LOCUS       NM_006887               3693 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens ZFP36 ring finger protein like 2 (ZFP36L2), mRNA.
ACCESSION   NM_006887
VERSION     NM_006887.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3693)
  AUTHORS   Rui,X., Zhang,X., Jia,X., Han,J., Wang,C., Cao,Q., Zhong,O.,
            Ding,J., Zhao,C., Zhang,J., Ling,X., Li,H., Ma,X., Meng,Q. and
            Huo,R.
  TITLE     Variants in NLRP2 and ZFP36L2, non-core components of the human
            subcortical maternal complex, cause female infertility with
            embryonic development arrest
  JOURNAL   Mol Hum Reprod 30 (9) (2024)
   PUBMED   39178021
  REMARK    GeneRIF: Variants in NLRP2 and ZFP36L2, non-core components of the
            human subcortical maternal complex, cause female infertility with
            embryonic development arrest.
REFERENCE   2  (bases 1 to 3693)
  AUTHORS   Sun,J., Li,M., Sun,H., Lin,Z., Shi,B. and Jia,Z.
  TITLE     Genetic association and functional validation of ZFP36L2 in
            non-syndromic orofacial cleft subtypes
  JOURNAL   J Hum Genet 69 (3-4), 139-144 (2024)
   PUBMED   38321215
  REMARK    GeneRIF: Genetic association and functional validation of ZFP36L2
            in non-syndromic orofacial cleft subtypes.
            Erratum:[J Hum Genet. 2024 Apr;69(3-4):169. doi:
            10.1038/s10038-024-01239-4.. PMID: 38443624]
REFERENCE   3  (bases 1 to 3693)
  AUTHORS   Zhou,Z., Fan,H., Shi,R., Zeng,Y., Liu,R., Gu,H., Li,Q., Sang,Q.,
            Wang,L., Shi,J. and Chen,B.
  TITLE     A novel homozygous variant in ZFP36L2 cause female infertility due
            to oocyte maturation defect
  JOURNAL   Clin Genet 104 (4), 461-465 (2023)
   PUBMED   37211617
  REMARK    GeneRIF: A novel homozygous variant in ZFP36L2 cause female
            infertility due to oocyte maturation defect.
REFERENCE   4  (bases 1 to 3693)
  AUTHORS   Balducci,E., Steimle,T., Smith,C., Villarese,P., Feroul,M.,
            Payet-Bornet,D., Kaltenbach,S., Couronne,L., Lhermitte,L.,
            Touzart,A., Dourthe,M.E., Simonin,M., Baruchel,A., Dombret,H.,
            Ifrah,N., Boissel,N., Nadel,B., Macintyre,E., Cieslak,A. and
            Asnafi,V.
  TITLE     TREC mediated oncogenesis in human immature T lymphoid malignancies
            preferentially involves ZFP36L2
  JOURNAL   Mol Cancer 22 (1), 108 (2023)
   PUBMED   37430263
  REMARK    GeneRIF: TREC mediated oncogenesis in human immature T lymphoid
            malignancies preferentially involves ZFP36L2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3693)
  AUTHORS   Novosad,V.O. and Maltseva,D.V.
  TITLE     The RNA-Binding Proteins OAS1, ZFP36L2, and DHX58 Are Involved in
            the Regulation of CD44 mRNA Splicing in Colorectal Cancer Cells
  JOURNAL   Bull Exp Biol Med 175 (1), 144-149 (2023)
   PUBMED   37336810
  REMARK    GeneRIF: The RNA-Binding Proteins OAS1, ZFP36L2, and DHX58 Are
            Involved in the Regulation of CD44 mRNA Splicing in Colorectal
            Cancer Cells.
REFERENCE   6  (bases 1 to 3693)
  AUTHORS   Jackson,R.S. 2nd, Cho,Y.J. and Liang,P.
  TITLE     TIS11D is a candidate pro-apoptotic p53 target gene
  JOURNAL   Cell Cycle 5 (24), 2889-2893 (2006)
   PUBMED   17172869
  REMARK    GeneRIF: These data suggest TIS11D as a candidate p53 target gene
            that may be part of the network of genes responsible for
            p53-dependent apoptosis.
REFERENCE   7  (bases 1 to 3693)
  AUTHORS   Hudson,B.P., Martinez-Yamout,M.A., Dyson,H.J. and Wright,P.E.
  TITLE     Recognition of the mRNA AU-rich element by the zinc finger domain
            of TIS11d
  JOURNAL   Nat Struct Mol Biol 11 (3), 257-264 (2004)
   PUBMED   14981510
  REMARK    GeneRIF: Sequence specificity in RNA recognition is achieved by a
            network of intermolecular hydrogen bonds, mostly between TIS11d
            main-chain functional groups and the Watson-Crick edges of the
            bases
REFERENCE   8  (bases 1 to 3693)
  AUTHORS   Blackshear,P.J., Phillips,R.S., Vazquez-Matias,J. and
            Mohrenweiser,H.
  TITLE     Polymorphisms in the genes encoding members of the tristetraprolin
            family of human tandem CCCH zinc finger proteins
  JOURNAL   Prog Nucleic Acid Res Mol Biol 75, 43-68 (2003)
   PUBMED   14604009
  REMARK    GeneRIF: polymorphisms sequenced in genomic DNA encoding the TTP
            protein (ZFP36) and those of its two known mammalian relatives,
            ZFP36L1 and ZFP36L2, from 72 to 92 anonymous human subjects from
            various geographical and ethnic backgrounds
REFERENCE   9  (bases 1 to 3693)
  AUTHORS   Ino,T., Yasui,H., Hirano,M. and Kurosawa,Y.
  TITLE     Identification of a member of the TIS11 early response gene family
            at the insertion point of a DNA fragment containing a gene for the
            T-cell receptor beta chain in an acute T-cell leukemia
  JOURNAL   Oncogene 11 (12), 2705-2710 (1995)
   PUBMED   8545129
REFERENCE   10 (bases 1 to 3693)
  AUTHORS   Nie,X.F., Maclean,K.N., Kumar,V., McKay,I.A. and Bustin,S.A.
  TITLE     ERF-2, the human homologue of the murine Tis11d early response gene
  JOURNAL   Gene 152 (2), 285-286 (1995)
   PUBMED   7835719
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010883.8 and N67537.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006887.4.
            
            Summary: This gene is a member of the TIS11 family of early
            response genes. Family members are induced by various agonists such
            as the phorbol ester TPA and the polypeptide mitogen EGF. The
            encoded protein contains a distinguishing putative zinc finger
            domain with a repeating cys-his motif. This putative nuclear
            transcription factor most likely functions in regulating the
            response to growth factors. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HY062296.1, SRR3476690.434295.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282388.4/ ENSP00000282388.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-342               AC010883.8         114614-114955       c
            343-3311            AC010883.8         111133-114101       c
            3312-3693           N67537.1           10-391              c
FEATURES             Location/Qualifiers
     source          1..3693
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p21"
     gene            1..3693
                     /gene="ZFP36L2"
                     /gene_synonym="BRF2; ERF-2; ERF2; OOMD13; OZEMA13;
                     RNF162C; TIS11D"
                     /note="ZFP36 ring finger protein like 2"
                     /db_xref="GeneID:678"
                     /db_xref="HGNC:HGNC:1108"
                     /db_xref="MIM:612053"
     exon            1..342
                     /gene="ZFP36L2"
                     /gene_synonym="BRF2; ERF-2; ERF2; OOMD13; OZEMA13;
                     RNF162C; TIS11D"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..1776
                     /gene="ZFP36L2"
                     /gene_synonym="BRF2; ERF-2; ERF2; OOMD13; OZEMA13;
                     RNF162C; TIS11D"
                     /note="zinc finger protein 36, C3H type-like 1;
                     EGF-response factor 2; zinc finger protein, C3H type,
                     36-like 2; zinc finger protein 36, C3H1 type-like 2;
                     ZFP36-like 2; zinc finger protein 36, C3H type-like 2;
                     TPA-induced sequence 11d; butyrate response factor 2
                     (EGF-response factor 2)"
                     /codon_start=1
                     /product="mRNA decay activator protein ZFP36L2"
                     /protein_id="NP_008818.3"
                     /db_xref="CCDS:CCDS1811.1"
                     /db_xref="GeneID:678"
                     /db_xref="HGNC:HGNC:1108"
                     /db_xref="MIM:612053"
                     /translation="MSTTLLSAFYDVDFLCKTEKSLANLNLNNMLDKKAVGTPVAAAP
                     SSGFAPGFLRRHSASNLHALAHPAPSPGSCSPKFPGAANGSSCGSAAAGGPTSYGTLK
                     EPSGGGGTALLNKENKFRDRSFSENGDRSQHLLHLQQQQKGGGGSQINSTRYKTELCR
                     PFEESGTCKYGEKCQFAHGFHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNA
                     DERRPAPSGGASGDLRAFGTRDALHLGFPREPRPKLHHSLSFSGFPSGHHQPPGGLES
                     PLLLDSPTSRTPPPPSCSSASSCSSSASSCSSASAASTPSGAPTCCASAAAAAAAALL
                     YGTGGAEDLLAPGAPCAACSSASCANNAFAFGPELSSLITPLAIQTHNFAAVAAAAYY
                     RSQQQQQQQGLAPPAQPPAPPSATLPAGAAAPPSPPFSFQLPRRLSDSPVFDAPPSPP
                     DSLSDRDSYLSGSLSSGSLSGSESPSLDPGRRLPIFSRLSISDD"
     exon            343..3693
                     /gene="ZFP36L2"
                     /gene_synonym="BRF2; ERF-2; ERF2; OOMD13; OZEMA13;
                     RNF162C; TIS11D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3668..3673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP36L2"
                     /gene_synonym="BRF2; ERF-2; ERF2; OOMD13; OZEMA13;
                     RNF162C; TIS11D"
                     /note="hexamer: AATAAA"
     polyA_site      3693
                     /gene="ZFP36L2"
                     /gene_synonym="BRF2; ERF-2; ERF2; OOMD13; OZEMA13;
                     RNF162C; TIS11D"
                     /note="major polyA site"
ORIGIN      
        1 gagttccagc agtccgcgag ctgccgtcgg ctccgcgggg ggggcgggcc gggcaccccg
       61 gggcgcggag gagcgctcct cgcttctctc cttcccccct gccgcactcc gccggaccct
      121 cccgccggcc cgcgccgctg cactcgccct ctcctctcgc cccccggcaa actttcggcc
      181 cctccccgcc cctcgcccgt tattcgtcgt ggctcaagcc cggccacgcc gccccaaggg
      241 ctcctcccga cctcccggcc tgccgctccg gccactgcgg gatccagaaa catgtcgacc
      301 acacttctgt ccgccttcta cgatgtcgac ttcttgtgca agacagagaa atccctggcc
      361 aacctcaacc tgaacaacat gctggacaag aaggcggtgg ggacgcctgt ggccgccgcc
      421 cccagctcgg gcttcgcgcc gggattcctc cgacggcact cggccagcaa cctgcatgca
      481 ctcgcccacc ccgcgcccag ccccggcagc tgctcgccca agttcccggg cgccgctaac
      541 ggcagcagct gcggcagcgc ggcggccggc ggtccgacct cctacggcac ccttaaggag
      601 ccgtcggggg gcggcggcac agccctgctc aacaaggaga acaaattccg ggaccgctcg
      661 tttagcgaga acggcgatcg cagccagcac ctcctgcacc tgcagcagca gcagaagggg
      721 ggcggcggct cccagatcaa ctccacgcgc tacaagaccg agctgtgccg gcccttcgag
      781 gagagcggca cgtgcaagta cggcgaaaag tgccagttcg cgcatggctt ccacgagctg
      841 cgcagcctga ctcgccatcc gaagtacaag accgagctgt gccgcacctt tcataccatc
      901 ggcttctgcc cctatgggcc gcgctgccac ttcatccaca acgcggacga gcggcggccc
      961 gcgccgtcgg ggggcgcctc cggggacctg cgtgcctttg gcacgcgcga tgcgttgcac
     1021 ctgggcttcc cgcgggagcc gcggcccaag ttgcaccaca gcctcagctt ctcgggcttc
     1081 ccgtcgggcc accatcagcc cccgggcggc ctcgagtcgc cgctgctgct cgacagcccc
     1141 acgtcgcgca cgccgccgcc gccctcctgc tcttcggcct cgtcctgctc ctcctccgcc
     1201 tcctcctgtt cctcggcctc cgcggcctcc acgccctcgg gcgccccgac atgctgcgcc
     1261 tccgcggcgg ccgcggctgc ggccgctctg ctgtacggca ccgggggcgc cgaggacctg
     1321 ctggcgccgg gggccccgtg cgcggcctgc tcgtcggcct cgtgcgccaa caacgccttc
     1381 gccttcggtc cggagctcag cagcctcatc acgccgctcg ccatccagac ccacaacttt
     1441 gccgccgtgg ccgccgccgc ctactaccgc agtcagcagc agcagcagca gcagggcctg
     1501 gcgccccccg cgcagccgcc ggcgccgccc agcgcgaccc tccccgccgg ggccgccgca
     1561 cctccctcgc cgcccttcag cttccagctg ccgcgccgcc tgtccgactc gcccgtgttc
     1621 gacgcgcccc ccagcccccc ggactcgctg tcggaccgcg acagctacct aagcggctcc
     1681 ctgagctccg gcagcctcag cggctctgag tctcccagcc tcgaccctgg ccgccgcctg
     1741 ccaatcttca gccgcctctc catctccgac gactgaggca agagggcgcc agtgaggagg
     1801 aagggaaggc ggttcagaga tgttggagga cacccctcgc catctcgccc ttgctggggg
     1861 cacgggagtg gggggggtga catgggccct aggcagactg caagcccgac cgagcacttg
     1921 gactcgaact ctgtgccggg aggggccccc acccctcctt tttcggtttc ctcttgtctt
     1981 ttttttttta tttttattac gaagtttcat tctttttgag caaaaaagtc gaactttttc
     2041 tgttgaacaa aatattcaca acagggcagt tgtgatacga atagaacaaa aaaaaaaaaa
     2101 aaacacttaa actttgttag gactccgatg agtttgggac ttcaggaaaa atcaacccag
     2161 caccagcagc taccaaccac cattccatct cttcacttga acagcattag ttaagtccag
     2221 atgtgggaac ccttctcttg gaagaagttc ctaattgtgt ctcagaccgg tgtaaacaaa
     2281 ccagccagcc gccaccttgc taaacctata agctttttaa aatccaatat attctgccaa
     2341 gaatatgcct tgatagttag ccctcagccc ataggtgttt tttgtttttt aacagaatta
     2401 tatatgtctg ggggtgaaaa aacccttgca ttccaaaggt ccatactggt tacttggttt
     2461 cattgccacc acttagtgga tgttcagttt agaaccattt tgtctgctcc ctctggaagc
     2521 cttgcgcaga gcttactttg taattgttgg agaataactg ctgaattttt agctgttttg
     2581 agttgattcg caccactgca ccacaactca atatgaaaac tatttaactt atttattatc
     2641 ttgtgaaaag tatacaatga aaattttgtt catactgtat ttatcaagta tgatgaaaag
     2701 caatagatat atattctttt attatgttaa attatgattg ccattattaa tcggcaaaat
     2761 gtggagtgta tgttcttttc acagtaatat atgccttttg taacttcact tggttatttt
     2821 attgtaaatg agtacaaaat tcttaattta agagattgta tgtaatattt atttcattaa
     2881 tttctttcct tgtttacgta aattttgaaa gattgcatga tttcttgaca gaaatcgatc
     2941 ttgatgctgt ggaagtagtt tgaggaacat cctatgagtt ttcttagaat gtataaaggt
     3001 tgtagcccat ccaacttcaa agaaaaaaat gaccacatac tttgcaatca ggctgaaatg
     3061 tggcatgctt ttctaattcc aactttataa actagcaaaa aagtgtttgc ttattccacc
     3121 agttctactg tgacatactc gagtataaag acatgtagca ataacgggga gtgggggggg
     3181 agtctcacag tgcctttgga agggcccgaa cttgccttaa atcttcctca accaaataag
     3241 tattttatta gtgcttgaga gaatctgaat gtaggatggg ttcaactgca caaaaggaaa
     3301 agatttttac cacttttttt atatagatat aaagtgaagc aaccgcctta gtgctgaaat
     3361 atgtagtaca tgaatatgcc ttgtttaatt acagaaaatt ccaaaacttg tactattttt
     3421 ttttccatgt agaaaggcag gaatgtctcc taagctttcc tggacagcag atgaatgagc
     3481 ggtagcttta gtttgtacgt aggtacagtt ggagcactat atgtactctc tggactactt
     3541 tggacagaag taggtttttg aatgtaacaa gataagtcaa cttgagttgt aatatatttt
     3601 ggggaatcag ctcactacaa attgtgactg taaacattgt actgtaaatg ttttgtagtt
     3661 ttcccccaat aaaatttttg ggaaaaaaag gta
//
