LOCUS       NM_182491                878 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger AN1-type containing 2A (ZFAND2A),
            transcript variant 1, mRNA.
ACCESSION   NM_182491
VERSION     NM_182491.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 878)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 878)
  AUTHORS   Pizzato Scomazzon,S., Riccio,A., Santopolo,S., Lanzilli,G.,
            Coccia,M., Rossi,A. and Santoro,M.G.
  TITLE     The Zinc-Finger AN1-Type Domain 2a Gene Acts as a Regulator of Cell
            Survival in Human Melanoma: Role of E3-Ligase cIAP2
  JOURNAL   Mol Cancer Res 17 (12), 2444-2456 (2019)
   PUBMED   31540997
  REMARK    GeneRIF: The findings identify ZFAND2A/AIRAP as a novel
            stress-regulated survival factor implicated in the stabilization of
            the antiapoptotic protein cIAP2 and as a new potential therapeutic
            target in melanoma
REFERENCE   3  (bases 1 to 878)
  AUTHORS   Zach,L., Braunstein,I. and Stanhill,A.
  TITLE     Stress-induced start codon fidelity regulates arsenite-inducible
            regulatory particle-associated protein (AIRAP) translation
  JOURNAL   J Biol Chem 289 (30), 20706-20716 (2014)
   PUBMED   24898249
  REMARK    GeneRIF: arsenite- inducible regulatory particle-associated protein
            (AIRAP) transcript to be translationally induced during arsenite
            stress conditions.
REFERENCE   4  (bases 1 to 878)
  AUTHORS   Rossi,A., Riccio,A., Coccia,M., Trotta,E., La Frazia,S. and
            Santoro,M.G.
  TITLE     The proteasome inhibitor bortezomib is a potent inducer of zinc
            finger AN1-type domain 2a gene expression: role of heat shock
            factor 1 (HSF1)-heat shock factor 2 (HSF2) heterocomplexes
  JOURNAL   J Biol Chem 289 (18), 12705-12715 (2014)
   PUBMED   24619424
  REMARK    GeneRIF: Data indicate that both heat shock factors HSF1 and HSF2
            are recruited to the arsenite-inducible RNA-associated protein
            (AIRAP) promoter and regulate bortezomib-induced AIRAP expression.
REFERENCE   5  (bases 1 to 878)
  AUTHORS   Rossi,A., Trotta,E., Brandi,R., Arisi,I., Coccia,M. and
            Santoro,M.G.
  TITLE     AIRAP, a new human heat shock gene regulated by heat shock factor 1
  JOURNAL   J Biol Chem 285 (18), 13607-13615 (2010)
   PUBMED   20185824
  REMARK    GeneRIF: The HSF1 binding HSE sequence in the AIRAP promoter
            critical for heat-induced transcription was identified.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091729.4, BC029558.1 and AI435373.1.
            
            On Aug 31, 2019 this sequence version replaced NM_182491.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029558.1, AK027118.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316495.8/ ENSP00000314619.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               AC091729.4         86852-87052         c
            202-433             BC029558.1         168-399
            434-878             AI435373.1         7-451               c
FEATURES             Location/Qualifiers
     source          1..878
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..878
                     /gene="ZFAND2A"
                     /gene_synonym="AIRAP"
                     /note="zinc finger AN1-type containing 2A"
                     /db_xref="GeneID:90637"
                     /db_xref="HGNC:HGNC:28073"
                     /db_xref="MIM:610699"
     exon            1..233
                     /gene="ZFAND2A"
                     /gene_synonym="AIRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            234..333
                     /gene="ZFAND2A"
                     /gene_synonym="AIRAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..716
                     /gene="ZFAND2A"
                     /gene_synonym="AIRAP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     arsenite inducible RNA associated protein; AN1-type zinc
                     finger protein 2A; zinc finger, AN1-type domain 2A"
                     /codon_start=1
                     /product="AN1-type zinc finger protein 2A isoform 1"
                     /protein_id="NP_872297.2"
                     /db_xref="CCDS:CCDS5323.1"
                     /db_xref="GeneID:90637"
                     /db_xref="HGNC:HGNC:28073"
                     /db_xref="MIM:610699"
                     /translation="MEFPDLGKHCSEKTCKQLDFLPVKCDACKQDFCKDHFPYAAHKC
                     PFAFQKDVHVPVCPLCNTPIPVKKGQIPDVVVGDHIDRDCDSHPGKKKEKIFTYRCSK
                     EGCKKKEMLQMVCAQCHGNFCIQHRHPLDHSCRHGSRPTIKAG"
     exon            334..428
                     /gene="ZFAND2A"
                     /gene_synonym="AIRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            429..560
                     /gene="ZFAND2A"
                     /gene_synonym="AIRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            561..878
                     /gene="ZFAND2A"
                     /gene_synonym="AIRAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      855..860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFAND2A"
                     /gene_synonym="AIRAP"
                     /note="hexamer: AATAAA"
     polyA_site      878
                     /gene="ZFAND2A"
                     /gene_synonym="AIRAP"
                     /note="major polyA site"
ORIGIN      
        1 aaggcccaga cggctctcag atccgggggc tgcggataaa tccccgtagg ccgcgggcag
       61 cgagatgttg cgttccggtg tgggtgtggg tgtgcctccg acggcgtctc ggtgccagtg
      121 tcgaggttct ttctgcttag ctacccggag ccgactacgg aggaggacac ctgagtttac
      181 gtctcttcca tctgctgctc acctcagctg cctgggtccc cgacgagagc caggtgacac
      241 ttaactccgc catctgcgtt ttgagcactg ttctcataat ggagtttcct gatttgggga
      301 agcattgttc agaaaagact tgcaagcagc tagattttct tccagtaaaa tgtgatgcat
      361 gtaaacaaga tttctgtaaa gatcattttc catacgctgc acataagtgt ccgtttgcat
      421 tccagaagga tgttcacgtc ccagtatgcc cactctgtaa tacccccatc ccagtaaaaa
      481 agggccagat accagacgtg gtggttggtg atcacattga cagagactgt gactctcacc
      541 ctgggaagaa gaaagagaag atttttacat accgttgctc aaaagagggc tgcaagaaga
      601 aagagatgct gcagatggta tgtgcccaat gtcacggcaa cttctgtatc cagcacagac
      661 accctttgga ccacagctgc agacacggga gtcgccccac catcaaagct gggtgagaag
      721 agactccgct gcgatggctc ggagcacgca gtagcatgcg tggaagcagc ttacactcta
      781 gtgggaagtg gagccccatt gagcaccatc ccacactggc tgctgatctt gtttgttgag
      841 ggagatggga ctataataaa attgaatgct gaagttga
//
