LOCUS       NM_021943               3138 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger AN1-type containing 3 (ZFAND3), transcript
            variant 1, mRNA.
ACCESSION   NM_021943
VERSION     NM_021943.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3138)
  AUTHORS   Schuster,A., Klein,E., Neirinckx,V., Knudsen,A.M., Fabian,C.,
            Hau,A.C., Dieterle,M., Oudin,A., Nazarov,P.V., Golebiewska,A.,
            Muller,A., Perez-Hernandez,D., Rodius,S., Dittmar,G., Bjerkvig,R.,
            Herold-Mende,C., Klink,B., Kristensen,B.W. and Niclou,S.P.
  TITLE     AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional
            regulator that drives Glioblastoma invasion
  JOURNAL   Nat Commun 11 (1), 6366 (2020)
   PUBMED   33311477
  REMARK    GeneRIF: AN1-type zinc finger protein 3 (ZFAND3) is a
            transcriptional regulator that drives Glioblastoma invasion.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3138)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3138)
  AUTHORS   Muller,Y.L., Piaggi,P., Chen,P., Wiessner,G., Okani,C., Kobes,S.,
            Knowler,W.C., Bogardus,C., Hanson,R.L. and Baier,L.J.
  TITLE     Assessing variation across 8 established East Asian loci for type 2
            diabetes mellitus in American Indians: Suggestive evidence for new
            sex-specific diabetes signals in GLIS3 and ZFAND3
  JOURNAL   Diabetes Metab Res Rev 33 (4) (2017)
   PUBMED   27862917
  REMARK    GeneRIF: Replication of lead type 2 diabetes mellitus SNPs in
            GLIS3, KCNK16, and ZFAND3 was observed in American Indians.
            Sex-specific T2DM signals in GLIS3 and ZFAND3, which are distinct
            from the East Asian GWAS signals, were also identified.
REFERENCE   4  (bases 1 to 3138)
  AUTHORS   Ndiaye,F.K., Ortalli,A., Canouil,M., Huyvaert,M.,
            Salazar-Cardozo,C., Lecoeur,C., Verbanck,M., Pawlowski,V.,
            Boutry,R., Durand,E., Rabearivelo,I., Sand,O., Marselli,L.,
            Kerr-Conte,J., Chandra,V., Scharfmann,R., Poulain-Godefroy,O.,
            Marchetti,P., Pattou,F., Abderrahmani,A., Froguel,P. and
            Bonnefond,A.
  TITLE     Expression and functional assessment of candidate type 2 diabetes
            susceptibility genes identify four new genes contributing to human
            insulin secretion
  JOURNAL   Mol Metab 6 (6), 459-470 (2017)
   PUBMED   28580277
  REMARK    GeneRIF: ZFAND3 was identified as a type 2 diabetes susceptibility
            gene. ZFAND3 plays a role in insulin secretion in vitro.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3138)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3138)
  AUTHORS   de Luis,O., Lopez-Fernandez,L.A. and del Mazo,J.
  TITLE     Tex27, a gene containing a zinc-finger domain, is up-regulated
            during the haploid stages of spermatogenesis
  JOURNAL   Exp Cell Res 249 (2), 320-326 (1999)
   PUBMED   10366431
REFERENCE   7  (bases 1 to 3138)
  AUTHORS   Lopez-Fernandez,L.A. and del Mazo,J.
  TITLE     Characterization of genes expressed early in mouse spermatogenesis,
            isolated from a subtractive cDNA library
  JOURNAL   Mamm Genome 7 (9), 698-700 (1996)
   PUBMED   8703127
REFERENCE   8  (bases 1 to 3138)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI817165.1, BP305887.1, BC031481.2, AL137302.1 and AW023961.1.
            
            On Nov 23, 2018 this sequence version replaced NM_021943.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK023284.1, SRR1163657.526115.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287218.9/ ENSP00000287218.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AI817165.1         197-271
            76-656              BP305887.1         1-581
            657-1145            BC031481.2         469-957
            1146-3133           AL137302.1         169-2156
            3134-3138           AW023961.1         189-193
FEATURES             Location/Qualifiers
     source          1..3138
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.2"
     gene            1..3138
                     /gene="ZFAND3"
                     /gene_synonym="TEX27"
                     /note="zinc finger AN1-type containing 3"
                     /db_xref="GeneID:60685"
                     /db_xref="HGNC:HGNC:18019"
                     /db_xref="MIM:607455"
     exon            1..290
                     /gene="ZFAND3"
                     /gene_synonym="TEX27"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..903
                     /gene="ZFAND3"
                     /gene_synonym="TEX27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     testis expressed sequence 27; AN1-type zinc finger protein
                     3; zinc finger, AN1-type domain 3; testis-expressed
                     protein 27"
                     /codon_start=1
                     /product="AN1-type zinc finger protein 3 isoform 1"
                     /protein_id="NP_068762.1"
                     /db_xref="CCDS:CCDS4836.1"
                     /db_xref="GeneID:60685"
                     /db_xref="HGNC:HGNC:18019"
                     /db_xref="MIM:607455"
                     /translation="MGDAGSERSKAPSLPPRCPCGFWGSSKTMNLCSKCFADFQKKQP
                     DDDSAPSTSNSQSDLFSEETTSDNNNTSITTPTLSPSQQPLPTELNVTSPSKEECGPC
                     TDTAHVSLITPTKRSCGTDSQSENEASPVKRPRLLENTERSEETSRSKQKSRRRCFQC
                     QTKLELVQQELGSCRCGYVFCMLHRLPEQHDCTFDHMGRGREEAIMKMVKLDRKVGRS
                     CQRIGEGCS"
     exon            291..331
                     /gene="ZFAND3"
                     /gene_synonym="TEX27"
                     /inference="alignment:Splign:2.1.0"
     exon            332..514
                     /gene="ZFAND3"
                     /gene_synonym="TEX27"
                     /inference="alignment:Splign:2.1.0"
     exon            515..580
                     /gene="ZFAND3"
                     /gene_synonym="TEX27"
                     /inference="alignment:Splign:2.1.0"
     exon            581..748
                     /gene="ZFAND3"
                     /gene_synonym="TEX27"
                     /inference="alignment:Splign:2.1.0"
     exon            749..3138
                     /gene="ZFAND3"
                     /gene_synonym="TEX27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3119..3124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFAND3"
                     /gene_synonym="TEX27"
                     /note="hexamer: ATTAAA"
     polyA_site      3138
                     /gene="ZFAND3"
                     /gene_synonym="TEX27"
                     /note="major polyA site"
ORIGIN      
        1 ctccccgtct ccgcaggccg agtggtgcgg cccgcctcca gctgaccggc ctggaatccc
       61 ggctccgagc cccggactcg cgcccgcccg cgcgcccgct ccttccccct ccccccgccc
      121 cgagcccccc gacgccgccg ccaccgcctc ctcagagcgg ggcccgggcc cagccgccgc
      181 caccgctgcc gccgccgagc tccgccgccg ccgagcacca tgggagacgc tgggagcgag
      241 cgcagcaaag cgcccagcct gccgcctcgc tgtccctgcg gcttctgggg gtccagcaag
      301 actatgaatc tctgttccaa atgctttgct gattttcaaa agaaacagcc agacgatgat
      361 tccgctccaa gtacaagtaa cagccaatca gatttgtttt ccgaagagac caccagtgac
      421 aacaacaata cctcgataac cacgccaact cttagtccca gccagcagcc gcttccgaca
      481 gaactgaatg taacttcacc gagtaaagag gagtgtgggc catgcacaga cacagctcat
      541 gtctcattaa tcacaccaac aaaaagatcc tgtggtacag attcacagtc tgagaatgag
      601 gcttcaccag taaaacggcc acgactactt gagaatacgg aacggtccga ggaaaccagt
      661 cgatctaaac agaagagtcg acgtcggtgc ttccagtgcc aaaccaaact ggagctggtg
      721 cagcaggaat tgggatcgtg tcgctgcggt tatgtgttct gtatgttaca tcgcctcccc
      781 gagcagcacg actgcacatt cgaccacatg ggccgtggcc gggaggaagc catcatgaaa
      841 atggtgaagc tggaccggaa agtggggcgc tcctgccagc gcatcgggga ggggtgctcc
      901 tgaaggccag gcatggccac cacgtgacgc tgttcttagt tcactaatgt tagccttatt
      961 taggacaaag tcagccagac accttgtact gggcacgcgt cagactgcag ccagtccgtt
     1021 tcctttcttt agccagccat cctggtactg tagtttaggg gttgatggtg gttgaaattg
     1081 atttctggct ggttactaag gtgcctgcta gccattgtat aaaattaaaa catgaagaat
     1141 attttttttt tgagcatggc tagtggattt aaaacaacac atacctgtca ctgctggagt
     1201 caaacttata aaaagcctta agtggaaagt gttccagacg gagactctga gttaatagag
     1261 gagtagaagc tggtgttaaa gttcccacga cgcacatggc tttgccagaa actctgttta
     1321 atgatcggcc tttcacctct tcacttatcc ttagtcccag tagccaggat acctgatggc
     1381 cacgtgtgcc ttggccacgg gaggctgctg agattggcca cgtggctggg ctgggtggtg
     1441 gcctcactct cccacagagc tggaaatggg gggtggggga cagattctta cggaaatttt
     1501 tttacctgac ttgctatgaa aaaactcatc acacaagaag agaaacagta acctcacttt
     1561 gaaaattagc tccactcaag actagtccac gaacgagacc cgccttttct acacaggatc
     1621 caaggtcacg agaagcagcc agagtgcccc gcctccgccg gctctggtct gccattcgcc
     1681 agtgcaggga tctggcacgg accagatgtg gcgaatggca gcacagcgcg gtggctgggt
     1741 ctgcacactg gcctctgcag ccagatttct atattgggag ttttttaaaa agacatttca
     1801 tagccaacaa gaatcagtag aagtgctggg agcagcagct ggggaagctg ccgcccacgg
     1861 gctctgcccc ttccagctgg agccgcccgt gcctccaggg gccaagagga tgatgtcgtg
     1921 gcctccattc tcgtttctat gcagccccat agtccaagga cacccagtcc acatctacca
     1981 tatagcaagt ttagtaaggg aaggcagcat acgtcccagg gacagtgggt ttggatctgt
     2041 ctagaacagc ggtttgtggc tgtggcccag ctccgagagt gatatttgct ctggtaggtg
     2101 agggcctgag ggtacatttc tccacctgtg ccccctcatg ttcacagagg atttcagcag
     2161 ctgcaactgc gcacgccagg tggggaaggg tgggggtggg cctggttgcc ccatgttagg
     2221 aaatcactac cagtcaggtg gggctggggc tgggtggaca ggatcaggat tcccttgaaa
     2281 gcccaggcag ggtgagcagt cccagtggtc ctagtgccgc atcagatcca ggtgggtgag
     2341 ggcaggaggc ccctgcggag gcagcgtgga tctgcccaca cataggctac tggaatagtt
     2401 taacccagca actttccttt ttataaaaca acaaatggtt caactctgtc tgcaaattaa
     2461 cagctgaaca cctgcaactg caaatgtttt ttgatccgac gtactgaaat aggaagtcat
     2521 gctcttccca ccctccaccc accagagtgg aacccgctgc aaaatcccca gccttaattc
     2581 ttgcttcagg acccagaccg gtgtcttgct ctagggcaac ccagggcaga ggggccaggt
     2641 ctgcccagcg tttaccactg ctgtcaagcc acagcccttg gccaccatac gggccatcct
     2701 cagtgaggca gccccccata ggcttccgcc aagctctggt cccgaagagg ctgtgcgagc
     2761 ccttcccggc cctccccagg gccccccgcc ccctcctctg cctgctgcgt ggaggcagcc
     2821 atgggaagga gcccagggga gctggcctgg gggagcgaag cccatgttcg cttcctgact
     2881 tagagctggg gggggtgggg ggtggggctt gttcccctgc agtatctgtt ctgtgaagtt
     2941 tgttaaatgt aaggaaagct taaattcttg tatctttaaa agagaaaatc ttatttaacc
     3001 cttttgtgtt ctagatttac ttacacacat agcctagagc tcagttttag ttttaacatt
     3061 gtgaaaatat taaaagaatc ttgtaacttt attctttttt ctcctgctga aaaaaaaaat
     3121 taaaccaatc gtatgaaa
//
