LOCUS       NM_020863               4594 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger and AT-hook domain containing (ZFAT),
            transcript variant 1, mRNA.
ACCESSION   NM_020863 XM_114619
VERSION     NM_020863.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4594)
  AUTHORS   Ishikura,S., Yoshida,K., Tsunoda,T. and Shirasawa,S.
  TITLE     Death domain-associated protein DAXX regulates noncoding RNA
            transcription at the centromere through the transcription regulator
            ZFAT
  JOURNAL   J Biol Chem 298 (11), 102528 (2022)
   PUBMED   36162510
  REMARK    GeneRIF: Death domain-associated protein DAXX regulates noncoding
            RNA transcription at the centromere through the transcription
            regulator ZFAT.
REFERENCE   2  (bases 1 to 4594)
  AUTHORS   Ishikura,S., Yoshida,K., Hashimoto,S., Nakabayashi,K., Tsunoda,T.
            and Shirasawa,S.
  TITLE     CENP-B promotes the centromeric localization of ZFAT to control
            transcription of noncoding RNA
  JOURNAL   J Biol Chem 297 (4), 101213 (2021)
   PUBMED   34547289
  REMARK    GeneRIF: CENP-B promotes the centromeric localization of ZFAT to
            control transcription of noncoding RNA.
REFERENCE   3  (bases 1 to 4594)
  AUTHORS   Ishikura,S., Nakabayashi,K., Nagai,M., Tsunoda,T. and Shirasawa,S.
  TITLE     ZFAT binds to centromeres to control noncoding RNA transcription
            through the KAT2B-H4K8ac-BRD4 axis
  JOURNAL   Nucleic Acids Res 48 (19), 10848-10866 (2020)
   PUBMED   32997115
  REMARK    GeneRIF: ZFAT binds to centromeres to control noncoding RNA
            transcription through the KAT2B-H4K8ac-BRD4 axis.
REFERENCE   4  (bases 1 to 4594)
  AUTHORS   Abulaizi,A., Abula,A., Ababaikeli,G., Wan,X., Du,R. and Zhakeer,A.
  TITLE     Identification of pelvic organ prolapse risk susceptibility gene
            SNP locus in Xinjiang women
  JOURNAL   Int Urogynecol J 31 (1), 123-130 (2020)
   PUBMED   31270553
  REMARK    GeneRIF: Identification of pelvic organ prolapse risk
            susceptibility gene SNP locus in Xinjiang women.
REFERENCE   5  (bases 1 to 4594)
  AUTHORS   Doi,K., Tsunoda,T., Koyanagi,M., Tanaka,Y., Yamano,S., Fujikane,A.,
            Nishi,K., Ishikura,S. and Shirasawa,S.
  TITLE     Zfat Is Indispensable for the Development of Erythroid Cells in the
            Fetal Liver
  JOURNAL   Anticancer Res 39 (8), 4495-4502 (2019)
   PUBMED   31366551
  REMARK    GeneRIF: Zfat knockdown partially inhibited CD71(-/low)Ter119(-) to
            CD71(high)Ter119(-) transition of fetal liver erythroid progenitors
            with impairment in the elevation of CD71 expression.  Zfat plays a
            critical role for erythropoiesis in the fetal liver
REFERENCE   6  (bases 1 to 4594)
  AUTHORS   Zhu,X., Feng,T., Li,Y., Lu,Q. and Elston,R.C.
  TITLE     Detecting rare variants for complex traits using family and
            unrelated data
  JOURNAL   Genet Epidemiol 34 (2), 171-187 (2010)
   PUBMED   19847924
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 4594)
  AUTHORS   Fujimoto,T., Doi,K., Koyanagi,M., Tsunoda,T., Takashima,Y.,
            Yoshida,Y., Sasazuki,T. and Shirasawa,S.
  TITLE     ZFAT is an antiapoptotic molecule and critical for cell survival in
            MOLT-4 cells
  JOURNAL   FEBS Lett 583 (3), 568-572 (2009)
   PUBMED   19162026
  REMARK    GeneRIF: ZFAT protein is a critical regulator involved in apoptosis
            and cell survival for immune-related cells
REFERENCE   8  (bases 1 to 4594)
  AUTHORS   Koyanagi,M., Nakabayashi,K., Fujimoto,T., Gu,N., Baba,I.,
            Takashima,Y., Doi,K., Harada,H., Kato,N., Sasazuki,T. and
            Shirasawa,S.
  TITLE     ZFAT expression in B and T lymphocytes and identification of
            ZFAT-regulated genes
  JOURNAL   Genomics 91 (5), 451-457 (2008)
   PUBMED   18329245
REFERENCE   9  (bases 1 to 4594)
  AUTHORS   Shirasawa,S., Harada,H., Furugaki,K., Akamizu,T., Ishikawa,N.,
            Ito,K., Ito,K., Tamai,H., Kuma,K., Kubota,S., Hiratani,H.,
            Tsuchiya,T., Baba,I., Ishikawa,M., Tanaka,M., Sakai,K., Aoki,M.,
            Yamamoto,K. and Sasazuki,T.
  TITLE     SNPs in the promoter of a B cell-specific antisense transcript,
            SAS-ZFAT, determine susceptibility to autoimmune thyroid disease
  JOURNAL   Hum Mol Genet 13 (19), 2221-2231 (2004)
   PUBMED   15294872
  REMARK    GeneRIF: Polymorphism, Single Nucleotide in ZFAT is associated with
            autoimmune thyroid disease
REFERENCE   10 (bases 1 to 4594)
  AUTHORS   Sakai,K., Shirasawa,S., Ishikawa,N., Ito,K., Tamai,H., Kuma,K.,
            Akamizu,T., Tanimura,M., Furugaki,K., Yamamoto,K. and Sasazuki,T.
  TITLE     Identification of susceptibility loci for autoimmune thyroid
            disease to 5q31-q33 and Hashimoto's thyroiditis to 8q23-q24 by
            multipoint affected sib-pair linkage analysis in Japanese
  JOURNAL   Hum Mol Genet 10 (13), 1379-1386 (2001)
   PUBMED   11440990
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL832066.1, BC101768.1,
            AB040918.1, AC135075.5 and BC046180.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_020863.3.
            
            Summary: This gene encodes a protein that likely binds DNA and
            functions as a transcriptional regulator involved in apoptosis and
            cell survival. This gene resides in a susceptibility locus for
            autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative
            splicing results in multiple transcript variants encoding distinct
            isoforms. [provided by RefSeq, Nov 2009].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB167738.1, SRR1660805.91402.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377838.8/ ENSP00000367069.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AL832066.1         19-87
            70-972              BC101768.1         1-903
            973-3551            AB040918.1         389-2967
            3552-3660           AC135075.5         46179-46287         c
            3661-4557           AC135075.5         14385-15281         c
            4558-4594           BC046180.1         1500-1536
FEATURES             Location/Qualifiers
     source          1..4594
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.22"
     gene            1..4594
                     /gene="ZFAT"
                     /gene_synonym="AITD3; ZFAT1; ZNF406"
                     /note="zinc finger and AT-hook domain containing"
                     /db_xref="GeneID:57623"
                     /db_xref="HGNC:HGNC:19899"
                     /db_xref="MIM:610931"
     exon            1..187
                     /gene="ZFAT"
                     /gene_synonym="AITD3; ZFAT1; ZNF406"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..3900
                     /gene="ZFAT"
                     /gene_synonym="AITD3; ZFAT1; ZNF406"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger gene in autoimmune thyroid disease; zinc finger
                     protein 406; zinc finger protein ZFAT; zinc-finger gene in
                     AITD susceptibility region"
                     /codon_start=1
                     /product="zinc finger protein ZFAT isoform 1"
                     /protein_id="NP_065914.2"
                     /db_xref="CCDS:CCDS47924.1"
                     /db_xref="GeneID:57623"
                     /db_xref="HGNC:HGNC:19899"
                     /db_xref="MIM:610931"
                     /translation="METRAAENTAIFMCKCCNLFSPNQSELLSHVSEKHMEEGVNVDE
                     IIIPLRPLSTPEPPNSSKTGDEFLVMKRKRGRPKGSTKKSSTEEELAENIVSPTEDSP
                     LAPEEGNSLPPSSLECSKCCRKFSNTRQLRKHICIIVLNLGEEEGEAGNESDLELEKK
                     CKEDDREKASKRPRSQKTEKVQKISGKEARQLSGAKKPIISVVLTAHEAIPGATKIVP
                     VEAGPPETGATNSETTSADLVPRRGYQEYAIQQTPYEQPMKSSRLGPTQLKIFTCEYC
                     NKVFKFKHSLQAHLRIHTNEKPYKCPQCSYASAIKANLNVHLRKHTGEKFACDYCSFT
                     CLSKGHLKVHIERVHKKIKQHCRFCKKKYSDVKNLIKHIRDAHDPQDKKVKEALDELC
                     LMTREGKRQLLYDCHICERKFKNELDRDRHMLVHGDKWPFACELCGHGATKYQALELH
                     VRKHPFVYVCAVCRKKFVSSIRLRTHIKEVHGAAQEALVFTSSINQSFCLLEPGGDIQ
                     QEALGDQLQLVEEEFALQGVNALKEEACPGDTQLEEGRKEPEAPGEMPAPAVHLASPQ
                     AESTALPPCELETTVVSSSDLHSQEVVSDDFLLKNDTSSAEAHAAPEKPPDMQHRSSV
                     QTQGEVITLLLSKAQSAGSDQESHGAQSPLGEGQNMAVLSAGDPDPSRCLRSNPAEAS
                     DLLPPVAGGGDTITHQPDSCKAAPEHRSGITAFMKVLNSLQKKQMNTSLCERIRKVYG
                     DLECEYCGKLFWYQVHFDMHVRTHTREHLYYCSQCHYSSITKNCLKRHVIQKHSNILL
                     KCPTDGCDYSTPDKYKLQAHLKVHTALDKRSYSCPVCEKSFSEDRLIKSHIKTNHPEV
                     SMSTISEVLGRRVQLKGLIGKRAMKCPYCDFYFMKNGSDLQRHIWAHEGVKPFKCSLC
                     EYATRSKSNLKAHMNRHSTEKTHLCDMCGKKFKSKGTLKSHKLLHTADGKQFKCTVCD
                     YTAAQKPQLLRHMEQHVSFKPFRCAHCHYSCNISGSLKRHYNRKHPNEEYANVGTGEL
                     AAEVLIQQGGLKCPVCSFVYGTKWEFNRHLKNKHGLKVVEIDGDPKWETATEAPEEPS
                     TQYLHITEAEEDVQGTQAAVAALQDLRYTSESGDRLDPTAVNILQQIIELGAETHDAT
                     ALASVVAMAPGTVTVVKQVTEEEPSSNHTVMIQETVQQASVELAEQHHLVVSSDDVEG
                     IETVTVYTQGGEASEFIVYVQEAMQPVEEQAVEQPAQEL"
     exon            188..364
                     /gene="ZFAT"
                     /gene_synonym="AITD3; ZFAT1; ZNF406"
                     /inference="alignment:Splign:2.1.0"
     exon            365..616
                     /gene="ZFAT"
                     /gene_synonym="AITD3; ZFAT1; ZNF406"
                     /inference="alignment:Splign:2.1.0"
     exon            617..802
                     /gene="ZFAT"
                     /gene_synonym="AITD3; ZFAT1; ZNF406"
                     /inference="alignment:Splign:2.1.0"
     exon            803..953
                     /gene="ZFAT"
                     /gene_synonym="AITD3; ZFAT1; ZNF406"
                     /inference="alignment:Splign:2.1.0"
     exon            954..2410
                     /gene="ZFAT"
                     /gene_synonym="AITD3; ZFAT1; ZNF406"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2643
                     /gene="ZFAT"
                     /gene_synonym="AITD3; ZFAT1; ZNF406"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2731
                     /gene="ZFAT"
                     /gene_synonym="AITD3; ZFAT1; ZNF406"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2881
                     /gene="ZFAT"
                     /gene_synonym="AITD3; ZFAT1; ZNF406"
                     /inference="alignment:Splign:2.1.0"
     exon            2882..3055
                     /gene="ZFAT"
                     /gene_synonym="AITD3; ZFAT1; ZNF406"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3144
                     /gene="ZFAT"
                     /gene_synonym="AITD3; ZFAT1; ZNF406"
                     /inference="alignment:Splign:2.1.0"
     exon            3145..3283
                     /gene="ZFAT"
                     /gene_synonym="AITD3; ZFAT1; ZNF406"
                     /inference="alignment:Splign:2.1.0"
     exon            3284..3402
                     /gene="ZFAT"
                     /gene_synonym="AITD3; ZFAT1; ZNF406"
                     /inference="alignment:Splign:2.1.0"
     exon            3403..3529
                     /gene="ZFAT"
                     /gene_synonym="AITD3; ZFAT1; ZNF406"
                     /inference="alignment:Splign:2.1.0"
     exon            3530..3660
                     /gene="ZFAT"
                     /gene_synonym="AITD3; ZFAT1; ZNF406"
                     /inference="alignment:Splign:2.1.0"
     exon            3661..4594
                     /gene="ZFAT"
                     /gene_synonym="AITD3; ZFAT1; ZNF406"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4572..4577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFAT"
                     /gene_synonym="AITD3; ZFAT1; ZNF406"
                     /note="hexamer: AATAAA"
     polyA_site      4594
                     /gene="ZFAT"
                     /gene_synonym="AITD3; ZFAT1; ZNF406"
                     /note="major polyA site"
ORIGIN      
        1 atccgccatg ttggatgccg cagattcgcc ataacctcgc cggctctttt cttaaaaaaa
       61 taaaaataaa aagcgaagcg tcagcagggc gccccgcccc ctcggtcggc acgggagggg
      121 gcccggaaga gcccgaggct tttttttcct ccgcggtggg gcgttgccat ggagacgcgg
      181 gcggcagaaa acacggccat ctttatgtgt aaatgttgta acctcttctc accaaatcag
      241 tcggaactcc tctcccacgt ttcagagaag cacatggaag aaggggttaa tgttgatgag
      301 attattattc cccttaggcc tctgagtaca cctgaacccc ccaactcaag caaaaccgga
      361 gatgagtttt tggtcatgaa gaggaagaga ggcaggccta aggggtccac gaagaagtcc
      421 agcacagaag aggagctggc agaaaacatc gtgagtccga ctgaggacag cccgctggct
      481 ccggaggaag ggaacagcct gcctccaagc agcttggagt gtagcaagtg ctgtcggaag
      541 ttctccaaca cgcgccagct gcggaagcac atctgcatta tcgtgctgaa tttgggtgag
      601 gaggaaggag aagcaggtaa cgagtctgac cttgaactag aaaagaagtg taaggaagat
      661 gatcgggaaa aagcctcgaa aagaccacgg tcacagaaaa cagagaaagt ccagaagatc
      721 tcaggaaagg aggccagaca gctttctggg gcgaagaaac ccatcataag tgtggtttta
      781 actgcacacg aagcaattcc aggtgctacc aagattgtgc cagtggaggc tgggccccct
      841 gaaacaggag ctacaaattc tgagaccact tcagcagacc tggtgcctcg gagaggctac
      901 caggaatacg ccattcagca gacaccttat gagcaaccaa tgaagtcaag caggctaggt
      961 cccactcagc tcaaaatctt cacttgtgaa tactgcaaca aggtcttcaa gttcaagcac
     1021 tcgctgcagg cccacctgag gatccacacc aatgaaaagc catacaagtg cccccagtgc
     1081 agctatgcca gtgccatcaa ggccaacctc aatgtgcacc tgcgcaagca cactggagag
     1141 aagttcgcct gcgactattg ctcgttcacc tgcctgagca agggccacct caaggtgcac
     1201 atcgagcgag tgcacaagaa gatcaagcag cactgccgct tctgcaagaa gaagtactct
     1261 gacgtcaaga acctcatcaa gcacatccga gacgcgcatg acccacagga caagaaggtc
     1321 aaagaggcct tggacgagct ctgcctgatg acgagggagg gcaagcggca gctgctctat
     1381 gactgccaca tctgtgagcg caagttcaag aacgagctgg accgtgaccg ccatatgctg
     1441 gtccacggag acaagtggcc ttttgcctgt gagctctgtg gccatggggc caccaagtac
     1501 caggcgctgg aactgcatgt caggaagcac cccttcgtgt acgtctgtgc cgtctgccgc
     1561 aagaagttcg tcagctccat caggctgcgc acccacatca aagaggtgca cggggctgcc
     1621 caggaggcct tggtcttcac cagttccatc aaccagagct tctgcctcct ggaacctggt
     1681 ggggacatcc agcaagaagc tctgggggac cagctacagc tggtggaaga ggagtttgcc
     1741 ctccagggcg tgaatgcact caaggaagag gcctgtcctg gggacactca gctggaggag
     1801 ggccggaagg agccggaggc ccctggggaa atgcctgccc cagctgtgca cctggcctcc
     1861 ccgcaggccg aaagcacagc cctgccaccc tgtgagctgg aaaccaccgt ggtctcctcc
     1921 tcagacctgc attctcaaga ggtggtttca gatgattttt tgttgaaaaa tgatacctcc
     1981 tccgcagagg ctcatgctgc tcctgagaag cccccagaca tgcagcacag aagctcagtc
     2041 cagacgcaag gtgaagtgat cacactactg ctgtccaagg cccagagtgc tgggtcagat
     2101 caggaaagcc atggcgccca gagcccccta ggggaagggc agaacatggc tgtgctttca
     2161 gctggtgacc cagatcccag caggtgtctc aggtcaaacc cagctgaggc ctcagacctc
     2221 ctccctccag tagctggtgg tggggacacc atcacacatc agcctgactc ttgcaaagct
     2281 gcccctgagc accggtcagg catcaccgct ttcatgaagg tcctgaacag tttacagaag
     2341 aagcaaatga acaccagctt gtgtgagcgg atccggaagg tttatggaga cctggagtgt
     2401 gaatactgtg gcaaactttt ttggtaccaa gtgcattttg atatgcatgt ccgcacccac
     2461 acccgggaac atctgtatta ttgctctcag tgtcattatt cttccatcac caaaaactgc
     2521 cttaaacgcc acgtaattca gaaacacagt aacatcttgc tgaagtgtcc caccgatggc
     2581 tgtgactact caactccaga taaatataag ctacaggcac atcttaaagt tcacacagca
     2641 ctggacaaaa ggagttattc ttgtcctgtt tgtgaaaagt ctttttcaga ggatcgattg
     2701 ataaagtcac atatcaagac caaccatcct gaggtctcca tgagcaccat ttctgaggtt
     2761 ctcgggagga gggttcagct gaaagggcta attggaaaga gagccatgaa atgcccatat
     2821 tgtgactttt atttcatgaa gaatggctca gaccttcagc gtcatatttg ggctcatgaa
     2881 ggtgtgaagc ccttcaagtg ttctttgtgt gagtatgcaa ctcgtagcaa gagtaacctc
     2941 aaggctcata tgaatcgtca cagcactgag aaaacccacc tatgtgacat gtgtggcaag
     3001 aaattcaaat caaaagggac actgaaaagt cacaaactcc ttcacactgc agatgggaag
     3061 cagtttaagt gcacggtgtg tgactacaca gcggcccaga agccacagct gctgcggcac
     3121 atggaacagc atgtctcctt caagcctttc cgctgtgccc attgccatta ctcctgcaac
     3181 atatctggct ctctgaagcg gcactacaac aggaagcacc ctaatgagga gtatgccaac
     3241 gtgggcaccg gggagctggc agcggaggtg ctcatccagc aaggtggttt gaagtgtcct
     3301 gtttgcagct ttgtatatgg caccaaatgg gagttcaata ggcacttgaa gaacaaacat
     3361 ggcttgaagg tggtggaaat tgatggagac cccaagtggg agacagcaac agaagctcct
     3421 gaggagccct ccacccagta tctccacatc acagaggccg aagaagacgt tcaagggaca
     3481 caggcagcgg tggccgcgct ccaggacctg agatacacct ctgagagtgg cgaccgactg
     3541 gaccccacgg ccgtgaacat cctgcagcag atcattgagc tgggcgccga gacccatgac
     3601 gccactgccc ttgcctcggt ggttgccatg gcaccaggga cggtgactgt ggttaagcag
     3661 gtcaccgagg aggagcccag ctccaaccac acggtcatga tccaggagac ggtccagcaa
     3721 gcgtccgtgg agcttgccga gcagcaccac ctggtggtgt cctccgacga cgtggagggc
     3781 attgagacgg tgactgtcta cacgcagggc ggggaggcct cggagttcat cgtctacgtg
     3841 caggaggcca tgcagcctgt ggaggagcag gctgtggagc agccggccca ggaactctag
     3901 aggacatgtg gcatcggatg gccacagggc ggggctgcca ggctctgcag gcacccaggg
     3961 tggggaggcc acccttcctg ccctacccgc agaatggtgc tctcctttgc cctccctgcc
     4021 cagcagcctg ataggactct cctagtccaa cttggggtgg gcaaggcagt cagcatcacc
     4081 agcaatacca caggaccctc accccagcat agacacacac cccctgaccc ttaccatctg
     4141 cttcctgaaa gacttcagtg tcagctcccc tacacacacc ccacaccttc accccttgct
     4201 tcaagattca aacagagact cccagtcccc ctcagcatct tccctgaatc acagccccag
     4261 ctccttgacc cccatctagg tgccaaatgt tcatctgcaa ccgctatgca gtctggtgag
     4321 agggagacag ccatcacata gaaagtgacc gtacgggttt ttaatcactg ctgggtgggg
     4381 tgggggtagg gggattgtcc tggctttgtc gacaaagtcc cacttccccg agtattaagg
     4441 gcccttggta tcaagtgagg taaattcacc catcacaggg tctcgcccta ccatcctgga
     4501 attatttcac ttttaagata aatgcactat ttcactgttc gcctcccatt ctaaggaggt
     4561 gaggtggttg gaataaaaac agttcctgtc tgaa
//
