LOCUS       NM_174890               3760 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens zinc finger AN1-type containing 4 (ZFAND4), transcript
            variant 1, mRNA.
ACCESSION   NM_174890
VERSION     NM_174890.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3760)
  AUTHORS   Kurihara-Shimomura,M., Sasahira,T., Nakamura,H., Nakashima,C.,
            Kuniyasu,H. and Kirita,T.
  TITLE     Zinc finger AN1-type containing 4 is a novel marker for predicting
            metastasis and poor prognosis in oral squamous cell carcinoma
  JOURNAL   J Clin Pathol 71 (5), 436-441 (2018)
   PUBMED   29074611
  REMARK    GeneRIF: Suggest that ZFAND4 is a useful marker for predicting
            metastasis and poor prognosis in patients with oral squamous cell
            carcinoma.
REFERENCE   2  (bases 1 to 3760)
  AUTHORS   Tang,L., Chen,F., Pang,E.J., Zhang,Z.Q., Jin,B.W. and Dong,W.F.
  TITLE     MicroRNA-182 inhibits proliferation through targeting oncogenic
            ANUBL1 in gastric cancer
  JOURNAL   Oncol Rep 33 (4), 1707-1716 (2015)
   PUBMED   25682742
  REMARK    GeneRIF: In gastric cancer cells, ANUBL1 was upregulated and
            promoted proliferation of SGC-7901 cells. Over-expression decreased
            miR-182 expression. ANUBL1 expression was in turn directly
            downregulated by miR-182 in a negative feedback loop.
REFERENCE   3  (bases 1 to 3760)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 3760)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL445201.14, DB456684.1, DB454939.1, AF311324.1, BC048968.1 and
            DB522994.1.
            
            On May 17, 2019 this sequence version replaced NM_174890.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a). Variants 1 and 2 encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF311324.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344646.10/ ENSP00000339484.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AL445201.14        131482-131521       c
            41-44               DB456684.1         1-4
            45-424              DB454939.1         59-438
            425-1076            AF311324.1         1-652
            1077-2078           BC048968.1         681-1682
            2079-3430           AF311324.1         1655-3006
            3431-3759           DB522994.1         122-450
            3760-3760           AL445201.14        74249-74249         c
FEATURES             Location/Qualifiers
     source          1..3760
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.22"
     gene            1..3760
                     /gene="ZFAND4"
                     /gene_synonym="ANUBL1"
                     /note="zinc finger AN1-type containing 4"
                     /db_xref="GeneID:93550"
                     /db_xref="HGNC:HGNC:23504"
     exon            1..523
                     /gene="ZFAND4"
                     /gene_synonym="ANUBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            524..824
                     /gene="ZFAND4"
                     /gene_synonym="ANUBL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             641..2824
                     /gene="ZFAND4"
                     /gene_synonym="ANUBL1"
                     /note="isoform a is encoded by transcript variant 1;
                     AN1-type zinc finger and ubiquitin domain-containing
                     protein 1; AN1-type zinc finger protein 4; AN1,
                     ubiquitin-like, homolog; zinc finger, AN1-type domain 4;
                     AN1-type zinc finger and ubiquitin domain-containing
                     protein-like 1"
                     /codon_start=1
                     /product="AN1-type zinc finger protein 4 isoform a"
                     /protein_id="NP_777550.2"
                     /db_xref="CCDS:CCDS7214.1"
                     /db_xref="GeneID:93550"
                     /db_xref="HGNC:HGNC:23504"
                     /translation="MDNRKEPPFFNDDNMGPFYYRLHFCDTMELFIETLTGTCFELRV
                     SPFETVISVKAKIRRLEGIPICRQHLIWNNMELENDYCLNDYNISEGCTLKLVLAMRG
                     GPINTRRVPTDDPLRKMAEYLDSSRVEVWEKTSCSKQVTFLVYQEGDQLNFFPAVDRG
                     DGTLTPLSDSSKKIDFHLHVLRRKGEHRMSGGSMYNSDTDEDEETEPSSSGQQIIENS
                     ITMNKMKLLKAKMKNMNLSKKPKKAVKIKPHPPVAPRPSSGSTAPSRHRLLRVLPNIG
                     QSCSPAFGNAYPPEISRNGISSLATQLSAERYISSITGEFLKEDNSWENNTLSHFSSN
                     VKLPPQIPHLELGNDQELADSVLHLGSSLPRQTKHFLGNLPSSNGNIVLPSEECVTEQ
                     SLLPKVGSLASFAEGNADEQSSGLEGACKVNLELLLTNADKGLKAPEQHLKHVAGVLN
                     GESVETSVLNYRELSPHKNRLLSPLRCSAPMSLHNSLVKPERQSKCFEFGKLQPSSSQ
                     SLDVQNITDSSFSRTTCFQGVKVDSLGKRSDVISKVEARDITEMTNKASKEPVGCVNN
                     ISFLASLAGSTSRNRLQSTRGAGRLQNSGTGLSTNLQHFQEENFRKSSPQLEHTGVFL
                     STHGVGMNGNNAAAGKSVGECTTHHLPPVKAPLQTKKKTTNHCFLCGKKTGLASSYEC
                     RCGNNFCASHRYAETHGCTYDYKSAGRRYLHEANPVVNAPKLPKI"
     exon            825..900
                     /gene="ZFAND4"
                     /gene_synonym="ANUBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            901..968
                     /gene="ZFAND4"
                     /gene_synonym="ANUBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1209
                     /gene="ZFAND4"
                     /gene_synonym="ANUBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1357
                     /gene="ZFAND4"
                     /gene_synonym="ANUBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..2512
                     /gene="ZFAND4"
                     /gene_synonym="ANUBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2567
                     /gene="ZFAND4"
                     /gene_synonym="ANUBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2688
                     /gene="ZFAND4"
                     /gene_synonym="ANUBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..3760
                     /gene="ZFAND4"
                     /gene_synonym="ANUBL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3645..3650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFAND4"
                     /gene_synonym="ANUBL1"
                     /note="hexamer: AATAAA"
     polyA_site      3669
                     /gene="ZFAND4"
                     /gene_synonym="ANUBL1"
                     /note="major polyA site"
     regulatory      3705..3710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFAND4"
                     /gene_synonym="ANUBL1"
                     /note="hexamer: AATAAT"
     polyA_site      3728
                     /gene="ZFAND4"
                     /gene_synonym="ANUBL1"
ORIGIN      
        1 gttgtcggcc agtgccttcc gtgaagttgc tcgccgggtc gttgggccct gtcgacctgt
       61 aggcgggcga gcgagccagc ggacaagact gcgggtgagg ctgagctagc gagcggccgg
      121 cagggggggc gcccgggctg cgagccgctg agcccagccg cgctgccgcc gccggccgtc
      181 gtggggccgg aatggcgcaa ggccggagtg gcgcgggcgc tcggcgctgg gctgccgggt
      241 agagtcctgt ccccgcccct cgccttgcgg cctgacgccg gccgctgctg cccggggacc
      301 ggagcggcgg gccgcctttg cccaggacac acgctctggc gtttgttcct ttgggcgtga
      361 cgccagcttc aacgggtacg cggctttccc gacgggtgct gatctccgag tcgctgttgt
      421 cacgcggact gctgtcctcc agattcaggc cggtgggtct ggggagcccg gattggtctt
      481 ggaggagcaa cggctgcgca ggtgactcgg tggcctcaag tgtgtacaaa actcaaaaca
      541 tgaacaacaa tatatattac caatcttcaa acctggtttg cctagaactg gaatacagtt
      601 gcctgcgaca tattttagaa gaactagaaa agtcaaagta atggataaca gaaaagagcc
      661 tccattcttc aatgatgata acatgggacc attttactac agacttcatt tctgtgatac
      721 catggagctc ttcattgaaa cattaactgg aacatgtttt gagctgagag tttcaccttt
      781 tgaaactgtt atttctgtga aagcaaaaat tcgaagattg gaaggtattc ccatctgtcg
      841 acaacactta atttggaata acatggaact tgaaaatgat tattgcttga atgattacaa
      901 catttcagaa gggtgtacct tgaagctagt tttggctatg cgtggcggac ctataaatac
      961 tagaagagtt cctacagacg atccacttag gaagatggca gagtacttgg attccagtcg
     1021 agttgaggtc tgggagaaga cctcctgcag caaacaagtt acatttttgg tataccaaga
     1081 aggagatcaa ttgaatttct ttcctgcagt agatagggga gatggcactt taacaccgtt
     1141 atctgactct tcaaagaaaa tagattttca tttgcatgtc ctacggagaa aaggagaaca
     1201 tcgtatgagt ggtggttcta tgtataattc agatacagat gaggatgaag aaactgagcc
     1261 ttcttcttct gggcaacaga taattgaaaa ttcaataact atgaataaga tgaagctgct
     1321 gaaggctaag atgaagaaca tgaatctcag caaaaagcct aagaaagctg tcaagataaa
     1381 acctcaccca cctgtagctc ctcgaccttc tagtggttcc actgcaccat ctcgccaccg
     1441 attgttaagg gtcctcccca acattggtca atcttgttca cctgcttttg ggaatgcata
     1501 tccgcccgaa atctccagga atggaatttc aagtttggca actcaactct ctgctgagag
     1561 atacatatct tctatcactg gtgaatttct taaggaagat aatagctggg agaataacac
     1621 actgtctcac ttcagtagca acgtcaaact acctcctcag ataccccatt tggagttggg
     1681 aaatgaccag gagcttgctg actctgttct ccatcttgga tcatccctgc ctaggcaaac
     1741 aaaacatttt ttaggaaact tgccatctag taatgggaac attgtcttac cttcagaaga
     1801 atgtgtaacc gaacaatcac ttctacctaa agtgggctca ctggcttcat ttgcagaagg
     1861 aaatgctgat gaacagagca gcggcttaga aggtgcgtgc aaagtgaatc tggagttgct
     1921 actcactaat gctgacaaag ggttgaaagc tccagagcag catctcaagc atgttgcagg
     1981 agtgctgaat ggggaatcag tagagacttc agttcttaac taccgggaat taagtcctca
     2041 caagaataga ctcttgtcac ctcttcgctg ttctgcacca atgtcgctac ataattctct
     2101 ggtgaaacca gagagacagt ccaaatgttt tgagtttggg aagctacagc cttcttcttc
     2161 tcagtcactg gatgttcaaa acataactga ttcttctttc tctaggacta cttgctttca
     2221 aggtgttaaa gttgattcac ttgggaaaag atctgatgtt atttccaaag ttgaggctcg
     2281 ggatatcaca gaaatgacta acaaggcttc caaagagcct gttggttgtg taaataatat
     2341 cagttttctt gcctcactgg ccgggagcac aagcagaaat agattacaga gcacacgtgg
     2401 ggcaggcagg cttcagaact ctggaactgg gctgtctaca aacctccagc attttcagga
     2461 agaaaacttt aggaaaagtt ctccccagtt agaacataca ggagtttttt tgtctaccca
     2521 tggtgttgga atgaatggaa ataatgcagc agcagggaaa agcgtaggag aatgtactac
     2581 tcatcacctc ccacctgtga aagcccctct tcagacaaag aagaaaacaa caaatcattg
     2641 ttttctttgt ggaaagaaaa caggactggc tagtagctac gaatgcagat gtggaaacaa
     2701 cttctgtgca tctcatcgtt atgcagaaac tcatggctgt acctatgatt acaagagtgc
     2761 agggaggaga tacttgcacg aggcaaatcc tgtggttaat gcaccaaagc ttccaaaaat
     2821 ctaactcttc ctctacatct tactgttctg cccgggattc gtattataat gacagaagaa
     2881 atgttgttta gactattatt tttgttcgac tctaaaagat ttgccaaata acaaaagcat
     2941 acaatgcata ctgttggaga acaagaatgc tactgtattt tacatcttta tttcttggtg
     3001 aaacaaaagt tttaaaagta gttttaacaa ctttacactg gaatgattta gctttgttat
     3061 tgcatgtctt gtgttaagtg ttttgtatat gatattgcag ttttactagg caaatcttca
     3121 aaagatgcac tttaggaaac gaaatatttc ctaaataacc aggcttccac attgtacaga
     3181 atgagcagtc atgtaatgaa tggctctact cagattgacc atatgggttt tttctttttc
     3241 tttcttttat tcttctcctt cttttttttt cagaggtggg atgggtggag attttttaaa
     3301 aatcccacgt gtgaaagttt actggcttta ttagcaagtt cctttttact tcaagctact
     3361 ttttataaaa aagaacattt ttccagtgtg gtttttaaca gataatacat ttcttccaca
     3421 ttcagattag tattcggaca tgaatccatt ctataaaaca catcgtgttc atgatagtgt
     3481 atattttact actttttgaa tgttaatttt aaaatagaag atgtcccact tgccattaaa
     3541 tatagaagcc aactttttac cttttgaaat atggctacat ttaaaacaaa atctcacagc
     3601 tcggtttttc ttatttgttg agtgctatta ccaggagaaa ttcaaataaa tattcaattt
     3661 cattatgaat ttcattattt atttataata gtttttcttt tataaataat ttttctttta
     3721 taaaactatt taattaaatg agtgatttat tttacgtgga
//
