LOCUS       NM_023070               2217 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ZFP69 zinc finger protein B (ZFP69B), transcript
            variant 1, mRNA.
ACCESSION   NM_023070
VERSION     NM_023070.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2217)
  AUTHORS   Oleksiewicz,U., Machnik,M., Sobocinska,J., Molenda,S.,
            Olechnowicz,A., Florczak,A., Mierzejewska,J., Adamczak,D.,
            Smolibowski,M., Kaczmarek,M. and Mackiewicz,A.
  TITLE     ZNF643/ZFP69B Exerts Oncogenic Properties and Associates with Cell
            Adhesion and Immune Processes
  JOURNAL   Int J Mol Sci 24 (22), 16380 (2023)
   PUBMED   38003570
  REMARK    GeneRIF: ZNF643/ZFP69B Exerts Oncogenic Properties and Associates
            with Cell Adhesion and Immune Processes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2217)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2217)
  AUTHORS   Serebrenik,Y.V., Hellerschmied,D., Toure,M., Lopez-Giraldez,F.,
            Brookner,D. and Crews,C.M.
  TITLE     Targeted protein unfolding uncovers a Golgi-specific
            transcriptional stress response
  JOURNAL   Mol Biol Cell 29 (11), 1284-1298 (2018)
   PUBMED   29851555
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031985.10, CN256362.1 and BC017498.1.
            
            On Nov 22, 2018 this sequence version replaced NM_023070.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.48808.1,
                                           SRR1803617.218797.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361584.5/ ENSP00000354547.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               AL031985.10        123239-123427
            190-568             CN256362.1         86-464
            569-2217            BC017498.1         1-1649
FEATURES             Location/Qualifiers
     source          1..2217
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..2217
                     /gene="ZFP69B"
                     /gene_synonym="ZKSCAN23B; ZNF643; ZSCAN54B"
                     /note="ZFP69 zinc finger protein B"
                     /db_xref="GeneID:65243"
                     /db_xref="HGNC:HGNC:28053"
     exon            1..613
                     /gene="ZFP69B"
                     /gene_synonym="ZKSCAN23B; ZNF643; ZSCAN54B"
                     /inference="alignment:Splign:2.1.0"
     CDS             487..2091
                     /gene="ZFP69B"
                     /gene_synonym="ZKSCAN23B; ZNF643; ZSCAN54B"
                     /note="novel zinc finger protein; zinc finger protein 643;
                     zinc finger protein ZFP69B"
                     /codon_start=1
                     /product="zinc finger protein 69 homolog B"
                     /protein_id="NP_075558.2"
                     /db_xref="CCDS:CCDS452.2"
                     /db_xref="GeneID:65243"
                     /db_xref="HGNC:HGNC:28053"
                     /translation="MLQQLLITLPTEASTWVKLRHPKAATERVALWEDVTKMFKAEAL
                     LSQDADETQGESLESRVTLGSLTAESQELLTFKDVSVDFTQEEWGQLAPAHRNLYREV
                     MLENYGNLVSVGCQLSKPGVISQLEKGEEPWLMERDISGVPSSDLKSKTKTKESALQN
                     DISWEELHCGLMMERFTKGSSMYSTLGRISKCNKLESQQENQRMGKGQIPLMCKKTFT
                     QERGQESNRFEKRINVKSEVMPGPIGLPRKRDRKYDTPGKRSRYNIDLVNHSRSYTKM
                     KTFECNICEKIFKQLIHLTEHMRIHTGEKPFRCKECGKAFSQSSSLIPHQRIHTGEKP
                     YECKECGKTFRHPSSLTQHVRIHTGEKPYECRVCEKAFSQSIGLIQHLRTHVREKPFT
                     CKDCGKAFFQIRHLRQHEIIHTGVKPYICNVCSKTFSHSTYLTQHQRTHTGERPYKCK
                     ECGKAFSQRIHLSIHQRVHTGVKPYECSHCGKAFRHDSSFAKHQRIHTGEKPYDCNEC
                     GKAFSCSSSLIRHCKTHLRNTFSNVV"
     exon            614..699
                     /gene="ZFP69B"
                     /gene_synonym="ZKSCAN23B; ZNF643; ZSCAN54B"
                     /inference="alignment:Splign:2.1.0"
     exon            700..826
                     /gene="ZFP69B"
                     /gene_synonym="ZKSCAN23B; ZNF643; ZSCAN54B"
                     /inference="alignment:Splign:2.1.0"
     exon            827..922
                     /gene="ZFP69B"
                     /gene_synonym="ZKSCAN23B; ZNF643; ZSCAN54B"
                     /inference="alignment:Splign:2.1.0"
     exon            923..2217
                     /gene="ZFP69B"
                     /gene_synonym="ZKSCAN23B; ZNF643; ZSCAN54B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2196..2201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP69B"
                     /gene_synonym="ZKSCAN23B; ZNF643; ZSCAN54B"
                     /note="hexamer: ATTAAA"
     polyA_site      2217
                     /gene="ZFP69B"
                     /gene_synonym="ZKSCAN23B; ZNF643; ZSCAN54B"
                     /note="major polyA site"
ORIGIN      
        1 gtattcgtct ctttgtgctt cctgacatgt gcgcggtgct ttgaattttg tgggctgtgt
       61 ctgcccaccg tctccgtgta tcttttggaa acattttaca gtgatccata tatgttctag
      121 cgttctgccc tatgactgag cctccttagt cctttgctga ttctaatgtc ttctgctcag
      181 catctgcagg ggctgctgag agtaaatact tggcgcctcc agctgctggc caaggagaca
      241 gatggagctc aagttgggag atacgccctg agagccgatg atagacacaa gtccagatct
      301 cggattttga tactgtatgt tccctgggtt cctgagagag gacattgagg agtaggagtc
      361 ggcgattaag gagatcggta caattgggaa gcctcctgtc agagcttcca gcaatttcct
      421 catcagaggt ggacaagccc tatgggctaa gacagagggt cctcagaaag gagtgcggac
      481 gccgtcatgc tgcagcagct cctgatcacc ctgcccaccg aggccagcac ctgggtgaag
      541 ttgcgtcatc caaaggcggc cacggagcgg gtggccctgt gggaggatgt gactaagatg
      601 tttaaagcag aagctctgct gtctcaggat gctgatgaga cccagggcga aagtttagag
      661 agtagagtga cccttggatc cctgacagca gaatcccagg aactgttaac cttcaaggac
      721 gtatctgtgg acttcactca ggaggagtgg gggcagctgg cccctgctca ccggaatctg
      781 taccgggagg tgatgctgga gaactatggg aacctggtct cagtgggatg tcagctttcc
      841 aaacctggcg tgatttccca gttggagaaa ggagaagaac catggctgat ggagagagat
      901 atttcaggag ttccaagttc agacttgaag agcaaaacaa aaaccaaaga gtcagcctta
      961 cagaatgata tttcgtggga agaactacat tgtggcctaa tgatggaaag atttacaaaa
     1021 ggaagcagca tgtattccac cttgggaaga atctccaaat gtaataagct agaaagccaa
     1081 caagagaacc aaagaatggg taaggggcaa atccccctga tgtgcaagaa aacattcact
     1141 caggagagag gccaagagtc taatagattt gagaaaagaa ttaatgtgaa gtcagaagtt
     1201 atgccaggac caataggtct tccaagaaaa agagatcgta aatatgacac acctggaaag
     1261 agaagcagat acaacataga tttagttaat cattcaagga gttatacaaa aatgaaaacc
     1321 tttgagtgta atatttgtga aaaaatcttc aaacagctta ttcaccttac tgaacacatg
     1381 agaattcata ccggggagaa acctttcaga tgtaaggaat gtggaaaagc ctttagccaa
     1441 agttcatctc ttattccgca tcagagaatt catactggtg agaaacccta tgaatgtaag
     1501 gagtgtggga aaaccttcag acatccttca tcgcttactc aacatgttag aattcatacc
     1561 ggggaaaagc cctatgaatg tagggtatgt gagaaagcct tcagccagag cattggactg
     1621 atccagcatt tgagaactca tgttagagag aaacctttta catgcaaaga ctgtggaaaa
     1681 gcgtttttcc agattagaca ccttaggcaa catgagatta ttcatactgg tgtgaaaccc
     1741 tatatttgta atgtatgtag taaaaccttc agccatagta catacctaac tcaacaccag
     1801 agaactcata ctggagaaag accatataaa tgtaaggaat gtgggaaagc ctttagccag
     1861 agaatacatc tttctatcca tcagagagtc catactggag taaaacctta tgaatgcagt
     1921 cattgtggga aagcctttag gcatgattca tcctttgcta aacatcagag aattcatact
     1981 ggagaaaaac cttatgattg taatgagtgt ggaaaagcct tcagctgtag ttcatccctt
     2041 attagacact gcaaaacaca tttaagaaat accttcagca atgttgtgtg aaatatacta
     2101 aacatcaaag aatctatgtt ggagcacaag attctaaatc agtggttccc tgatccctca
     2161 aaaatccatt tgtttttgga tttccaaaaa cgaacattaa aaaaaaatgg tttggca
//
