LOCUS       NM_020828               4094 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens ZFP28 zinc finger protein (ZFP28), transcript variant
            1, mRNA.
ACCESSION   NM_020828
VERSION     NM_020828.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4094)
  AUTHORS   Yajima,I., Kumasaka,M., Thang,N.D., Yanagishita,T., Ohgami,N.,
            Kallenberg,D., Naito,Y., Yoshikawa,T., Sakashita,N. and Kato,M.
  TITLE     Zinc finger protein 28 as a novel melanoma-related molecule
  JOURNAL   J Dermatol Sci 55 (1), 68-70 (2009)
   PUBMED   19329283
  REMARK    GeneRIF: these results suggest that murine and human Zfp28/ZFP28 is
            correlated with the pathogenesis of melanoma.
REFERENCE   2  (bases 1 to 4094)
  AUTHORS   Zhou,L., Zhu,C., Luo,K., Li,Y., Pi,H., Yuan,W., Wang,Y., Huang,C.,
            Liu,M. and Wu,X.
  TITLE     Identification and characterization of two novel zinc finger genes,
            ZNF359 and ZFP28, in human development
  JOURNAL   Biochem Biophys Res Commun 295 (4), 862-868 (2002)
   PUBMED   12127974
  REMARK    GeneRIF: Characterization of ZFP28 and its role in human
            development
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF507045.1 and AC005498.1.
            
            On May 17, 2019 this sequence version replaced NM_020828.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF507045.1, AB037852.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301318.8/ ENSP00000301318.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4087              AF507045.1         1-4087
            4088-4094           AC005498.1         36837-36843
FEATURES             Location/Qualifiers
     source          1..4094
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..4094
                     /gene="ZFP28"
                     /gene_synonym="mkr5"
                     /note="ZFP28 zinc finger protein"
                     /db_xref="GeneID:140612"
                     /db_xref="HGNC:HGNC:17801"
                     /db_xref="MIM:616798"
     exon            1..279
                     /gene="ZFP28"
                     /gene_synonym="mkr5"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..2678
                     /gene="ZFP28"
                     /gene_synonym="mkr5"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger factor X6; zfp-28; krueppel-like zinc finger factor
                     X6; zinc finger protein 28 homolog"
                     /codon_start=1
                     /product="zinc finger protein 28 homolog isoform 1"
                     /protein_id="NP_065879.1"
                     /db_xref="CCDS:CCDS12946.1"
                     /db_xref="GeneID:140612"
                     /db_xref="HGNC:HGNC:17801"
                     /db_xref="MIM:616798"
                     /translation="MRGAASASVREPTPLPGRGAPRTKPRAGRGPTVGTPATLALPAR
                     GRPRSRNGLASKGQRGAAPTGPGHRALPSRDTALPQERNKKLEAVGTGIEPKAMSQGL
                     VTFGDVAVDFSQEEWEWLNPIQRNLYRKVMLENYRNLASLGLCVSKPDVISSLEQGKE
                     PWTVKRKMTRAWCPDLKAVWKIKELPLKKDFCEGKLSQAVITERLTSYNLEYSLLGEH
                     WDYDALFETQPGLVTIKNLAVDFRQQLHPAQKNFCKNGIWENNSDLGSAGHCVAKPDL
                     VSLLEQEKEPWMVKRELTGSLFSGQRSVHETQELFPKQDSYAEGVTDRTSNTKLDCSS
                     FRENWDSDYVFGRKLAVGQETQFRQEPITHNKTLSKERERTYNKSGRWFYLDDSEEKV
                     HNRDSIKNFQKSSVVIKQTGIYAGKKLFKCNECKKTFTQSSSLTVHQRIHTGEKPYKC
                     NECGKAFSDGSSFARHQRCHTGKKPYECIECGKAFIQNTSLIRHWRYYHTGEKPFDCI
                     DCGKAFSDHIGLNQHRRIHTGEKPYKCDVCHKSFRYGSSLTVHQRIHTGEKPYECDVC
                     RKAFSHHASLTQHQRVHSGEKPFKCKECGKAFRQNIHLASHLRIHTGEKPFECAECGK
                     SFSISSQLATHQRIHTGEKPYECKVCSKAFTQKAHLAQHQKTHTGEKPYECKECGKAF
                     SQTTHLIQHQRVHTGEKPYKCMECGKAFGDNSSCTQHQRLHTGQRPYECIECGKAFKT
                     KSSLICHRRSHTGEKPYECSVCGKAFSHRQSLSVHQRIHSGKKPYECKECRKTFIQIG
                     HLNQHKRVHTGERSYNYKKSRKVFRQTAHLAHHQRIHTGESSTCPSLPSTSNPVDLFP
                     KFLWNPSSLPSP"
     exon            280..371
                     /gene="ZFP28"
                     /gene_synonym="mkr5"
                     /inference="alignment:Splign:2.1.0"
     exon            372..498
                     /gene="ZFP28"
                     /gene_synonym="mkr5"
                     /inference="alignment:Splign:2.1.0"
     exon            499..594
                     /gene="ZFP28"
                     /gene_synonym="mkr5"
                     /inference="alignment:Splign:2.1.0"
     exon            595..758
                     /gene="ZFP28"
                     /gene_synonym="mkr5"
                     /inference="alignment:Splign:2.1.0"
     exon            759..873
                     /gene="ZFP28"
                     /gene_synonym="mkr5"
                     /inference="alignment:Splign:2.1.0"
     exon            874..969
                     /gene="ZFP28"
                     /gene_synonym="mkr5"
                     /inference="alignment:Splign:2.1.0"
     exon            970..4094
                     /gene="ZFP28"
                     /gene_synonym="mkr5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2886..2891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP28"
                     /gene_synonym="mkr5"
                     /note="hexamer: AGTAAA"
     polyA_site      2908
                     /gene="ZFP28"
                     /gene_synonym="mkr5"
                     /note="major polyA site"
     regulatory      3140..3145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP28"
                     /gene_synonym="mkr5"
                     /note="hexamer: ATTAAA"
     polyA_site      3162
                     /gene="ZFP28"
                     /gene_synonym="mkr5"
                     /note="major polyA site"
     regulatory      3544..3549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP28"
                     /gene_synonym="mkr5"
                     /note="hexamer: AATAAA"
     polyA_site      3576
                     /gene="ZFP28"
                     /gene_synonym="mkr5"
     regulatory      4049..4054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP28"
                     /gene_synonym="mkr5"
                     /note="hexamer: AATAAA"
     regulatory      4061..4066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP28"
                     /gene_synonym="mkr5"
                     /note="hexamer: AATAAA"
     polyA_site      4070
                     /gene="ZFP28"
                     /gene_synonym="mkr5"
     polyA_site      4094
                     /gene="ZFP28"
                     /gene_synonym="mkr5"
ORIGIN      
        1 cgggcgggtg tggccagggg tgtgggtctg tgagggaccg gtcggaaggg cgtcgcgcgg
       61 cctcgggtga catgcggggg gcggcgagcg cgagtgtccg cgagccgacg ccgctcccgg
      121 gtagaggcgc cccccgcaca aagccccggg cgggccgagg cccgactgta gggactccag
      181 ccaccttggc cctccctgcc cggggaaggc cgcgctcaag gaatggcctc gcatccaaag
      241 gccagcgagg agcggcccct acggggcctg ggcacagagc tctgccttcc agggacactg
      301 ctcttcccca ggagagaaac aagaagctgg aggctgtggg gacaggaatt gaacctaaag
      361 ccatgtccca gggcttggtg acatttgggg atgtggctgt agatttctcc caagaggagt
      421 gggagtggct gaaccccatt cagaggaact tgtacaggaa ggtgatgttg gagaactaca
      481 ggaacctggc atcgctggga ctttgtgttt ctaagcccga tgtgatctcc tcgttggaac
      541 aaggaaaaga gccttggaca gtgaagcgaa agatgacaag agcctggtgc ccagacttga
      601 aggctgtgtg gaagatcaag gagttacctc tcaagaagga cttctgcgaa ggaaagctat
      661 cccaggcagt gataacagag agactcacaa gctataatct ggagtactct ctgttagggg
      721 aacactggga ttatgatgct ctgtttgaga cacagccggg cttggtgact atcaaaaacc
      781 tggctgttga cttccgccag cagctacacc cagctcagaa gaatttctgt aagaatggga
      841 tatgggagaa caacagtgac ctgggatcag caggacattg tgtggctaag ccagatttag
      901 tctctttact agagcaagag aaggagccct ggatggtgaa gcgagagctg acaggaagcc
      961 tgttctcagg ccagcgatct gtacatgaga cccaggaatt atttccaaag caagattcat
     1021 atgctgaagg ggtaacagac agaacctcaa acactaaact tgattgttcc agtttcagag
     1081 aaaattggga ttctgactat gtgtttggaa ggaagcttgc agtaggtcaa gagacacaat
     1141 tcaggcaaga gccaattact cataacaaaa ccctctctaa ggaaagagaa cgtacatata
     1201 acaaatctgg aagatggttc tatttggacg attcagaaga gaaagttcat aatcgtgatt
     1261 caattaaaaa ttttcaaaaa agttcagtgg taataaaaca aacaggcatc tatgcaggaa
     1321 aaaagctttt caagtgtaat gaatgtaaga aaacttttac ccagagctca tctcttactg
     1381 ttcatcagag aattcacact ggagagaaac cttataaatg taatgaatgt gggaaggcct
     1441 ttagtgacgg ctcatccttt gcccgacacc agagatgtca cactggcaag aagccctatg
     1501 agtgcattga gtgtgggaaa gctttcatac agaacacatc ccttatccgt cactggagat
     1561 actatcatac tggggagaaa ccctttgatt gcatcgattg tgggaaagcc ttcagtgacc
     1621 acatagggct taatcaacac aggagaattc atactggaga gaaaccttac aaatgtgatg
     1681 tatgtcacaa atccttcagg tatggttcct cccttactgt acatcaaagg attcataccg
     1741 gagaaaaacc atatgaatgt gatgtttgca gaaaagcctt cagccatcat gcatcactca
     1801 ctcaacatca aagagtacat tctggagaaa agccttttaa gtgtaaagag tgcggaaaag
     1861 cttttaggca gaatatacac cttgccagtc atttaaggat tcatactggg gagaagcctt
     1921 ttgaatgtgc ggagtgtgga aaatccttca gcatcagttc tcagcttgcc actcatcaga
     1981 gaatccatac tggagagaag ccctatgaat gtaaggtttg tagtaaagcg ttcacccaga
     2041 aggctcacct tgcacagcat cagaaaaccc atacaggaga gaaaccatat gagtgcaagg
     2101 aatgcggtaa agccttcagc cagaccacac acctcattca acatcagaga gttcacactg
     2161 gtgagaaacc ctataaatgt atggaatgtg ggaaggcctt tggtgataac tcatcctgta
     2221 ctcaacatca aagactgcac actggccaaa gaccttatga atgtattgag tgtggaaagg
     2281 cattcaagac aaaatcctcc cttatttgtc atcgcagaag tcatactgga gaaaaacctt
     2341 atgaatgcag tgtgtgtggc aaagccttta gtcatcgtca atcccttagt gtacatcaga
     2401 gaatccattc tggaaagaaa ccatatgaat gtaaggaatg taggaaaacc ttcatccaaa
     2461 ttggacacct taatcaacat aagagagttc atactggaga gagatcttat aactataaga
     2521 aaagcagaaa agtcttcagg caaactgctc acttagctca tcatcagcga attcatactg
     2581 gagagtcgtc aacatgcccc tctttacctt ccacgtcaaa tcctgtggat ctgtttccca
     2641 aatttctctg gaatccatcc tccctcccat caccatagcc tcgagacgtc atttctgttt
     2701 gactactcca gcagtttaaa accccatctc cctgcccttt tgttttcttt ttgtccctta
     2761 ttagttagtt cttcacataa gtgtaaatgt aacttattca ctcctcttgt aaaacttata
     2821 gtttctttaa attggttaat gtgtgagatg tgctcagcac agtgcctggt ccatagtaag
     2881 tgctcagtaa acttagctgt tttaaaaact ttgtatttga acattgaaaa gttacagtag
     2941 tcagctctga taaaaaaatg atgcagtagg gtgagggtag gaaaaagcac attttctatc
     3001 aggaacagaa ttctccagta gtgggtgagg ttttgccttt gttggtttta aaacttgatt
     3061 ctataatgcc aagttagttt tgtggctttc catctgaccc tatgtgaatg taaggtgatg
     3121 tgaccttgtt ggtgagaaaa ttaaacttta catttgactt gatttgtttt agaaagtcta
     3181 gggaccatga atgaataggc cagctgggac aaatgaattt aaaaaatcag aaaaatgcaa
     3241 gatttatatg catgaagtta aaacaactga cgttactcaa gaattagaaa actttgcaag
     3301 atttgacttg tttaaaaatc acatttataa gtgaaccgta ttaaaacttt taaggaacca
     3361 ttcattgtga ggtaaactga tccagaatag gggtcagcaa actatgactc atggccacag
     3421 tctcactgac tgtttttgta tggtccatga tctagaattt aaaaaaattt taaagggttg
     3481 aaaaaagtga aaagaatatt ttcaacatga aaattatatg aaatttaagt tttggtgtct
     3541 gtaaataaag ttttgttggc ttcagccaca cagtgattta caccttgatt gtgctgcttc
     3601 caggctgtag cagcagagtt gagcagttgt gacaggagac catgtggcct gcagagccca
     3661 aatatctact gtctgatcct acacagaaaa tgtgtgtgat ccctgctatg gagcagaggt
     3721 tatcaaacta aagcccatgg accaaatcct atctgctgct tgtttttgta aatagagttt
     3781 tatcaaacca cagccatgct tacttgttta gctattgact atggctgctt tagacaactg
     3841 tgacagacta tatggctcgc aaaactgcaa atatttccta tcctttaaca gaaagtttgc
     3901 caacctctgc tctagagtag agaaaaatgt ataaaagatt ttaattttat gagggcaata
     3961 caactgtcac atcagaaaca agaaaacaaa tgataaagga actcatttat caatagaggt
     4021 gaaaggaaat tattaaacta tattgaaaaa taaagatgtc aataaaagga gaaatgatat
     4081 ttttctagat gaaa
//
