LOCUS       NM_001320179            2796 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ZFP69 zinc finger protein (ZFP69), transcript variant
            2, mRNA.
ACCESSION   NM_001320179 XM_006710607
VERSION     NM_001320179.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2796)
  AUTHORS   Scherneck,S., Nestler,M., Vogel,H., Bluher,M., Block,M.D., Berriel
            Diaz,M., Herzig,S., Schulz,N., Teichert,M., Tischer,S.,
            Al-Hasani,H., Kluge,R., Schurmann,A. and Joost,H.G.
  TITLE     Positional cloning of zinc finger domain transcription factor
            Zfp69, a candidate gene for obesity-associated diabetes contributed
            by mouse locus Nidd/SJL
  JOURNAL   PLoS Genet 5 (7), e1000541 (2009)
   PUBMED   19578398
  REMARK    GeneRIF: Zfp69 is the most likely candidate for the diabetogenic
            effect of Nidd/SJL locus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603839.9, BC041873.1, AK122618.1 and BM677727.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001320179.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and uses
            an alternate in-frame splice site in the 5' coding region, compared
            to variant 1. It encodes isoform 2, which is shorter than isoform 1
            by a single amino acid. Variants 2 and 3 encode the same isoform
            (2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041873.1, SRR1660803.62440.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372706.6/ ENSP00000361791.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               AL603839.9         12316-12655
            341-1405            BC041873.1         417-1481
            1406-1702           AK122618.1         769-1065
            1703-2498           BC041873.1         1779-2574
            2499-2796           BM677727.1         18-315              c
FEATURES             Location/Qualifiers
     source          1..2796
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..2796
                     /gene="ZFP69"
                     /gene_synonym="ZFP69A; ZKSCAN23A; ZNF642; ZSCAN54A"
                     /note="ZFP69 zinc finger protein"
                     /db_xref="GeneID:339559"
                     /db_xref="HGNC:HGNC:24708"
                     /db_xref="MIM:617939"
     exon            1..605
                     /gene="ZFP69"
                     /gene_synonym="ZFP69A; ZKSCAN23A; ZNF642; ZSCAN54A"
                     /inference="alignment:Splign:2.1.0"
     exon            606..1058
                     /gene="ZFP69"
                     /gene_synonym="ZFP69A; ZKSCAN23A; ZNF642; ZSCAN54A"
                     /inference="alignment:Splign:2.1.0"
     CDS             932..2512
                     /gene="ZFP69"
                     /gene_synonym="ZFP69A; ZKSCAN23A; ZNF642; ZSCAN54A"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger protein 642; ZFP69 zinc finger protein A; zinc
                     finger protein ZFP69; zinc finger protein 69 homolog"
                     /codon_start=1
                     /product="zinc finger protein 69 homolog isoform 2"
                     /protein_id="NP_001307108.1"
                     /db_xref="CCDS:CCDS30686.1"
                     /db_xref="GeneID:339559"
                     /db_xref="HGNC:HGNC:24708"
                     /db_xref="MIM:617939"
                     /translation="MPQQLLITLPTEASTWVKLQHPKKAVEGAPLWEDVTKMFEGEAL
                     LSQDAEDVKTQRESLEDEVTPGLPTAESQELLTFKDISIDFTQEEWGQLAPAHQNLYR
                     EVMLENYSNLVSVGYQLSKPSVISQLEKGEEPWMAEKEGPGDPSSDLKSKIETIESTA
                     KSTISQERLYHGIMMESFMRDDIIYSTLRKVSTYDDVLERHQETCMRDVRQAILTHKK
                     RVQETNKFGENIIVHSNVIIEQRHHKYDTPTKRNTYKLDLINHPTSYIRTKTYECNIC
                     EKIFKQPIHLTEHMRIHTGEKPFRCKECGRAFSQSASLSTHQRIHTGEKPFECEECGK
                     AFRHRSSLNQHHRTHTGEKPYVCDKCQKAFSQNISLVQHLRTHSGEKPFTCNECGKTF
                     RQIRHLSEHIRIHTGEKPYACTACCKTFSHRAYLTHHQRIHTGERPYKCKECGKAFRQ
                     RIHLSNHKTVHTGVKAYECNRCGKAYRHDSSFKKHQRHHTGEKPYECNECGKAFSYNS
                     SLSRHHEIHRRNAFRNKV"
     exon            1059..1150
                     /gene="ZFP69"
                     /gene_synonym="ZFP69A; ZKSCAN23A; ZNF642; ZSCAN54A"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1277
                     /gene="ZFP69"
                     /gene_synonym="ZFP69A; ZKSCAN23A; ZNF642; ZSCAN54A"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1373
                     /gene="ZFP69"
                     /gene_synonym="ZFP69A; ZKSCAN23A; ZNF642; ZSCAN54A"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..2796
                     /gene="ZFP69"
                     /gene_synonym="ZFP69A; ZKSCAN23A; ZNF642; ZSCAN54A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2693..2698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP69"
                     /gene_synonym="ZFP69A; ZKSCAN23A; ZNF642; ZSCAN54A"
                     /note="hexamer: ATTAAA"
     regulatory      2717..2722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP69"
                     /gene_synonym="ZFP69A; ZKSCAN23A; ZNF642; ZSCAN54A"
                     /note="hexamer: AATGAA"
     polyA_site      2718
                     /gene="ZFP69"
                     /gene_synonym="ZFP69A; ZKSCAN23A; ZNF642; ZSCAN54A"
     polyA_site      2739
                     /gene="ZFP69"
                     /gene_synonym="ZFP69A; ZKSCAN23A; ZNF642; ZSCAN54A"
                     /note="major polyA site"
     regulatory      2775..2780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP69"
                     /gene_synonym="ZFP69A; ZKSCAN23A; ZNF642; ZSCAN54A"
                     /note="hexamer: AATAAA"
     polyA_site      2796
                     /gene="ZFP69"
                     /gene_synonym="ZFP69A; ZKSCAN23A; ZNF642; ZSCAN54A"
ORIGIN      
        1 caacccgccg gaagacgcgc gggttgtggc agctgcagcg ggaccgcgtg gggtgggccc
       61 cgggaccgcc agggctgcag cgagagcggc cggcggtgca agcggccggg agggcgcggc
      121 cggaggcaga ggccaggcga gacacccggc tgcggcctaa gaggccaggc tgggtgggct
      181 tggctgcagc cgccagcccc gtgttaaagc ggcagccagg gaggtgtatc ctccccgggg
      241 tctgcaagac gccggctcag ggcatccctc ccattccggc cctcaaagcc tcgctcctgg
      301 gggcgctgct gggaaagccc acccgcctgg gcgggccctt gatgggaatg tggagcagac
      361 cctcgtccac tccggaggcc gagggtcctc cgggcttccg aaggaagccg acctcaacgc
      421 tggacgcttc ttggagaatg attgcgttga gtggagatgt ggtctgtcta taaaaggccg
      481 ggagggaaca atatctgtta ccactcagtc cgtctctaaa gagacactct ttaccgctga
      541 aaacctcaag agtgagcact cccacgcccc cgtctctggt cctacctggg tccaaggccg
      601 atgtgattct ggagttctgg agacaagtgc ttctggatcc ctcttccctt cccttttgct
      661 cctctaaaga gtatggagac atgaactcaa acctaactaa ctggctgcct cccaaagaaa
      721 gtgcttgatt taaaggggag tttgttttcc agaattgtta aagtcacatc agtctctagg
      781 aacccccagg tcctggtgct gcagggacac accagagtcc tgagggcagg tgattggaat
      841 ctgagcaaca ccccacaact gtgaagcgtc tcatcaagag cttctggcaa tttcctcacc
      901 agaagtggac aagtccagta aggcaggcat catgccacag cagctcctga tcaccctgcc
      961 taccgaggcc agcacctggg tgaagctgca acatccaaag aaggccgtgg agggggcgcc
     1021 cctgtgggag gatgtgacta aaatgtttga aggagaagct ctgctgtctc aggatgctga
     1081 ggacgtaaag acccagagag aaagtttaga ggatgaagtg acccctggac tcccgacagc
     1141 agaatcccag gaattgttga ctttcaagga catatctatt gacttcaccc aggaagagtg
     1201 ggggcagctg gctcctgctc accagaatct ataccgagag gtgatgctgg agaactacag
     1261 caacttggtg tcagtgggat atcaactttc caaacctagt gtgatatccc agttagagaa
     1321 aggagaagag ccatggatgg cagagaaaga aggcccagga gatcccagtt cagacttgaa
     1381 gagtaaaata gaaaccattg agtcaactgc aaagagtacc atttcacagg agcgcttata
     1441 tcatggcatt atgatggaaa gtttcatgag ggatgatata atttattcca cgttgagaaa
     1501 agtctccaca tatgatgatg tcttagaaag gcaccaggaa acttgtatga gagatgtgag
     1561 acaagccatc ttgacccata agaagagagt ccaagaaact aacaaatttg gggaaaatat
     1621 cattgtgcat tcaaatgtta ttattgaaca gaggcaccat aaatatgata cacctacaaa
     1681 gcggaacaca tacaaattag atttgattaa tcatccaaca agttacataa gaacaaaaac
     1741 ctatgaatgt aatatatgtg aaaaaatctt caaacaacct attcacctta ctgaacatat
     1801 gagaattcat actggtgaga aacctttcag atgtaaggaa tgtggaaggg cctttagtca
     1861 aagtgcatcc ctcagtacac accagagaat ccatactggt gagaaaccct ttgaatgtga
     1921 ggaatgtggg aaagccttca gacatcgctc atcacttaat cagcatcata gaactcacac
     1981 tggggagaaa ccctatgtat gtgataaatg tcagaaagct ttcagccaga acattagctt
     2041 ggttcaacat ttgaggactc attctggaga gaaacctttt acttgcaatg aatgtgggaa
     2101 aacctttaga cagattagac accttagtga acatataaga attcataccg gggagaagcc
     2161 ctatgcatgc actgcatgtt gtaaaacctt tagtcataga gcgtatctaa cacatcacca
     2221 gagaatccat actggggaga gaccctacaa atgtaaagaa tgtggaaaag cctttaggca
     2281 gaggatacac cttagcaacc ataaaactgt tcatacagga gtgaaagcat atgaatgcaa
     2341 ccgctgtgga aaagcctata ggcatgattc atcctttaaa aaacatcaga gacatcacac
     2401 tggagaaaaa ccttacgaat gtaacgaatg tggaaaagcc ttcagctata actcttcact
     2461 tagtcgacat catgaaatac acaggaggaa cgccttccga aataaggtgt aaaaacagat
     2521 atttgacttg agaacaaaag ccaagtgtaa attggtgatt tagagtgctt taaaatttca
     2581 ggactcagat atgaggaatt gatgtaatga tgccaacttt taatttttcc cattgtaaat
     2641 aaacattaca ttgacaggta ttgactacta acacctctaa aaagtactta agattaaaat
     2701 ctggtcctta aaattaaatg aattcagcat tatgaaaaat tcataacagt ttttttctga
     2761 tttcatggtg gattaataaa ttattcttca tgggta
//
