LOCUS       NM_030613               2410 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ZFP2 zinc finger protein (ZFP2), mRNA.
ACCESSION   NM_030613
VERSION     NM_030613.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2410)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2410)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2410)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB059183.1, BC142989.1, DA694775.1, BC132779.1 and AK131367.1.
            
            On Nov 23, 2018 this sequence version replaced NM_030613.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC142989.1, SRR1660807.56633.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361362.7/ ENSP00000354453.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DB059183.1         20-33
            15-361              BC142989.1         2-348
            362-571             DA694775.1         360-569
            572-1332            BC132779.1         364-1124
            1333-2018           AK131367.1         1331-2016
            2019-2410           BC142989.1         2007-2398
FEATURES             Location/Qualifiers
     source          1..2410
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..2410
                     /gene="ZFP2"
                     /gene_synonym="zfp-2; ZNF751"
                     /note="ZFP2 zinc finger protein"
                     /db_xref="GeneID:80108"
                     /db_xref="HGNC:HGNC:26138"
     exon            1..62
                     /gene="ZFP2"
                     /gene_synonym="zfp-2; ZNF751"
                     /inference="alignment:Splign:2.1.0"
     exon            63..198
                     /gene="ZFP2"
                     /gene_synonym="zfp-2; ZNF751"
                     /inference="alignment:Splign:2.1.0"
     exon            199..288
                     /gene="ZFP2"
                     /gene_synonym="zfp-2; ZNF751"
                     /inference="alignment:Splign:2.1.0"
     exon            289..434
                     /gene="ZFP2"
                     /gene_synonym="zfp-2; ZNF751"
                     /inference="alignment:Splign:2.1.0"
     exon            435..2410
                     /gene="ZFP2"
                     /gene_synonym="zfp-2; ZNF751"
                     /inference="alignment:Splign:2.1.0"
     CDS             512..1897
                     /gene="ZFP2"
                     /gene_synonym="zfp-2; ZNF751"
                     /note="zinc finger protein 751; zinc finger protein 2
                     homolog"
                     /codon_start=1
                     /product="zinc finger protein ZFP2"
                     /protein_id="NP_085116.2"
                     /db_xref="CCDS:CCDS4440.1"
                     /db_xref="GeneID:80108"
                     /db_xref="HGNC:HGNC:26138"
                     /translation="MEREGIWHSTLGETWEPNNWLEGQQDSHLSQVGVTHKETFTEMR
                     VCGGNEFERCSSQDSILDTQQSIPMVKRPHNCNSHGEDATQNSELIKTQRMFVGKKIY
                     ECNQCSKTFSQSSSLLKHQRIHTGEKPYKCNVCGKHFIERSSLTVHQRIHTGEKPYKC
                     NECGKAFSQSMNLTVHQRTHTGEKPYQCKECGKAFHKNSSLIQHERIHTGEKPYKCNE
                     CGKAFTQSMNLTVHQRTHTGEKPYECNECGKAFSQSMHLIVHQRSHTGEKPYECSQCG
                     KAFSKSSTLTLHQRNHTGEKPYKCNKCGKSFSQSTYLIEHQRLHSGVKPFECNECGKA
                     FSKNSSLTQHRRIHTGEKPYECMVCGKHFTGRSSLTVHQVIHTGEKPYECNECGKAFS
                     QSAYLIEHQRIHTGEKPYECDQCGKAFIKNSSLTVHQRTHTGEKPYQCNECGKAFSRS
                     TNLTRHQRTHT"
     regulatory      2390..2395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP2"
                     /gene_synonym="zfp-2; ZNF751"
                     /note="hexamer: AATATA"
     polyA_site      2410
                     /gene="ZFP2"
                     /gene_synonym="zfp-2; ZNF751"
                     /note="major polyA site"
ORIGIN      
        1 gggctgtaag cgccggtcgc ggctgtgtcg gtcgccgctg ctcccgctcc tgctgggaga
       61 ggtttcagga gtcagtgacc ttcaaggatg tgtccataga tttctcttgg gaagagtgga
      121 ttcaagcaga ttctgctcag aggatgaccg tgtatgggga ggtgatgctg gagaactaca
      181 ggaacccggt ctcactggga aatcaccttt ccaaacccaa tgggacttcc cagctggaac
      241 gagaactgag tctgatgcaa aaagaaccgc ctgagggtgg ctttcgagat tttcttggat
      301 attgctgtca gattaatctg acatttagtc ctctcattat cctgtcccag tcaaggggag
      361 aaagtattga ctgagtgctg tgctcagctc ttccacagcc agcatctcac ttacttgaca
      421 caaaacatct atagactggg agacaagact tgaaaccaaa gagccaactc cgaagccggg
      481 tattactgaa gatttatgcc atggggtaac aatggaaagg gaaggtatct ggcattctac
      541 tctaggggaa acctgggaac ctaataattg gttagaggga caacaggata gtcatctgag
      601 ccaagtggga gttacccata aggaaacctt cactgagatg agagtatgtg gaggtaatga
      661 atttgaaaga tgttccagtc aggattcaat ccttgataca cagcaaagca ttcctatggt
      721 aaaaaggccc cataactgta attcacatgg agaagatgcc acacaaaatt ctgagttaat
      781 taaaactcaa agaatgtttg taggaaagaa gatctatgaa tgtaatcagt gcagcaaaac
      841 cttcagtcag agctcatccc ttcttaagca ccagaggatt catactgggg agaaacccta
      901 taagtgtaat gtatgtggga aacacttcat tgaacgatcc tcccttactg tacatcaaag
      961 aattcatact ggagagaaac cctataaatg taatgaatgt gggaaagcct ttagtcagag
     1021 catgaatctt actgtccatc aacgaactca caccggagag aaaccctatc agtgtaaaga
     1081 gtgtggcaaa gccttccata agaattcatc tcttattcag catgaaagga ttcatactgg
     1141 agagaaaccc tacaaatgta atgaatgtgg taaagctttt acccaaagca tgaatttgac
     1201 agttcatcag agaactcata caggagaaaa accctatgaa tgtaatgaat gtggaaaagc
     1261 cttcagtcaa agcatgcatc ttattgtaca tcagagaagc catactggag aaaaacccta
     1321 tgagtgtagt caatgtggaa aagcctttag taagagctca actcttaccc tacatcagcg
     1381 aaatcacact ggagaaaaac cttacaaatg taacaaatgc gggaaatcct ttagccaaag
     1441 tacatatctt atagaacatc agagacttca ttctggagta aaaccttttg aatgtaacga
     1501 gtgtggaaaa gctttcagta agaattcatc tctaactcaa catcggagaa ttcacactgg
     1561 agagaaacct tatgagtgta tggtgtgtgg aaaacatttc actggacgat catcccttac
     1621 cgtgcatcag gtcattcaca ctggagagaa accttatgag tgcaatgaat gtggaaaggc
     1681 attcagccag agtgcttacc ttattgaaca tcaaagaatt catactggtg agaaacccta
     1741 tgaatgtgat cagtgtggaa aagccttcat taagaattca tcccttacag tgcatcagag
     1801 aactcataca ggagagaaac cctatcagtg taatgaatgc ggaaaagcct tcagccggag
     1861 tacaaacctt acacgacatc aaagaactca tacgtgagga atgttttcac tggcccttac
     1921 ctcatgatta actcttcagt aataatcata tgagacatac aatgtagaaa cctaataaat
     1981 gtaatgattg tgggaatctt tcagttgaag tacaatatgt catatcagat aataccactg
     2041 cagagaatcc atctaaaagt agagaaatct tgattcagaa tgtataattt cctttatatc
     2101 agaaggttta aatagctaat ataaacaatg aagagtcatg ctgaagataa gttctgttat
     2161 atcataccgc acattctcct ttggctatca gagactttac actggagaga aaaatgtgag
     2221 agtgtttaac tggacagccc agagacctgg tatgtagtcc taatctgcca ctgccttgga
     2281 caacttgcct acttccacca ggttatggtt ctttatttgg taaatgaatg attttggagt
     2341 tagaaatctt gtaggagctc tgttagctct aaaatgctac aactctataa atataatgaa
     2401 tgctgggaaa
//
