LOCUS       NM_033400               9296 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens zinc finger homeobox 2 (ZFHX2), mRNA.
ACCESSION   NM_033400 XM_033370
VERSION     NM_033400.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9296)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 9296)
  AUTHORS   Habib,A.M., Matsuyama,A., Okorokov,A.L., Santana-Varela,S.,
            Bras,J.T., Aloisi,A.M., Emery,E.C., Bogdanov,Y.D., Follenfant,M.,
            Gossage,S.J., Gras,M., Humphrey,J., Kolesnikov,A., Le Cann,K.,
            Li,S., Minett,M.S., Pereira,V., Ponsolles,C., Sikandar,S.,
            Torres,J.M., Yamaoka,K., Zhao,J., Komine,Y., Yamamori,T.,
            Maniatis,N., Panov,K.I., Houlden,H., Ramirez,J.D., Bennett,D.L.H.,
            Marsili,L., Bachiocco,V., Wood,J.N. and Cox,J.J.
  TITLE     A novel human pain insensitivity disorder caused by a point
            mutation in ZFHX2
  JOURNAL   Brain 141 (2), 365-376 (2018)
   PUBMED   29253101
  REMARK    GeneRIF: this study demonstrate that a A novel human pain
            insensitivity disorder caused by a point mutation in ZFHX2.
REFERENCE   3  (bases 1 to 9296)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   4  (bases 1 to 9296)
  AUTHORS   Schon,K.R., Parker,A.P.J. and Woods,C.G.
  TITLE     Congenital Insensitivity to Pain Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   29419974
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL135999.4, AB028979.1, BC144336.1, BC150606.1, AL132855.4,
            AB051549.1 and AI093184.1.
            
            On Nov 23, 2018 this sequence version replaced NM_033400.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: KY781180.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000419474.5/ ENSP00000413418.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AL135999.4         48940-49055         c
            117-1889            AB028979.1         1-1773
            1890-1890           AL135999.4         31198-31198         c
            1891-2119           AB028979.1         1775-2003
            2120-2120           AL135999.4         30968-30968         c
            2121-3023           AB028979.1         2005-2907
            3024-3031           AL135999.4         29857-29864         c
            3032-3272           AL135999.4         28771-29011         c
            3273-3347           AL135999.4         27410-27484         c
            3348-3406           AL135999.4         27000-27058         c
            3407-3607           AL135999.4         24894-25094         c
            3608-3734           AL135999.4         24137-24263         c
            3735-5105           BC144336.1         124-1494
            5106-8256           BC150606.1         1495-4645
            8257-8257           AL132855.4         155908-155908       c
            8258-9263           AB051549.1         4450-5455
            9264-9296           AI093184.1         9-41                c
FEATURES             Location/Qualifiers
     source          1..9296
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..9296
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /note="zinc finger homeobox 2"
                     /db_xref="GeneID:85446"
                     /db_xref="HGNC:HGNC:20152"
                     /db_xref="MIM:617828"
     exon            1..423
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /inference="alignment:Splign:2.1.0"
     exon            424..2513
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /inference="alignment:Splign:2.1.0"
     CDS             473..8191
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /note="zinc finger protein 409; ZFH-2; zinc finger
                     homeodomain protein 2"
                     /codon_start=1
                     /product="zinc finger homeobox protein 2"
                     /protein_id="NP_207646.2"
                     /db_xref="CCDS:CCDS55907.1"
                     /db_xref="GeneID:85446"
                     /db_xref="HGNC:HGNC:20152"
                     /db_xref="MIM:617828"
                     /translation="MATLNSASTTGTTPSPGHNAPSLPSDTFSSSTPSDPVTKDPPAA
                     SSTSENMRSSEPGGQLLESGCGLVPPKEIGEPQEGPDCGHFPPNDPGVEKDKEQEEEE
                     EGLPPMDLSNHLFFTAGGEAYLVAKLSLPGGSELLLPKGFPWGEAGIKEEPSLPFLAY
                     PPPSHLTALHIQHGFDPIQGFSSSDQILSHDTSAPSPAACEERHGAFWSYQLAPNPPG
                     DPKDGPMGNSGGNHVAVFWLCLLCRLGFSKPQAFMDHTQSHGVKLTPAQYQGLSGSPA
                     VLQEGDEGCKALISFLEPKLPARPSSDIPLDNSSTVNMEANVAQTEDGPPEAEVQALI
                     LLDEEVMALSPPSPPTATWDPSPTQAKESPVAAGEAGPDWFPEGQEEDGGLCPPLNQS
                     SPTSKEGGTLPAPVGSPEDPSDPPQPYRLADDYTPAPAAFQGLSLSSHMSLLHSRNSC
                     KTLKCPKCNWHYKYQQTLDVHMREKHPESNSHCSYCSAGGAHPRLARGESYNCGYKPY
                     RCDVCNYSTTTKGNLSIHMQSDKHLANLQGFQAGPGGQGSPPEASLPPSAGDKEPKTK
                     SSWQCKVCSYETNISRNLRIHMTSEKHMQNVLMLHQGLPLGLPPGLMGPGPPPPPGAT
                     PTSPPELFQYFGPQALGQPQTPLAGPGLRPDKPLEAQLLLNGFHHVGAPARKFPTSAP
                     GSLSPDAHLPPSQLLGSSSDSLPTSPPPDDSLSLKVFRCLVCQAFSTDSLELLLYHCS
                     IGRSLPEAEWKEVAGDTHRCKLCCYGTQLKANFQLHLKTDKHAQKYQLAAHLREGGGA
                     MGTPSPASLGDGAPYGSVSPLHLRCNICDFESNSKEKMQLHARGAAHEENSQIYKFLL
                     DMEGAEAGAELGLYHCLLCAWETPSRLAVLQHLRTPAHRDAQAQRRLQLLQNGPTTEE
                     GLAALQSILSFSHGQLRTPGKAPVTPLAEPPTPEKDAQNKTEQLASEETENKTGPSRD
                     SANQTTVYCCPYCSFLSPESSQVRAHTLSQHAVQPKYRCPLCQEQLVGRPALHFHLSH
                     LHNVVPECVEKLLLVATTVEMTFTTKVLSAPTLSPLDNGQEPPTHGPEPTPSRDQAAE
                     GPNLTPEASPDPLPEPPLASVEVPDKPSGSPGQPPSPAPSPVPEPDAQAEDVAPPPTM
                     AEEEEGTTGELRSAEPAPADSRHPLTYRKTTNFALDKFLDPARPYKCTVCKESFTQKN
                     ILLVHYNSVSHLHKMKKAAIDPSAPARGEAGAPPTTTAATDKPFKCTVCRVSYNQSST
                     LEIHMRSVLHQTRSRGTKTDSKIEGPERSQEEPKEGETEGEVGTEKKGPDTSGFISGL
                     PFLSPPPPPLDLHRFPAPLFTPPVLPPFPLVPESLLKLQQQQLLLPFYLHDLKVGPKL
                     TLAGPAPVLSLPAATPPPPPQPPKAELAEREWERPPMAKEGNEAGPSSPPDPLPNEAA
                     RTAAKALLENFGFELVIQYNEGKQAVPPPPTPPPPEALGGGDKLACGACGKLFSNMLI
                     LKTHEEHVHRRFLPFEALSRYAAQFRKSYDSLYPPLAEPPKPPDGSLDSPVPHLGPPF
                     LVPEPEAGGTRAPEERSRAGGHWPIEEEESSRGNLPPLVPAGRRFSRTKFTEFQTQAL
                     QSFFETSAYPKDGEVERLASLLGLASRVVVVWFQNARQKARKNACEGGSMPTGGGTGG
                     ASGCRRCHATFSCVFELVRHLKKCYDDQTLEEEEEEAERGEEEEEVEEEEVEEEQGLE
                     PPAGPEGPLPEPPDGEELSQAEATKAGGKEPEEKATPSPSPAHTCDQCAISFSSQDLL
                     TSHRRLHFLPSLQPSAPPQLLDLPLLVFGERNPLVAATSPMPGPPLKRKHEDGSLSPT
                     GSEAGGGGEGEPPRDKRLRTTILPEQLEILYRWYMQDSNPTRKMLDCISEEVGLKKRV
                     VQVWFQNTRARERKGQFRSTPGGVPSPAVKPPATATPASLPKFNLLLGKVDDGTGREA
                     PKREAPAFPYPTATLASGPQPFLPPGKEATTPTPEPPLPLLPPPPPSEEEGPEEPPKA
                     SPESEACSLSAGDLSDSSASSLAEPESPGAGGTSGGPGGGTGVPDGMGQRRYRTQMSS
                     LQLKIMKACYEAYRTPTMQECEVLGEEIGLPKRVIQVWFQNARAKEKKAKLQGTAAGS
                     TGGSSEGLLAAQRTDCPYCDVKYDFYVSCRGHLFSRQHLAKLKEAVRAQLKSESKCYD
                     LAPAPEAPPALKAPPATTPASMPLGAAPTLPRLAPVLLSGPALAQPPLGNLAPFNSGP
                     AASSGLLGLATSVLPTTTVVQTAGPGRPLPQRPMPDQTNTSTAGTTDPVPGPPTEPLG
                     DKVSSERKPVAGPTSSSNDALKNLKALKTTVPALLGGQFLPFPLPPAGGTAPPAVFGP
                     QLQGAYFQQLYGMKKGLFPMNPMIPQTLIGLLPNALLQPPPQPPEPTATAPPKPPELP
                     APGEGEAGEVDELLTGSTGISTVDVTHRYLCRQCKMAFDGEAPATAHQRSFCFFGRGS
                     GGSMPPPLRVPICTYHCLACEVLLSGREALASHLRSSAHRRKAAPPQGGPPISITNAA
                     TAASAAVAFAKEEARLPHTDSNPKTTTTSTLLAL"
     exon            2514..3031
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3272
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /inference="alignment:Splign:2.1.0"
     exon            3273..3347
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /inference="alignment:Splign:2.1.0"
     exon            3348..3406
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /inference="alignment:Splign:2.1.0"
     exon            3407..3607
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /inference="alignment:Splign:2.1.0"
     exon            3608..3734
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /inference="alignment:Splign:2.1.0"
     exon            3735..7211
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /inference="alignment:Splign:2.1.0"
     exon            7212..9296
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9259..9264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /note="hexamer: AATACA"
     polyA_site      9296
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /note="major polyA site"
ORIGIN      
        1 attccattgt gtgggacgcc tagactccag ccagtgaatg aggcggagga gtgagggcga
       61 ggaggaggag gaggaggagg gcgaggagga gaaggaggag gaggaggagg aggcagggag
      121 cgagcgagtg cccagggtga atcaatggaa accccctcac gaagccgggg aaacacttca
      181 gccgcagcca aatagcattg attattttcc ttcacttccc tcaccgccgt gaatttattt
      241 atttattttt ttccgtctcc gtccctgacg ccccggagcg agcgctggag ggagggagga
      301 ggaggggaaa aaagaggaat caacacatcg gagaagtccc ttccaagagc cgccccctcc
      361 cctccccgcc tcgcgctgct cggtggccgc ggttcgactc ccgtccctgc ttccagctga
      421 ggtggtactg gctgtcacgc tgacatgagc ccccagcact cctccgtcta ccatggccac
      481 ccttaactca gcctctacca ctggtaccac cccctcccct gggcacaatg ccccgtccct
      541 gccttcggac accttctcct ccagcacccc ctctgatcct gtcaccaaag atccccctgc
      601 tgcctcctcc acctctgaga acatgaggtc ctcagagcca gggggacagc tcctggagtc
      661 gggctgtggc ctcgtcccac caaaggagat tggggagccc caggaagggc ctgactgtgg
      721 tcacttccca ccaaatgacc caggggtgga aaaggacaag gagcaggagg aggaagaaga
      781 agggctccct cccatggacc taagcaacca cttattcttc acagctggag gtgaggccta
      841 cctagtggcc aagctgtccc tgccaggtgg cagtgaactc ctgttaccaa agggcttccc
      901 ctggggtgag gcgggcatca aggaagagcc cagtctgccc ttccttgcct acccaccccc
      961 ctcacacctc actgcccttc acatccaaca tggctttgac ccaatccaag gctttagctc
     1021 ttctgaccaa attctgtccc atgatacctc agcaccatct ccggctgcct gtgaggaaag
     1081 gcatggagct ttctggagct accagctggc tccaaatcca cccggagatc ccaaagatgg
     1141 ccccatgggg aacagcgggg gcaaccacgt ggcggtcttc tggctctgcc ttctgtgccg
     1201 cctgggtttc agcaagcccc aggcctttat ggatcacaca cagtctcatg gggtgaagct
     1261 aacccctgcc caatatcagg gcctgtcagg tagcccagct gtactccagg agggagatga
     1321 aggctgcaag gccctcataa gctttctgga gccaaaactc cctgctcgcc cctcttctga
     1381 catacccctt gacaacagca gcacagtgaa catggaggcg aatgtggccc agacagagga
     1441 tggcccccct gaggcagaag tccaggccct tatcctcctg gatgaagaag ttatggccct
     1501 cagcccaccc tctccaccca cagccacctg ggaccccagc ccaacccaag ccaaagaatc
     1561 gccagtagca gcaggcgagg cagggccaga ttggttccct gaggggcaag aagaggatgg
     1621 agggctctgc cccccactca accaaagctc acccacctcc aaggaggggg gcactctccc
     1681 tgccccagtg ggctcccccg aagaccccag tgacccaccc cagccctatc gcctagctga
     1741 tgactacacc ccagcccctg cagccttcca gggcctcagc ctgtccagcc acatgtccct
     1801 gctccactca cgcaactcct gcaagacact caagtgtccc aagtgcaact ggcactacaa
     1861 gtaccagcag accctggatg tgcacatgcg agagaagcac cctgagagca acagtcactg
     1921 cagctactgc agtgctgggg gcgcccaccc ccgccttgct cgtggagaga gctacaactg
     1981 tggctacaaa ccctaccgct gtgacgtctg caactactct acaaccacca aaggcaacct
     2041 cagcatccat atgcagtctg acaagcacct ggccaaccta cagggcttcc aggcgggccc
     2101 tggtgggcag ggaagtccac cagaggcatc actcccaccc tccgcgggag acaaagagcc
     2161 taagaccaaa tcatcctggc agtgcaaggt gtgcagctac gagacaaaca tctcccgtaa
     2221 cctgcgcatc catatgacct ctgagaagca catgcagaat gtcctaatgc tgcaccaggg
     2281 gctgccgctg ggcctgccac ctggattgat ggggccaggc cctcctcccc caccaggggc
     2341 tacccccact agcccccctg aactcttcca gtactttggg ccccaggccc tagggcagcc
     2401 tcagactccc ttggctggcc cggggctgag gccagacaag cccctggaag cccagctact
     2461 tctcaatggt ttccaccacg taggagcacc tgcccgcaag ttccccacat ccgcccctgg
     2521 aagcctatcc cctgatgccc acctgcctcc aagtcagctc ctgggttcct catctgacag
     2581 cctgcccacc tcaccacccc cagacgacag cctgtccctg aaggtgttcc gctgcctagt
     2641 gtgccaggcc ttcagcacag acagcctgga gctgctgctc taccactgca gcataggccg
     2701 gagcctcccg gaagctgaat ggaaggaggt ggctggtgac acccaccgct gcaagctttg
     2761 ctgctatggc acccagctca aggccaactt ccaactccac ctcaagactg acaaacatgc
     2821 tcagaagtac cagctggcag cccacctgcg ggaggggggt ggagccatgg gcaccccttc
     2881 cccagcatcc ctgggagatg gggctcctta tgggtctgtc tccccactac acctgcgctg
     2941 caacatctgt gactttgagt ccaacagcaa ggagaagatg cagctgcatg ccaggggtgc
     3001 agcccacgaa gaaaacagcc aaatctataa gtttctgctg gacatggagg gagcggaggc
     3061 aggggcagag ctggggctat accactgcct gttgtgtgcg tgggagacac cctcccgctt
     3121 ggctgtgctg caacacctgc gcacacctgc ccaccgcgat gcccaggccc agaggcgtct
     3181 gcagctgcta cagaatggcc caaccactga ggaaggactc gcagctcttc agagcatcct
     3241 gagcttcagc cacgggcagc tccggactcc cgggaaggct cctgtcaccc ccttagctga
     3301 gccacccacc cctgagaaag atgcccagaa caagacagaa caattggctt cagaagagac
     3361 agaaaacaag actggccctt ccagagacag tgccaaccag accacggtat actgctgtcc
     3421 atactgcagc ttcctgagcc cagagtccag ccaggtgagg gctcatacac tctcccagca
     3481 tgcagtgcag cccaagtaca gatgcccact gtgccaggaa cagctggtgg gccggcctgc
     3541 cctgcacttc caccttagcc accttcacaa cgtggtgccc gagtgcgttg agaagctgct
     3601 gcttgtagct acaactgtag aaatgacatt tacaaccaaa gtgctgtctg cacccacatt
     3661 aagccctctg gacaatggcc aagaaccccc cactcatggg ccagagccta caccgagcag
     3721 agaccaggca gcagaaggcc ctaacctgac cccagaagcc agtccagatc ctcttcctga
     3781 gcctcccctg gcctcagttg aggtcccaga caaaccctca ggaagccctg gccaaccccc
     3841 ttctccagcc ccatctccag tccctgaacc tgatgcccaa gctgaagacg tagctcctcc
     3901 gcccaccatg gctgaggagg aagaggggac cactggggag ctccgctctg cagagccagc
     3961 tccagctgac tctcgccacc ctctgaccta tcggaaaacc accaactttg ccctggacaa
     4021 gtttctcgac cctgcccggc cctataagtg cactgtgtgt aaggagtcct tcacccagaa
     4081 gaatattctg ttggttcatt ataattctgt ctcccacctt cacaagatga agaaggctgc
     4141 cattgacccc tctgcccctg cacggggaga ggccggtgcc ccacccacca ccactgctgc
     4201 cacagacaag ccctttaagt gcacagtctg cagagtctcc tacaaccaga gctccaccct
     4261 ggagatccac atgcggtcag ttctgcatca gactcgctct cggggaacca agactgattc
     4321 caagattgaa gggccagaac gcagccaaga agagcccaag gaaggcgaga cagaggggga
     4381 ggtgggcact gagaagaagg gccctgacac cagtggcttc atatctggat tgcctttcct
     4441 gtcccctccc ccacctccct tggacctgca ccgattccca gcccctctct tcaccccacc
     4501 agtcctgccc cccttccctc tggtgcccga atcactgctt aagctccagc agcagcagct
     4561 gctcctgccc ttctacctcc acgatctcaa ggtggggccc aagctgacac tagctgggcc
     4621 tgcacctgtg ctgtccctgc cagctgccac ccctcctcct ccaccccaac ctcccaaggc
     4681 tgagctggct gagcgggagt gggagcggcc ccccatggcc aaagagggta atgaggcagg
     4741 gccttcctca ccccccgacc cattgcccaa cgaggctgcc cgcactgcag ccaaagccct
     4801 tctagaaaac tttggctttg agctggtgat ccagtacaat gaagggaagc aagctgtgcc
     4861 ccctccccct accccacccc cacctgaggc cctcgggggt ggggacaagc tggcctgtgg
     4921 ggcctgtggg aaactcttct ccaatatgct tatcctcaag acacacgagg aacatgtcca
     4981 ccgccgcttt ctgccctttg aagccctgag ccgttatgct gctcagtttc gaaagagcta
     5041 tgacagccta tacccgcccc ttgcagagcc tcccaaacct cctgatgggt ctctggattc
     5101 acctgttccc catctgggcc cacccttcct ggtcccagag cctgaggcag gggggacccg
     5161 tgcccctgaa gagcgaagtc gagcaggggg acactggccc atagaagagg aagaaagctc
     5221 cagagggaat cttcctcccc tggtgcctgc cggccgccgg ttctccagaa ccaagttcac
     5281 agagttccag acccaagccc tgcagtcttt ctttgagact agcgcctacc ccaaagacgg
     5341 agaggtggag cgactcgcaa gtctgttggg tctggctagc cgtgtggtgg tggtgtggtt
     5401 ccagaatgcc cgccagaaag cacgcaaaaa tgcctgtgag ggtgggtcca tgccaaccgg
     5461 aggaggcact gggggagcct ccggctgcag gcgttgccac gccactttct cctgtgtttt
     5521 tgagttggtg cgccacctca agaagtgcta tgatgaccag acccttgaag aggaggagga
     5581 agaggcagag agaggggaag aggaggaaga ggtggaagaa gaagaagtag aggaggaaca
     5641 gggccttgaa cctccagcag ggcctgaggg cccattacca gagcctccag atggggagga
     5701 gctgagccaa gcagaggcaa caaaggcagg aggcaaagag cctgaagaga aggctactcc
     5761 atcaccttcc ccagcccata cctgtgacca gtgtgccatt tctttctcca gccaggacct
     5821 cctgaccagt caccgccgac tacatttcct gccatctctg cagcccagtg ctccccccca
     5881 actcctagat ctgcccttgc tggtgtttgg ggagagaaac cccctggtgg cagccacctc
     5941 accaatgcca ggtccacctc tcaaacggaa gcatgaggac ggcagcttgt ctcccacagg
     6001 cagtgaagca gggggaggag gggagggcga gccccccagg gacaagcgcc tgcgcaccac
     6061 catcttgcct gagcagctag agatcctgta ccgttggtac atgcaggatt ccaacccaac
     6121 acgcaagatg ctcgactgca tctccgagga ggtggggctc aaaaagcgag tggtacaggt
     6181 ctggttccag aataccaggg cccgggagag gaaaggccag tttcgaagca cccctggggg
     6241 ggtgcctagt ccagcagtga aaccgcctgc cacagccacc cctgcatcct tgcccaagtt
     6301 caacctctta ttaggcaagg tagatgatgg cactgggagg gaagccccaa agagggaagc
     6361 acctgctttt ccctacccca ctgccacgct tgcttctggg ccccagcctt tcctaccacc
     6421 tgggaaagag gccaccaccc caacaccaga gccacctcta cctctcctac ctccccctcc
     6481 acccagtgag gaagagggcc cagaggaacc acctaaagct tctccagaga gtgaggcttg
     6541 cagtctctct gcaggagatc tgagtgattc atctgcttcc agcctagctg aaccagaatc
     6601 ccctggggct ggagggacca gtgggggacc tggaggtggg actggggttc cagatggaat
     6661 ggggcagcgg cgctacagga cccagatgag cagcctgcag ctgaagatca tgaaagcctg
     6721 ctatgaagct taccgcaccc ccaccatgca ggagtgtgag gtgctgggag aggagattgg
     6781 gctgcccaag agagtcatcc aggtctggtt ccagaatgct cgtgccaagg aaaagaaggc
     6841 caaactacag gggacagccg ctgggagcac tgggggcagc agtgagggcc tcttagcagc
     6901 ccagcgcact gactgcccct attgtgatgt caagtatgat ttctatgtct cctgccgagg
     6961 ccatctcttt tcccgtcagc acctggccaa gctcaaggag gcggttcgag cccagctgaa
     7021 gagtgaaagc aagtgctacg acttggcccc agcacctgag gctcccccag ctctcaaggc
     7081 cccacctgcc accacacctg cctccatgcc cctcggggct gccccaacct tgcctcgcct
     7141 ggcgccggtc ctcttatctg gcccagctct ggctcagccc ccgctgggca acttagctcc
     7201 tttcaattca ggcccggcag cctcctcagg cctcctcggc ctcgccactt cggtcctgcc
     7261 taccaccaca gtggtccaga ctgctggccc aggccgcccc ttacctcaga gacccatgcc
     7321 cgaccaaacc aacacctcca cagcaggcac cactgaccct gtcccaggcc ctcctactga
     7381 gcccttgggg gacaaggtct ccagtgagcg aaagccagtt gcaggcccca ccagctcctc
     7441 caatgatgcc ctcaagaacc tcaaagcatt gaagaccact gtcccagccc tgttgggggg
     7501 ccagttcctg ccctttccat tgccccctgc tgggggaaca gcaccgccag ctgtctttgg
     7561 cccccagcta cagggggcct acttccaaca gctctatggc atgaagaagg ggctatttcc
     7621 catgaacccc atgatacctc agaccctcat tgggctgctc cccaatgccc tcctccagcc
     7681 gccaccccag ccccctgagc ccacagccac agcacctcca aagcctcctg aactgcctgc
     7741 tccaggggag ggggaagctg gtgaggttga tgagctgctg acaggcagca ctggcatctc
     7801 caccgtggat gtaacccatc gctacctgtg ccgccagtgc aagatggcat ttgacgggga
     7861 ggccccggct actgcccacc agagatcctt ctgcttcttt gggcggggct ctgggggctc
     7921 catgccaccc ccattgcggg tgcccatctg cacctaccac tgcctggcat gtgaggtgct
     7981 gctgagtggg cgtgaagccc tagcctccca cctgcgctcc tcggcccaca ggcgcaaggc
     8041 agccccacct caagggggcc cacccatctc catcaccaac gccgccactg ctgcctcggc
     8101 tgctgtggct tttgccaaag aggaagcaag attacctcac acggactcca acccaaaaac
     8161 tacgactacc tctacacttc tagctttata aacagattaa ccaagatggg gagaggggag
     8221 ggcctcaggg ctccctcttt taccccaagg ggtgttcggt gggagctcaa atccctcacc
     8281 ccaccccctg gccccgccca cctcacagga actgttcagt tcccaccctc agtgggcacc
     8341 acacacccca cttccagcag agtcctgcct cctcccaatc cccacagaca cacacattga
     8401 tcctcctcct cagctccttg cagatgtagc ccttgcccat cttcacagac acatacaccc
     8461 atcttggcac cctgattatt catacatgtc tgcctaccac acacaaaata tatccttggt
     8521 tctatcttcc ttttcctcac tgaattccca gctccccatc cccataaatg catacacata
     8581 catgcacaca cacacgttat cccatgatgt tccactgaga aaacaccaaa aaattttgaa
     8641 aaagaagata aaaagaagaa acgaaaaaga aagcccaagg caaagaaggg ggaaggaaaa
     8701 caaacttcgc cactctctct tctccttcct aaccctttgt ctagagcacc acaccgctca
     8761 caaactcttt ccaaatgctc agttggctcc caaagttgga gcctggcatg ggcagggagc
     8821 ccacaaaact ctaaccaaac tggaggctgg catgggagaa gtgcttctgg ttcactcttc
     8881 ctaccctctc cctcctaacc ctctccttgc ctgacagggg agcccctgtg gcctggactc
     8941 taggggatgc cgccaccaga aacccctctg ccaatcccta ccttgcaccc tgggaactgc
     9001 agtaacttat tctcaaaggc tttaaacaca gagatcctct cagcggccgt gggcctgccc
     9061 cttgtcctag ccctgccacg tgagggtcca gcctccaggg acaggcactg cccaccaacg
     9121 gcaaatccaa agttctttca aaaaaaaaaa ctgaaacaca accaaaaaag caagagcgag
     9181 agagagtacg tgcacacgcg cacaaaagag agaaacggac accagaggaa tgaactaaag
     9241 aaaaacgtaa acttggaaaa tacagaaaaa aaaaaaaagg aagaaaactc ccatca
//
