LOCUS       NM_144982               7037 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens zinc finger C3H1-type containing (ZFC3H1), mRNA.
ACCESSION   NM_144982 XM_352900
VERSION     NM_144982.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7037)
  AUTHORS   Contreras,X., Depierre,D., Akkawi,C., Srbic,M., Helsmoortel,M.,
            Nogaret,M., LeHars,M., Salifou,K., Heurteau,A., Cuvier,O. and
            Kiernan,R.
  TITLE     PAPgamma associates with PAXT nuclear exosome to control the
            abundance of PROMPT ncRNAs
  JOURNAL   Nat Commun 14 (1), 6745 (2023)
   PUBMED   37875486
  REMARK    GeneRIF: PAPgamma associates with PAXT nuclear exosome to control
            the abundance of PROMPT ncRNAs.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7037)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7037)
  AUTHORS   Liang,W., Chen,W., Wei,J., Yao,H., Shi,J., Hou,X., Deng,Y. and
            Ou,M.
  TITLE     Zinc finger C3H1-type containing serves as a novel prognostic
            biomarker in human pan-cancer
  JOURNAL   Gene 820, 146251 (2022)
   PUBMED   35131366
  REMARK    GeneRIF: Zinc finger C3H1-type containing serves as a novel
            prognostic biomarker in human pan-cancer.
REFERENCE   4  (bases 1 to 7037)
  AUTHORS   Huang,H., Xu,H., Li,P., Ye,X., Chen,W., Chen,W. and Huang,X.
  TITLE     Zinc finger C3H1 domain-containing protein (ZFC3H1) evaluates the
            prognosis and treatment of prostate adenocarcinoma (PRAD): A study
            based on TCGA data
  JOURNAL   Bioengineered 12 (1), 5504-5515 (2021)
   PUBMED   34514952
  REMARK    GeneRIF: Zinc finger C3H1 domain-containing protein (ZFC3H1)
            evaluates the prognosis and treatment of prostate adenocarcinoma
            (PRAD): A study based on TCGA data.
REFERENCE   5  (bases 1 to 7037)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 7037)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   7  (bases 1 to 7037)
  AUTHORS   Tomita,T., Ieguchi,K., Coin,F., Kato,Y., Kikuchi,H., Oshima,Y.,
            Kurata,S. and Maru,Y.
  TITLE     ZFC3H1, a zinc finger protein, modulates IL-8 transcription by
            binding with celastramycin A, a potential immune suppressor
  JOURNAL   PLoS One 9 (9), e108957 (2014)
   PUBMED   25268596
  REMARK    GeneRIF: ZFC3H1 participates in the transcriptional activation of
            IL-8.
            Erratum:[PLoS One. 2015 Sep 11;10(9):e0138262. doi:
            10.1371/journal.pone.0138262.. Coin, Fredric [corrected to Coin,
            Frederic]. PMID: 26360022]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7037)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   9  (bases 1 to 7037)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   10 (bases 1 to 7037)
  AUTHORS   Miyamoto-Sato,E., Fujimori,S., Ishizaka,M., Hirai,N., Masuoka,K.,
            Saito,R., Ozawa,Y., Hino,K., Washio,T., Tomita,M., Yamashita,T.,
            Oshikubo,T., Akasaka,H., Sugiyama,J., Matsumoto,Y. and Yanagawa,H.
  TITLE     A comprehensive resource of interacting protein regions for
            refining human transcription factor networks
  JOURNAL   PLoS One 5 (2), e9289 (2010)
   PUBMED   20195357
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073612.17, AB011118.2 and BX647709.1.
            
            On May 14, 2019 this sequence version replaced NM_144982.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647709.1, SRR14038192.3524325.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378743.9/ ENSP00000368017.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC073612.17        44593-44621
            30-5967             AB011118.2         1-5938
            5968-7037           BX647709.1         5969-7038
FEATURES             Location/Qualifiers
     source          1..7037
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.1"
     gene            1..7037
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /note="zinc finger C3H1-type containing"
                     /db_xref="GeneID:196441"
                     /db_xref="HGNC:HGNC:28328"
                     /db_xref="MIM:620956"
     exon            1..836
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..6208
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /note="proline/serine-rich coiled-coil 2; coiled-coil
                     domain containing 131; coiled-coil domain-containing
                     protein 131; proline/serine-rich coiled-coil protein 2"
                     /codon_start=1
                     /product="zinc finger C3H1 domain-containing protein"
                     /protein_id="NP_659419.3"
                     /db_xref="CCDS:CCDS41813.1"
                     /db_xref="GeneID:196441"
                     /db_xref="HGNC:HGNC:28328"
                     /db_xref="MIM:620956"
                     /translation="MATADTPAPASSGLSPKEEGELEDGEISDDDNNSQIRSRSSSSS
                     SGGGLLPYPRRRPPHSARGGGSGGGGGSSSSSSSSQQQLRNFSRSRHASERGHLRGPS
                     SYRPKEPFRSHPPSVRMPSSSLSESSPRPSFWERSHLALDRFRFRGRPYRGGSRWSRG
                     RGVGERGGKPGCRPPLGGGAGSGFSSSQSWREPSPPRKSSKSFGRSPSRKQNYSSKNE
                     NCVEETFEDLLLKYKQIQLELECINKDEKLALSSKEENVQEDPKTLNFEDQTSTDNVS
                     ITKDSSKEVAPEEKTQVKTFQAFELKPLRQKLTLPGDKNRLKKVKDGAKPLSLKSDTT
                     DSSQGLQDKEQNLTRRISTSDILSEKKLGEDEEELSELQLRLLALQSASKKWQQKEQQ
                     VMKESKEKLTKTKTVQQKVKTSTKTHSAKKVSTTAKQALRKQQTKAWKKLQQQKEQER
                     QKEEDQRKQAEEEERRKREEEIRKIRDLSNQEEQYNRFMKLVGGKRRSRSKSSDPDLR
                     RSLDKQPTDSGGGIYQYDNYEEVAMDTDSETSSPAPSPVQPPFFSECSLGYFSPAPSL
                     SLPPPPQVSSLPPLSQPYVEGLCVSLEPLPPLPPLPPLPPEDPEQPPKPPFADEEEEE
                     EMLLREELLKSLANKRAFKPEETSSNSDPPSPPVLNNSHPVPRSNLSIVSINTVSQPR
                     IQNPKFHRGPRLPRTVISLPKHKSVVVTLNDSDDSESDGEASKSTNSVFGGLESMIKE
                     ARRTAEQASKPKVPPKSEKENDPLRTPEALPEEKKIEYRLLKEEIANREKQRLIKSDQ
                     LKTSSSSPANSDVEIDGIGRIAMVTKQVTDAESKLKKHRILLMKDESVLKNLVQQEAK
                     KKESVRNAEAKITKLTEQLQATEKILNVNRMFLKKLQEQIHRVQQRVTIKKALTLKYG
                     EELARAKAVASKEIGKRKLEQDRFGPNKMMRLDSSPVSSPRKHSAELIAMEKRRLQKL
                     EYEYALKIQKLKEARALKAKEQQNISPVVEEEPEFSLPQPSLHDLTQDKLTLDTEEND
                     VDDEILSGSSRERRRSFLESNYFTKPNLKHTDTANKECINKLNKNTVEKPELFLGLKI
                     GELQKLYSKADSLKQLILKTTTGITEKVLHGQEISVDVDFVTAQSKTMEVKPCPFRPY
                     HSPLLVFKSYRFSPYYRTKEKLPLSSVSYSNMIEPDQCFCRFDLTGTCNDDDCQWQHI
                     QDYTLSRKQLFQDILSYNLSLIGCAETSTNEEITASAEKYVEKLFGVNKDRMSMDQMA
                     VLLVSNINESKGHTPPFTTYKDKRKWKPKFWRKPISDNSFSSDEEQSTGPIKYAFQPE
                     NQINVPALDTVVTPDDVRYFTNETDDIANLEASVLENPSHVQLWLKLAYKYLNQNEGE
                     CSESLDSALNVLARALENNKDNPEIWCHYLRLFSKRGTKDEVQEMCETAVEYAPDYQS
                     FWTFLHLESTFEEKDYVCERMLEFLMGAAKQETSNILSFQLLEALLFRVQLHIFTGRC
                     QSALAILQNALKSANDGIVAEYLKTSDRCLAWLAYIHLIEFNILPSKFYDPSNDNPSR
                     IVNTESFVMPWQAVQDVKTNPDMLLAVFEDAVKACTDESLAVEERIEACLPLYTNMIA
                     LHQLLERYEAAMELCKSLLESCPINCQLLEALVALYLQTNQHDKARAVWLTAFEKNPQ
                     NAEVFYHMCKFFILQNRGDNLLPFLRKFIASFFKPGFEKYNNLDLFRYLLNIPGPIDI
                     PSRLCKGNFDDDMFNHQVPYLWLIYCLCHPLQSSIKETVEAYEAALGVAMRCDIVQKI
                     WMDYLVFANNRAAGSRNKVQEFKFFTDLVNRCLVTVPARYPIPFSSADYWSNYEFHNR
                     VIFFYLSCVPKTQHSKTLERFCSVMPANSGLALRLLQHEWEESNVQILKLQAKMFTYN
                     IPTCLATWKIAIAAEIVLKGQREVHRLYQRALQKLPLCASLWKDQLLFEASEGGKTDN
                     LRKLVSKCQEIGVSLNELLNLNSNKTESKNH"
     exon            837..1253
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1318
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1517
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1741
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1865
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1963
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2173
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2338
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2476
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2598
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..2748
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2923
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2924..3055
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3598
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3599..3708
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3709..3840
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3841..3962
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3963..4064
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            4065..4184
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            4185..4368
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            4369..4555
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            4556..4744
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            4745..4982
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            4983..5088
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            5089..5287
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            5288..5382
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            5383..5493
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            5494..5598
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            5599..5764
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            5765..5865
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            5866..5967
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            5968..6007
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            6008..6070
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            6071..7037
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6921..6926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /note="hexamer: AATAAA"
     polyA_site      6946
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /note="major polyA site"
     regulatory      7015..7020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
                     /note="hexamer: AATATA"
     polyA_site      7037
                     /gene="ZFC3H1"
                     /gene_synonym="CCDC131; CSRC2; PSRC2"
ORIGIN      
        1 agaaccccga tcgctgagga gcaagggggc gctaggaaag ggaactgggt tgcgacggtc
       61 cggcgagaga gagctggggt gctggggtgc ggggaagttg gggagcagag gccgcttggt
      121 gtccgagtag ggtaagaccg caccgaccca gtccgttagg aaagaaggga aacgaggcaa
      181 ttgtcgggcg gatccccgga cggagggcta aggttgtgtg gaaggcgctg ctccccggat
      241 ggcgaccgca gatactccgg ccccggcctc cagtggcctc tcgccgaagg aagaagggga
      301 gcttgaagat ggggaaatca gtgacgacga taataacagc cagatacgga gtcggagcag
      361 cagcagcagc agcggcggcg ggctgttacc ctatccgcgg cgaaggcctc ctcactcggc
      421 ccggggcggt ggatctggcg gaggcggtgg ctcttcctcg tcatcgtcct cttctcagca
      481 gcagctgagg aatttctcac gctcgcggca cgcgtctgag cggggccacc tcaggggacc
      541 cagcagctac cgacccaaag aaccgttccg gtctcatccg ccttctgtac ggatgccttc
      601 gagctcactg tccgaaagca gtccccggcc gtctttctgg gagcggagcc acctcgcctt
      661 ggaccgtttc cgctttcgag gcaggcctta ccggggtggg agtcgctgga gtcgggggcg
      721 aggagtgggt gagcgaggag gcaagccggg gtgcagacct cctctgggag gaggagcagg
      781 atccgggttc agcagcagtc agagctggcg agagccctct ccacctcgga agagctccaa
      841 aagttttgga aggtctccat caagaaaaca aaattattca tcaaaaaatg aaaactgtgt
      901 ggaagaaact tttgaagatt tgcttttaaa gtataaacaa atacagttgg aactagaatg
      961 catcaataag gatgaaaaac tagcattgag tagcaaagaa gagaatgtgc aggaagatcc
     1021 taaaacattg aacttcgagg accaaactag cactgataat gtcagtatta caaaggattc
     1081 aagtaaagaa gtagctcctg aggagaaaac acaagtcaaa acttttcagg catttgaatt
     1141 aaaaccactc aggcaaaaat tgactttacc aggagataag aaccgtttga aaaaagttaa
     1201 agatggagca aaaccacttt ccctgaaatc cgacactact gattctagtc aaggattaca
     1261 agataaagaa caaaatttaa caagaagaat tagtacctca gatattctgt ctgaaaagaa
     1321 acttggtgaa gatgaagagg aactatctga attacagctt cgccttttgg ctcttcagtc
     1381 agccagtaaa aaatggcaac aaaaagaaca gcaggtgatg aaagaaagca aagaaaagtt
     1441 gactaagacg aaaactgtac agcaaaaagt taaaacaagt acaaaaacac attcggccaa
     1501 aaaagttagc actacagcta aacaagcatt gaggaagcag caaacaaagg catggaagaa
     1561 actacaacaa caaaaagagc aggaaagaca gaaagaagag gatcagcgga aacaagctga
     1621 agaagaagag agaaggaaaa gagaggaaga aatcagaaaa attcgagatc tctcaaatca
     1681 ggaagaacag tacaatcgat tcatgaaatt ggttggtggc aagaggagat caagaagtaa
     1741 atcttcagat cctgacctga ggcgatcctt agataagcaa cctactgata gtggaggagg
     1801 catttatcag tatgataact atgaagaagt tgctatggat acagatagtg aaaccagttc
     1861 tccagctcct tcaccagtgc aaccgccatt tttctctgaa tgttcattgg ggtatttttc
     1921 tccagcacca tctctttctt tgcctccacc acctcaggtt tcttctctgc cacctttgag
     1981 ccagccttat gtggaaggct tgtgtgtttc tcttgaacct ctacctcctc taccaccatt
     2041 accacctctc ccacctgaag atccagaaca gcctccaaaa ccaccttttg cagatgagga
     2101 agaggaggaa gaaatgctgc ttcgagaaga actacttaaa tctctagcaa ataaaagagc
     2161 ttttaagcca gaggaaacat ccagtaatag tgacccacct tcacctccag ttctgaacaa
     2221 ttcacatcct gtgccaagaa gcaatctatc aatagtcagt attaacacag tgtctcagcc
     2281 taggatacag aatccaaagt ttcacagagg accccgtctt ccacgaactg tgatctcgct
     2341 tccaaagcat aaatcagtgg ttgtaacact aaatgattca gatgatagtg aatctgatgg
     2401 agaggcttcc aagtcaacaa atagtgtttt tggtggatta gagtccatga ttaaagaagc
     2461 aagacgaact gctgagcaag cttcaaaacc gaaagtacct ccaaaatctg aaaaagaaaa
     2521 tgatcctctg cgaacaccgg aggctttgcc tgaagaaaag aagattgaat atagattgtt
     2581 aaaggaagag attgccaacc gtgagaaaca gcgtttgatt aaatcagatc agctgaagac
     2641 aagttcatca tccccagcaa actctgatgt ggaaattgat ggtattggca ggatagcaat
     2701 ggttactaag caggttacag atgcagaatc aaaactgaaa aaacatagga ttctcttgat
     2761 gaaagatgaa tctgttttaa agaatttagt gcaacaagaa gctaagaaga aagaatctgt
     2821 tagaaatgct gaagcaaaga ttacaaaact tacagaacag cttcaagcaa ctgaaaaaat
     2881 tcttaatgtt aacagaatgt ttttgaagaa gcttcaggaa caaattcaca gagttcaaca
     2941 gcgtgttaca attaagaaag ctttgactct aaaatatgga gaagagcttg ctcgggcaaa
     3001 ggcagtggcc agtaaagaaa taggaaaacg taaactggaa caagatcgct ttgggccaaa
     3061 caaaatgatg agactggaca gttctccagt atcaagtcca agaaagcatt cagcagaact
     3121 aattgctatg gagaaaagac ggttacaaaa gctagaatat gaatatgccc tgaaaattca
     3181 aaaattaaaa gaagcccgtg cccttaaagc aaaggaacaa caaaatatct ctccagttgt
     3241 ggaagaggaa cccgaatttt ctttacctca accctcactt catgatctga cacaagataa
     3301 attaaccctg gacactgaag aaaatgatgt tgatgatgaa attttgtctg gttcaagcag
     3361 agagcgaaga agatcttttt tagaatccaa ttattttact aaacctaacc ttaagcacac
     3421 tgatactgct aacaaagaat gcataaacaa acttaataaa aatactgtag aaaaaccaga
     3481 actttttcta gggttaaaaa ttggtgaatt gcaaaaattg tattcaaaag ctgacagcct
     3541 aaaacagctg attttaaaaa ccaccacagg cattacagag aaggttttgc atggtcagga
     3601 gatttctgta gatgtggatt ttgtcacagc acaaagtaaa acaatggaag tgaagccatg
     3661 tccttttaga ccctaccata gtcctcttct agtttttaag tcctacagat ttagtccata
     3721 ttatcgaacc aaggaaaaac ttcccctgag ctcagtatca tacagtaata tgattgaacc
     3781 ggatcagtgt ttctgccgtt ttgatttaac aggaacatgt aatgatgatg attgtcaatg
     3841 gcagcatata caagactata cacttagccg aaaacagtta ttccaggaca ttctgtcata
     3901 taatctgtct ttgattggtt gtgcagagac aagtactaat gaagaaatta ctgcttcagc
     3961 agaaaaatat gttgagaaac tttttggagt aaacaaagat cgaatgtcaa tggaccagat
     4021 ggctgttctc cttgttagca atatcaatga aagtaaaggt catactcctc catttacaac
     4081 ctacaaagat aaaagaaagt ggaagccaaa gttttggaga aaacctattt cagataatag
     4141 cttcagtagt gatgaggaac agtctacagg accaattaag tatgctttcc agccagagaa
     4201 ccaaataaat gttccagctc tggatacagt tgtcactcca gatgatgtca gatactttac
     4261 aaatgagact gatgacatcg ctaatttaga agcaagtgtg cttgaaaatc cttctcatgt
     4321 acaactttgg ctcaagcttg cgtacaagta cttgaatcaa aatgaggggg agtgctcaga
     4381 atccttggat tctgctttaa atgttctggc gcgagcattg gaaaataaca aagacaatcc
     4441 agaaatttgg tgccattacc tcagattgtt ctcaaaaaga ggaaccaagg acgaggtgca
     4501 ggaaatgtgt gaaacagctg ttgaatatgc tccagattat caaagctttt ggacttttct
     4561 acacctagaa agtacctttg aagaaaagga ttacgtatgt gagagaatgt tggagtttct
     4621 gatgggagca gccaagcagg aaacatccaa tattttgtcc tttcagcttt tagaggctct
     4681 tttgtttaga gttcagctgc acatatttac tggaagatgc caaagtgcac tggcaatttt
     4741 acagaatgca ttgaaatctg ctaatgatgg aatagtagct gaatacctta aaaccagtga
     4801 tcgatgtttg gcatggttgg cctacataca tcttattgaa ttcaacattc tcccttcaaa
     4861 attttatgat ccatctaatg ataatccttc aagaattgtt aacactgaat catttgtaat
     4921 gccatggcaa gctgttcaag atgtaaagac taatcctgac atgttgttag cagtttttga
     4981 agatgcagtg aaagcttgca cagatgagag ccttgctgtt gaggaaagaa tagaggcctg
     5041 ccttccactt tacacaaaca tgattgctct gcaccaactc ctggagaggt atgaggctgc
     5101 aatggagctt tgtaaatctt tattggaatc atgtcctatt aactgccagt tgctggaagc
     5161 tcttgttgca ttatatttgc aaacaaatca gcatgacaaa gccagagcag tgtggcttac
     5221 tgcatttgaa aaaaatcctc agaatgcaga ggttttttat catatgtgca aattcttcat
     5281 cttacagaat cgaggcgata atcttcttcc atttttgcgg aaatttattg catccttctt
     5341 taaaccgggg tttgagaagt ataataactt ggatctgttt cggtatctct taaatattcc
     5401 aggaccaatt gacattccat ctcgtttatg taaagggaat tttgatgatg atatgtttaa
     5461 ccaccaagtt ccttatttgt ggctgattta ctgcctttgt catcctcttc aatcaagtat
     5521 taaagaaaca gtggaggcat atgaggcagc attaggggtg gctatgagat gtgatatagt
     5581 acagaagata tggatggatt atcttgtctt tgcaaataat agagctgctg gatccagaaa
     5641 caaagttcaa gaattcaaat tttttactga tttagtgaat agatgtttgg ttacagtccc
     5701 tgcccgatac cccattcctt ttagcagtgc tgattactgg tccaactatg aatttcataa
     5761 tagggttatt ttcttttatt tgagctgtgt tccaaagacc cagcattcca aaaccttgga
     5821 acggttttgt tcagttatgc cagctaattc tggacttgca ttgaggttac ttcaacatga
     5881 atgggaagaa agcaatgttc agattctgaa acttcaagcc aagatgttta catataatat
     5941 cccaacatgc ctggccacct ggaaaatagc cattgctgct gagattgttc taaagggaca
     6001 aagagaggtc caccgtttat atcagagagc cttacagaag ttacctcttt gtgcatcact
     6061 gtggaaagat caactcttgt ttgaagcatc agaaggaggt aaaactgata acctgagaaa
     6121 actagtttcc aagtgccaag agattggagt cagcctaaat gagctcttaa atttaaacag
     6181 taacaaaaca gaaagcaaga atcactgaac actgggtgca gtcagttcta agtccttata
     6241 ataattgcca aaattatttg aatgattctt caagattagg ctgatccctg gctaaggtct
     6301 gtgtaaggca gacaagcgtt attgatcata tcaagttccc tacaatatcc tgtcctcaaa
     6361 accggaagca atgaacatga tcctcttcgg ttggataaat gaacttcctg tttggcctgc
     6421 ttctaggccc tgccagattc tcataacatc atatacgtaa gtatagttcc tcaaagtgac
     6481 tgacatttat tttaattttg ctttgttttt ttttattttc tcccccattc ctttattttg
     6541 tgttattcct gactcacttg acactctctg atgcctgaga gattcctgtt tgggatttaa
     6601 tatccagggc tgtgtttaca gtaaaaaaag caggcagtcc cttttagttt ttccttttta
     6661 aatttttttg agattcttca tttcaggatt taaaactata gcagtccatc ttaaggaaag
     6721 tgtaactgcc atggccacaa gtctgctagt tgcacttgaa tgctctatca gggttgttta
     6781 ttaccctttc tacgttctgg actccttgcc gagactgttt aacttgaaga ttaaagaaac
     6841 tattgcaaat gccagtgcat cagaacctaa gagtggtcaa atattatgtg caattttttt
     6901 gtaaagaaat tttaatttat aataaagttt aacagtttaa agaacagtta atatttgaac
     6961 tgctttgtat tgaaatacta ctttgtagta ttgaaattgt ttatatactt ttttaatata
     7021 agttaacttt ctaaaaa
//
