Agents 33 (3), 721-729 (2019)
   PUBMED   31165610
  REMARK    GeneRIF: ZNF545 protein promoted the apoptosis of myeloma cells.
REFERENCE   2  (bases 1 to 5941)
  AUTHORS   Ye,L., Xiang,T., Fan,Y., Zhang,D., Li,L., Zhang,C., He,X.,
            Xiang,Q., Tao,Q. and Ren,G.
  TITLE     The 19q13 KRAB Zinc-finger protein ZFP82 suppresses the growth and
            invasion of esophageal carcinoma cells through inhibiting NF-kappaB
            transcription and inducing apoptosis
  JOURNAL   Epigenomics 11 (1), 65-80 (2019)
   PUBMED   30211622
  REMARK    GeneRIF: ZFP82 is a tumor suppressor and is disrupted by promoter
            CpG methylation during esophageal carcinogenesis.
REFERENCE   3  (bases 1 to 5941)
  AUTHORS   Xiang,S., Xiang,T., Xiao,Q., Li,Y., Shao,B. and Luo,T.
  TITLE     Zinc-finger protein 545 is inactivated due to promoter methylation
            and functions as a tumor suppressor through the Wnt/beta-catenin,
            PI3K/AKT and MAPK/ERK signaling pathways in colorectal cancer
  JOURNAL   Int J Oncol 51 (3), 801-811 (2017)
   PUBMED   28677721
  REMARK    GeneRIF: the results suggested that ZNF545 functions as a tumor
            suppressor in colorectal cancer and is frequently inactivated by
            promoter methylation.
REFERENCE   4  (bases 1 to 5941)
  AUTHORS   Deng,J., Liang,H., Ying,G., Dong,Q., Zhang,R., Yu,J., Fan,D. and
            Hao,X.
  TITLE     Poor survival is associated with the methylated degree of
            zinc-finger protein 545 (ZNF545) DNA promoter in gastric cancer
  JOURNAL   Oncotarget 6 (6), 4482-4495 (2015)
   PUBMED   25714013
  REMARK    GeneRIF: These findings indicated that the methylated CpG sites of
            the ZNF545 promoter could be used for the clinical prediction of
            the prognosis of gastric cancer
REFERENCE   5  (bases 1 to 5941)
  AUTHORS   Xiao,Y., Xiang,T., Luo,X., Li,C., Li,Q., Peng,W., Li,L., Li,S.,
            Wang,Z., Tang,L., Ren,G. and Tao,Q.
  TITLE     Zinc-finger protein 545 inhibits cell proliferation as a tumor
            suppressor through inducing apoptosis and is disrupted by promoter
            methylation in breast cancer
  JOURNAL   PLoS One 9 (10), e110990 (2014)
   PUBMED   25360542
  REMARK    GeneRIF: ZNF545 inhibits breast tumor cell proliferation through
            inducing apoptosis and is disrupted by promoter methylation in
            breast cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5941)
  AUTHORS   Wang,S., Cheng,Y., Du,W., Lu,L., Zhou,L., Wang,H., Kang,W., Li,X.,
            Tao,Q., Sung,J.J. and Yu,J.
  TITLE     Zinc-finger protein 545 is a novel tumour suppressor that acts by
            inhibiting ribosomal RNA transcription in gastric cancer
  JOURNAL   Gut 62 (6), 833-841 (2013)
   PUBMED   22580414
  REMARK    GeneRIF: ZNF545 acts as a functional tumour suppressor in gastric
            cancer by inhibiting rRNA transcription.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL834267.1, AC092296.2 and AL707725.1.
            
            On May 17, 2019 this sequence version replaced NM_133466.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.232932.1,
                                           SRR1803611.30687.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392161.4/ ENSP00000431265.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2612              AL834267.1         5-2616
            2613-5558           AC092296.2         78047-80992         c
            5559-5941           AL707725.1         54-436
FEATURES             Location/Qualifiers
     source          1..5941
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..5941
                     /gene="ZFP82"
                     /gene_synonym="ZNF545"
                     /note="ZFP82 zinc finger protein"
                     /db_xref="GeneID:284406"
                     /db_xref="HGNC:HGNC:28682"
     exon            1..153
                     /gene="ZFP82"
                     /gene_synonym="ZNF545"
                     /inference="alignment:Splign:2.1.0"
     exon            154..240
                     /gene="ZFP82"
                     /gene_synonym="ZNF545"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1830
                     /gene="ZFP82"
                     /gene_synonym="ZNF545"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 545; zinc finger protein 85; zinc finger
                     protein 82 homolog"
                     /codon_start=1
                     /product="zinc finger protein 82 homolog isoform 1"
                     /protein_id="NP_597723.1"
                     /db_xref="CCDS:CCDS12493.1"
                     /db_xref="GeneID:284406"
                     /db_xref="HGNC:HGNC:28682"
                     /translation="MALRSVMFSDVSIDFSPEEWEYLDLEQKDLYRDVMLENYSNLVS
                     LGCFISKPDVISSLEQGKEPWKVVRKGRRQYPDLETKYETKKLSLENDIYEINLSQWK
                     IMERIENHGLKGLILKNDWESTGKIEGQERPQEGYFSSVKMPSEKVSSYQKRTSVTPH
                     QRLHFVDKPYECKECGKAFRVRQQLTFHHRIHTGEKPYECKECGMAFRQTAHLTRHQR
                     LHSGEKLYECKECGEAFICGADLRVHQKMHIGEKPYECKECGKAFRVRGQLTLHQRIH
                     TGEKPYVCKECGKAFRQYAHLTRHQKLNSADRLYECKECGKAFLCGSGLRVHHKLHTG
                     EKPYECKECGKAFRVRQQLTLHQRIHTGEKPYECKECGKTFSRGYHLILHHRIHTGEK
                     PYECKECWKAFSRYSQLISHQSIHIGVKPYDCKECGKAFRLLSQLTQHQSIHIGEKPY
                     KCKECGKAFRLRQKLTLHQSIHTGEKPFECKECRKAFRLNSSLIQHLRIHSGEKPYEC
                     KECKKAFRQHSHLTHHLKIHNVKI"
     exon            241..367
                     /gene="ZFP82"
                     /gene_synonym="ZNF545"
                     /inference="alignment:Splign:2.1.0"
     exon            368..460
                     /gene="ZFP82"
                     /gene_synonym="ZNF545"
                     /inference="alignment:Splign:2.1.0"
     exon            461..5941
                     /gene="ZFP82"
                     /gene_synonym="ZNF545"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2586..2591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP82"
                     /gene_synonym="ZNF545"
                     /note="hexamer: AATAAA"
     polyA_site      2611
                     /gene="ZFP82"
                     /gene_synonym="ZNF545"
                     /note="major polyA site"
     polyA_site      4213
                     /gene="ZFP82"
                     /gene_synonym="ZNF545"
     regulatory      4875..4880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP82"
                     /gene_synonym="ZNF545"
                     /note="hexamer: AATAAA"
     polyA_site      4908
                     /gene="ZFP82"
                     /gene_synonym="ZNF545"
     regulatory      5201..5206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP82"
                     /gene_synonym="ZNF545"
                     /note="hexamer: AATAAA"
     polyA_site      5228
                     /gene="ZFP82"
                     /gene_synonym="ZNF545"
     regulatory      5818..5823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP82"
                     /gene_synonym="ZNF545"
                     /note="hexamer: AATAAA"
     regulatory      5838..5843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP82"
                     /gene_synonym="ZNF545"
                     /note="hexamer: AATAAA"
     polyA_site      5844
                     /gene="ZFP82"
                     /gene_synonym="ZNF545"
     polyA_site      5876
                     /gene="ZFP82"
                     /gene_synonym="ZNF545"
ORIGIN      
        1 aggccccggg gattgtggcg tgacccggca gcggcttcct ccgttcgggc atcgctgtgc
       61 ctcgggttcg cgccccgagt gagcagtcct ggcccggagc gtcggtcctg gtaatctgta
      121 ggaaaagcgc tgcggcccag ggggtaaaga gagatcagcc tctgtggact cggtgcttct
      181 cctggcaagt aaaccccaag gaggactgac cagttcttga atttctatac catggccctt
      241 cgatcagtga tgttcagtga tgtatccata gacttctctc cagaagagtg ggaatacctg
      301 gacttggaac aaaaggactt gtacagagat gtcatgttgg agaactacag caacttggtc
      361 tcactgggat gcttcatttc taaaccagat gtgatttcct cattggagca aggaaaagag
      421 ccttggaaag ttgtgaggaa aggaagaaga caatatccag atttggagac caagtatgag
      481 accaagaagt tatctttaga aaatgacatt tatgaaataa atttatccca gtggaagata
      541 atggaaagaa ttgaaaacca tggccttaag ggtctcattt taaaaaatga ttgggaatcc
      601 acaggaaaaa ttgaaggaca ggagagacct caagaaggat acttcagtag tgtgaaaatg
      661 ccatctgaaa aggtgtcctc ttaccagaaa cgcacatctg ttactccaca tcagagactt
      721 cattttgttg ataaacccta tgaatgtaag gaatgtggga aggcgttcag agtgcgccaa
      781 cagcttactt ttcatcacag aattcatact ggtgaaaaac cgtatgaatg taaggaatgt
      841 gggatggcct tcagacagac tgcacacctt actcgacatc agagacttca ttctggtgaa
      901 aaactctatg aatgtaagga atgtggggaa gctttcatat gtggtgcaga tcttagagta
      961 catcagaaaa tgcatattgg tgagaagccc tatgaatgta aagaatgtgg gaaggctttt
     1021 agggtacgag gacaacttac tctgcatcag aggattcata ctggtgagaa accctatgtg
     1081 tgtaaagagt gtggaaaagc ctttagacag tacgcacacc tgactcggca tcagaagctt
     1141 aatagtgctg acaggctcta tgaatgcaaa gaatgtggga aggccttttt gtgtggctct
     1201 ggtcttagag tacatcacaa acttcatact ggtgagaaac cctatgaatg taaggaatgc
     1261 gggaaggcct ttagagtgcg acaacaacta acactccatc agagaattca tactggtgag
     1321 aaaccctatg aatgtaagga atgtggaaag acctttagcc gtggttatca tcttattctc
     1381 catcacagaa ttcatactgg tgaaaaacct tacgaatgta aggaatgctg gaaagccttt
     1441 agtcgctact cacaacttat ttcacatcag agtattcata ttggtgttaa gccctatgac
     1501 tgtaaggaat gcgggaaggc cttcagacta ctttcacaac tcacacagca tcagagtatt
     1561 catattggtg agaaacctta taaatgtaag gaatgtggca aggcctttag attgcgccaa
     1621 aaacttactc tacatcagag cattcatact ggcgaaaaac cctttgagtg taaggaatgt
     1681 aggaaggcct ttagacttaa ttcatccctt attcaacatc tgagaattca ttctggtgag
     1741 aaaccctatg aatgtaagga atgtaagaag gcctttaggc aacattcaca ccttactcat
     1801 catctgaaaa ttcataatgt aaaaatctaa gaaagtcttt tcaacttctg tgttatagaa
     1861 cattctatga atgtagtaat taatctattt tgctccatac atgcaactgc gttggcatta
     1921 gaggttttat accattaaaa gagtgtgaca atgtattgta gtccatcatc actcaaacct
     1981 gaaacttcag catatttgtt ctaaaaacta atcctgttat aagaatgaaa aagacattta
     2041 ccgtcatccc tatcccatca ctttgtgtca tactggacaa gacgcttaac tgctctgtgc
     2101 tataattttt taatttatga catggtcata taagagtgca gcagtttgac acactttcaa
     2161 tcaagaggtg gaatctacat ccctctgttg tatacaggaa tctacatccc tctgtgactg
     2221 cttcgcccag tagaatatgg tagacgtact gctgtgctgg tttcttgact cagactttac
     2281 tggtagggtt acttcatctc atgaaatgac agaactgtct tgttacaaag tctggctact
     2341 ttgctgaaga gaccacatga agaggccctg aaactacgta gagagggaga ggcacctgct
     2401 gaaccctgtc ttcttgacat ccaccaagat accagacatt tgagtgaaat tttggatcca
     2461 ccagaccagc caccagctaa atgccagtga gcgacttggt aacctgaact gatgccatgt
     2521 agaatggaag aattgaccag ctgagcccct ggcccaaatt tctgacccac aaaaacatga
     2581 gatataataa aatggttgtt gttttaagcc actaaacttt cttttattat catactaaat
     2641 atttattttt acataattca tactaaaggc tgtgggcata atgagtatag aaatgccttc
     2701 caccaacatt taatcttcat tgaacttgag atatcttatt ctcgttaaaa tattgaaagt
     2761 aaggaattcc tttccagttt gttcattaaa aaacagatac cctagaccag gtgaggtggc
     2821 ccatgcctgt aaatccagca ctttgggagg ccaagtaagg acgattgctt gaggccagaa
     2881 gttcgagacc agcctgggca acatggtgag accctgtctc taccaaaaaa ctttaaaaat
     2941 tagctgggca taatggtgca tgcctgtagt cctagctact cgaggctgag gtgggaggat
     3001 catttgaacc caagagttga ggcttcagtg agctgtgatt gtaccactgc actccagctt
     3061 gagtgactgc aagaccctgt ctcaaaaaaa aaaaaaaact acaatcagta ttctctggcc
     3121 ccagtcaata ttaaaaattg acaaaggata acatgaaact ttggaaatta aaagtcacct
     3181 gtattatgaa gccccattaa ttttttaaac tacttcattg ttttttaaaa atgctaaatt
     3241 gtcaatttag cattttgagg caatcccctc aaattggctc ctgtgtcctt ttatcatgac
     3301 cactccaacc tttgagcttt tttttttcct gaaccaaatg cattgattag ttatggagca
     3361 tactagagca ttattaacaa ataaaggaaa agaatggaat atttaccttg cctatccttt
     3421 acaaactata tttcaagaca accaaaagtt ggtgaaggaa agttgttgat tagagaattc
     3481 caactggtta aaaggtcaaa ggaggccagg cgcggtggct caagcctgta atcccagcac
     3541 tttgggaggc cgaggcaggt ggatcgtgag gtcaggagat caagaccatc ctggctaaca
     3601 cggtgaaacc ccatctctac taaaaataca aaaaattcgc cgggcgtggt ggcaggcgcc
     3661 tgtagtccca gctactcagg aggctgaggc aggagaatgg cttgaacccg ggaggcggag
     3721 cttgcagtga gccgagatcg cgccactgca ctccagcctg ggtgacagac cgagactctg
     3781 tctcaaacaa aaaacaaaaa acaaaacaaa acaaagatca aatgaatgat agaatttgaa
     3841 aactacgctc tttaatttta caaaatcatg gattttcgtg gtgatagcaa tggatgcgaa
     3901 gaccattagg tgaaaaatgg ataggaagct tataatgcat ggagcagaat gacaggacac
     3961 taatctatat taacatctct aaatgagatc agccagatga acttgatgtg atgaaatgga
     4021 tacacacagt ggacacctgt gaagttttct tggctccccc aaaactgaga agtacaagtt
     4081 agtctccaaa cctaattacc agtttacagg aaacatgggg aataaaagaa caaattaaca
     4141 acacaaagaa gcaaacaacc aaatgcacaa tttgggaaat tctgcagaag taatggccta
     4201 gttttttaac caatacatgt caaaaaaaaa aaaaaaaaag acaaaaatgg aatcctacac
     4261 tttaaaggag actaagaaac gtatccttca aatacagtgt atggagcatt ttaggatcct
     4321 tgtgttaaaa tgcgcttggg atttgtttta atcaatcatg gtgagacagg cagacatgga
     4381 aattattgtc atgaaggaag aagtttatac gcagatccca caaacgggag gcatggcatg
     4441 gcatgcaggg tcacgtaaag aagcacctgg gtgtatcagg aggcagaggg tgagagcaca
     4501 gcatggccca gagcttttat tgggggtttt catgggaagg aatggacaag gcaggggtag
     4561 gcacactggt aagcttagga ttgaatagtt tgagtaattt tgttggtctc tgggatctag
     4621 gggggattcg taattgtcta gttagggcag gggaatattg aattggtgta tgagagtttg
     4681 gtaaaggaga tagttgggag tatgggctct ggattggttg gtttgtatat gaaaggcatg
     4741 cttgcagtgg agtttatcat ctatgcatta gcttgccctg ggaggggcag cctatccagg
     4801 atcaaggccc caagtggcca gagcatcagg aatacagaaa ataaagaaaa catagtcaat
     4861 acaagatttg aaggaataaa atgtctctac atattgtaca aatgtaaaca tggattggtt
     4921 actaaatgat acgaaataat ttattgttca tatgttaggc atgactatgg cattatgggt
     4981 atatgtgtat gagtccttaa gtgttagaga ttcatactga ggtatttaag gctgaaatgt
     5041 tatgcctgtg atttactttt aaatacttaa aaacaaaagg tgggagggat agatgaaaca
     5101 agattagcaa aatgttggta aatgtttaat ctggatcatt aggtacacag ggttcattgt
     5161 gccgttctta ctatctttac atatatttta aattttccat aataaagttt tttaaagtag
     5221 aaaatcaagt ttgggccagg cgtggtggct catgcctgta atcgcagtac tttgggaggc
     5281 caaggtgggt ggatcatttg aggccaggag atcaagacca tcctggccaa catggtgaaa
     5341 ctctgtctct actaaaaata caaaaattag ctggacatgg tggcacgcct gtagtcccag
     5401 ctactcggga ggctgaggca ggaaaatcgc ttgaacccag gaggcggagg ttgcagtgag
     5461 ctgagatcac accactgcac tccagcctgg caatagagtg agactccatc tcaaaaaaaa
     5521 aaaaaaagaa agaaaatcaa gtctgaaatt gtagactatt tagtgatgaa tgatcacatg
     5581 ttgcctacag ataacttggg ggaaatcacc aaccaaagct ctacttggta gaaaatttaa
     5641 agcaatgcat ttagaacatc tggattgaga aataagtatt tgtgttgttc accattctgt
     5701 tcacacacct acagtgcctg tcacataaca ggcaatttat gggaaaaaat aaggattaac
     5761 ttaagctaga aatttttaaa aactaaggtg aataacagca agtagtttat atgatcaaat
     5821 aaattaatgg aatagttaat aaaataacag actaaggata ttctctttga aaagaacatt
     5881 aatatagaat tggcagttat tgagggaaaa acatgactca cagctttatg tatggaaaaa
     5941 g
//
