LOCUS       NM_003408               6277 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ZFP37 zinc finger protein (ZFP37), transcript variant
            3, mRNA.
ACCESSION   NM_003408
VERSION     NM_003408.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6277)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 6277)
  AUTHORS   Dreyer,S.D., Zhou,L., Machado,M.A., Horton,W.A., Zabel,B.,
            Winterpacht,A. and Lee,B.
  TITLE     Cloning, characterization, and chromosomal assignment of the human
            ortholog of murine Zfp-37, a candidate gene for Nager syndrome
  JOURNAL   Mamm Genome 9 (6), 458-462 (1998)
   PUBMED   9585434
REFERENCE   3  (bases 1 to 6277)
  AUTHORS   Payen,E., Verkerk,T., Michalovich,D., Dreyer,S.D., Winterpacht,A.,
            Lee,B., De Zeeuw,C.I., Grosveld,F. and Galjart,N.
  TITLE     The centromeric/nucleolar chromatin protein ZFP-37 may function to
            specify neuronal nuclear domains
  JOURNAL   J Biol Chem 273 (15), 9099-9109 (1998)
   PUBMED   9535899
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC126390.1, AL162588.22,
            AI005346.1 and AI002852.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_003408.2.
            
            Summary: This gene encodes a transcription factor that belongs to a
            large family of zinc finger proteins. A similar protein in mouse is
            thought to play a role in regulating the structures of the
            nucleolus and centromere in neurons. Alternate splicing results in
            multiple transcript variants. [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site in the coding region compared to variant 1. This
            results in a shorter protein (isoform 3), compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.40712.1,
                                           SRR1660805.228855.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152568 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374227.8/ ENSP00000363344.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                BC126390.1         36-90
            56-56               AL162588.22        69665-69665         c
            57-2413             BC126390.1         92-2448
            2414-2832           AI005346.1         6-424               c
            2833-2839           AI002852.1         1-7                 c
            2840-6277           AL162588.22        51373-54810         c
FEATURES             Location/Qualifiers
     source          1..6277
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32"
     gene            1..6277
                     /gene="ZFP37"
                     /gene_synonym="zfp-37; ZNF906"
                     /note="ZFP37 zinc finger protein"
                     /db_xref="GeneID:7539"
                     /db_xref="HGNC:HGNC:12863"
                     /db_xref="MIM:602951"
     exon            1..168
                     /gene="ZFP37"
                     /gene_synonym="zfp-37; ZNF906"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1929
                     /gene="ZFP37"
                     /gene_synonym="zfp-37; ZNF906"
                     /note="isoform 3 is encoded by transcript variant 3; zinc
                     finger protein homologous to Zfp37 in mouse; zinc finger
                     protein 37 homolog"
                     /codon_start=1
                     /product="zinc finger protein 37 homolog isoform 3"
                     /protein_id="NP_003399.1"
                     /db_xref="CCDS:CCDS6787.1"
                     /db_xref="GeneID:7539"
                     /db_xref="HGNC:HGNC:12863"
                     /db_xref="MIM:602951"
                     /translation="MSVSSGVQILTKPETVDRRRSAETTKEAGRPLEMAVSEPEASAA
                     EWKQLDPAQSNLYNDVMLENYCNQASMGCQAPKPDMISKLEKGEAPWLGKGKRPSQGC
                     PSKIARPKQKETDGKVQKDDDQLENIQKSQNKLLREVAVKKKTQAKKNGSDCGSLGKK
                     NNLHKKHVPSKKRLLKFESCGKILKQNLDLPDHSRNCVKRKSDAAKEHKKSFNHSLSD
                     TRKGKKQTGKKHEKLSSHSSSDKCNKTGKKHDKLCCHSSSHIKQDKIQTGEKHEKSPS
                     LSSSTKHEKPQACVKPYECNQCGKVLSHKQGLIDHQRVHTGEKPYECNECGIAFSQKS
                     HLVVHQRTHTGEKPYECIQCGKAHGHKHALTDHLRIHTGEKPYECAECGKTFRHSSNL
                     IQHVRSHTGEKPYECKECGKSFRYNSSLTEHVRTHTGEIPYECNECGKAFKYSSSLTK
                     HMRIHTGEKPFECNECGKAFSKKSHLIIHQRTHTKEKPYKCNECGKAFGHSSSLTYHM
                     RTHTGESPFECNQCGKGFKQIEGLTQHQRVHTGEKPYECNECGKAFSQKSHLIVHQRT
                     HTGEKPYECNECEKAFNAKSQLVIHQRSHTGEKPYECNECGKTFKQNASLTKHVKTHS
                     EDKSHE"
     exon            169..250
                     /gene="ZFP37"
                     /gene_synonym="zfp-37; ZNF906"
                     /inference="alignment:Splign:2.1.0"
     exon            251..385
                     /gene="ZFP37"
                     /gene_synonym="zfp-37; ZNF906"
                     /inference="alignment:Splign:2.1.0"
     exon            386..6277
                     /gene="ZFP37"
                     /gene_synonym="zfp-37; ZNF906"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2695..2700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP37"
                     /gene_synonym="zfp-37; ZNF906"
                     /note="hexamer: AATAAA"
     polyA_site      2722
                     /gene="ZFP37"
                     /gene_synonym="zfp-37; ZNF906"
     regulatory      2812..2817
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP37"
                     /gene_synonym="zfp-37; ZNF906"
                     /note="hexamer: ATTAAA"
     polyA_site      2836
                     /gene="ZFP37"
                     /gene_synonym="zfp-37; ZNF906"
                     /note="major polyA site"
     regulatory      2988..2993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP37"
                     /gene_synonym="zfp-37; ZNF906"
                     /note="hexamer: CATAAA"
     polyA_site      3009
                     /gene="ZFP37"
                     /gene_synonym="zfp-37; ZNF906"
     regulatory      3119..3124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP37"
                     /gene_synonym="zfp-37; ZNF906"
                     /note="hexamer: AATGAA"
     polyA_site      3141
                     /gene="ZFP37"
                     /gene_synonym="zfp-37; ZNF906"
     regulatory      6254..6259
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP37"
                     /gene_synonym="zfp-37; ZNF906"
                     /note="hexamer: AATAAA"
     polyA_site      6277
                     /gene="ZFP37"
                     /gene_synonym="zfp-37; ZNF906"
ORIGIN      
        1 gccggacccg ctaaggccgc cctccgggta gccgccatgt cggtctccag cggcgtccag
       61 attctgacaa agccagagac cgtggaccgg aggagaagtg cggaaacgac caaagaggcc
      121 gggcgaccac tggagatggc tgtgtccgag cccgaggcca gcgccgcgga atggaagcaa
      181 ctggatcctg ctcagagcaa cctgtataat gatgtgatgc tggagaacta ctgcaaccaa
      241 gcctcaatgg ggtgtcaagc tcccaaacca gacatgatct ccaagttgga aaaaggagaa
      301 gcaccatggt tggggaaggg gaaaagaccc agtcaaggtt gtccaagtaa aatagcaaga
      361 cccaagcaaa aagaaactga tggaaaagtc cagaaagatg atgaccagct tgaaaatatc
      421 cagaaatctc aaaacaaact cctcagggaa gttgcagtca agaagaaaac tcaagctaag
      481 aagaatggca gtgactgtgg ttcactgggg aaaaaaaata atttgcataa aaaacatgtt
      541 ccttcaaaga aaaggcttct taaatttgag tcatgtggaa aaattttgaa acagaattta
      601 gatttacctg atcactcaag aaactgtgta aaaaggaaat ctgatgcagc taaagaacac
      661 aagaagtcat tcaaccatag cttatctgat acaaggaaag gcaaaaagca aactggaaag
      721 aaacatgaga aattatccag ccatagctca tctgataagt gtaacaaaac tggcaaaaaa
      781 catgacaaat tatgctgtca tagttcatcc catattaaac aggacaaaat tcaaactgga
      841 gagaaacatg agaaatcacc cagccttagc tcatctacta agcatgaaaa acctcaagct
      901 tgtgtgaaac cctatgaatg taatcaatgt ggaaaggttc tcagccataa acaaggactc
      961 attgaccatc agagagttca tactggggag aaaccatatg aatgtaatga atgtgggata
     1021 gcctttagcc aaaagtcaca ccttgttgta catcagagaa ctcacaccgg agaaaaacca
     1081 tatgaatgta ttcagtgtgg caaagcccat ggtcataaac atgcactcac tgaccatcta
     1141 agaattcata ctggagaaaa gccctatgaa tgtgctgaat gtgggaaaac cttcagacac
     1201 agctcaaacc ttattcaaca tgtgagatct cacacaggtg agaagccata tgaatgtaag
     1261 gaatgtggga agtcttttag gtataactca tctcttaccg aacatgtgag aacacataca
     1321 ggtgaaatac catatgaatg caatgaatgt ggaaaagcct ttaagtatag ctcatccctt
     1381 actaaacaca tgagaattca tacaggtgag aaaccctttg aatgtaatga atgtgggaaa
     1441 gctttcagca agaagtcaca cctcattata catcaaagaa ctcatactaa ggagaaacct
     1501 tataaatgta atgagtgtgg aaaagccttt ggacatagct catctcttac ttaccatatg
     1561 agaactcata caggtgaaag tccctttgaa tgtaatcaat gtgggaaagg ctttaaacaa
     1621 attgaaggcc ttactcaaca tcagagagtt catactggag agaaaccgta tgagtgtaat
     1681 gaatgtggga aagcctttag ccaaaagtct cacctcattg tacatcagag aactcatact
     1741 ggggagaaac cttatgaatg taacgaatgt gaaaaagcct ttaatgcaaa atcacagctt
     1801 gttatacatc agcgatccca cactggagaa aaaccctatg aatgtaatga atgtgggaaa
     1861 actttcaaac aaaatgcatc cctaaccaaa catgtgaaaa ctcattcaga agataaatct
     1921 catgagtgaa gttaatgtgg gaaatttgtt aactaaattt aaggttttgt tgaaccttgg
     1981 aaatatgctg attttaaaga gtgttagaaa gcctttagca agatgtcaca ccttgttgta
     2041 catgagaaac tttgaaaatg gatcttcata tagaatcagt ggatggaaac aagggtttaa
     2101 acttgataca aaacctttta taaaaaatat tgttttaact actcaattat tataaatgat
     2161 ctacatgttc agattgaaat tgaaagcttt aaaaattgtg aattatttga atattcaaag
     2221 caatggagaa acaagttata tatgctgaca gttcctgtgt ttcttcttgt tttgtactta
     2281 agcaccatat attagagttg aatttgcata tctgtttatt gccttatgta aatgagtgtg
     2341 gccatctgta taagcctctt tgacattttc acccagctct ttcttaatgt ctgtgttggc
     2401 ttctgcatca gcagaaatct ttttaaaagg gttgttatat atgtaaaaaa tgttaacagg
     2461 aaaatgagag aaaataaagc agctgaggat acaaatgtgc tggtagggag cgatattcaa
     2521 gatatattgt gaagtgtgaa aaagtaggtt gctgaaccat gtatatagta tgttcccctt
     2581 tgtgtacaaa agggtatgtt tgtttaacct ctgtctctta tctctgtatg tgtatgtatc
     2641 tttgtatgca tatatacatg tatctgtatg tgaatagact ttgaaaaaat acagaataaa
     2701 cttcatggtg gttgccattg ggcagaggag tataggactg gggtctagga taggagcaag
     2761 acttccttgt atatttggat ttttaaatca tgcacatgta ttatttttat aattaaaata
     2821 ttttaatatg cataaatcaa cattatttaa ggttgtcact gagcccctcc acaacatgtg
     2881 agatcaacat gtgagatctc agattttgac agagttaaaa tctttgtatg cttattcatg
     2941 aatgatgatg aatctaaagt atatagtatg aaacttgatg ttgaattcat aaagactttt
     3001 tctatcacac acaagttctt tcattaacat agtgaattat aacagcactg tttctacatt
     3061 tgccattttt tgatgttgaa ttgtgattgc aggtgatgat gaattgtgat tgcaggtgaa
     3121 tgaaagtgat tttatgaata atcaccctgt tttatctcat attcaaagaa ctaacacaca
     3181 aacacctcaa tcagggaatt cgaatgaaac aaatgtcacc cctccctgtt ctcgctcaat
     3241 attgggcatt atttactgga tcactgtact ctttctgagt gaacccagag ttggcctcag
     3301 aatcattgtg cagcgtgcat tccagaaggt actatgcatc aacttggact gtcacaggag
     3361 acctatttgc cattgcacac ctggattttt tttactcttg agccatagat taaaaatact
     3421 tctggctggg catggtgggt gcctgtaatc tccagcactg tgggaggcca aggtgggtgg
     3481 atcacttgag gccaggagtt tgagatcaga ctagccaaca caatgaaacc ccatctctac
     3541 taaaaataca aaaaattatc tgggcatgct gtaatccctg taatcccagc cactcaggag
     3601 gctgaggcaa gagagttgct tgcacccagg agatggaggt tacagtgcac tccagcctgg
     3661 gcagcagagt gaggctctgt ctcaaaaaaa agaaatacaa aaaatgcaca aaacttctga
     3721 actattttga aatctaagtt gttacactaa aagcagagac ataagtacag aaatggtttt
     3781 caaaaacatc atacctttat tttaatacaa tattaattta cataatataa aatattataa
     3841 tttggcatgt tatcttttat attttttaaa gcacaatccc tacattattt catttattcc
     3901 tcagaactaa catatgagca gtaatcggga cttgtctagt catgttcaat cctgttgagt
     3961 aaatatttca cctagacagt aatttagcat aataatgggc cccaaagaaa tatgtgctta
     4021 aatgccatct ttacaaatat ttatcattca agctccttcc ttcctgacct catttcagag
     4081 aattataatg tgttaatata atatattgag aatggaatat gtgttcgtgt atgtgcatgt
     4141 gcacacatgc atacacatgc acgggttgaa agctcaactc atgaatatat cccctcattt
     4201 ccaagtaact tatttatcac atgggaagaa aatgcaatat gaaagccatt tctaccagta
     4261 atttcttaac aagtggaaat atagcactat gcacagaatg agtcatcact gtctagagct
     4321 gtagaaagcc tgcacttttt agatggatga aacagttgca ggttatggct atgttgaatt
     4381 tccacatgtc ttggggaacc catagtattg ccacatctga gacagtgaga attataggta
     4441 tgcctgaatg atataaatga atgctgaaag ccactttgtg cagtaataaa atgaattaaa
     4501 agttagcatt gatgaatgag gaaaggatgt ctaaatacaa ttggaggtta gtataggaaa
     4561 acagacacac agtggtaagt ctgaatcgat acgtaaactc tagtgtgcat aaaaattgcc
     4621 tgaatgattt gttaaaacac agacttgaga atgcaaattc ttgggcctcg tcacagacat
     4681 attggatcag aaaccctgtg ggtgggcctt gagaatttgc attttaataa gtttccagtg
     4741 gattcctgtg ctgctggtct ggggaccacc ctttgagaac cactaatcta aatcatggtg
     4801 taagtaagtt taaaaaatta tttttaaact gtttttcaga tcctctttaa gaaaatgaag
     4861 gggcataaaa gtaaattatt attaacagtt ttgaaacatt tatttattca agtgatatga
     4921 tcatctaagt gcctgagata cagcagtcta caaaacaaaa agaaagcaaa caaacaaaac
     4981 aaaaccctgt tctcatagac cttaattcta gaggaggaca taggtaataa ataaacaact
     5041 acaatataaa gtataacaga tcactggatg gcaaaaagca aaccaaggaa ggggagggaa
     5101 gtgttgggga atgtaatttt aaatatagtg atgggaagca ggcagtaagc ttacttagat
     5161 ggtgacaaaa gcaaagaccc agagagggta aaagagcaaa ccatgtatat atatatgacg
     5221 gaagagcatt ccagggatat atcttttaga atctgagggt gtgggaagag aaagatgtta
     5281 aactcctctg acataaagaa gaggaaaaaa agtggaaaca tttttttaaa tcaagattta
     5341 aaaaaaaatt acatttgtga taggtagaaa acaatctgtc acacactgct tttggtagtt
     5401 gtgtaagttt gtacaaccta ccaaaatgta aatctgacag tatacatcaa agccttatga
     5461 tggtcggcag tccatcgagg aatctattct atgttgtaca atcaaggcgt actatgatat
     5521 ttattgcaga acagagagaa atagcatata cattgctagt taattgatta aataaagcat
     5581 gattccttca aaaattgagt aatatgacat taaaaaccac aatttcaaac tatatttaag
     5641 aagatacaaa taattcttta ttattacttt tactctcagg aatgtgtttg agtgatgcat
     5701 ctccaggcat caagtgagta atccaatatt gaagaaaatt aaaattttcc acaaagtccc
     5761 ccttctagaa gaatgtgctc atatcttttg accagaaatg agtcacatga ccacacctag
     5821 tttcaggtgg cttgaggaaa ttgaatcttt ctttttttgt tttattttgt tttgagacaa
     5881 agtctctgtc acccagactg gagtgtgcag tagtgcaatc ttggctcatt acaatctcta
     5941 cctcccaggc ttaagcactc ctcccacctt agccttccta gtagctggga ctacaggtgc
     6001 atgccaccaa gctaattttt tttttttttt tttggtggaa acagagtttt gccatgttac
     6061 tcaggctggt ctcaaacttc tgggctcaag tgatctgccc accttggcct cccaaagtgc
     6121 tgtgattaaa agtgtgagct accacatttg gccaaatctt taatttctta accttcatag
     6181 taaaggaaat aaagagacat gggcattgaa aaatggatgt tgtacaaacc aacctgtagc
     6241 atctaaaata ctaaataaaa aacagtttac aaaacta
//
