LOCUS       NM_004926               3017 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens ZFP36 ring finger protein like 1 (ZFP36L1), transcript
            variant 1, mRNA.
ACCESSION   NM_004926
VERSION     NM_004926.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3017)
  AUTHORS   Lu,F., Yao,L.P., Gao,D.D., Alinejad,T., Jiang,X.Q., Wu,Q.,
            Zhai,Q.C., Liu,M., Zhu,S.M., Qian,M.X., Xu,L.F., Chen,C.S. and
            Zhang,F.
  TITLE     MicroRNA-377-3p exacerbates chronic obstructive pulmonary disease
            through suppressing ZFP36L1 expression and inducing lung fibroblast
            senescence
  JOURNAL   Respir Res 25 (1), 67 (2024)
   PUBMED   38317146
  REMARK    GeneRIF: MicroRNA-377-3p exacerbates chronic obstructive pulmonary
            disease through suppressing ZFP36L1 expression and inducing lung
            fibroblast senescence.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3017)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 3017)
  AUTHORS   Momin,T., Villasenor,A., Singh,A., Darweesh,M., Singh,A. and
            Rajput,M.
  TITLE     ZFP36 ring finger protein like 1 significantly suppresses human
            coronavirus OC43 replication
  JOURNAL   PeerJ 11, e14776 (2023)
   PUBMED   36846448
  REMARK    GeneRIF: ZFP36 ring finger protein like 1 significantly suppresses
            human coronavirus OC43 replication.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3017)
  AUTHORS   Ding,K., Zhang,F., Qi,G., Lin,M., Chen,M., Chen,Y., Zheng,J. and
            Zhou,F.
  TITLE     ZFP36L1 Promotes Gastric Cancer Progression via Regulating JNK and
            p38 MAPK Signaling Pathways
  JOURNAL   Recent Pat Anticancer Drug Discov 18 (1), 80-91 (2023)
   PUBMED   35611776
  REMARK    GeneRIF: ZFP36L1 Promotes Gastric Cancer Progression via Regulating
            JNK and p38 MAPK Signaling Pathways.
REFERENCE   5  (bases 1 to 3017)
  AUTHORS   Chen,H.Y., Durmaz,Y.T., Li,Y., Sabet,A.H., Vajdi,A., Denize,T.,
            Walton,E., Laimon,Y.N., Doench,J.G., Mahadevan,N.R., Losman,J.A.,
            Barbie,D.A., Tolstorukov,M.Y., Rudin,C.M., Sen,T., Signoretti,S.
            and Oser,M.G.
  TITLE     Regulation of neuroendocrine plasticity by the RNA-binding protein
            ZFP36L1
  JOURNAL   Nat Commun 13 (1), 4998 (2022)
   PUBMED   36008402
  REMARK    GeneRIF: Regulation of neuroendocrine plasticity by the RNA-binding
            protein ZFP36L1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3017)
  AUTHORS   Stoecklin,G., Colombi,M., Raineri,I., Leuenberger,S., Mallaun,M.,
            Schmidlin,M., Gross,B., Lu,M., Kitamura,T. and Moroni,C.
  TITLE     Functional cloning of BRF1, a regulator of ARE-dependent mRNA
            turnover
  JOURNAL   EMBO J 21 (17), 4709-4718 (2002)
   PUBMED   12198173
REFERENCE   7  (bases 1 to 3017)
  AUTHORS   Ning,Z.Q., Norton,J.D., Li,J. and Murphy,J.J.
  TITLE     Distinct mechanisms for rescue from apoptosis in Ramos human B
            cells by signaling through CD40 and interleukin-4 receptor: role
            for inhibition of an early response gene, Berg36
  JOURNAL   Eur J Immunol 26 (10), 2356-2363 (1996)
   PUBMED   8898945
REFERENCE   8  (bases 1 to 3017)
  AUTHORS   Maclean,K.N., See,C.G., McKay,I.A. and Bustin,S.A.
  TITLE     The human immediate early gene BRF1 maps to chromosome 14q22-q24
  JOURNAL   Genomics 30 (1), 89-90 (1995)
   PUBMED   8595910
REFERENCE   9  (bases 1 to 3017)
  AUTHORS   Bustin,S.A., Nie,X.F., Barnard,R.C., Kumar,V., Pascall,J.C.,
            Brown,K.D., Leigh,I.M., Williams,N.S. and McKay,I.A.
  TITLE     Cloning and characterization of ERF-1, a human member of the Tis11
            family of early-response genes
  JOURNAL   DNA Cell Biol 13 (5), 449-459 (1994)
   PUBMED   8024689
REFERENCE   10 (bases 1 to 3017)
  AUTHORS   Barnard,R.C., Pascall,J.C., Brown,K.D., McKay,I.A., Williams,N.S.
            and Bustin,S.A.
  TITLE     Coding sequence of ERF-1, the human homologue of Tis11b/cMG1,
            members of the Tis11 family of early response genes
  JOURNAL   Nucleic Acids Res 21 (15), 3580 (1993)
   PUBMED   8346037
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK024202.1, BC018340.1,
            BM712842.1, BQ894292.1, CN312799.1, DR423896.1, DB522201.1 and
            AI493871.1.
            
            On Jul 19, 2019 this sequence version replaced NM_004926.3.
            
            Summary: This gene is a member of the TIS11 family of early
            response genes, which are induced by various agonists such as the
            phorbol ester TPA and the polypeptide mitogen EGF. This gene is
            well conserved across species and has a promoter that contains
            motifs seen in other early-response genes. The encoded protein
            contains a distinguishing putative zinc finger domain with a
            repeating cys-his motif. This putative nuclear transcription factor
            most likely functions in regulating the response to growth factors.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Sep
            2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes isoform 1. Variants 1 and 2 encode the same
            isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.246696.1,
                                           SRR11853567.9290.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000439696.3/ ENSP00000388402.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-374               AK024202.1         1672-2045
            375-1448            BC018340.1         368-1441
            1449-1724           BM712842.1         290-565
            1725-1795           BQ894292.1         185-255
            1796-2086           CN312799.1         10-300
            2087-2531           DR423896.1         176-620
            2532-2735           DB522201.1         2-205
            2736-3017           AI493871.1         2-283               c
FEATURES             Location/Qualifiers
     source          1..3017
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.1"
     gene            1..3017
                     /gene="ZFP36L1"
                     /gene_synonym="Berg36; BRF1; cMG1; ERF-1; ERF1; RNF162B;
                     TIS11B"
                     /note="ZFP36 ring finger protein like 1"
                     /db_xref="GeneID:677"
                     /db_xref="HGNC:HGNC:1107"
                     /db_xref="MIM:601064"
     exon            1..186
                     /gene="ZFP36L1"
                     /gene_synonym="Berg36; BRF1; cMG1; ERF-1; ERF1; RNF162B;
                     TIS11B"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1146
                     /gene="ZFP36L1"
                     /gene_synonym="Berg36; BRF1; cMG1; ERF-1; ERF1; RNF162B;
                     TIS11B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     EGF-response factor 1; early response factor Berg36; zinc
                     finger protein, C3H type, 36-like 1; butyrate response
                     factor 1; zinc finger protein 36, C3H1 type-like 1; zinc
                     finger protein 36, C3H type-like 1; ZFP36-like 1;
                     TPA-induced sequence 11b; mRNA decay activator protein
                     ZFP36L1"
                     /codon_start=1
                     /product="mRNA decay activator protein ZFP36L1 isoform 1"
                     /protein_id="NP_004917.2"
                     /db_xref="CCDS:CCDS9791.1"
                     /db_xref="GeneID:677"
                     /db_xref="HGNC:HGNC:1107"
                     /db_xref="MIM:601064"
                     /translation="MTTTLVSATIFDLSEVLCKGNKMLNYSAPSAGGCLLDRKAVGTP
                     AGGGFPRRHSVTLPSSKFHQNQLLSSLKGEPAPALSSRDSRFRDRSFSEGGERLLPTQ
                     KQPGGGQVNSSRYKTELCRPFEENGACKYGDKCQFAHGIHELRSLTRHPKYKTELCRT
                     FHTIGFCPYGPRCHFIHNAEERRALAGARDLSADRPRLQHSFSFAGFPSAAATAAATG
                     LLDSPTSITPPPILSADDLLGSPTLPDGTNNPFAFSSQELASLFAPSMGLPGGGSPTT
                     FLFRPMSESPHMFDSPPSPQDSLSDQEGYLSSSSSSHSGSDSPTLDNSRRLPIFSRLS
                     ISDD"
     exon            187..3017
                     /gene="ZFP36L1"
                     /gene_synonym="Berg36; BRF1; cMG1; ERF-1; ERF1; RNF162B;
                     TIS11B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2994..2999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP36L1"
                     /gene_synonym="Berg36; BRF1; cMG1; ERF-1; ERF1; RNF162B;
                     TIS11B"
                     /note="hexamer: AATAAA"
     polyA_site      3017
                     /gene="ZFP36L1"
                     /gene_synonym="Berg36; BRF1; cMG1; ERF-1; ERF1; RNF162B;
                     TIS11B"
                     /note="major polyA site"
ORIGIN      
        1 ggagtcagaa aggcgagggg cgccgggaac tggcgtgtgg gactccagac aggagaggct
       61 gcgccttccc cgcaccggga ccttcgcgac acaccagatc ctcgcccctg gctcgcgcga
      121 acgcacagga tgaccaccac cctcgtgtct gccaccatct tcgacttgag cgaagtttta
      181 tgcaagggta acaagatgct caactatagt gctcccagtg cagggggttg cctgctggac
      241 agaaaggcag tgggcacccc tgctggtggg ggcttccctc ggaggcactc agtcaccctg
      301 cccagctcca agttccacca gaaccagctc ctcagcagcc tcaagggtga gccagccccc
      361 gctctgagct cgcgagacag ccgcttccga gaccgctcct tctcggaagg gggcgagcgg
      421 ctgctgccca cccagaagca gcccgggggc ggccaggtca actccagccg ctacaagacg
      481 gagctgtgcc gcccctttga ggaaaacggt gcctgtaagt acggggacaa gtgccagttc
      541 gcacacggca tccacgagct ccgcagcctg acccgccacc ccaagtacaa gacggagctg
      601 tgccgcacct tccacaccat cggcttttgc ccctacgggc cccgctgcca cttcatccac
      661 aacgctgaag agcgccgtgc cctggccggg gcccgggacc tctccgctga ccgtccccgc
      721 ctccagcata gctttagctt tgctgggttt cccagtgccg ctgccaccgc cgctgccacc
      781 gggctgctgg acagccccac gtccatcacc ccacccccta ttctgagcgc cgatgacctc
      841 ctgggctcac ctaccctgcc cgatggcacc aataaccctt ttgccttctc cagccaggag
      901 ctggcaagcc tctttgcccc tagcatgggg ctgcccgggg gtggctcccc gaccaccttc
      961 ctcttccggc ccatgtccga gtcccctcac atgtttgact ctccccccag ccctcaggat
     1021 tctctctcgg accaggaggg ctacctgagc agctccagca gcagccacag tggctcagac
     1081 tccccgacct tggacaactc aagacgcctg cccatcttca gcagactttc catctcagat
     1141 gactaagcca gggtagggag ggacctcctg cctactccag cccctaccct gcacccacat
     1201 cccataccct cttctcccta cccatcccat tccccacagg ccctacatta acaaggttaa
     1261 gctcaacccc tttcccccag cacctcagaa tgtgccctcc ctctccccct cataacccca
     1321 cctaacataa ggacaagtca atttgtcagt agcttcttct ggcttgaaac cccctccctg
     1381 gattttatag cccacttacc atgcataaca gacaagtccc atattttgtc agtagatgcc
     1441 tttttttttc cggcttaagc cttaagtgcc aaatcacaag agaaaaagca gtaacagttt
     1501 acagaagcaa cttagtgcct tgtaatctaa ctttgtcact gtgactacat tacctcttca
     1561 gcgccagagg gcacccgtgg gcctcccgga gcctctgccc atggcggggt ggagacccgg
     1621 aaccagcagc cccctccact ggcgacacaa ctgcaccttc cctcatttca gtctcccgca
     1681 cacttattcc tcctcccctc ttcccggtgg cacctctcca cctgtacccg cccccccacc
     1741 ccccccaccc ctgccccttg gaagagttgt tgccagacca gggttttggg ggaaacctgt
     1801 cttgacattc aaaacctttt tcttcccgat ctgaacccct gttgactaat cttgcctggg
     1861 tttgtgtagg tctgcaggaa ggaaggctga aaaagcggac gaagattttg acttaagtgg
     1921 gactttgtga tttaattttt tctttttttt aagtggggag gaaggggaag ctagatggac
     1981 taggagagac ttgattttgg tgctaaagtt ccccagttca tatgtgacat ctttttaaaa
     2041 aaaataacaa caaaaaaaaa atgagagaaa agctaaaaaa aaaaaagtaa ggggtgagca
     2101 gttaatggta ttcattccac atacaatatc tgtgtaaaac gatttcctgt agaagtagct
     2161 ttaatggttt ttgctctaga ataccgtagg tctatcctta gagcactcac gccatgcttt
     2221 cttccctggg ttttaaactt catataactt tcagaaattg gagagcaaaa attttgcttg
     2281 tcactgcaca tcaatataaa aaagcttatt taacttatca aaacgtattt attgccaaac
     2341 tatgcttttt tttgttaatt ttgttcatat ttatcgggat gacaaatcca tagaatatat
     2401 tcttttatgt taaattatga tcttcatatt aatcttaaaa ttttgtgacg tgtctttttc
     2461 ctttttttcc acagttttaa tatattattc ttcaacgaca ttttttgtaa ctttacactt
     2521 ttttggttat tttattttaa aaaaatgaaa aattaattta aaaaaatgca aaaaactgtt
     2581 ggattattta ttttagaaat tccccccttt gtgttggact gcaaattgag tttctttctc
     2641 tttaggcctt tcacaactag gactgagaat gtatgtaaaa gttctgtgac agtacagaag
     2701 gaaaacaact ttttatgtat agcttctaaa aggggaaaaa aaaaaaaaga gaaacccttt
     2761 gacttccacg tgcccatctc aagacattcc actcacagat ttgaggttct ggattccagg
     2821 tctggagttt tccaatgtta atgtaaacag aactggcaca cacacattaa gatgaatgta
     2881 attattattc ctcttgctgg tcactaccgt cgctttctat ttctctttct ttgtgtgaat
     2941 ttatttaaaa gaaaaaaaaa ctttttgtaa cgactatttg cagtttaaaa atcaataaac
     3001 cccgtttttt caagaaa
//
