LOCUS       NM_024699               2184 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens zinc finger AN1-type containing 1 (ZFAND1), transcript
            variant 1, mRNA.
ACCESSION   NM_024699
VERSION     NM_024699.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2184)
  AUTHORS   Lai,C.H., Ko,K.T., Fan,P.J., Yu,T.A., Chang,C.F., Draczkowski,P.
            and Hsu,S.D.
  TITLE     Structural insight into the ZFAND1-p97 interaction involved in
            stress granule clearance
  JOURNAL   J Biol Chem 300 (5), 107230 (2024)
   PUBMED   38537699
  REMARK    GeneRIF: Structural insight into the ZFAND1-p97 interaction
            involved in stress granule clearance.
REFERENCE   2  (bases 1 to 2184)
  AUTHORS   Turakhiya,A., Meyer,S.R., Marincola,G., Bohm,S., Vanselow,J.T.,
            Schlosser,A., Hofmann,K. and Buchberger,A.
  TITLE     ZFAND1 Recruits p97 and the 26S Proteasome to Promote the Clearance
            of Arsenite-Induced Stress Granules
  JOURNAL   Mol Cell 70 (5), 906-919 (2018)
   PUBMED   29804830
  REMARK    GeneRIF: By recruiting the 26S proteasome and the
            ubiquitin-selective ATPase p97 to arsenite-induced stress granules,
            ZFAND1 ensures their timely clearance and prevents their
            aberration.
REFERENCE   3  (bases 1 to 2184)
  AUTHORS   Sa-Moura,B., Funakoshi,M., Tomko,R.J. Jr., Dohmen,R.J., Wu,Z.,
            Peng,J. and Hochstrasser,M.
  TITLE     A conserved protein with AN1 zinc finger and ubiquitin-like domains
            modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway
  JOURNAL   J Biol Chem 288 (47), 33682-33696 (2013)
   PUBMED   24121501
REFERENCE   4  (bases 1 to 2184)
  AUTHORS   Pharoah,P.D., Tsai,Y.Y., Ramus,S.J., Phelan,C.M., Goode,E.L.,
            Lawrenson,K., Buckley,M., Fridley,B.L., Tyrer,J.P., Shen,H.,
            Weber,R., Karevan,R., Larson,M.C., Song,H., Tessier,D.C., Bacot,F.,
            Vincent,D., Cunningham,J.M., Dennis,J., Dicks,E., Aben,K.K.,
            Anton-Culver,H., Antonenkova,N., Armasu,S.M., Baglietto,L.,
            Bandera,E.V., Beckmann,M.W., Birrer,M.J., Bloom,G., Bogdanova,N.,
            Brenton,J.D., Brinton,L.A., Brooks-Wilson,A., Brown,R., Butzow,R.,
            Campbell,I., Carney,M.E., Carvalho,R.S., Chang-Claude,J.,
            Chen,Y.A., Chen,Z., Chow,W.H., Cicek,M.S., Coetzee,G., Cook,L.S.,
            Cramer,D.W., Cybulski,C., Dansonka-Mieszkowska,A., Despierre,E.,
            Doherty,J.A., Dork,T., du Bois,A., Durst,M., Eccles,D., Edwards,R.,
            Ekici,A.B., Fasching,P.A., Fenstermacher,D., Flanagan,J., Gao,Y.T.,
            Garcia-Closas,M., Gentry-Maharaj,A., Giles,G., Gjyshi,A., Gore,M.,
            Gronwald,J., Guo,Q., Halle,M.K., Harter,P., Hein,A., Heitz,F.,
            Hillemanns,P., Hoatlin,M., Hogdall,E., Hogdall,C.K., Hosono,S.,
            Jakubowska,A., Jensen,A., Kalli,K.R., Karlan,B.Y., Kelemen,L.E.,
            Kiemeney,L.A., Kjaer,S.K., Konecny,G.E., Krakstad,C.,
            Kupryjanczyk,J., Lambrechts,D., Lambrechts,S., Le,N.D., Lee,N.,
            Lee,J., Leminen,A., Lim,B.K., Lissowska,J., Lubinski,J.,
            Lundvall,L., Lurie,G., Massuger,L.F., Matsuo,K., McGuire,V.,
            McLaughlin,J.R., Menon,U., Modugno,F., Moysich,K.B., Nakanishi,T.,
            Narod,S.A., Ness,R.B., Nevanlinna,H., Nickels,S., Noushmehr,H.,
            Odunsi,K., Olson,S., Orlow,I., Paul,J., Pejovic,T., Pelttari,L.M.,
            Permuth-Wey,J., Pike,M.C., Poole,E.M., Qu,X., Risch,H.A.,
            Rodriguez-Rodriguez,L., Rossing,M.A., Rudolph,A., Runnebaum,I.,
            Rzepecka,I.K., Salvesen,H.B., Schwaab,I., Severi,G., Shen,H.,
            Shridhar,V., Shu,X.O., Sieh,W., Southey,M.C., Spellman,P.,
            Tajima,K., Teo,S.H., Terry,K.L., Thompson,P.J., Timorek,A.,
            Tworoger,S.S., van Altena,A.M., van den Berg,D., Vergote,I.,
            Vierkant,R.A., Vitonis,A.F., Wang-Gohrke,S., Wentzensen,N.,
            Whittemore,A.S., Wik,E., Winterhoff,B., Woo,Y.L., Wu,A.H.,
            Yang,H.P., Zheng,W., Ziogas,A., Zulkifli,F., Goodman,M.T., Hall,P.,
            Easton,D.F., Pearce,C.L., Berchuck,A., Chenevix-Trench,G.,
            Iversen,E., Monteiro,A.N., Gayther,S.A., Schildkraut,J.M. and
            Sellers,T.A.
  CONSRTM   Australian Cancer Study; Australian Ovarian Cancer Study Group
  TITLE     GWAS meta-analysis and replication identifies three new
            susceptibility loci for ovarian cancer
  JOURNAL   Nat Genet 45 (4), 362-370 (2013)
   PUBMED   23535730
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ427843.1, BC022251.2, AC132219.3 and BU678501.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024699.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.63941.1,
                                           SRR1803614.277179.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000220669.10/ ENSP00000220669.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BQ427843.1         5-15
            12-1108             BC022251.2         1-1097
            1109-1775           AC132219.3         11084-11750         c
            1776-2065           BU678501.1         143-432             c
            2066-2184           BU678501.1         23-141              c
FEATURES             Location/Qualifiers
     source          1..2184
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.13"
     gene            1..2184
                     /gene="ZFAND1"
                     /note="zinc finger AN1-type containing 1"
                     /db_xref="GeneID:79752"
                     /db_xref="HGNC:HGNC:25858"
     exon            1..74
                     /gene="ZFAND1"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..826
                     /gene="ZFAND1"
                     /EC_number="3.1.3.25"
                     /note="isoform a is encoded by transcript variant 1;
                     AN1-type zinc finger protein 1; zinc finger
                     AN1-type-containing protein 1; zinc finger, AN1-type
                     domain 1"
                     /codon_start=1
                     /product="AN1-type zinc finger protein 1 isoform a"
                     /protein_id="NP_078975.2"
                     /db_xref="CCDS:CCDS6232.1"
                     /db_xref="GeneID:79752"
                     /db_xref="HGNC:HGNC:25858"
                     /translation="MAELDIGQHCQVEHCRQRDFLPFVCDDCSGIFCLEHRSRESHGC
                     PEVTVINERLKTDQHTSYPCSFKDCAERELVAVICPYCEKNFCLRHRHQSDHECEKLE
                     IPKPRMAATQKLVKDIIDSKTGETASKRWKGAKNSETAAKVALMKLKMHADGDKSLPQ
                     TERIYFQVFLPKGSKEKSKPMFFCHRWSIGKAIDFAASLARLKNDNNKFTAKKLRLCH
                     ITSGEALPLDHTLETWIAKEDCPLYNGGNIILEYLNDEEQFCKNVESYLE"
     exon            75..117
                     /gene="ZFAND1"
                     /inference="alignment:Splign:2.1.0"
     exon            118..157
                     /gene="ZFAND1"
                     /inference="alignment:Splign:2.1.0"
     exon            158..285
                     /gene="ZFAND1"
                     /inference="alignment:Splign:2.1.0"
     exon            286..377
                     /gene="ZFAND1"
                     /inference="alignment:Splign:2.1.0"
     exon            378..499
                     /gene="ZFAND1"
                     /inference="alignment:Splign:2.1.0"
     exon            500..655
                     /gene="ZFAND1"
                     /inference="alignment:Splign:2.1.0"
     exon            656..2184
                     /gene="ZFAND1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1781..1786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFAND1"
                     /note="hexamer: AATAAA"
     polyA_site      1799
                     /gene="ZFAND1"
                     /note="major polyA site"
     regulatory      2157..2162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZFAND1"
                     /note="hexamer: AGTAAA"
     polyA_site      2184
                     /gene="ZFAND1"
ORIGIN      
        1 cccttacggc gccggagaga tggcggagtt ggacatcggg cagcactgcc aggtggagca
       61 ttgccggcag cgagattttc ttccatttgt gtgtgatgat tgttcaggaa tattttgcct
      121 tgaacacaga agcagggagt ctcatggttg tcctgaggtg actgtaatca atgagagact
      181 gaagacagat caacatacat cttacccatg ctctttcaaa gactgtgctg agagagaact
      241 tgtggcagtt atatgtcctt attgtgagaa gaatttttgc ctgagacacc gtcatcagtc
      301 agatcatgag tgtgaaaaac tggaaatccc aaagcctcga atggctgcca ctcagaaact
      361 tgttaaagac attattgatt ccaagacagg agaaacagca agtaaacgat ggaaaggtgc
      421 caaaaatagt gaaacagctg caaaggttgc attgatgaaa ttaaagatgc atgctgatgg
      481 cgataagtca ttaccacaga cagaaagaat ttactttcag gttttcttac ctaaagggag
      541 caaagagaag agcaaaccaa tgttcttttg ccaccgatgg agcattggaa aggccataga
      601 ctttgccgct tctctagcca ggcttaaaaa tgacaataac aaatttacag ctaagaaatt
      661 aaggctgtgt cacattactt caggagaagc cttacccttg gatcatactt tggaaacctg
      721 gattgctaag gaggattgtc ctttatataa tggtggaaat ataatcttgg aatatcttaa
      781 tgatgaagaa caattctgta aaaatgttga atcttacttg gaatagtcat tcaaagattc
      841 aagtcagaaa tcacagggaa aattctatta catgtttaag tccatttatt ttactacaaa
      901 tactattttt gtaattttta aaagttgctt tttaacttat ttccccttat gtcacatttt
      961 aaattatgag ttttctatta gagttttttg gttttaagtt taattgtgta cggatcctca
     1021 attattagca aattcttata tttaattagc tttcattagt ttatgctgta gtgacaacaa
     1081 caaagatgta tttcctggtg ggggatgtca gctgttgatt ggctgtgaca ctgctttgtg
     1141 tcatcttctt accatgatca aaggcaaagg aagggatctc ttttgggaca ttgtgattgt
     1201 tttagcagag agagaaagag atgaaataca cttcggtttt ctcttaaaag atgcatgtat
     1261 catacgtgct ttaagcaagt catgtggcca agcctagcat catggagcca gaaagtatag
     1321 ccttgctgtc tgtctacatc atgatgtata aattgatata tctacatgaa ttatagaaac
     1381 ttagaagtga tctttattca gtcttataat ttttacatga agaatcttag gcctaggagg
     1441 agaaaatgat tttctttcta ttacctaact agattggggc atatttctga taaagaccca
     1501 cctctagtga gattcatctt ttttgtttgt gtgactatat tccatagaga agaaagatgg
     1561 gatagctcaa cttcattata taccaaagca aaacacatgc caaatgatga ctacatttta
     1621 ccaacatatt tagacgagta ttcttgacta gtgtttacta tctatacccc caaaactact
     1681 actatataga cagaatggaa agtatttcta tttgtccttt ttttgttttc tgttctaatt
     1741 gtcagggaca tatgtagtgg ctataggttt acttaaaagg aataaatttg gaatgctcat
     1801 ttggtttatt tcctttctaa ttcttcatat tatttttatg tgaggaatgg agataatttc
     1861 caacttttat tatgttcttg tactttcatt cattagcata gttatttgag ttcccactaa
     1921 atgtagggat ttgtcctaat tgccatgatt aatacaatga tgatatgtat acatacaggt
     1981 ataccttgga aatattgtgg gttcagtttc agactaccac acaaagcaaa tattggagta
     2041 tattgagcca gacaaatttt tttttgtttc ccagggcata taaaaattat gtttacacta
     2101 tactatagtc tatttaatgt gcaatagcat tatgtctaaa aaatgtatat actttaagta
     2161 aaaaaatact ttattgctaa aaaa
//
