LOCUS       NM_153688               3287 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens ZFP1 zinc finger protein (ZFP1), transcript variant 1,
            mRNA.
ACCESSION   NM_153688
VERSION     NM_153688.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3287)
  AUTHORS   Yao,J., Ma,F., Shi,D. and Da,M.
  TITLE     ZFP1 is a biomarker related to poor prognosis and immunity in
            gastric cancer
  JOURNAL   Sci Rep 14 (1), 21233 (2024)
   PUBMED   39261568
  REMARK    GeneRIF: ZFP1 is a biomarker related to poor prognosis and immunity
            in gastric cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3287)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3287)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   4  (bases 1 to 3287)
  AUTHORS   Wolpin,B.M., Rizzato,C., Kraft,P., Kooperberg,C., Petersen,G.M.,
            Wang,Z., Arslan,A.A., Beane-Freeman,L., Bracci,P.M., Buring,J.,
            Canzian,F., Duell,E.J., Gallinger,S., Giles,G.G., Goodman,G.E.,
            Goodman,P.J., Jacobs,E.J., Kamineni,A., Klein,A.P., Kolonel,L.N.,
            Kulke,M.H., Li,D., Malats,N., Olson,S.H., Risch,H.A., Sesso,H.D.,
            Visvanathan,K., White,E., Zheng,W., Abnet,C.C., Albanes,D.,
            Andreotti,G., Austin,M.A., Barfield,R., Basso,D., Berndt,S.I.,
            Boutron-Ruault,M.C., Brotzman,M., Buchler,M.W.,
            Bueno-de-Mesquita,H.B., Bugert,P., Burdette,L., Campa,D.,
            Caporaso,N.E., Capurso,G., Chung,C., Cotterchio,M., Costello,E.,
            Elena,J., Funel,N., Gaziano,J.M., Giese,N.A., Giovannucci,E.L.,
            Goggins,M., Gorman,M.J., Gross,M., Haiman,C.A., Hassan,M.,
            Helzlsouer,K.J., Henderson,B.E., Holly,E.A., Hu,N., Hunter,D.J.,
            Innocenti,F., Jenab,M., Kaaks,R., Key,T.J., Khaw,K.T., Klein,E.A.,
            Kogevinas,M., Krogh,V., Kupcinskas,J., Kurtz,R.C., LaCroix,A.,
            Landi,M.T., Landi,S., Le Marchand,L., Mambrini,A., Mannisto,S.,
            Milne,R.L., Nakamura,Y., Oberg,A.L., Owzar,K., Patel,A.V.,
            Peeters,P.H., Peters,U., Pezzilli,R., Piepoli,A., Porta,M.,
            Real,F.X., Riboli,E., Rothman,N., Scarpa,A., Shu,X.O.,
            Silverman,D.T., Soucek,P., Sund,M., Talar-Wojnarowska,R.,
            Taylor,P.R., Theodoropoulos,G.E., Thornquist,M., Tjonneland,A.,
            Tobias,G.S., Trichopoulos,D., Vodicka,P., Wactawski-Wende,J.,
            Wentzensen,N., Wu,C., Yu,H., Yu,K., Zeleniuch-Jacquotte,A.,
            Hoover,R., Hartge,P., Fuchs,C., Chanock,S.J.,
            Stolzenberg-Solomon,R.S. and Amundadottir,L.T.
  TITLE     Genome-wide association study identifies multiple susceptibility
            loci for pancreatic cancer
  JOURNAL   Nat Genet 46 (9), 994-1000 (2014)
   PUBMED   25086665
REFERENCE   5  (bases 1 to 3287)
  AUTHORS   Dastani,Z., Pajukanta,P., Marcil,M., Rudzicz,N., Ruel,I.,
            Bailey,S.D., Lee,J.C., Lemire,M., Faith,J., Platko,J., Rioux,J.,
            Hudson,T.J., Gaudet,D., Engert,J.C. and Genest,J.
  TITLE     Fine mapping and association studies of a high-density lipoprotein
            cholesterol linkage region on chromosome 16 in French-Canadian
            subjects
  JOURNAL   Eur J Hum Genet 18 (3), 342-347 (2010)
   PUBMED   19844255
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 3287)
  AUTHORS   Chowdhury,K., Dietrich,S., Balling,R., Guenet,J.L. and Gruss,P.
  TITLE     Structure, expression and chromosomal localization of Zfp-1, a
            murine zinc finger protein gene
  JOURNAL   Nucleic Acids Res 17 (24), 10427-10438 (1989)
   PUBMED   2574853
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC388176.1, AK296560.1,
            BC064604.1, AK091562.1, BC033774.1 and BP219674.1.
            
            On Nov 23, 2018 this sequence version replaced NM_153688.3.
            
            Summary: This gene belongs to the zinc finger protein family. Some
            members of this family bind to DNA by zinc-mediated secondary
            structures called zinc fingers, and are involved in transcriptional
            regulation. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Jan
            2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1 and 2 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.130869.1,
                                           SRR1803615.202415.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000570010.6/ ENSP00000457044.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                DC388176.1         41-62
            23-1425             AK296560.1         55-1457
            1426-1597           BC064604.1         1387-1558
            1598-2386           AK091562.1         908-1696
            2387-2918           BC033774.1         1863-2394
            2919-3022           BP219674.1         480-583
            3023-3287           BC064604.1         3014-3278
FEATURES             Location/Qualifiers
     source          1..3287
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.1"
     gene            1..3287
                     /gene="ZFP1"
                     /gene_synonym="ZNF475"
                     /note="ZFP1 zinc finger protein"
                     /db_xref="GeneID:162239"
                     /db_xref="HGNC:HGNC:23328"
                     /db_xref="MIM:617230"
     exon            1..120
                     /gene="ZFP1"
                     /gene_synonym="ZNF475"
                     /inference="alignment:Splign:2.1.0"
     exon            121..178
                     /gene="ZFP1"
                     /gene_synonym="ZNF475"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1387
                     /gene="ZFP1"
                     /gene_synonym="ZNF475"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 475; zinc finger protein 1 homolog"
                     /codon_start=1
                     /product="zinc finger protein 1 homolog isoform 1"
                     /protein_id="NP_710155.2"
                     /db_xref="CCDS:CCDS10914.2"
                     /db_xref="GeneID:162239"
                     /db_xref="HGNC:HGNC:23328"
                     /db_xref="MIM:617230"
                     /translation="MNKSQGSVSFTDVTVDFTQEEWEQLDPSQRILYMDVMLENYSNL
                     LSVEVWKADDQMERDHRNPDEQARQFLILKNQTPIEERGDLFGKALNLNTDFVSLRQV
                     PYKYDLYEKTLKYNSDLLNSNRSYAGKQTDECNEFGKALLYLKQEKTHSGVEYSEYNK
                     SGKALSHKAAIFKHQKIKNLVQPFICTYCDKAFSFKSLLISHKRIHTGEKPYECNVCK
                     KTFSHKANLIKHQRIHTGEKPFECPECGKAFTHQSNLIVHQRAHMEKKPYECSECGKT
                     FAQKFELTTHQRIHTGERPYECNECAKTFFKKSNLIIHQKIHTGEKRYECSECGKSFI
                     QNSQLIIHMRTHTGEKPYECTECGKTFSQRSTLRLHLRIHTGEKPYECSECGKAFSRK
                     SRLSVHQRVHIGEKP"
     exon            179..305
                     /gene="ZFP1"
                     /gene_synonym="ZNF475"
                     /inference="alignment:Splign:2.1.0"
     exon            306..3287
                     /gene="ZFP1"
                     /gene_synonym="ZNF475"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3122..3127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP1"
                     /gene_synonym="ZNF475"
                     /note="hexamer: AATAAA"
     polyA_site      3141
                     /gene="ZFP1"
                     /gene_synonym="ZNF475"
                     /note="major polyA site"
     regulatory      3268..3273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFP1"
                     /gene_synonym="ZNF475"
                     /note="hexamer: AATAAA"
     polyA_site      3287
                     /gene="ZFP1"
                     /gene_synonym="ZNF475"
                     /note="major polyA site"
ORIGIN      
        1 gcccttcccc caccaccagc ggcgagtggg tgacagagcc cccgtctccg cgcgtcttcg
       61 ccgccctgcg ccgtgacccg ctgtggcact gggccacgag tggaggctgc gcccctccag
      121 ttctgccttc atagttctct gcctttgccc aaaactgcag aaaatgaaca aatcccaggg
      181 atcagtttca ttcacggatg tgactgtgga ctttacccag gaggaatggg aacaactgga
      241 cccctctcag aggatcctat acatggatgt gatgctggag aattatagca acttactttc
      301 agtggaagtg tggaaggctg atgaccagat ggagagagac cacagaaacc cagacgagca
      361 ggcgaggcaa tttttaattc ttaagaacca aaccccaatt gaggaaagag gcgatctctt
      421 tggaaaagca cttaatctga acacagactt tgtttcttta agacaagtac cttataaata
      481 tgacttatat gaaaaaactt tgaaatataa ttcagacttg cttaatagta atagaagcta
      541 tgcaggaaag cagactgatg agtgtaatga atttggaaaa gcacttctct acctgaagca
      601 agagaaaacc cacagtggag tagaatattc tgaatacaat aaaagtggaa aagccctcag
      661 ccataaagca gccattttta aacatcagaa aataaaaaac ttggttcaac ctttcatttg
      721 tacttactgt gacaaggctt tctcctttaa gtcactcctc attagtcata agagaataca
      781 tactggagaa aagccatatg aatgcaatgt atgtaagaaa accttctccc ataaggccaa
      841 cctcatcaaa catcagagaa ttcacactgg ggagaaacct ttcgagtgtc cggaatgtgg
      901 aaaagctttc acccaccagt caaacctcat tgtacaccag agagcacata tggagaagaa
      961 gccctatgag tgcagtgaat gtggaaagac atttgcccaa aagtttgaac tcaccacaca
     1021 ccagagaatt catacaggag agcgacccta tgagtgtaac gaatgtgcaa aaaccttctt
     1081 taagaagtca aaccttatca tacatcagaa gattcacacg ggggagaaac gctatgagtg
     1141 cagtgaatgt ggaaaatcct ttatccagaa ctcacagctc atcatacaca tgagaactca
     1201 tacaggagag aaaccctatg aatgtactga gtgcggcaaa actttcagcc agaggtcaac
     1261 tcttagatta cacttgcgaa tccacacagg agagaaacca tatgagtgtt ccgaatgtgg
     1321 gaaggccttt agcaggaagt cccgactcag tgtccatcag agagttcaca tcggggagaa
     1381 accctgaaac tccagccagg tcttactgtg gaaaactcct gccagaactc ttcaagcggg
     1441 tgaaaaacct catgacagta ttgagggaac atgggaattc atactgagat gcaatctctc
     1501 aactcaaaaa tgtattaaaa ataggatccc atgagaacat tatactggaa gttacatgtg
     1561 atacccagct aaagaataca tatcagaata tatccagttg taaatagcca tacccagttg
     1621 tactacaatg agctttttaa aatcttgaat gaattgagta ttctagacag cagcataaga
     1681 aatatacaaa cagtatccta tgaatttagt ggttttatgt ggatatgcca caaaacacaa
     1741 gtggtatgct ttagatctgc acatgtgaat ttagcataat cactgggaat ttgaaattct
     1801 tgtcctctgt gataattagg acataacaag attttccata ctaaacatca catgtgtttt
     1861 tcagtatctc tgcaatccag tatgcattcc aaatgaaatg tgtaacattt aaagtagcat
     1921 ggaacctacg tctttcccta ctgcttgctg gcatatatca gttggtatga acattgttct
     1981 tgagctgcct cttaggaaac agaagacagt gttgaagttt tccctgcttc tggtttgctg
     2041 aagattttct agaagcacta tttacacaaa tatgcaaatg tgaaataacc gatctataac
     2101 gtgaaggagg cagacatgag ctgtactact cagtatgcac cacagaataa gagtttgccg
     2161 tgtaaagaca atatccccat tcgtcatgct cttattttcc cgtgggatat ttgcatacaa
     2221 atgcatgtct gttaccaaaa tattgtgtaa cacagacaga aaccacctgt ttttgtcttt
     2281 ccttgtttcc cttaatattt catgaattgt ctagcaaaaa tggtaggatg cttctgtagt
     2341 tcacaaatgt tacatttcag agactttaga ggaaaaatta ttttaaataa ctgtcaactg
     2401 tttcattgct ttttaaattt ttcacgtgca taaccccctt tagaagtaaa tttttacact
     2461 attttgttgt ttaaaggagg catttctact tccttgagtt ttgctgttgc caacctaaaa
     2521 catttccctt tggaacatga gttataagtt attacttttc ctttacatgt ttacactttt
     2581 ataaaaatca gatttttcag tggtctctcc agatattaac aagaattgtt gtgtaactca
     2641 aagatttgct tttatagact tgatttcaaa ttcttaagtt cagcctttcc ctatcaatca
     2701 caaatcatgt attggaaatt ataaatggca accaaaaact ggcttttaaa aaatattttt
     2761 ggatatcatt gatgtgctgt cacactatat attgagtgac tttctgaaca aatttatcca
     2821 gaacatccat agcccaataa gcttttgtct aagttgtcat cttacttact cacaaaggag
     2881 gggaaaacgt tattttcata gctgctttta gaaatgtaaa ttgtaacagc ctccttggac
     2941 aacattgtga gtctgtttta acattaatat actcttacaa cctaggaatc tcctgggaat
     3001 ctatccctaa ggaataaaaa gcgccagcac ttaagattat atgtttacta atgtatattg
     3061 tattttttgg taaggaccaa aaaaacaaac aaaaaaaaga ccatcagtaa gggaatggat
     3121 gaataaattg tggtaaaaac ataccatggc tgaatggtat ttccttgaaa agaatgtgtg
     3181 ggaacaaact ccaaacttct ctaggtcaaa tgaggaaagc aagaggggag agagagagtg
     3241 tatgtgtgtg tgtagcagtt tttataaaat aaagataaac ccttata
//
