LOCUS       NM_174900               2647 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ZFP42 zinc finger protein (ZFP42), transcript variant
            1, mRNA.
ACCESSION   NM_174900
VERSION     NM_174900.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2647)
  AUTHORS   Liu,W., Xie,A., Tu,C. and Liu,W.
  TITLE     REX-1 Represses RASSF1a and Activates the MEK/ERK Pathway to
            Promote Tumorigenesis in Prostate Cancer
  JOURNAL   Mol Cancer Res 19 (10), 1666-1675 (2021)
   PUBMED   34183450
  REMARK    GeneRIF: REX-1 Represses RASSF1a and Activates the MEK/ERK Pathway
            to Promote Tumorigenesis in Prostate Cancer.
REFERENCE   2  (bases 1 to 2647)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2647)
  AUTHORS   Zeng,Y.T., Liu,X.F., Yang,W.T. and Zheng,P.S.
  TITLE     REX1 promotes EMT-induced cell metastasis by activating the
            JAK2/STAT3-signaling pathway by targeting SOCS1 in cervical cancer
  JOURNAL   Oncogene 38 (43), 6940-6957 (2019)
   PUBMED   31409905
  REMARK    GeneRIF: REX1 overexpression could play a crucial role in the
            metastasis and invasion of cervical cancer by upregulating the
            activity of the JAK2/STAT3 pathway by trans-suppressing SOCS1
            expression.
REFERENCE   4  (bases 1 to 2647)
  AUTHORS   Fontana,L., Bedeschi,M.F., Maitz,S., Cereda,A., Fare,C., Motta,S.,
            Seresini,A., D'Ursi,P., Orro,A., Pecile,V., Calvello,M.,
            Selicorni,A., Lalatta,F., Milani,D., Sirchia,S.M., Miozzo,M. and
            Tabano,S.
  TITLE     Characterization of multi-locus imprinting disturbances and
            underlying genetic defects in patients with chromosome 11p15.5
            related imprinting disorders
  JOURNAL   Epigenetics 13 (9), 897-909 (2018)
   PUBMED   30221575
  REMARK    GeneRIF: ZFP42 missense mutation was identified in patients with
            multilocus imprinting disturbances. ZFP42 pathogenic mutation
            affects protein conformation and activity.
REFERENCE   5  (bases 1 to 2647)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   6  (bases 1 to 2647)
  AUTHORS   Mongan,N.P., Martin,K.M. and Gudas,L.J.
  TITLE     The putative human stem cell marker, Rex-1 (Zfp42): structural
            classification and expression in normal human epithelial and
            carcinoma cell cultures
  JOURNAL   Mol Carcinog 45 (12), 887-900 (2006)
   PUBMED   16865673
  REMARK    GeneRIF: REX1 functions in normal adult epithelial cells and
            tumorigenic stem cells.
REFERENCE   7  (bases 1 to 2647)
  AUTHORS   Raman,J.D., Mongan,N.P., Liu,L., Tickoo,S.K., Nanus,D.M.,
            Scherr,D.S. and Gudas,L.J.
  TITLE     Decreased expression of the human stem cell marker, Rex-1 (zfp-42),
            in renal cell carcinoma
  JOURNAL   Carcinogenesis 27 (3), 499-507 (2006)
   PUBMED   16344273
REFERENCE   8  (bases 1 to 2647)
  AUTHORS   Moriscot,C., de Fraipont,F., Richard,M.J., Marchand,M.,
            Savatier,P., Bosco,D., Favrot,M. and Benhamou,P.Y.
  TITLE     Human bone marrow mesenchymal stem cells can express insulin and
            key transcription factors of the endocrine pancreas developmental
            pathway upon genetic and/or microenvironmental manipulation in
            vitro
  JOURNAL   Stem Cells 23 (4), 594-603 (2005)
   PUBMED   15790780
  REMARK    GeneRIF: MAPCs express the OCT4 and REX1 transcription factors, two
            specific markers of undifferentiated embryonic stem (ES) cells.
REFERENCE   9  (bases 1 to 2647)
  AUTHORS   Richards,M., Tan,S.P., Tan,J.H., Chan,W.K. and Bongso,A.
  TITLE     The transcriptome profile of human embryonic stem cells as defined
            by SAGE
  JOURNAL   Stem Cells 22 (1), 51-64 (2004)
   PUBMED   14688391
REFERENCE   10 (bases 1 to 2647)
  AUTHORS   Henderson,J.K., Draper,J.S., Baillie,H.S., Fishel,S., Thomson,J.A.,
            Moore,H. and Andrews,P.W.
  TITLE     Preimplantation human embryos and embryonic stem cells show
            comparable expression of stage-specific embryonic antigens
  JOURNAL   Stem Cells 20 (4), 329-337 (2002)
   PUBMED   12110702
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY429593.1, AC108073.3 and AA641545.1.
            
            On Nov 22, 2018 this sequence version replaced NM_174900.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY429593.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968968,
                                           SAMEA2148874 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326866.5/ ENSP00000317686.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               AY429593.1         1-194
            195-195             AC108073.3         105821-105821
            196-670             AY429593.1         196-670
            671-2262            AC108073.3         109659-111250
            2263-2646           AY429593.1         2266-2649
            2647-2647           AA641545.1         14-14               c
FEATURES             Location/Qualifiers
     source          1..2647
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q35.2"
     gene            1..2647
                     /gene="ZFP42"
                     /gene_synonym="REX-1; REX1; zfp-42; ZNF754"
                     /note="ZFP42 zinc finger protein"
                     /db_xref="GeneID:132625"
                     /db_xref="HGNC:HGNC:30949"
                     /db_xref="MIM:614572"
     exon            1..70
                     /gene="ZFP42"
                     /gene_synonym="REX-1; REX1; zfp-42; ZNF754"
                     /inference="alignment:Splign:2.1.0"
     exon            71..236
                     /gene="ZFP42"
                     /gene_synonym="REX-1; REX1; zfp-42; ZNF754"
                     /inference="alignment:Splign:2.1.0"
     exon            237..313
                     /gene="ZFP42"
                     /gene_synonym="REX-1; REX1; zfp-42; ZNF754"
                     /inference="alignment:Splign:2.1.0"
     exon            314..2647
                     /gene="ZFP42"
                     /gene_synonym="REX-1; REX1; zfp-42; ZNF754"
                     /inference="alignment:Splign:2.1.0"
     CDS             409..1341
                     /gene="ZFP42"
                     /gene_synonym="REX-1; REX1; zfp-42; ZNF754"
                     /note="REX1 transcription factor; zinc finger protein 754;
                     reduced expression protein 1"
                     /codon_start=1
                     /product="zinc finger protein 42 homolog"
                     /protein_id="NP_777560.2"
                     /db_xref="CCDS:CCDS3849.1"
                     /db_xref="GeneID:132625"
                     /db_xref="HGNC:HGNC:30949"
                     /db_xref="MIM:614572"
                     /translation="MSQQLKKRAKTRHQKGLGGRAPSGAKPRQGKSSQDLQAEIEPVS
                     AVWALCDGYVCYEPGPQALGGDDFSDCYIECVIRGEFSQPILEEDSLFESLEYLKKGS
                     EQQLSQKVFEASSLECSLEYMKKGVKKELPQKIVGENSLEYSEYMTGKKLPPGGIPGI
                     DLSDPKQLAEFARKKPPINKEYDSLSAIACPQSGCTRKLRNRAALRKHLLIHGPRDHV
                     CAECGKAFVESSKLKRHFLVHTGEKPFRCTFEGCGKRFSLDFNLRTHVRIHTGEKRFV
                     CPFQGCNRRFIQSNNLKAHILTHANTNKNEQEGK"
     regulatory      2627..2632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP42"
                     /gene_synonym="REX-1; REX1; zfp-42; ZNF754"
                     /note="hexamer: ATTAAA"
     polyA_site      2647
                     /gene="ZFP42"
                     /gene_synonym="REX-1; REX1; zfp-42; ZNF754"
                     /note="major polyA site"
ORIGIN      
        1 agtttctcct ttgttttacg tttgggagga ggtggcattg gaaatagcag agtgcttcgc
       61 ggtaacaggg gttggagtgc aatggtgtga tctcagctca ctgcaacccc tgcctcccag
      121 gctccagcga tcctcccacc tcagcctcct gaatagctga ccaccagcac actaggcaaa
      181 cccaccccac tcacggcctc ccttgggaat tcagacctaa ccatcgctga gctgaaacaa
      241 atgtactgag gctggagcct gtgtgaacag aacagaagag gccttcactc tagtagtgct
      301 cacagtccag caggtgtttg ctgaagacag cttactcaga tcactactgc ctggaggtgg
      361 ttgatatatc ctggtgtaaa ccttcaagaa gggcacaggc aggaaaacat gagccagcaa
      421 ctgaagaaac gggcaaagac aagacaccag aaaggcctgg gtggaagagc ccccagtggg
      481 gctaagccca ggcaaggcaa gtcaagccaa gacctgcagg cggaaataga acctgtcagc
      541 gcggtgtggg ccttatgtga tggctatgtg tgctatgagc ctggccctca ggctctcgga
      601 ggggatgatt tctcagactg ttacatagaa tgcgtcataa ggggtgagtt ttctcaaccc
      661 atcctggaag aggactcact ttttgagtcc ttggaatacc taaagaaagg atcagaacaa
      721 cagctttctc aaaaggtttt cgaagcaagc tcccttgaat gttctttgga atacatgaaa
      781 aaaggggtaa agaaagagct tccacaaaag atagttggag agaattcgct tgagtattct
      841 gagtacatga caggcaagaa gcttccgcct ggaggaatac ctggcattga cctatcagat
      901 cctaaacagc tcgcagaatt tgctagaaag aagcccccca taaataaaga atatgacagt
      961 ctgagcgcaa tcgcttgtcc tcagagtgga tgcactagga agttgaggaa tagagctgcc
     1021 ctgagaaagc atctcctcat tcatggtccc cgagaccacg tctgtgcgga atgtgggaaa
     1081 gcgttcgttg agagctcaaa actaaagaga catttcctgg ttcatactgg agagaagccg
     1141 tttcggtgca cttttgaagg gtgcggaaag cgcttctctc tggactttaa tttgcgtacg
     1201 cacgtgcgca tccacacggg ggagaaacgt ttcgtgtgtc cctttcaagg ctgcaacagg
     1261 aggtttattc agtcaaataa cctgaaagcc cacatcctaa cgcatgcaaa tacgaacaag
     1321 aatgaacaag agggaaagta gtcctccaac aggatgaagc agattaacag aagagtgatc
     1381 agtgacaaac atgcctcatt gattattgtt tctaggaagg aatttctaaa tcaatattgc
     1441 aaccccaaaa gcggttataa tttggtgtta ctaagatgct cctacacttt gtgataccgt
     1501 tttaaggaca tggtgcattt ttttttcttt tatttgtttt atttagaact ttttttattt
     1561 gttttattta gaactttgtg tgttcttaaa gtgtgcttcc aacaggaagg tcagtgataa
     1621 attttcaaaa gcataacctt caatatatta tctgttggat tattggatat aagacttatt
     1681 ttcatgtact ataaatatga aaataacttt gatttttaat tgtgtagttt ccatttctta
     1741 gcttttgcct tttaaattta tacttcagcc aggcatagtg actgatgcct gtaatcccaa
     1801 cactttgttg ggaggccaaa gcaggaggat agcttgaggc caggagttcc agaccagcct
     1861 gggcaacata gtgagatcct gtctctacaa aaaaatttgt ttttatttgt atttatatat
     1921 ttttattttt gtttttgttg gtaggcgtct cgctctgtca cccaggctgg agtctagtgt
     1981 cgtgatcttg gctcactgca acctccacct cccgggttca agtgattctc tggcctcagc
     2041 ctcccaagta gctgggacta caggtgtgtg tcaccacgcc cggctaattt ttgtattttt
     2101 agtagagatg gggtttcacc atgttggcca ggctagtctc aaactcctga cctccagtga
     2161 tctgcccacc tcggcctccc aaagtgctgg gattacaggt gtgagccact gtgcctggcc
     2221 ccccacaaca tgtttaaact tagctaggcc tggttgcata cgcctgtgtt cccagctact
     2281 caggaggctg aagcaggagg atagcttgag cccaggagtt tgaggctaca gtgagctgtg
     2341 attgcaccac tgtactccag actggataac agcaagagcc catcttttaa aaaaagtaaa
     2401 aattaaaaat atacttcatg gttcatgtca tagccctaga gaatgaaaaa tttgcagtag
     2461 atagtcaata aatgaatcag tagttaaata ttccttaaag tcaactgtat ttcattgtga
     2521 tttttgtttt ctttttatca ttgtatcaaa ctatatggaa atcatatggt tagatgtgat
     2581 tatttgataa tgttagtcca tttgaatcca ttttagatat ttcacaatta aagaatatga
     2641 aacttca
//
