LOCUS       NM_003407               1747 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens ZFP36 ring finger protein (ZFP36), mRNA.
ACCESSION   NM_003407
VERSION     NM_003407.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1747)
  AUTHORS   Lu,Z., Cao,R., Geng,F. and Pan,Y.
  TITLE     Persistent infection with Porphyromonas gingivalis increases the
            tumorigenic potential of human immortalised oral epithelial cells
            through ZFP36 inhibition
  JOURNAL   Cell Prolif 57 (6), e13609 (2024)
   PUBMED   38351596
  REMARK    GeneRIF: Persistent infection with Porphyromonas gingivalis
            increases the tumorigenic potential of human immortalised oral
            epithelial cells through ZFP36 inhibition.
REFERENCE   2  (bases 1 to 1747)
  AUTHORS   Schutt,W.R., Conde,J.N., Mladinich,M.C., Himmler,G.E. and
            Mackow,E.R.
  TITLE     ZIKV induction of tristetraprolin in endothelial and Sertoli cells
            post-transcriptionally inhibits IFNbeta/lambda expression and
            promotes ZIKV persistence
  JOURNAL   mBio 14 (5), e0174223 (2023)
   PUBMED   37707056
  REMARK    GeneRIF: ZIKV induction of tristetraprolin in endothelial and
            Sertoli cells post-transcriptionally inhibits IFNbeta/lambda
            expression and promotes ZIKV persistence.
REFERENCE   3  (bases 1 to 1747)
  AUTHORS   Zhang,T., Qiu,L., Cao,J., Li,Q., Zhang,L., An,G., Ni,J., Jia,H.,
            Li,S. and Li,K.
  TITLE     ZFP36 loss-mediated BARX1 stabilization promotes malignant
            phenotypes by transactivating master oncogenes in NSCLC
  JOURNAL   Cell Death Dis 14 (8), 527 (2023)
   PUBMED   37587140
  REMARK    GeneRIF: ZFP36 loss-mediated BARX1 stabilization promotes malignant
            phenotypes by transactivating master oncogenes in NSCLC.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1747)
  AUTHORS   Chen,Z., Fan,N., Shen,G. and Yang,J.
  TITLE     Silencing lncRNA CDKN2B-AS1 Alleviates Childhood Asthma Progression
            Through Inhibiting ZFP36 Promoter Methylation and Promoting NR4A1
            Expression
  JOURNAL   Inflammation 46 (2), 700-717 (2023)
   PUBMED   36422840
  REMARK    GeneRIF: Silencing lncRNA CDKN2B-AS1 Alleviates Childhood Asthma
            Progression Through Inhibiting ZFP36 Promoter Methylation and
            Promoting NR4A1 Expression.
REFERENCE   5  (bases 1 to 1747)
  AUTHORS   Asadi,M.R., Gharesouran,J., Sabaie,H., Moslehian,M.S., Dehghani,H.,
            Arsang-Jang,S., Taheri,M., Mortazavi,D., Hussen,B.M., Sayad,A. and
            Rezazadeh,M.
  TITLE     Assessing the expression of two post-transcriptional BDNF
            regulators, TTP and miR-16 in the peripheral blood of patients with
            Schizophrenia
  JOURNAL   BMC Psychiatry 22 (1), 771 (2022)
   PUBMED   36476595
  REMARK    GeneRIF: Assessing the expression of two post-transcriptional BDNF
            regulators, TTP and miR-16 in the peripheral blood of patients with
            Schizophrenia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1747)
  AUTHORS   Taylor,G.A., Thompson,M.J., Lai,W.S. and Blackshear,P.J.
  TITLE     Phosphorylation of tristetraprolin, a potential zinc finger
            transcription factor, by mitogen stimulation in intact cells and by
            mitogen-activated protein kinase in vitro
  JOURNAL   J Biol Chem 270 (22), 13341-13347 (1995)
   PUBMED   7768935
REFERENCE   7  (bases 1 to 1747)
  AUTHORS   Heximer,S.P. and Forsdyke,D.R.
  TITLE     A human putative lymphocyte G0/G1 switch gene homologous to a
            rodent gene encoding a zinc-binding potential transcription factor
  JOURNAL   DNA Cell Biol 12 (1), 73-88 (1993)
   PUBMED   8422274
REFERENCE   8  (bases 1 to 1747)
  AUTHORS   Taylor,G.A., Lai,W.S., Oakey,R.J., Seldin,M.F., Shows,T.B.,
            Eddy,R.L. Jr. and Blackshear,P.J.
  TITLE     The human TTP protein: sequence, alignment with related proteins,
            and chromosomal localization of the mouse and human genes
  JOURNAL   Nucleic Acids Res 19 (12), 3454 (1991)
   PUBMED   2062660
REFERENCE   9  (bases 1 to 1747)
  AUTHORS   DuBois,R.N., McLane,M.W., Ryder,K., Lau,L.F. and Nathans,D.
  TITLE     A growth factor-inducible nuclear protein with a novel
            cysteine/histidine repetitive sequence
  JOURNAL   J Biol Chem 265 (31), 19185-19191 (1990)
   PUBMED   1699942
REFERENCE   10 (bases 1 to 1747)
  AUTHORS   Lai,W.S., Stumpo,D.J. and Blackshear,P.J.
  TITLE     Rapid insulin-stimulated accumulation of an mRNA encoding a
            proline-rich protein
  JOURNAL   J Biol Chem 265 (27), 16556-16563 (1990)
   PUBMED   2204625
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M92843.1 and AC011500.7.
            
            On May 17, 2019 this sequence version replaced NM_003407.4.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.647245.1,
                                           SRR3476690.665021.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000597629.3/
                                                ENSP00000469647.2
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1745              M92843.1           2-1746
            1746-1747           AC011500.7         14230-14231
FEATURES             Location/Qualifiers
     source          1..1747
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1747
                     /gene="ZFP36"
                     /gene_synonym="G0S24; GOS24; NUP475; RNF162A; TIS11; TTP;
                     zfp-36"
                     /note="ZFP36 ring finger protein"
                     /db_xref="GeneID:7538"
                     /db_xref="HGNC:HGNC:12862"
                     /db_xref="MIM:190700"
     exon            1..82
                     /gene="ZFP36"
                     /gene_synonym="G0S24; GOS24; NUP475; RNF162A; TIS11; TTP;
                     zfp-36"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1039
                     /gene="ZFP36"
                     /gene_synonym="G0S24; GOS24; NUP475; RNF162A; TIS11; TTP;
                     zfp-36"
                     /note="tristetraprolin; tristetraproline; zinc finger
                     protein 36 homolog; G0/G1 switch regulatory protein 24;
                     growth factor-inducible nuclear protein NUP475; zinc
                     finger protein 36, C3H type, homolog"
                     /codon_start=1
                     /product="mRNA decay activator protein ZFP36"
                     /protein_id="NP_003398.3"
                     /db_xref="CCDS:CCDS12534.3"
                     /db_xref="GeneID:7538"
                     /db_xref="HGNC:HGNC:12862"
                     /db_xref="MIM:190700"
                     /translation="MDLTAIYESLLSLSPDVPVPSDHGGTESSPGWGSSGPWSLSPSD
                     SSPSGVTSRLPGRSTSLVEGRSCGWVPPPPGFAPLAPRLGPELSPSPTSPTATSTTPS
                     RYKTELCRTFSESGRCRYGAKCQFAHGLGELRQANRHPKYKTELCHKFYLQGRCPYGS
                     RCHFIHNPSEDLAAPGHPPVLRQSISFSGLPSGRRTSPPPPGLAGPSLSSSSFSPSSS
                     PPPPGDLPLSPSAFSAAPGTPLARRDPTPVCCPSCRRATPISVWGPLGGLVRTPSVQS
                     LGSDPDEYASSGSSLGGSDSPVFEAGVFAPPQPVAAPRRLPIFNRISVSE"
     exon            83..1747
                     /gene="ZFP36"
                     /gene_synonym="G0S24; GOS24; NUP475; RNF162A; TIS11; TTP;
                     zfp-36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1728..1733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP36"
                     /gene_synonym="G0S24; GOS24; NUP475; RNF162A; TIS11; TTP;
                     zfp-36"
                     /note="hexamer: AATAAA"
     polyA_site      1747
                     /gene="ZFP36"
                     /gene_synonym="G0S24; GOS24; NUP475; RNF162A; TIS11; TTP;
                     zfp-36"
                     /note="major polyA site"
ORIGIN      
        1 agcctgactt cagcgctccc actctcggcc gacacccctc atggccaacc gttacaccat
       61 ggatctgact gccatctacg agagcctcct gtcgctgagc cctgacgtgc ccgtgccatc
      121 cgaccatgga gggactgagt ccagcccagg ctggggctcc tcgggaccct ggagcctgag
      181 cccctccgac tccagcccgt ctggggtcac ctcccgcctg cctggccgct ccaccagcct
      241 agtggagggc cgcagctgtg gctgggtgcc cccaccccct ggcttcgcac cgctggctcc
      301 ccgcctgggc cctgagctgt caccctcacc cacttcgccc actgcaacct ccaccacccc
      361 ctcgcgctac aagactgagc tatgtcggac cttctcagag agtgggcgct gccgctacgg
      421 ggccaagtgc cagtttgccc atggcctggg cgagctgcgc caggccaatc gccaccccaa
      481 atacaagacg gaactctgtc acaagttcta cctccagggc cgctgcccct acggctctcg
      541 ctgccacttc atccacaacc ctagcgaaga cctggcggcc ccgggccacc ctcctgtgct
      601 tcgccagagc atcagcttct ccggcctgcc ctctggccgc cggacctcac caccaccacc
      661 aggcctggcc ggcccttccc tgtcctccag ctccttctcg ccctccagct ccccaccacc
      721 acctggggac cttccactgt caccctctgc cttctctgct gcccctggca cccccctggc
      781 tcgaagagac cccaccccag tctgttgccc ctcctgccga agggccactc ctatcagcgt
      841 ctgggggccc ttgggtggcc tggttcggac cccctctgta cagtccctgg gatccgaccc
      901 tgatgaatat gccagcagcg gcagcagcct ggggggctct gactctcccg tcttcgaggc
      961 gggagttttt gcaccacccc agcccgtggc agccccccgg cgactcccca tcttcaatcg
     1021 catctctgtt tctgagtgac aaagtgactg cccggtcaga tcagctggat ctcagcgggg
     1081 agccacgtct cttgcactgt ggtctctgca tggaccccag ggctgtgggg acttggggga
     1141 cagtaatcaa gtaatcccct tttccagaat gcattaaccc actcccctga cctcacgctg
     1201 gggcaggtcc ccaagtgtgc aagctcagta ttcatgatgg tgggggatgg agtgtcttcc
     1261 gaggttcttg ggggaaaaaa aattgtagca tatttaaggg aggcaatgaa ccctctcccc
     1321 cacctcttcc ctgcccaaat ctgtctccta gaatcttatg tgctgtgaat aataggcctt
     1381 cactgcccct ccagttttta tagacctgag gttccagtgt ctcctggtaa ctggaacctc
     1441 tcctgagggg gaatcctggt gctcaaatta ccctccaaaa gcaagtagcc aaagccgttg
     1501 ccaaacccca cccataaatc aatgggccct ttatttatga cgactttatt tattctaata
     1561 tgattttata gtatttatat atattgggtc gtctgcttcc cttgtatttt tcttcctttt
     1621 tttgtaatat tgaaaacgac gatataatta ttataagtag actataatat atttagtaat
     1681 atatattatt accttaaaag tctatttttg tgttttgggc atttttaaat aaacaatctg
     1741 agtgtaa
//
