LOCUS       NM_001320669            5826 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ZFP30 zinc finger protein (ZFP30), transcript variant
            5, mRNA.
ACCESSION   NM_001320669 XM_011526631
VERSION     NM_001320669.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5826)
  AUTHORS   Chen,W., Schwalie,P.C., Pankevich,E.V., Gubelmann,C., Raghav,S.K.,
            Dainese,R., Cassano,M., Imbeault,M., Jang,S.M., Russeil,J.,
            Delessa,T., Duc,J., Trono,D., Wolfrum,C. and Deplancke,B.
  TITLE     ZFP30 promotes adipogenesis through the KAP1-mediated activation of
            a retrotransposon-derived Pparg2 enhancer
  JOURNAL   Nat Commun 10 (1), 1809 (2019)
   PUBMED   31000713
  REMARK    GeneRIF: Using murine and human in vitro and in vivo models, study
            demonstrated that ZFP30 promotes adipogenesis by directly targeting
            and activating a retrotransposon-derived Pparg2 enhancer. Through
            mechanistic studies, study further show that ZFP30 recruits the
            co-regulator KAP1, which acts as a ZFP30 co-activator in this
            adipogenic context.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5826)
  AUTHORS   Bosch,D.G., Boonstra,F.N., de Leeuw,N., Pfundt,R., Nillesen,W.M.,
            de Ligt,J., Gilissen,C., Jhangiani,S., Lupski,J.R., Cremers,F.P.
            and de Vries,B.B.
  TITLE     Novel genetic causes for cerebral visual impairment
  JOURNAL   Eur J Hum Genet 24 (5), 660-665 (2016)
   PUBMED   26350515
REFERENCE   3  (bases 1 to 5826)
  AUTHORS   Yoshida,T., Kato,K., Yokoi,K., Oguri,M., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Association of genetic variants with hemorrhagic stroke in Japanese
            individuals
  JOURNAL   Int J Mol Med 25 (4), 649-656 (2010)
   PUBMED   20198315
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 5826)
  AUTHORS   Oguri,M., Kato,K., Yokoi,K., Yoshida,T., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Assessment of a polymorphism of SDK1 with hypertension in Japanese
            Individuals
  JOURNAL   Am J Hypertens 23 (1), 70-77 (2010)
   PUBMED   19851296
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 5826)
  AUTHORS   Denny,P. and Ashworth,A.
  TITLE     Zfp30, a KRAB domain containing zinc finger protein gene, maps to
            mouse chromosome 7
  JOURNAL   Mamm Genome 5 (10), 643-645 (1994)
   PUBMED   7849402
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093227.3, GU388430.1, AC022148.6 and AI377404.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001320669.2.
            
            Transcript Variant: This variant (5) differs in the 5' UTR compared
            to variant 1. Variants 1-5 encode the same protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.433885.1,
                                           SRR18074967.1359756.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684514.1/ ENSP00000508019.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AC093227.3         19418-19463         c
            47-4344             GU388430.1         143-4440
            4345-5639           AC022148.6         36409-37703
            5640-5823           AI377404.1         7-190               c
            5824-5826           AC022148.6         37888-37890
FEATURES             Location/Qualifiers
     source          1..5826
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..5826
                     /gene="ZFP30"
                     /gene_synonym="ZNF745"
                     /note="ZFP30 zinc finger protein"
                     /db_xref="GeneID:22835"
                     /db_xref="HGNC:HGNC:29555"
                     /db_xref="MIM:617317"
     exon            1..46
                     /gene="ZFP30"
                     /gene_synonym="ZNF745"
                     /inference="alignment:Splign:2.1.0"
     exon            47..214
                     /gene="ZFP30"
                     /gene_synonym="ZNF745"
                     /inference="alignment:Splign:2.1.0"
     exon            215..300
                     /gene="ZFP30"
                     /gene_synonym="ZNF745"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..1851
                     /gene="ZFP30"
                     /gene_synonym="ZNF745"
                     /note="isoform 1 is encoded by transcript variant 5; zinc
                     finger protein 745; zinc finger protein 30 homolog"
                     /codon_start=1
                     /product="zinc finger protein 30 homolog isoform 1"
                     /protein_id="NP_001307598.1"
                     /db_xref="CCDS:CCDS33005.1"
                     /db_xref="GeneID:22835"
                     /db_xref="HGNC:HGNC:29555"
                     /db_xref="MIM:617317"
                     /translation="MARDLVMFRDVAVDFSQEEWECLNSYQRNLYRDVILENYSNLVS
                     LAGCSISKPDVITLLEQGKEPWMVVRDEKRRWTLDLESRYDTKKLFQGKDIYEMNLSQ
                     WKVMERIKSCGLEEQESPHEVCFRQVTKTTSEKMPTYRKLTSLPLYQKSHNREKPYEC
                     GECGKAFRVRQQLTFHQRIHTGEKPYECKECGKAFRQCAHLSRHQRIHTSDKLYECKK
                     CGKIFTCGSDLRVHQRIHIGEKPYECKECGKAFRVRGQLNLHQRIHTGEKPYECKECG
                     KAFRQYAHLTRHQRLNIAEKCYECKECGQAFLCSTGLRLHHKLHTGEKPYECKECGKA
                     FRVRQQLTLHQRIHTGEKPYDCKECGKTFSRGYHLTLHQRIHTGEKPYECKECQKFFR
                     RYSELISHQGIHIGEKPYECKECGKAFRLFSQLTQHQSIHFGEKPFKCKECEKTFRLL
                     SQLTQHQSIHTGEKPYDCKECGKAFRLHSSLIQHQRIHSGEKPYKCKECKKAFRQHSH
                     LTYHQRIHNVT"
     exon            301..427
                     /gene="ZFP30"
                     /gene_synonym="ZNF745"
                     /inference="alignment:Splign:2.1.0"
     exon            428..526
                     /gene="ZFP30"
                     /gene_synonym="ZNF745"
                     /inference="alignment:Splign:2.1.0"
     exon            527..5826
                     /gene="ZFP30"
                     /gene_synonym="ZNF745"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4327..4332
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP30"
                     /gene_synonym="ZNF745"
                     /note="hexamer: AATAAA"
     polyA_site      4344
                     /gene="ZFP30"
                     /gene_synonym="ZNF745"
                     /note="major polyA site"
     regulatory      5234..5239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP30"
                     /gene_synonym="ZNF745"
                     /note="hexamer: AATAAA"
     polyA_site      5256
                     /gene="ZFP30"
                     /gene_synonym="ZNF745"
     regulatory      5494..5499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP30"
                     /gene_synonym="ZNF745"
                     /note="hexamer: AATAAA"
     polyA_site      5516
                     /gene="ZFP30"
                     /gene_synonym="ZNF745"
     regulatory      5803..5808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP30"
                     /gene_synonym="ZNF745"
                     /note="hexamer: AATAAA"
     polyA_site      5826
                     /gene="ZFP30"
                     /gene_synonym="ZNF745"
ORIGIN      
        1 attctggcgc cgctgactcc cagggctggg ctatcctctg agtcgggtgg cggttagttg
       61 gggccaggga agcgtggagg gtgggttcca atcgagtcaa gaaaagcctg gggtgtcctg
      121 aactctgcct gcttccccag ccctgccagt ttccagagaa ggcgcttgag aaggagaaac
      181 gaatcgctgc tgctcttcta aaagccggtt ccctctctgg tgtctgtgga ccctgcttct
      241 gaagtacatg aaccttgagg aaaattgacc agttctagca gttctaaaat catggctcgt
      301 gatttggtga tgttcagaga tgtggctgta gacttttctc aggaagaatg ggaatgcctg
      361 aactcatatc agaggaattt gtacagagat gtgatattag agaactatag caacttggtg
      421 tcactggcag gatgttctat ttctaagcca gatgtgatca ccctattgga acaagggaaa
      481 gagccctgga tggttgtgag ggatgagaaa agaagatgga ctctagattt ggaatccaga
      541 tatgacacta aaaagttatt tcaaggaaag gatatttatg aaatgaactt atctcagtgg
      601 aaggtaatgg aaagaattaa aagctgtgga cttgaagaac aagaaagtcc tcatgaggtg
      661 tgtttcaggc aagtgacaaa aaccacctct gaaaaaatgc ctacttacag aaaactcaca
      721 tctcttcctc tgtatcagaa aagtcataac agagagaaac cctacgaatg tggggaatgt
      781 gggaaggctt ttagagtacg acaacaactt actttccatc aaagaattca tactggtgag
      841 aaaccctatg aatgtaaaga atgtggaaaa gcctttagac agtgtgccca cctcagtcga
      901 catcagagaa ttcatacttc tgacaaactc tatgaatgta aaaaatgtgg aaagatcttc
      961 acatgtggct cagaccttcg agtacatcag agaattcata ttggtgagaa gccgtatgaa
     1021 tgtaaagaat gtgggaaagc ctttagagtt agaggacaac ttaatctcca tcaaaggatt
     1081 cacacgggtg agaaacccta tgaatgtaaa gaatgtggga aggcctttag gcagtatgca
     1141 caccttactc gacatcagag actgaacatt gctgagaagt gctatgagtg taaggaatgt
     1201 ggtcaggcct ttctgtgtag tacaggcctt cgactacatc acaaacttca tactggagaa
     1261 aaaccctatg aatgtaagga gtgtggaaag gcctttagag tgcggcagca acttactctc
     1321 catcagagaa ttcacactgg tgagaagcct tatgattgta aggaatgtgg gaagactttc
     1381 agtcgtggct atcatctaac tctccatcag agaatacata ctggtgaaaa gccctatgaa
     1441 tgtaaggaat gtcagaagtt ctttcgtcgt tactcagaac ttatttcaca tcagggtatt
     1501 cacattggag agaaacctta tgaatgtaag gaatgtggga aggcatttag gctgttctca
     1561 cagcttactc aacatcagag tattcatttt ggtgagaaac cctttaagtg taaggaatgt
     1621 gagaagactt ttagactgct ttcacaactt acccaacatc aaagtattca tactggtgaa
     1681 aagccctatg actgtaagga atgtggaaag gcctttagac ttcattcatc actgattcaa
     1741 catcagagaa ttcattctgg tgagaaacca tacaaatgta aggaatgtaa aaaggcattt
     1801 agacaacatt cacatcttac ttaccatcag cgaattcata atgtaactta ataattatta
     1861 gaactcttcc tttgcgaatt ttatgttgag cataggaagt acattctaga ggaaaggttt
     1921 ttgaacgtgg gaatcccttt tgcttcatgc tcacaactaa gcataggaag ttttatttaa
     1981 aggaaagaat atgttaatga acatatagaa gcctttcatc acctttgaaa ccatgttaaa
     2041 ctttaggaaa ttcatcctag aaaagaactt tattacagga ctgaatgtgg aaaagctttt
     2101 gatcttacct attattatct ccatattctt ccatctgtgt atatacacac gaaggttgct
     2161 agggaaccac ttcattctga aaatgtgtaa atgaaaggaa agtcatttag tctgcatttc
     2221 ctgtaggaac tgtatttcag ggcaaccaga agttaaggag gtaaagttct tctttattag
     2281 aaaattccag gctaatgaat gcagaaagaa taatagaaaa ttatattaga aaaactattg
     2341 tgtaacacat aatgaaataa tggatctagg catgattctc tgtacaggtt gacaccattc
     2401 agtgaaggtt gtgaacttta tagtgaatag atgagactga caacgtctga acccactcat
     2461 catctcaact tcacaaaaag caagagagta aaaattacgt gcctcctaat gtgctacagt
     2521 aagatataca catcttgcca aaaatattga acctgaattt aagcctcaag agccaactcc
     2581 cagtttagag aaaattcaag gaatggaaga gtaaattaca tgacacaaaa aggagcaatt
     2641 aaatctaaaa taagggtaat tctacaagag gaatcacctg gtttcccaac caataaaatg
     2701 gcattttaag aaataaggtg gaactcctag gtattgacag acttgagaca tcagtcaaat
     2761 gcaatgaaac agtggttttt acttagatca tgagttgaac aaacatgtaa aagaagagat
     2821 acttaacaat aattgggaga atggaatatt gacaatatta gataatatta agaaactttg
     2881 ttatgtgtga taatagcatt gtggttatgt aaaagtgtat ttgttagaga taatttctga
     2941 agtctataca caggagatga tatatctgga atgtcctttt gttcatacaa aagaaaaatg
     3001 aggatgaata acaagtttgg caaaatgatg gtaacctaag tcttggatac atggttttta
     3061 tttgttttgt ttttgctatt ctacttttgt gtatttaaaa ttttccatga tgttctttta
     3121 aagatcaaat tatccatgaa attatagcca gtttaaaatg aattatttta aaaaaaattt
     3181 ctggctgggc ccggtggctc atgcctgtaa tcccagcact ttgggaggcc ggtgggcaga
     3241 tcatgaggtc aggagttcga gaccagcctg accatcatgg tgaaacctca tctccactaa
     3301 aaatacaaaa attagccagg cgtggtcaca tgcgcctgta atcccagcta ctcgggcagc
     3361 tgagacagga gaatcacttg aacccaggag gcagaggttg cagtgagccg agatcacgcc
     3421 attgcactcc agcctgggca acaagagcaa aactctatct caaagaaaaa aagaaaattt
     3481 ctacatatta aaacttgtgg atgttgccaa agctctacac attgggattg gaatattaat
     3541 tacactataa tgacgataat gtattcagga agttaaaatg taggtccaca ttttatttag
     3601 ttgacctctc tatctctata ttatagtacc catggtatgc accttttttt tttttttttt
     3661 tgagacggag tctcgctctt tcgcccaggc tggcgtgcag tggcacagtc tcggctcact
     3721 gcaagctctg cctcccgggt tcaagccatt ctcctccctc agacttccga gtggctggga
     3781 ttacaggcgc ccgccaccac accaggttga tttttgtatt tttagtagag atggggtttc
     3841 accatgttgg ccaagctggt ctcaactcct gacctcaggt gatccacctg ccttggcctc
     3901 ccaaggtgct gggattacag gcgtgagcca ccatgcccga ctctcacttc atatgtttaa
     3961 agaatgagta aaagaaagca attactactg ctaaatgtgg gaaataatgg actagacctg
     4021 tactaatata tggtagtcac tagcaacctg ttgagcactt gaaattgagt tattgagcac
     4081 tgaaatgtgg ctagtccaaa ttcaaatggt gtttttttgt aaaacacaag attctgaaga
     4141 cttagttatt ttaaaaaagt taagtatctc aatttttcat attgagtaca tattgaaata
     4201 atattttaga tatattggtt caaataaaat acattaaaat gaataacact tttttgtttt
     4261 taaaattgtt ataggaaaat ttatatatgt agctcacgta tttctattgt cagcgctggc
     4321 ataaacaata aaaagtagac ttggtttttt tgtgtgtgtt tctttaaaag ataccaatat
     4381 agtcaagacc tttgcagttt tgatcacaga aatatgaaag attacacagc tacagctata
     4441 tgaatgataa aagtgacagc tatggatttt taaagttata agttgctata ctacatatat
     4501 gtaatgtgtg tgtgtatagt gtgtaggtat atatatttat atttatacac acactataca
     4561 tgtattttaa aatattgaaa atccagaatt attttatggt aaaaattact aaaattgact
     4621 tcacatgctg aatgaagaga gcctgagtag accaacaaac aaatgaaaaa ttaagacggt
     4681 tagaagatac gctttctaaa agaatacatt tagaatctaa ctttaaaaaa aaaaaatcct
     4741 actctcctga gccagagtgg tctcagagag actccgagaa cctaattttt tacaagtaaa
     4801 atctttgaag aattggtaat tgctaaattt ttccaacata ctattctaca agactaacct
     4861 aaaactgatt ataagaacta ggtgaggagg gctggcaaaa cgaaaatcta gacattttcc
     4921 gtatgaagag aaatctggta attctaattt ctatgggaaa ttatatccaa cagtttagaa
     4981 tagaaaatca tttatgtgga ataacttgga ccagatccat ccagctttaa ttatatattt
     5041 agattctagg cattctacct tcagaacatc ataatgatag taaaagagat acgattctgg
     5101 cccagtatca tctcaattca tgcttattgt cttttttttt tttttttttt tagctttcta
     5161 tgtattaaga atggaatgaa ttttatgtat gtaaaagtgt aacccaacac cttaaaatta
     5221 ccttctcaaa attaataaag acagagttct tataaatgat tgcatcagtt ggacttcggt
     5281 gatttcaccg tggtcatcca ttatgaactg tatttgctgt tataattggg aagccatgat
     5341 gttcagtgta ttacatcatt atattccatt tctcaaatgg aatatgaaac ttgatagcat
     5401 ttgaaaccat ttcccaggaa acactagtgc ttgatggtat ttttagaaag cattctgtgg
     5461 ttaaatgagc atattaaaat taataattaa gaaaataaaa ctatagcttc tccaaataat
     5521 gaagtaatga gagtttaatt gattttattt aacttaatgt atctgaagca ccttttaccc
     5581 tgtaactttc actcttaatg cttgtgagta tgggatatga acccatttta acagataagt
     5641 gctgtaacca aaacaggtga cagcaaaggt ggaaagttcg gacctcatgt caggtggtta
     5701 gttgtgttgg aaggtggatg tgaggtatgt ttccctggat gtggcatcat gttctaaagt
     5761 cacctgttct ttctgaatat tgaactgttg cttttctgca gaaataaaat ttctgaatca
     5821 acacta
//
