LOCUS       NM_019006               1706 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger AN1-type containing 6 (ZFAND6), transcript
            variant 1, mRNA.
ACCESSION   NM_019006
VERSION     NM_019006.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1706)
  AUTHORS   Walia,G.K., Sharma,P., Agarwal,T., Lal,M., Negandhi,H.,
            Prabhakaran,D., Khadgawat,R., Sachdeva,M.P. and Gupta,V.
  TITLE     Genetic associations of TMEM154, PRC1 and ZFAND6 loci with type 2
            diabetes in an endogamous business community of North India
  JOURNAL   PLoS One 18 (9), e0291339 (2023)
   PUBMED   37738238
  REMARK    GeneRIF: Genetic associations of TMEM154, PRC1 and ZFAND6 loci with
            type 2 diabetes in an endogamous business community of North India.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1706)
  AUTHORS   Huang,X., Tan,W., Liu,Z., Fu,X., Li,Z., Lai,S., Li,Q., Zhong,X.,
            Qu,F., Zhang,H. and Li,H.
  TITLE     EIF4A3-induced circZFAND6 promotes breast cancer proliferation and
            metastasis through the miR-647/FASN axis
  JOURNAL   Life Sci 324, 121745 (2023)
   PUBMED   37127184
  REMARK    GeneRIF: EIF4A3-induced circZFAND6 promotes breast cancer
            proliferation and metastasis through the miR-647/FASN axis.
REFERENCE   3  (bases 1 to 1706)
  AUTHORS   Binjawhar,D.N., Ansari,M.G.A., Sabico,S., Hussain,S.D.,
            Alenad,A.M., Alokail,M.S., Al-Masri,A.A. and Al-Daghri,N.M.
  TITLE     Genetic Variants of HNF4A, WFS1, DUSP9, FTO, and ZFAND6 Genes Are
            Associated with Prediabetes Susceptibility and Inflammatory Markers
            in the Saudi Arabian Population
  JOURNAL   Genes (Basel) 14 (3), 536 (2023)
   PUBMED   36980809
  REMARK    GeneRIF: Genetic Variants of HNF4A, WFS1, DUSP9, FTO, and ZFAND6
            Genes Are Associated with Prediabetes Susceptibility and
            Inflammatory Markers in the Saudi Arabian Population.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1706)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1706)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1706)
  AUTHORS   Chang,E.J., Ha,J., Kang,S.S., Lee,Z.H. and Kim,H.H.
  TITLE     AWP1 binds to tumor necrosis factor receptor-associated factor 2
            (TRAF2) and is involved in TRAF2-mediated nuclear factor-kappaB
            signaling
  JOURNAL   Int J Biochem Cell Biol 43 (11), 1612-1620 (2011)
   PUBMED   21810480
  REMARK    GeneRIF: The AN1 domain of AWP1 mediated the functional interaction
            with tumor necrosis factor receptor-associated factor 2, and the
            A20 domain was responsible for the negative regulation of nuclear
            factor kappaB activation.
REFERENCE   7  (bases 1 to 1706)
  AUTHORS   de Miguel-Yanes,J.M., Shrader,P., Pencina,M.J., Fox,C.S.,
            Manning,A.K., Grant,R.W., Dupuis,J., Florez,J.C., D'Agostino,R.B.
            Sr., Cupples,L.A. and Meigs,J.B.
  CONSRTM   MAGIC Investigators; DIAGRAM+ Investigators
  TITLE     Genetic risk reclassification for type 2 diabetes by age below or
            above 50 years using 40 type 2 diabetes risk single nucleotide
            polymorphisms
  JOURNAL   Diabetes Care 34 (1), 121-125 (2011)
   PUBMED   20889853
  REMARK    GeneRIF: Observational study of gene-disease association, gene-gene
            interaction, and gene-environment interaction. (HuGE Navigator)
REFERENCE   8  (bases 1 to 1706)
  AUTHORS   Cao,Y.K., Mo,Y.Y., Tian,F.Z., Liu,Y.W., Deng,P., Qin,Q.H. and
            Jiang,Y.
  TITLE     [Construction of GFP-AWP1 fusion gene vector and its expression in
            293 cells]
  JOURNAL   Di Yi Jun Yi Da Xue Xue Bao 25 (2), 174-176 (2005)
   PUBMED   15698998
REFERENCE   9  (bases 1 to 1706)
  AUTHORS   Duan,W., Sun,B., Li,T.W., Tan,B.J., Lee,M.K. and Teo,T.S.
  TITLE     Cloning and characterization of AWP1, a novel protein that
            associates with serine/threonine kinase PRK1 in vivo
  JOURNAL   Gene 256 (1-2), 113-121 (2000)
   PUBMED   11054541
REFERENCE   10 (bases 1 to 1706)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB050060.1, BC005283.1 and AW571396.1.
            
            On Nov 22, 2018 this sequence version replaced NM_019006.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). Variants 1-7 all
            encode isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.47581.1,
                                           SRR3476690.304742.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261749.11/ ENSP00000261749.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 DB050060.1         109-111
            4-1677              BC005283.1         1-1674
            1678-1706           AW571396.1         14-42               c
FEATURES             Location/Qualifiers
     source          1..1706
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.1"
     gene            1..1706
                     /gene="ZFAND6"
                     /gene_synonym="AWP1; ZA20D3; ZFAND5B"
                     /note="zinc finger AN1-type containing 6"
                     /db_xref="GeneID:54469"
                     /db_xref="HGNC:HGNC:30164"
                     /db_xref="MIM:610183"
     exon            1..134
                     /gene="ZFAND6"
                     /gene_synonym="AWP1; ZA20D3; ZFAND5B"
                     /inference="alignment:Splign:2.1.0"
     exon            135..297
                     /gene="ZFAND6"
                     /gene_synonym="AWP1; ZA20D3; ZFAND5B"
                     /inference="alignment:Splign:2.1.0"
     exon            298..468
                     /gene="ZFAND6"
                     /gene_synonym="AWP1; ZA20D3; ZFAND5B"
                     /inference="alignment:Splign:2.1.0"
     CDS             315..941
                     /gene="ZFAND6"
                     /gene_synonym="AWP1; ZA20D3; ZFAND5B"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger, A20 domain containing 3; protein associated with
                     PRK1; AN1-type zinc finger protein 6; zinc finger,
                     AN1-type domain 6"
                     /codon_start=1
                     /product="AN1-type zinc finger protein 6 isoform a"
                     /protein_id="NP_061879.2"
                     /db_xref="CCDS:CCDS10313.1"
                     /db_xref="GeneID:54469"
                     /db_xref="HGNC:HGNC:30164"
                     /db_xref="MIM:610183"
                     /translation="MAQETNHSQVPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQNSS
                     NGRISPPATSVSSLSESLPVQCTDGSVPEAQSALDSTSSSMQPSPVSNQSLLSESVAS
                     SQLDSTSVDKAVPETEDVQASVSDTAQQPSEEQSKSLEKPKQKKNRCFMCRKKVGLTG
                     FECRCGNVYCGVHRYSDVHNCSYNYKADAAEKIRKENPVVVGEKIQKI"
     exon            469..577
                     /gene="ZFAND6"
                     /gene_synonym="AWP1; ZA20D3; ZFAND5B"
                     /inference="alignment:Splign:2.1.0"
     exon            578..678
                     /gene="ZFAND6"
                     /gene_synonym="AWP1; ZA20D3; ZFAND5B"
                     /inference="alignment:Splign:2.1.0"
     exon            679..792
                     /gene="ZFAND6"
                     /gene_synonym="AWP1; ZA20D3; ZFAND5B"
                     /inference="alignment:Splign:2.1.0"
     exon            793..1706
                     /gene="ZFAND6"
                     /gene_synonym="AWP1; ZA20D3; ZFAND5B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1243..1248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFAND6"
                     /gene_synonym="AWP1; ZA20D3; ZFAND5B"
                     /note="hexamer: ATTAAA"
     polyA_site      1262
                     /gene="ZFAND6"
                     /gene_synonym="AWP1; ZA20D3; ZFAND5B"
                     /note="major polyA site"
     regulatory      1675..1680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFAND6"
                     /gene_synonym="AWP1; ZA20D3; ZFAND5B"
                     /note="hexamer: AATAAA"
     polyA_site      1706
                     /gene="ZFAND6"
                     /gene_synonym="AWP1; ZA20D3; ZFAND5B"
                     /note="major polyA site"
ORIGIN      
        1 aataaacagc ggacggaggg gccggcggtg gcggagccgg agcaagcagg ggttcggcgg
       61 cattacctgt acccattcac cggcggctac cggcggcggc gcgcagcgtg tcaggcggag
      121 agacccgccg ccaggaatga atctgaagtc tgctgcagta aaacacagaa ggctttaaaa
      181 tgttttcttg cataaaattc aaaactttta agtagctgct tatgagaata gggaaggcag
      241 aaagctaatg tctgtctcaa gatacaggac agctgtttgc tcatcaacct caactgtgtg
      301 tgcaactgag gaacatggct caagaaacta atcacagcca agtgcctatg ctttgttcca
      361 ctggctgtgg attttatgga aaccctcgta caaatggcat gtgttcagta tgctataaag
      421 aacatcttca aagacagaat agtagtaatg gtagaataag cccacctgca acctctgtca
      481 gtagtctgtc tgaatcttta ccagttcaat gcacagatgg cagtgtgcca gaagcccagt
      541 cagcattaga ctctacatct tcatctatgc agcccagccc tgtatcaaat cagtcacttt
      601 tatcagaatc tgtagcatct tctcaattgg acagtacatc tgtggacaaa gcagtacctg
      661 aaacagaaga tgtgcaggct tcagtatcag acacagcaca gcagccatct gaagagcaaa
      721 gcaagtctct tgaaaaaccg aaacaaaaaa agaatcgctg tttcatgtgc aggaagaaag
      781 tgggacttac tgggtttgaa tgccggtgtg gaaatgttta ctgtggtgta caccgttact
      841 cagatgtaca caattgctct tacaattaca aagccgatgc tgctgagaaa atcagaaaag
      901 aaaatccagt agttgttggt gaaaagatcc aaaagatttg aactcctgct ggaatacaaa
      961 attcttgagc atctgcaaac taaaaattga cttgaggttt tttttttcct agtcattggg
     1021 aatgtagagc agtgtatctt gcatgtcatc ggaagaatag atttttgttt tggttttgtt
     1081 ttgaaaatga ctctgaacat ttatttccat tgcaatttct gtggctgagg agacttaaac
     1141 tttacaagta ttatcctttt aagatcattt taattttagt tgagtgcaga gggcttttat
     1201 aacaaacgtg cagaaatttt ggagggctgt gatttttcca gtattaaaca tgcatgcatt
     1261 aatcttgcag tttattttct cattgtgtat gtatatatcg cttttctctg cagcacgatt
     1321 tctcttttga taatgccctt tagggcacaa ctagttatca gtaactgaat gtatcttaat
     1381 cattatggct gcttctgttt tttcattaac aaaggttatt catatgttag catatagttt
     1441 ctttgcaccc actatttatg tctgaatcat ttgtcacaag agagtgtgtg ctgatgagat
     1501 tgtaagtttg tgtgtttaaa cttttttttg agcgagggaa gaaaaagctg tatgcatttc
     1561 attgctgtct acaggtttct ttcagattat gttcatgggt ttgtgtgtat acaatatgaa
     1621 gaatgatctg aagtaattgt gctgtattta tgtttattca ccagtctttg attaaataaa
     1681 aaggaaaacc agaatgctcc cttgta
//
