LOCUS       NM_001102420            5841 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger AN1-type containing 5 (ZFAND5), transcript
            variant a, mRNA.
ACCESSION   NM_001102420
VERSION     NM_001102420.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5841)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5841)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 5841)
  AUTHORS   Mincione,G., Di Marcantonio,M.C., Tarantelli,C., Savino,L.,
            Ponti,D., Marchisio,M., Lanuti,P., Sancilio,S., Calogero,A., Di
            Pietro,R. and Muraro,R.
  TITLE     Identification of the zinc finger 216 (ZNF216) in human carcinoma
            cells: a potential regulator of EGFR activity
  JOURNAL   Oncotarget 7 (46), 74947-74965 (2016)
   PUBMED   27732953
  REMARK    GeneRIF: Our results indicate that ZNF216 overexpression sensitizes
            to apoptosis the NIH3T3/EGFR/ZNF216 cells thus antagonizing the
            effect of activated EGFR-mediated survival in control cells that do
            not overexpress the ZNF216.
REFERENCE   4  (bases 1 to 5841)
  AUTHORS   He,G., Sun,D., Ou,Z. and Ding,A.
  TITLE     The protein Zfand5 binds and stabilizes mRNAs with AU-rich elements
            in their 3'-untranslated regions
  JOURNAL   J Biol Chem 287 (30), 24967-24977 (2012)
   PUBMED   22665488
  REMARK    GeneRIF: Zfand5 can enhance ARE-containing mRNA stability by
            competing with tristetraprolin for mRNA binding.
REFERENCE   5  (bases 1 to 5841)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 5841)
  AUTHORS   Hishiya,A., Iemura,S., Natsume,T., Takayama,S., Ikeda,K. and
            Watanabe,K.
  TITLE     A novel ubiquitin-binding protein ZNF216 functioning in muscle
            atrophy
  JOURNAL   EMBO J 25 (3), 554-564 (2006)
   PUBMED   16424905
REFERENCE   7  (bases 1 to 5841)
  AUTHORS   Hishiya,A., Ikeda,K. and Watanabe,K.
  TITLE     A RANKL-inducible gene Znf216 in osteoclast differentiation
  JOURNAL   J Recept Signal Transduct Res 25 (3), 199-216 (2005)
   PUBMED   16194934
  REMARK    GeneRIF: ZNF216 is a potent inhibitory factor for osteoclast
            differentiation and the mechanism is unlikely due to direct
            attenuation of the NF-kappa B pathway
REFERENCE   8  (bases 1 to 5841)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   9  (bases 1 to 5841)
  AUTHORS   Huang,J., Teng,L., Li,L., Liu,T., Li,L., Chen,D., Xu,L.G., Zhai,Z.
            and Shu,H.B.
  TITLE     ZNF216 Is an A20-like and IkappaB kinase gamma-interacting
            inhibitor of NFkappaB activation
  JOURNAL   J Biol Chem 279 (16), 16847-16853 (2004)
   PUBMED   14754897
  REMARK    GeneRIF: redundant and distinct roles in regulating NFkappaB
            activation and apoptosis
REFERENCE   10 (bases 1 to 5841)
  AUTHORS   Scott,D.A., Greinwald,J.H. Jr., Marietta,J.R., Drury,S.,
            Swiderski,R.E., Vinas,A., DeAngelis,M.M., Carmi,R., Ramesh,A.,
            Kraft,M.L., Elbedour,K., Skworak,A.B., Friedman,R.A., Srikumari
            Srisailapathy,C.R., Verhoeven,K., Van Gamp,G., Lovett,M.,
            Deininger,P.L., Batzer,M.A., Morton,C.C., Keats,B.J., Smith,R.J.
            and Sheffield,V.C.
  TITLE     Identification and mutation analysis of a cochlear-expressed, zinc
            finger protein gene at the DFNB7/11 and dn hearing-loss loci on
            human chromosome 9q and mouse chromosome 19
  JOURNAL   Gene 215 (2), 461-469 (1998)
   PUBMED   9758550
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL135924.11.
            
            On Nov 23, 2018 this sequence version replaced NM_001102420.2.
            
            Transcript Variant: This variant (a) represents the longest
            transcript. All six variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.105859.1,
                                           SRR3476690.58625.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376962.10/ ENSP00000366161.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-513               AL135924.11        41231-41743
            514-650             AL135924.11        42833-42969
            651-810             AL135924.11        45652-45811
            811-922             AL135924.11        46218-46329
            923-1026            AL135924.11        46918-47021
            1027-1152           AL135924.11        49383-49508
            1153-5841           AL135924.11        50338-55026
FEATURES             Location/Qualifiers
     source          1..5841
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.13"
     gene            1..5841
                     /gene="ZFAND5"
                     /gene_synonym="ZA20D2; ZFAND5A; ZNF216"
                     /note="zinc finger AN1-type containing 5"
                     /db_xref="GeneID:7763"
                     /db_xref="HGNC:HGNC:13008"
                     /db_xref="MIM:604761"
     exon            1..513
                     /gene="ZFAND5"
                     /gene_synonym="ZA20D2; ZFAND5A; ZNF216"
                     /inference="alignment:Splign:2.1.0"
     exon            514..650
                     /gene="ZFAND5"
                     /gene_synonym="ZA20D2; ZFAND5A; ZNF216"
                     /inference="alignment:Splign:2.1.0"
     exon            651..810
                     /gene="ZFAND5"
                     /gene_synonym="ZA20D2; ZFAND5A; ZNF216"
                     /inference="alignment:Splign:2.1.0"
     CDS             660..1301
                     /gene="ZFAND5"
                     /gene_synonym="ZA20D2; ZFAND5A; ZNF216"
                     /note="zinc finger protein 216; zinc finger, A20 domain
                     containing 2; zinc finger A20 domain-containing protein 2;
                     zinc finger, AN1-type domain 5"
                     /codon_start=1
                     /product="AN1-type zinc finger protein 5"
                     /protein_id="NP_001095890.1"
                     /db_xref="CCDS:CCDS6642.1"
                     /db_xref="GeneID:7763"
                     /db_xref="HGNC:HGNC:13008"
                     /db_xref="MIM:604761"
                     /translation="MAQETNQTPGPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQQNS
                     GRMSPMGTASGSNSPTSDSASVQRADTSLNNCEGAAGSTSEKSRNVPVAALPVTQQMT
                     EMSISREDKITTPKTEVSEPVVTQPSPSVSQPSTSQSEEKAPELPKPKKNRCFMCRKK
                     VGLTGFDCRCGNLFCGLHRYSDKHNCPYDYKAEAAAKIRKENPVVVAEKIQRI"
     exon            811..922
                     /gene="ZFAND5"
                     /gene_synonym="ZA20D2; ZFAND5A; ZNF216"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1026
                     /gene="ZFAND5"
                     /gene_synonym="ZA20D2; ZFAND5A; ZNF216"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1152
                     /gene="ZFAND5"
                     /gene_synonym="ZA20D2; ZFAND5A; ZNF216"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..5841
                     /gene="ZFAND5"
                     /gene_synonym="ZA20D2; ZFAND5A; ZNF216"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2772..2777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFAND5"
                     /gene_synonym="ZA20D2; ZFAND5A; ZNF216"
                     /note="hexamer: AATAAA"
     polyA_site      2796
                     /gene="ZFAND5"
                     /gene_synonym="ZA20D2; ZFAND5A; ZNF216"
                     /note="major polyA site"
     regulatory      3171..3176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFAND5"
                     /gene_synonym="ZA20D2; ZFAND5A; ZNF216"
                     /note="hexamer: AATACA"
     polyA_site      3192
                     /gene="ZFAND5"
                     /gene_synonym="ZA20D2; ZFAND5A; ZNF216"
ORIGIN      
        1 gttagtcggc cgggacgcgg agctgtgtgc atctcctacg cgggctcgct cgctcccggg
       61 agccgcgcag cttccccggc ggtggcagga gcggcgaaga gcgccatcag cgggccctta
      121 cggccccagg cctcgcggcg cgcggtccgc tcgccctcct cgtccgccca acctgcggcc
      181 tgtggaggcg tgaggcgacg acaggcgagc gcctcgagca gcgttagccg ctgcggccgc
      241 cggtcctccc tccacctcct cctcggcccc ccctcgcttc cctcctccca cttcccgagc
      301 tccggcgtgt cccggccacg ctcgacgctg ctgcaggaac aaaggaagac cccgcggcgg
      361 cggcggcgcc acctccgcct gctgctccga cccgctcccg gcccgcggcg gcggcaccag
      421 ggcgcccggc tcagccttcc cggaggcctc ggcccggcct catcgtgccg gcttcgcgcg
      481 cgaacccggc tttcgcattt gggaccctgc agggccctga aaaggagcct ttaaaagtca
      541 attctactcc atttggcaaa gagggaactg aaatctggaa agtaaggact tgcccaaggt
      601 cactgactta gtggcagact agagacttga actcaggtct ccattcccag cagaaaaata
      661 tggctcagga gactaaccag accccggggc ccatgctgtg tagcacagga tgtggctttt
      721 atggaaatcc taggacaaat ggaatgtgtt cagtttgcta caaagaacat cttcagaggc
      781 agcaaaatag tggcagaatg agcccaatgg gaacagctag tggttccaac agtcctacct
      841 cagattctgc atctgtacag agagcagaca ctagcttaaa caactgtgaa ggtgctgctg
      901 gcagcacatc tgaaaaatca agaaatgtgc ctgtggctgc cttgcctgta actcagcaaa
      961 tgacagaaat gagcatttca agagaggaca aaataactac cccgaaaaca gaggtgtcag
     1021 agccagttgt cactcagccc agtccatcag tttctcagcc cagtacttct cagagtgaag
     1081 aaaaagctcc tgaattgccc aaaccaaaga aaaacagatg tttcatgtgc agaaagaaag
     1141 ttggtcttac agggtttgac tgccgatgtg gaaatttgtt ttgtggactt caccgttact
     1201 ctgacaagca caactgtccg tatgattaca aagcagaagc tgcagcaaaa atcagaaaag
     1261 agaatccagt tgttgtggct gaaaaaattc agagaatata aattacttct tgtgaagaga
     1321 ctgaaacttt gtttttattt taatatatcg taggaaaaca ttaaagagca gatgcatggc
     1381 catttttctt tgatgttctc cagagtttta cattacactt gtctgtctta taattgatat
     1441 tttaggatgt ttgggtgttt gttacaggca gaattggata gatacagccc tacaaatgta
     1501 tatgccctcc cctgaaaaaa attggatgaa aatctgcaca gcaaagtgaa acacacagat
     1561 aataggaaca aaatgtagtt cccatgtgcc aaacaaaata aatgaaatct ctgcatgttt
     1621 gcagcatatc tgccttttgg gaatgtaatc aaggtataat ctttggctag tgttatgtgc
     1681 ctgtattttt ttaaaatggt acaccagaaa aggactggca gtctacttct accatagtta
     1741 aacttcaccc tctttaattt cacaacatat tctttggaag caggaagaaa tgctcataaa
     1801 gaggatcaga ccttctttcc cgtgaaacca gtatttggcg ccatatataa gcctggttaa
     1861 attggtcatc taaagctgtc aaataagaca ttctgtgaaa ggtaaacatc gaaactggtt
     1921 ataagtaaaa ccatcaagcc aacaacaggg tcttgagata acctttgaag cttattgtac
     1981 tggcctgcac cagaagatgt ctgcattact cattgctaaa aatgtgtagc acagaactgc
     2041 actaggatta atttgtttac aagaagaaat ttaaactcta cgtttggttt tcacatacag
     2101 cagctctatt gaataacatg catctgaatt ttaagttgca aaggtatctg aataattttt
     2161 catgtgcatc ttttgtcgaa tgttttggtt caagaaagaa tgtttaaagc tttttaaaag
     2221 acttcagttc ttaatgtaac tgtacccttc tgcatggaaa atcataacca acatggctgc
     2281 agtagacttc ttagtggtat ccagcaccac ttgcagaggg ctgctttatc atattgtact
     2341 tgggtgtagg actctagtgt tcttgggtgt attgcatggg ctgcattatc tacagcattg
     2401 tacaataaca actagaaaag gcagtatact tcactgatgc ttgtctggta ataatcactt
     2461 ctgtgttata atggaaggtt ttttgtgatg tatgaaactt gtgtttttta tatataaatg
     2521 agtatagtta gtgttgtggt aatgcctgtt ttcatctgta aatagttaag tatgtacacg
     2581 aggcactact tctgatttat tgcaatgttc agtcctagtt tttactttta ttcttaaagc
     2641 attcagtttt gctttcaatt ttatgtacct tagttctgag ttagacctgc agatgtgtac
     2701 agatagttca tatttatgta ttgcacataa tcatgctatt cagcattgat gctatattgt
     2761 attatgtaaa taataaaagc catgtacaga gggaaacttc acttgttcat tgggttttta
     2821 agccatagtt ggagtcctaa agggggaaaa ttagaaaatg ttactttaca tggctatata
     2881 attttttttc ctttgccatc gctgaacttg ttcaagtgat aatcaagaga tattagaagc
     2941 atttgcaggt atgatacctg ataggcagtt tatttttgaa gaattcaata ggcacctttg
     3001 ggattaaaac aattttaaaa tttgagaaag atgaaatttg aacaattatg gcctacctcg
     3061 cttctccatg ttgtaaaaga tgatgtttta tgacaattct gaagaagaaa gtaggtatga
     3121 cttagtttac aaaaagagtt ctgttttatt tctgttttgg gtttggctct aatacagaga
     3181 ttcacccatg gacttggtct ctgtagcgtt tatgccagat cataaagaac aaggggtgac
     3241 aggtacatgt tgactttacc tggggtaaat gattaccaga gtgcaactgt tgcttctctg
     3301 tgatggagtt tggggtggaa ataccctagt tttatctgtc agttctttgc atgctgctac
     3361 ttttgcttca agttagggag gtacatatgt atgtcaaagt tcctatactg acatagggta
     3421 gtatttctct gaatatgaaa agtcacaatt gagttgaaaa tttagaagtt gaagatttag
     3481 aagggcaact taatttttca agttaaaaat ggaagtaaga gtggtataga gaaggtaaga
     3541 tgagccctcg gactccatca ctctgaaggt ctgagtagta gcaagagata gatttttgtt
     3601 tggccaggct gcagtgcaat ggcgtaatct tggctcactg caacctctgc ctcctgggtt
     3661 caagtgattc tcctgcctct gcctcctaag tagctgggat cacaggcacc agccaccacg
     3721 cccagctaat ttttgtattt ttaatagaga cagtttctcc atgttggtca ggctggtctt
     3781 gaactcctga cctcaggtga gctgcccgcc tcggcctccc aaagtgctgg gattacaggc
     3841 gtgaggcacc gcacccggcc aatcagtttt ttttgttttt tttttgtttg tttgttttac
     3901 aagaaacatt aaaccagatc agaacaaaga tttgtcaggg ttgtccattg actggggaga
     3961 aagggaatca gtgtgtaagg cacctgagag gactcagttc tacccaaatt cttgcattca
     4021 aacctgaatg caaggccatg aagtcctttg aaatgtacag atattaagca atttaataat
     4081 ataccatgtt tcccttacat aagcagacaa atatttacac ccccatgacc tgaagttttg
     4141 ttaggctgtg accacatgaa ttcgcagtat aaatgggtga gtcctttttg aaaacctcat
     4201 cttcagtgtg cctgatctgt aaaactagag cctcaggttt gatcctaggt aggcttccca
     4261 caacgtgggg aaaattagtt tgtgagggaa agctgtttct gagcattatg gcatagtgat
     4321 taagatgagg gaccctggaa ccagcccgtg attttgggca agttatttta ggtccacttt
     4381 ggactgcttc atctcttaaa tgaagacagc aaccaccttc aggagtgtga aggtgacaac
     4441 acttaaaact gtgcctggca cattgtattt gctattgtct taatgttctg gaataatggt
     4501 ttccataact tgggaagaaa actttgagaa caggattggt tacatcaagt tgtatagtga
     4561 aaagataaag atttgttatt taaacttgca gtttaaagtc attagaatca ttcttttccg
     4621 taaggctttc tttgcaagag atctgcatta aataaagttg ctaggaaata actaaaattg
     4681 gggaaataat ctaataatag caagatgtta agcatactat tattgtattt tgggggttgg
     4741 taataacatt cacatggatt tatcaataca cactgagaag caaagcctct caagctgtcc
     4801 catatcctcc atttcaaagg cacacataca ttttaggtaa ctcataattt agaaaggtta
     4861 tttaatcttt tccacatgta aatatttgaa tatgtacaaa gacttgattt gactcttgtc
     4921 tgtttttgtt ttgttttgtt tgtttgagac agaggctccg tcgcccaggc tggagtaaaa
     4981 tggcatggtc tcagctcact gcaagttccg cctcccgggt tcacgccatt ctcctggctc
     5041 agcctccgga gtagttggga ctacaggcac ccgtcaccac acctggctaa tgttttttgt
     5101 tttttgggtt tttttgtatt tttagtagag agagggtttc accgtgttag ccagggtggt
     5161 ctcgatctcc tgacctcatg atccgcccac cccggcctcc caaaatgctg ggattacagg
     5221 tgtgagccac tgcgcctggc cgactcttgt ctgtttgaat gcaaagttct caatagtggt
     5281 ttttgtccat aagtattaac ttataatttt ggagagtgat aggtatggtt gctggttgat
     5341 tagcaataag attatgtagc cttaaactag ctagaagagt ttgcatgggt gaggcaacag
     5401 gctgttaaca aaaagaaact ggaaatacag tttcccctgt ttgtttctcc tgtttgtaca
     5461 atctgcttta aaaacaagtg aacatgcacc atgtcagtca tggtgaatcg gccaacagcc
     5521 agcccttgcc agttgacatc acagtctaag atgggaaact ggtacagata gacatgaaga
     5581 gagcttagca gtggttgagg tggtgactaa atatacagtc attgaataaa taccgtgtag
     5641 caaatgtaaa aaaaaaaaaa aaagtacaac agaatacaaa agtgccattt aatattttat
     5701 agctatttct atgcacaagt gctggtttta aatttatata aaagcaaaga ctgtttctgt
     5761 gttttcttcc agagtatttc tgttacagcc atagaagtaa agttaataaa tgtaagactt
     5821 tttttgtttt gttttgtgcc a
//
