LOCUS       NM_018197               3057 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ZFP64 zinc finger protein (ZFP64), transcript variant
            1, mRNA.
ACCESSION   NM_018197
VERSION     NM_018197.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3057)
  AUTHORS   Han,R., Dermawan,J.K., Demicco,E.G., Ferguson,P.C., Griffin,A.M.,
            Swanson,D., Antonescu,C.R. and Dickson,B.C.
  TITLE     ZFP64::NCOA3 gene fusion defines a novel subset of spindle cell
            rhabdomyosarcoma
  JOURNAL   Genes Chromosomes Cancer 61 (11), 645-652 (2022)
   PUBMED   35521817
  REMARK    GeneRIF: ZFP64::NCOA3 gene fusion defines a novel subset of spindle
            cell rhabdomyosarcoma.
REFERENCE   2  (bases 1 to 3057)
  AUTHORS   Qiu,G. and Deng,Y.
  TITLE     ZFP64 transcriptionally activates PD-1 and CTLA-4 and plays an
            oncogenic role in esophageal cancer
  JOURNAL   Biochem Biophys Res Commun 622, 72-78 (2022)
   PUBMED   35843097
  REMARK    GeneRIF: ZFP64 transcriptionally activates PD-1 and CTLA-4 and
            plays an oncogenic role in esophageal cancer.
REFERENCE   3  (bases 1 to 3057)
  AUTHORS   Jiang,J., Zhang,J., Fu,K. and Zhang,T.
  TITLE     Function and mechanism exploration of zinc finger protein 64 in
            lung adenocarcinoma cell growth and metastasis
  JOURNAL   J Recept Signal Transduct Res 41 (5), 457-465 (2021)
   PUBMED   33054540
  REMARK    GeneRIF: Function and mechanism exploration of zinc finger protein
            64 in lung adenocarcinoma cell growth and metastasis.
REFERENCE   4  (bases 1 to 3057)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3057)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3057)
  AUTHORS   Sakamoto,K., Tamamura,Y., Katsube,K. and Yamaguchi,A.
  TITLE     Zfp64 participates in Notch signaling and regulates differentiation
            in mesenchymal cells
  JOURNAL   J Cell Sci 121 (Pt 10), 1613-1623 (2008)
   PUBMED   18430783
REFERENCE   7  (bases 1 to 3057)
  AUTHORS   Schymick,J.C., Scholz,S.W., Fung,H.C., Britton,A., Arepalli,S.,
            Gibbs,J.R., Lombardo,F., Matarin,M., Kasperaviciute,D.,
            Hernandez,D.G., Crews,C., Bruijn,L., Rothstein,J., Mora,G.,
            Restagno,G., Chio,A., Singleton,A., Hardy,J. and Traynor,B.J.
  TITLE     Genome-wide genotyping in amyotrophic lateral sclerosis and
            neurologically normal controls: first stage analysis and public
            release of data
  JOURNAL   Lancet Neurol 6 (4), 322-328 (2007)
   PUBMED   17362836
REFERENCE   8  (bases 1 to 3057)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   9  (bases 1 to 3057)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   10 (bases 1 to 3057)
  AUTHORS   Mack,H.G., Beck,F. and Bowtell,D.D.
  TITLE     A search for a mammalian homologue of the Drosophila photoreceptor
            development gene glass yields Zfp64, a zinc finger encoding gene
            which maps to the distal end of mouse chromosome 2
  JOURNAL   Gene 185 (1), 11-17 (1997)
   PUBMED   9034307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC041622.1 and AK001744.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018197.2.
            
            Transcript Variant: This variant (1) lacks several exons and
            includes an alternate 3' terminal exon resulting in a novel 3'
            coding region and 3' UTR compared to variant 4. The encoded isoform
            (a) has a longer and distinct C-terminus compared to isoform d.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012759.2, AK001596.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216923.5/ ENSP00000216923.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1324              BC041622.1         207-1530
            1325-2772           AK001744.1         1096-2543
            2773-3057           BC041622.1         2978-3262
FEATURES             Location/Qualifiers
     source          1..3057
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.2"
     gene            1..3057
                     /gene="ZFP64"
                     /gene_synonym="ZNF338"
                     /note="ZFP64 zinc finger protein"
                     /db_xref="GeneID:55734"
                     /db_xref="HGNC:HGNC:15940"
                     /db_xref="MIM:618111"
     exon            1..189
                     /gene="ZFP64"
                     /gene_synonym="ZNF338"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..2189
                     /gene="ZFP64"
                     /gene_synonym="ZNF338"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger protein 338; zinc finger protein 64 homolog"
                     /codon_start=1
                     /product="zinc finger protein 64 isoform a"
                     /protein_id="NP_060667.2"
                     /db_xref="CCDS:CCDS13440.1"
                     /db_xref="GeneID:55734"
                     /db_xref="HGNC:HGNC:15940"
                     /db_xref="MIM:618111"
                     /translation="MNASSEGESFAGSVQIPGGTTVLVELTPDIHICGICKQQFNNLD
                     AFVAHKQSGCQLTGTSAAAPSTVQFVSEETVPATQTQTTTRTITSETQTITVSAPEFV
                     FEHGYQTYLPTESNENQTATVISLPAKSRTKKPTTPPAQKRLNCCYPGCQFKTAYGMK
                     DMERHLKIHTGDKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKCKTCDYAAADSSSL
                     NKHLRIHSDERPFKCQICPYASRNSSQLTVHLRSHTGDAPFQCWLCSAKFKISSDLKR
                     HMRVHSGEKPFKCEFCNVRCTMKGNLKSHIRIKHSGNNFKCPHCDFLGDSKATLRKHS
                     RVHQSEHPEKCSECSYSCSSKAALRIHERIHCTDRPFKCNYCSFDTKQPSNLSKHMKK
                     FHGDMVKTEALERKDTGRQSSRQVAKLDAKKSFHCDICDASFMREDSLRSHKRQHSEY
                     SESKNSDVTVLQFQIDPSKQPATPLTVGHLQVPLQPSQVPQFSEGRVKIIVGHQVPQA
                     NTIVQAAAAAVNIVPPALVAQNPEELPGNSRLQILRQVSLIAPPQSSRCPSEAGAMTQ
                     PAVLLTTHEQTDGATLHQTLIPTASGGPQEGSGNQTFITSSGITCTDFEGLNALIQEG
                     TAEVTVVSDGGQNIAVATTAPPVFSSSSQQELPKQTYSIIQGAAHPALLCPADSIPD"
     exon            190..429
                     /gene="ZFP64"
                     /gene_synonym="ZNF338"
                     /inference="alignment:Splign:2.1.0"
     exon            430..591
                     /gene="ZFP64"
                     /gene_synonym="ZNF338"
                     /inference="alignment:Splign:2.1.0"
     exon            592..654
                     /gene="ZFP64"
                     /gene_synonym="ZNF338"
                     /inference="alignment:Splign:2.1.0"
     exon            655..906
                     /gene="ZFP64"
                     /gene_synonym="ZNF338"
                     /inference="alignment:Splign:2.1.0"
     exon            907..3057
                     /gene="ZFP64"
                     /gene_synonym="ZNF338"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3031..3036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP64"
                     /gene_synonym="ZNF338"
                     /note="hexamer: AATAAA"
     polyA_site      3057
                     /gene="ZFP64"
                     /gene_synonym="ZNF338"
                     /note="major polyA site"
ORIGIN      
        1 acatccgtcc tccccgcctc gcagagttgg gagaaggcag ggtggggggt gtggaaaaat
       61 aaaaggaaaa gtccttgcac catgtagatc agcgtccccc actttggcat cccggccggc
      121 cggggacctc ccagtctgcg gccatgaacg cgagcagcga gggcgagagc ttcgcgggct
      181 cggtgcaaat tccaggtggc acaacggtgc tggtggagct gactcccgac atccatatct
      241 gcggcatctg caagcagcag tttaacaacc tggatgcctt tgtagctcac aagcaaagtg
      301 gctgccagct gacaggcaca tccgcagcag cccccagcac ggtccagttt gtatcggagg
      361 aaacagtgcc tgccacccag actcagacca ccaccagaac catcacctcg gagacccaga
      421 caatcacagt ttcagctcca gaatttgttt ttgaacatgg ctatcaaact tacctgccca
      481 cggaaagtaa tgaaaaccag acagccactg tcatctctct ccctgccaag tcacgcacca
      541 aaaagcccac aacaccacct gctcagaaaa ggcttaactg ttgctatcca ggttgccaat
      601 tcaagactgc ttatggcatg aaggacatgg agcggcattt aaaaattcac acgggagaca
      661 aaccccataa gtgtgaagtc tgtggcaagt gctttagccg gaaagacaag ctgaaaactc
      721 acatgcggtg ccacacgggc gtgaagccct acaagtgtaa gacgtgtgac tacgccgctg
      781 ccgacagcag cagcctcaac aagcacctga ggatccactc ggacgagcgg cccttcaaat
      841 gccagatctg cccctacgcc agccgcaact ccagccagct cactgtccac ctgcgatccc
      901 acacggggga cgcccccttc cagtgctggc tctgtagcgc caagttcaaa atcagctcgg
      961 acttgaaaag gcacatgcgg gtgcactcgg gggagaagcc tttcaagtgc gagttctgca
     1021 atgtccgctg caccatgaag gggaacctca agtcgcacat ccgtatcaag cacagcggga
     1081 ataacttcaa gtgtcctcat tgcgacttcc tgggtgacag caaagccacc ctccggaagc
     1141 acagccgcgt gcaccagtcg gagcatcctg agaagtgctc ggaatgcagc tactcctgct
     1201 ccagcaaggc cgccctgcgc atccacgagc gtatccactg caccgaccgc cctttcaagt
     1261 gcaactactg cagcttcgac accaaacagc ccagcaacct gagcaagcac atgaagaagt
     1321 tccatgggga catggttaag actgaggctc tagagaggaa ggacaccggc aggcagagca
     1381 gccggcaggt ggccaagctg gatgccaaga agagtttcca ctgcgatata tgcgatgcct
     1441 ccttcatgcg ggaggactcg ctccgcagcc acaagagaca gcacagtgag tacagtgaga
     1501 gtaagaactc ggacgtgacc gttctccagt ttcagatcga ccccagcaag cagcccgcca
     1561 cgcccctcac tgtgggacac ctccaggtgc ccctccagcc cagccaagtg ccccagttca
     1621 gcgagggaag agtcaaaatc atcgttgggc atcaggtgcc ccaggcgaac accatcgtcc
     1681 aggctgccgc cgctgcagtg aacatcgtcc cgcctgcctt ggtggcccag aacccagagg
     1741 aactcccagg gaacagccgg ctgcagatcc tgcgccaggt cagtctgatc gccccccctc
     1801 agtcctcgcg gtgtccgagc gaggcgggcg caatgaccca gccggctgtc ctgctgacca
     1861 cccacgagca gacggacgga gccactctgc accagactct catccccacg gcctcaggtg
     1921 gcccccagga aggctctggc aatcaaactt tcattaccag ttcgggtatt acttgcactg
     1981 actttgaagg cctaaacgcc ttgattcagg aggggacagc agaagtgaca gtggtgagcg
     2041 atggaggcca gaacatcgca gtggccacca cagcgccacc ggtcttctcc tcctcttccc
     2101 agcaagaact acccaagcag acctactcca tcattcaagg ggcagcccat ccagctttgc
     2161 tctgtcccgc cgactccatt ccagattagt gcttaaaaaa acaaaaggag tgggggaaag
     2221 gaattgagaa aaagaaatct taagtagaat tctctaaaag gtttgctctt aatgttttct
     2281 ttgttttgtt ttgtttttga gacggagtct cgctctgttt cccaggctgg agtgcagtgg
     2341 cgctatcttg gctcactgca acgtccgcct cccaggttca agcgattctc atgcctcagc
     2401 cctccgagta gctgggacca caggtgtacg acatcatgac tggctaattt ttgtatattt
     2461 agtagagacg gggtttcatc atgttgaact cctgacctca agtgatctgc ccacctcagc
     2521 ctcccaaagt gctgggatta caggtgtgag ccaccatgcc tggccgtggt ttgctcttaa
     2581 tgtttttaag gatggttgtg aatccccctg gccccataat aaattgtaat tttatactgc
     2641 ttactataat ttttttaaca ctgtaacaac tttgagacca cctctgaatc gtcgcattat
     2701 aactgttgta gaatcttaaa tgttaccaag atgattccaa tgaggggttg gaattaaatg
     2761 cattaagtag tgaattcatg tgtttgtttc caacttgatt ttccaactct aataaaggtt
     2821 tctgtccatc ttattacatt tgtgtagtaa atggtacttc ccagcctctc ttttgcccca
     2881 ttctggaata ctccccagag tttgggggtg ttcatgtttt atacatgtaa gtctgttggc
     2941 atgaaggacc attttctaca taatatgaca tggatacttg acccaaaaaa aaatgtttag
     3001 tgctaatgag cagaaaatga atggttccat aataaattga tatctgatta aaatata
//
