LOCUS       NM_001109809            2082 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens ZFP57 zinc finger protein (ZFP57), transcript variant
            1, mRNA.
ACCESSION   NM_001109809 XM_011514570 XM_294093 XM_936098 XM_936136 XM_940744
VERSION     NM_001109809.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2082)
  AUTHORS   Moon,S.W., Mo,H.Y., Choi,E.J., Yoo,N.J. and Lee,S.H.
  TITLE     Mutational Alterations of DNA Methylation-related Genes CTCF,
            ZFP57, and ATF7IP Genes in Colon Cancers
  JOURNAL   Appl Immunohistochem Mol Morphol 30 (2), e16-e20 (2022)
   PUBMED   35175239
  REMARK    GeneRIF: Mutational Alterations of DNA Methylation-related Genes
            CTCF, ZFP57, and ATF7IP Genes in Colon Cancers.
REFERENCE   2  (bases 1 to 2082)
  AUTHORS   Jiang,W., Shi,J., Zhao,J., Wang,Q., Cong,D., Chen,F., Zhang,Y.,
            Liu,Y., Zhao,J., Chen,Q., Gu,L., Zhou,W., Wang,C., Fang,Z.,
            Geng,S., Xie,W., Chen,L.N., Yang,Y., Bai,Y., Lin,H. and Li,X.
  TITLE     ZFP57 dictates allelic expression switch of target imprinted genes
  JOURNAL   Proc Natl Acad Sci U S A 118 (5) (2021)
   PUBMED   33500348
  REMARK    GeneRIF: ZFP57 dictates allelic expression switch of target
            imprinted genes.
REFERENCE   3  (bases 1 to 2082)
  AUTHORS   Monteagudo-Sanchez,A., Hernandez Mora,J.R., Simon,C., Burton,A.,
            Tenorio,J., Lapunzina,P., Clark,S., Esteller,M., Kelsey,G.,
            Lopez-Siguero,J.P., de Nanclares,G.P., Torres-Padilla,M.E. and
            Monk,D.
  TITLE     The role of ZFP57 and additional KRAB-zinc finger proteins in the
            maintenance of human imprinted methylation and multi-locus
            imprinting disturbances
  JOURNAL   Nucleic Acids Res 48 (20), 11394-11407 (2020)
   PUBMED   33053156
  REMARK    GeneRIF: The role of ZFP57 and additional KRAB-zinc finger proteins
            in the maintenance of human imprinted methylation and multi-locus
            imprinting disturbances.
REFERENCE   4  (bases 1 to 2082)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2082)
  AUTHORS   Helleboid,P.Y., Heusel,M., Duc,J., Piot,C., Thorball,C.W.,
            Coluccio,A., Pontis,J., Imbeault,M., Turelli,P., Aebersold,R. and
            Trono,D.
  TITLE     The interactome of KRAB zinc finger proteins reveals the
            evolutionary history of their functional diversification
  JOURNAL   EMBO J 38 (18), e101220 (2019)
   PUBMED   31403225
REFERENCE   6  (bases 1 to 2082)
  AUTHORS   Li,X., Ito,M., Zhou,F., Youngson,N., Zuo,X., Leder,P. and
            Ferguson-Smith,A.C.
  TITLE     A maternal-zygotic effect gene, Zfp57, maintains both maternal and
            paternal imprints
  JOURNAL   Dev Cell 15 (4), 547-557 (2008)
   PUBMED   18854139
REFERENCE   7  (bases 1 to 2082)
  AUTHORS   Mackay,D.J., Callaway,J.L., Marks,S.M., White,H.E., Acerini,C.L.,
            Boonen,S.E., Dayanikli,P., Firth,H.V., Goodship,J.A., Haemers,A.P.,
            Hahnemann,J.M., Kordonouri,O., Masoud,A.F., Oestergaard,E.,
            Storr,J., Ellard,S., Hattersley,A.T., Robinson,D.O. and Temple,I.K.
  TITLE     Hypomethylation of multiple imprinted loci in individuals with
            transient neonatal diabetes is associated with mutations in ZFP57
  JOURNAL   Nat Genet 40 (8), 949-951 (2008)
   PUBMED   18622393
  REMARK    GeneRIF: Study reports mutations in ZFP57, which encodes a
            zinc-finger transcription factor expressed in early development, in
            seven pedigrees with a shared pattern of mosaic hypomethylation and
            a conserved range of clinical features.
REFERENCE   8  (bases 1 to 2082)
  AUTHORS   Alonso,M.B., Zoidl,G., Taveggia,C., Bosse,F., Zoidl,C., Rahman,M.,
            Parmantier,E., Dean,C.H., Harris,B.S., Wrabetz,L., Muller,H.W.,
            Jessen,K.R. and Mirsky,R.
  TITLE     Identification and characterization of ZFP-57, a novel zinc finger
            transcription factor in the mammalian peripheral nervous system
  JOURNAL   J Biol Chem 279 (24), 25653-25664 (2004)
   PUBMED   15070898
REFERENCE   9  (bases 1 to 2082)
  AUTHORS   Okazaki,S., Tanase,S., Choudhury,B.K., Setoyama,K., Miura,R.,
            Ogawa,M. and Setoyama,C.
  TITLE     A novel nuclear protein with zinc fingers down-regulated during
            early mammalian cell differentiation
  JOURNAL   J Biol Chem 269 (9), 6900-6907 (1994)
   PUBMED   8120052
REFERENCE   10 (bases 1 to 2082)
  AUTHORS   Temple,I.K. and Mackay,D.J.G.
  TITLE     Diabetes Mellitus, 6q24-Related Transient Neonatal
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301706
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645936.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 3, 2020 this sequence version replaced NM_001109809.4.
            
            Summary: The protein encoded by this gene is a zinc finger protein
            containing a KRAB domain. Studies in mouse suggest that this
            protein may function as a transcriptional repressor. Mutations in
            this gene have been associated with transient neonatal diabetes
            mellitus type 1 (TNDM1).[provided by RefSeq, Sep 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC157878.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376883.2/ ENSP00000366080.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AL645936.5         132048-132138       c
            92-577              AL645936.5         127867-128352       c
            578-704             AL645936.5         126919-127045       c
            705-806             AL645936.5         126372-126473       c
            807-2082            AL645936.5         123469-124744       c
FEATURES             Location/Qualifiers
     source          1..2082
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..2082
                     /gene="ZFP57"
                     /gene_synonym="bA145L22; bA145L22.2; C6orf40; TNDM1;
                     ZNF698"
                     /note="ZFP57 zinc finger protein"
                     /db_xref="GeneID:346171"
                     /db_xref="HGNC:HGNC:18791"
                     /db_xref="MIM:612192"
     exon            1..91
                     /gene="ZFP57"
                     /gene_synonym="bA145L22; bA145L22.2; C6orf40; TNDM1;
                     ZNF698"
                     /inference="alignment:Splign:2.1.0"
     exon            92..577
                     /gene="ZFP57"
                     /gene_synonym="bA145L22; bA145L22.2; C6orf40; TNDM1;
                     ZNF698"
                     /inference="alignment:Splign:2.1.0"
     CDS             455..2065
                     /gene="ZFP57"
                     /gene_synonym="bA145L22; bA145L22.2; C6orf40; TNDM1;
                     ZNF698"
                     /note="isoform 1 is encoded by transcript variant 1;
                     zfp-57; zinc finger protein 698; zinc finger protein 57
                     homolog"
                     /codon_start=1
                     /product="zinc finger protein 57 homolog isoform 1"
                     /protein_id="NP_001103279.2"
                     /db_xref="CCDS:CCDS43436.2"
                     /db_xref="GeneID:346171"
                     /db_xref="HGNC:HGNC:18791"
                     /db_xref="MIM:612192"
                     /translation="MFEQLKPIEPVQKTLPWVGEVAATLQEAMKRDCWREARVKKKPV
                     TFEDVAVNFTQEEWDCLDASQRVLYQDVMSETFKNLTSVARIFLHKPELITKLEQEEE
                     QWREFVHLPNTEGLSEGKKKELREQHPSLRDEGTSDDKVFLACRGAGQCPLSAPAGTM
                     DRTRVLQASQAGPPFFCYTCGKCFSRRSYLYSHQFVHNPKLTNSCSQCGKLFRSPKSL
                     SYHRRMHLGERPFCCTLCDKTYCDASGLSRHRRVHLGYRPHSCSVCGKSFRDQSELKR
                     HQKIHQNQEPVDGNQECTLRIPGTQAEFQTPIARSQRSIQGLLDVNHAPVARSQEPIF
                     RTEGPMAQNQASVLKNQAPVTRTQAPITGTLCQDARSNSHPVKPSRLNVFCCPHCSLT
                     FSKKSYLSRHQKAHLTEPPNYCFHCSKSFSSFSRLVRHQQTHWKQKSYLCPICDLSFG
                     EKEGLMDHWRGYKGKDLCQSSHHKCRVILGQWLGFSHDVPTMAGEEWKHGGDQSPPRI
                     HTPRRRGLREKACKGDKTKEAVSILKHK"
     exon            578..704
                     /gene="ZFP57"
                     /gene_synonym="bA145L22; bA145L22.2; C6orf40; TNDM1;
                     ZNF698"
                     /inference="alignment:Splign:2.1.0"
     exon            705..806
                     /gene="ZFP57"
                     /gene_synonym="bA145L22; bA145L22.2; C6orf40; TNDM1;
                     ZNF698"
                     /inference="alignment:Splign:2.1.0"
     exon            807..2082
                     /gene="ZFP57"
                     /gene_synonym="bA145L22; bA145L22.2; C6orf40; TNDM1;
                     ZNF698"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2061..2066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP57"
                     /gene_synonym="bA145L22; bA145L22.2; C6orf40; TNDM1;
                     ZNF698"
                     /note="hexamer: AATAAA"
     polyA_site      2082
                     /gene="ZFP57"
                     /gene_synonym="bA145L22; bA145L22.2; C6orf40; TNDM1;
                     ZNF698"
                     /note="major polyA site"
ORIGIN      
        1 gccgggactg cgggtgctcg gccggagcgc tccagccgct ggtccccggg agaccctgtg
       61 cccctaaatc gcggtccact gcgcgcgtca ggtttctaga agcagggtag aacagacggc
      121 agacacctag cccaggctgg tgttgttact aaacaatggc agctggtgag ccaagggtga
      181 ccagggccct gaactcggtg gcccagcttt gagggaagca aaattgttct caattgtgga
      241 agaggagaat ttggacagca gaacaaaaaa ggaagacagc ctcttggagc agatacattt
      301 gtcacaggaa gccacatcaa accctggggc ctttgctggg cctctccatc tgcccagtta
      361 ctgggaggta gatagcccca ggaaggaatc cagtcaggcc tgggcaccag gccaggagtg
      421 gataaagcta gaaagagaca ccacagaaga gaagatgttt gaacagctga agccaatcga
      481 acctgtacag aagacgctcc catgggtggg cgaggtagct gccaccctgc aggaagccat
      541 gaagagagat tgctggaggg aggcacgggt gaagaagaag ccagtcacct ttgaggatgt
      601 ggcagtgaat ttcacccagg aagagtggga ctgtctagat gccagccaga gggtccttta
      661 ccaggatgtt atgtcggaaa cctttaagaa tctaacatct gtggccagaa tctttctgca
      721 taagccagag ctaatcacca agcttgagca agaagaggaa cagtggagag agtttgtcca
      781 tctcccaaac acagaaggcc tttcagaagg caagaagaaa gagcttcgag aacaacatcc
      841 cagtctgaga gatgagggga ctagtgatga caaggtcttc cttgcatgca gaggggccgg
      901 ccagtgcccc ctatctgccc cagctgggac tatggacagg acccgggtgc ttcaagcatc
      961 ccaggctggg ccaccctttt tttgctacac ctgtggcaaa tgtttcagca ggcgctccta
     1021 cctctatagc caccagtttg ttcacaatcc caagctgact aacagctgca gtcagtgtgg
     1081 gaagttgttt cggagcccca agtccctcag ctatcacaga cgcatgcatc ttggggagag
     1141 gcccttctgt tgcacgctct gtgacaagac ctactgtgat gcttctggac taagtcgtca
     1201 ccgccgcgtc catctgggtt accggcccca ttcatgctct gtgtgtggga agagcttccg
     1261 ggaccagtct gagctcaaac gccaccagaa gatacaccaa aaccaggagc cagtggatgg
     1321 aaaccaggag tgtactttga ggattccagg cacccaggct gaattccaga cacccatcgc
     1381 cagaagccag aggtccatcc aggggctttt ggatgtgaac catgcaccag tggccaggtc
     1441 ccaggaaccc atatttagaa ctgagggtcc tatggcccag aaccaggcat ctgtacttaa
     1501 gaaccaagca cctgtgacca ggacccaggc acccatcact ggaaccctct gtcaggatgc
     1561 cagatccaac tctcatccag tgaagccctc aagactcaat gtcttctgtt gcccccattg
     1621 ttctttgact tttagcaaga aatcctatct ctccagacac cagaaggccc acctcacaga
     1681 gccgcccaac tactgcttcc attgcagcaa gtctttcagc tcattttcca ggctggtcag
     1741 acaccagcag acccactgga agcagaagag ctacctttgc cctatctgtg acctctcctt
     1801 tggggagaaa gagggcctta tggatcactg gaggggctat aaaggcaagg acctgtgcca
     1861 gagcagccac cataaatgcc gggtgatcct gggccagtgg cttggcttct ctcatgatgt
     1921 ccccactatg gctggggagg aatggaagca tggaggtgat caatctcccc ccaggatcca
     1981 tacccccagg agaagaggcc taagagagaa ggcctgcaaa ggagacaaaa caaaggaggc
     2041 agtgagcatc ttgaaacata aataaatggc ctttctgact ga
//
