LOCUS       NM_138802               1322 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger AN1-type containing 2B (ZFAND2B),
            transcript variant 1, mRNA.
ACCESSION   NM_138802
VERSION     NM_138802.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1322)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1322)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1322)
  AUTHORS   Rahighi,S., Braunstein,I., Ternette,N., Kessler,B., Kawasaki,M.,
            Kato,R., Matsui,T., Weiss,T.M., Stanhill,A. and Wakatsuki,S.
  TITLE     Selective Binding of AIRAPL Tandem UIMs to Lys48-Linked
            Tri-Ubiquitin Chains
  JOURNAL   Structure 24 (3), 412-422 (2016)
   PUBMED   26876100
REFERENCE   4  (bases 1 to 1322)
  AUTHORS   Osorio,F.G., Soria-Valles,C., Santiago-Fernandez,O., Bernal,T.,
            Mittelbrunn,M., Colado,E., Rodriguez,F., Bonzon-Kulichenko,E.,
            Vazquez,J., Porta-de-la-Riva,M., Ceron,J., Fueyo,A., Li,J.,
            Green,A.R., Freije,J.M. and Lopez-Otin,C.
  TITLE     Loss of the proteostasis factor AIRAPL causes myeloid
            transformation by deregulating IGF-1 signaling
  JOURNAL   Nat Med 22 (1), 91-96 (2016)
   PUBMED   26692333
  REMARK    GeneRIF: Consistent with its proposed role as a tumor suppressor of
            myeloid transformation, AIRAPL expression is widely abrogated in
            human myeloproliferative disorders.
REFERENCE   5  (bases 1 to 1322)
  AUTHORS   Braunstein,I., Zach,L., Allan,S., Kalies,K.U. and Stanhill,A.
  TITLE     Proteasomal degradation of preemptive quality control (pQC)
            substrates is mediated by an AIRAPL-p97 complex
  JOURNAL   Mol Biol Cell 26 (21), 3719-3727 (2015)
   PUBMED   26337389
  REMARK    GeneRIF: Results demonstrate that on specific translocation
            inhibition, a p97-AIRAPL complex directly binds and regulates the
            efficient processing of polyubiquitinated pQC substrates by the
            UPS. Results also demonstrate p97's role in pQC processing of
            preproinsulin in cases of naturally occurring mutations within the
            signal sequence of insulin.
REFERENCE   6  (bases 1 to 1322)
  AUTHORS   Lee,S.H., Park,M.Y., Kim,K.W., Wee,S.W. and Kim,J.C.
  TITLE     Zinc finger protein in severe dry eye syndrome
  JOURNAL   Curr Eye Res 39 (5), 431-438 (2014)
   PUBMED   24215362
  REMARK    GeneRIF: Zinc finger proteins may be associated with
            pathophysiology of severe dry eye syndrome.
REFERENCE   7  (bases 1 to 1322)
  AUTHORS   Glinka,T., Alter,J., Braunstein,I., Tzach,L., Wei Sheng,C.,
            Geifman,S., Edelmann,M.J., Kessler,B.M. and Stanhill,A.
  TITLE     Signal-peptide-mediated translocation is regulated by a p97-AIRAPL
            complex
  JOURNAL   Biochem J 457 (2), 253-261 (2014)
   PUBMED   24160817
  REMARK    GeneRIF: AIRAPL binds to p97 and forms a complex in the endoplasmic
            reticulum membrane.
REFERENCE   8  (bases 1 to 1322)
  AUTHORS   Hassan,W.M., Merin,D.A., Fonte,V. and Link,C.D.
  TITLE     AIP-1 ameliorates beta-amyloid peptide toxicity in a Caenorhabditis
            elegans Alzheimer's disease model
  JOURNAL   Hum Mol Genet 18 (15), 2739-2747 (2009)
   PUBMED   19414486
  REMARK    GeneRIF: An AIP-1 human homologue, ZFAND2B, has a similar
            protective effect against Abeta toxicity.
REFERENCE   9  (bases 1 to 1322)
  AUTHORS   Yun,C., Stanhill,A., Yang,Y., Zhang,Y., Haynes,C.M., Xu,C.F.,
            Neubert,T.A., Mor,A., Philips,M.R. and Ron,D.
  TITLE     Proteasomal adaptation to environmental stress links resistance to
            proteotoxicity with longevity in Caenorhabditis elegans
  JOURNAL   Proc Natl Acad Sci U S A 105 (19), 7094-7099 (2008)
   PUBMED   18467495
REFERENCE   10 (bases 1 to 1322)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC068946.4, BM852092.1 and
            BC018415.1.
            
            On Nov 23, 2018 this sequence version replaced NM_138802.2.
            
            Summary: This gene encodes a protein containing AN1-type
            zinc-fingers and ubiquitin-interacting motifs. The encoded protein
            likely associates with the proteosome to stimulate the degradation
            of toxic or misfolded proteins. Alternatively spliced transcript
            variants encoding multiple isoforms have been observed for this
            gene. [provided by RefSeq, Aug 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 2 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018415.1, SRR3476690.728063.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000289528.10/ ENSP00000289528.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC068946.4         101140-101141
            3-34                BM852092.1         1-32
            35-1322             BC018415.1         1-1288
FEATURES             Location/Qualifiers
     source          1..1322
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..1322
                     /gene="ZFAND2B"
                     /gene_synonym="AIRAPL"
                     /note="zinc finger AN1-type containing 2B"
                     /db_xref="GeneID:130617"
                     /db_xref="HGNC:HGNC:25206"
                     /db_xref="MIM:613474"
     exon            1..261
                     /gene="ZFAND2B"
                     /gene_synonym="AIRAPL"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..980
                     /gene="ZFAND2B"
                     /gene_synonym="AIRAPL"
                     /note="isoform 1 is encoded by transcript variant 1;
                     AN1-type zinc finger protein 2B; AIRAP-like protein;
                     arsenite-inducible RNA-associated protein-like protein;
                     zinc finger, AN1-type domain 2B"
                     /codon_start=1
                     /product="AN1-type zinc finger protein 2B isoform 1"
                     /protein_id="NP_620157.1"
                     /db_xref="CCDS:CCDS2435.1"
                     /db_xref="GeneID:130617"
                     /db_xref="HGNC:HGNC:25206"
                     /db_xref="MIM:613474"
                     /translation="MEFPDLGAHCSEPSCQRLDFLPLKCDACSGIFCADHVAYAQHHC
                     GSAYQKDIQVPVCPLCNVPVPVARGEPPDRAVGEHIDRDCRSDPAQQKRKIFTNKCER
                     AGCRQREMMKLTCERCSRNFCIKHRHPLDHDCSGEGHPTSRAGLAAISRAQAVASTST
                     VPSPSQTMPSCTSPSRATTRSPSWTAPPVIALQNGLSEDEALQRALEMSLAETKPQVP
                     SCQEEEDLALAQALSASEAEYQRQQAQSRSSKPSNCSLC"
     exon            262..356
                     /gene="ZFAND2B"
                     /gene_synonym="AIRAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            357..488
                     /gene="ZFAND2B"
                     /gene_synonym="AIRAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            489..640
                     /gene="ZFAND2B"
                     /gene_synonym="AIRAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            641..733
                     /gene="ZFAND2B"
                     /gene_synonym="AIRAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            734..794
                     /gene="ZFAND2B"
                     /gene_synonym="AIRAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            795..862
                     /gene="ZFAND2B"
                     /gene_synonym="AIRAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            863..935
                     /gene="ZFAND2B"
                     /gene_synonym="AIRAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1322
                     /gene="ZFAND2B"
                     /gene_synonym="AIRAPL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1292..1297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFAND2B"
                     /gene_synonym="AIRAPL"
                     /note="hexamer: AATAAA"
     polyA_site      1322
                     /gene="ZFAND2B"
                     /gene_synonym="AIRAPL"
                     /note="major polyA site"
ORIGIN      
        1 gtcagcgcgc cgcgcgcgcc gagggaggag cgggcgccgg gggccggctg gcgcgggggc
       61 tccggtaacc cgggctgggc gggggagagg aaggggcggg gcagggagcc cgccagagtg
      121 cggggtcgcg gtgcggactt cgagcacgag ccctaaagac gctcagcact cgtcgcttct
      181 cctagcagac cctgcccggc ttggcgatgg agtttccgga cctcggcgct cactgttcgg
      241 agccgagctg tcagcgcttg gattttctgc cgcttaagtg tgatgcctgc tcaggcatct
      301 tctgcgcaga ccatgtggcc tacgcccagc atcactgtgg atctgcttac caaaaggata
      361 tccaggtacc tgtgtgccct ctctgtaatg tgcctgtgcc tgtggccaga ggggagcccc
      421 ctgaccgtgc tgtgggagag cacattgaca gagactgtcg ctctgatcca gcacagcaaa
      481 aacgtaagat cttcaccaat aagtgtgaac gcgctggctg ccggcagcga gaaatgatga
      541 aactgacctg tgaacgctgt agccgaaact tctgcatcaa gcaccggcat ccactggacc
      601 atgattgctc tggggagggg cacccaacca gccgggcagg acttgctgcc atctccagag
      661 cacaagctgt ggcttctaca agcactgtcc ccagcccaag tcaaaccatg ccttcctgta
      721 cctctcccag cagagccaca acccgatctc cgtcctggac agcccctcca gtgattgctt
      781 tgcagaatgg cctgagtgag gatgaagctc tgcagcgggc cctggaaatg tccctggcag
      841 aaaccaaacc ccaggttcca agttgtcagg aggaagaaga cctagcttta gcacaagcac
      901 tgtcagccag tgaggcagaa taccagcggc agcaggccca gagccgcagc tcgaagccgt
      961 ccaactgcag cctgtgctag ggccctgggc ttggggaggg aggttcacct gaggaggact
     1021 gtggccctca cacctctagg gtacacaggg agaggaggcc cggagcaccc tggagggcag
     1081 agacaagcgg gagtgatgtg gaggtcgccc tgggagcctc tggaaggcct tgctagtgct
     1141 ccagctgcat ggaagagagc ggctagcaac tgttccctgg ttgggccctc agtggatgct
     1201 ggccaggccc tactcttagc cccttcatca tgtcatctcc cttatgctgg agctgccccg
     1261 atgtggagtg ggcaggaagg ggcctggaaa aaataaagga tcttggcagt tgataaaacg
     1321 ta
//
