LOCUS       NM_006336               4293 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zyg-11 related cell cycle regulator (ZER1), transcript
            variant 1, mRNA.
ACCESSION   NM_006336
VERSION     NM_006336.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4293)
  AUTHORS   Yan,X., Li,Y., Wang,G., Zhou,Z., Song,G., Feng,Q., Zhao,Y., Mi,W.,
            Ma,Z. and Dong,C.
  TITLE     Molecular basis for recognition of Gly/N-degrons by CRL2ZYG11B and
            CRL2ZER1
  JOURNAL   Mol Cell 81 (16), 3262-3274 (2021)
   PUBMED   34214466
  REMARK    GeneRIF: Molecular basis for recognition of Gly/N-degrons by
            CRL2(ZYG11B) and CRL2(ZER1).
REFERENCE   2  (bases 1 to 4293)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4293)
  AUTHORS   Timms,R.T., Zhang,Z., Rhee,D.Y., Harper,J.W., Koren,I. and
            Elledge,S.J.
  TITLE     A glycine-specific N-degron pathway mediates the quality control of
            protein N-myristoylation
  JOURNAL   Science 365 (6448) (2019)
   PUBMED   31273098
REFERENCE   4  (bases 1 to 4293)
  AUTHORS   Wade,T.D., Gordon,S., Medland,S., Bulik,C.M., Heath,A.C.,
            Montgomery,G.W. and Martin,N.G.
  TITLE     Genetic variants associated with disordered eating
  JOURNAL   Int J Eat Disord 46 (6), 594-608 (2013)
   PUBMED   23568457
REFERENCE   5  (bases 1 to 4293)
  AUTHORS   Cheng,C.Y., Schache,M., Ikram,M.K., Young,T.L., Guggenheim,J.A.,
            Vitart,V., MacGregor,S., Verhoeven,V.J., Barathi,V.A., Liao,J.,
            Hysi,P.G., Bailey-Wilson,J.E., St Pourcain,B., Kemp,J.P.,
            McMahon,G., Timpson,N.J., Evans,D.M., Montgomery,G.W., Mishra,A.,
            Wang,Y.X., Wang,J.J., Rochtchina,E., Polasek,O., Wright,A.F.,
            Amin,N., van Leeuwen,E.M., Wilson,J.F., Pennell,C.E., van
            Duijn,C.M., de Jong,P.T., Vingerling,J.R., Zhou,X., Chen,P., Li,R.,
            Tay,W.T., Zheng,Y., Chew,M., Burdon,K.P., Craig,J.E., Iyengar,S.K.,
            Igo,R.P. Jr., Lass,J.H. Jr., Chew,E.Y., Haller,T., Mihailov,E.,
            Metspalu,A., Wedenoja,J., Simpson,C.L., Wojciechowski,R., Hohn,R.,
            Mirshahi,A., Zeller,T., Pfeiffer,N., Lackner,K.J., Bettecken,T.,
            Meitinger,T., Oexle,K., Pirastu,M., Portas,L., Nag,A.,
            Williams,K.M., Yonova-Doing,E., Klein,R., Klein,B.E.,
            Hosseini,S.M., Paterson,A.D., Makela,K.M., Lehtimaki,T.,
            Kahonen,M., Raitakari,O., Yoshimura,N., Matsuda,F., Chen,L.J.,
            Pang,C.P., Yip,S.P., Yap,M.K., Meguro,A., Mizuki,N., Inoko,H.,
            Foster,P.J., Zhao,J.H., Vithana,E., Tai,E.S., Fan,Q., Xu,L.,
            Campbell,H., Fleck,B., Rudan,I., Aung,T., Hofman,A.,
            Uitterlinden,A.G., Bencic,G., Khor,C.C., Forward,H., Parssinen,O.,
            Mitchell,P., Rivadeneira,F., Hewitt,A.W., Williams,C., Oostra,B.A.,
            Teo,Y.Y., Hammond,C.J., Stambolian,D., Mackey,D.A., Klaver,C.C.,
            Wong,T.Y., Saw,S.M. and Baird,P.N.
  CONSRTM   Consortium for Refractive Error and Myopia; Fuchs' Genetics
            Multi-Center Study Group; Wellcome Trust Case Control Consortium 2;
            Diabetes Control and Complications Trial/Epidemiology of Diabetes
            Interventions, and Complications Research Group
  TITLE     Nine loci for ocular axial length identified through genome-wide
            association studies, including shared loci with refractive error
  JOURNAL   Am J Hum Genet 93 (2), 264-277 (2013)
   PUBMED   24144296
REFERENCE   6  (bases 1 to 4293)
  AUTHORS   Vasudevan,S., Starostina,N.G. and Kipreos,E.T.
  TITLE     The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a
            conserved family of CUL-2 complex components
  JOURNAL   EMBO Rep 8 (3), 279-286 (2007)
   PUBMED   17304241
REFERENCE   7  (bases 1 to 4293)
  AUTHORS   Feral,C., Wu,Y.Q., Pawlak,A. and Guellaen,G.
  TITLE     Meiotic human sperm cells express a leucine-rich homologue of
            Caenorhabditis elegans early embryogenesis gene, Zyg-11
  JOURNAL   Mol Hum Reprod 7 (12), 1115-1122 (2001)
   PUBMED   11719588
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL441992.17.
            
            On Nov 23, 2018 this sequence version replaced NM_006336.3.
            
            Summary: This gene encodes a subunit of an E3 ubiquitin ligase
            complex that may be involved in meiosis. The encoded protein
            contains three leucine-rich repeat motifs. [provided by RefSeq, Nov
            2012].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052563.1, SRR1803616.68263.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000291900.7/ ENSP00000291900.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-347               AL441992.17        72167-72513         c
            348-599             AL441992.17        55994-56245         c
            600-750             AL441992.17        54395-54545         c
            751-1187            AL441992.17        53750-54186         c
            1188-1364           AL441992.17        53259-53435         c
            1365-1479           AL441992.17        51999-52113         c
            1480-1626           AL441992.17        51708-51854         c
            1627-1800           AL441992.17        51202-51375         c
            1801-2016           AL441992.17        43116-43331         c
            2017-2058           AL441992.17        42386-42427         c
            2059-2178           AL441992.17        42121-42240         c
            2179-2294           AL441992.17        41358-41473         c
            2295-2483           AL441992.17        40517-40705         c
            2484-2581           AL441992.17        35920-36017         c
            2582-2684           AL441992.17        34012-34114         c
            2685-4293           AL441992.17        30372-31980         c
FEATURES             Location/Qualifiers
     source          1..4293
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..4293
                     /gene="ZER1"
                     /gene_synonym="C9orf60; ZYG; ZYG11BL"
                     /note="zyg-11 related cell cycle regulator"
                     /db_xref="GeneID:10444"
                     /db_xref="HGNC:HGNC:30960"
                     /db_xref="MIM:617764"
     exon            1..347
                     /gene="ZER1"
                     /gene_synonym="C9orf60; ZYG; ZYG11BL"
                     /inference="alignment:Splign:2.1.0"
     exon            348..599
                     /gene="ZER1"
                     /gene_synonym="C9orf60; ZYG; ZYG11BL"
                     /inference="alignment:Splign:2.1.0"
     CDS             442..2742
                     /gene="ZER1"
                     /gene_synonym="C9orf60; ZYG; ZYG11BL"
                     /note="isoform 1 is encoded by transcript variant 1; ZYG
                     homolog; protein zer-1 homolog; zyg-11 homolog B-like
                     protein; zyg11b-like protein"
                     /codon_start=1
                     /product="protein zer-1 homolog isoform 1"
                     /protein_id="NP_006327.2"
                     /db_xref="CCDS:CCDS6910.1"
                     /db_xref="GeneID:10444"
                     /db_xref="HGNC:HGNC:30960"
                     /db_xref="MIM:617764"
                     /translation="MASDTPESLMALCTDFCLRNLDGTLGYLLDKETLRLHPDIFLPS
                     EICDRLVNEYVELVNAACNFEPHESFFSLFSDPRSTRLTRIHLREDLVQDQDLEAIRK
                     QDLVELYLTNCEKLSAKSLQTLRSFSHTLVSLSLFGCTNIFYEEENPGGCEDEYLVNP
                     TCQVLVKDFTFEGFSRLRFLNLGRMIDWVPVESLLRPLNSLAALDLSGIQTSDAAFLT
                     QWKDSLVSLVLYNMDLSDDHIRVIVQLHKLRHLDISRDRLSSYYKFKLTREVLSLFVQ
                     KLGNLMSLDISGHMILENCSISKMEEEAGQTSIEPSKSSIIPFRALKRPLQFLGLFEN
                     SLCRLTHIPAYKVSGDKNEEQVLNAIEAYTEHRPEITSRAINLLFDIARIERCNQLLR
                     ALKLVITALKCHKYDRNIQVTGSAALFYLTNSEYRSEQSVKLRRQVIQVVLNGMESYQ
                     EVTVQRNCCLTLCNFSIPEELEFQYRRVNELLLSILNPTRQDESIQRIAVHLCNALVC
                     QVDNDHKEAVGKMGFVVTMLKLIQKKLLDKTCDQVMEFSWSALWNITDETPDNCEMFL
                     NFNGMKLFLDCLKEFPEKQELHRNMLGLLGNVAEVKELRPQLMTSQFISVFSNLLESK
                     ADGIEVSYNACGVLSHIMFDGPEAWGVCEPQREEVEERMWAAIQSWDINSRRNINYRS
                     FEPILRLLPQGISPVSQHWATWALYNLVSVYPDKYCPLLIKEGGMPLLRDIIKMATAR
                     QETKEMARKVIEHCSNFKEENMDTSR"
     exon            600..750
                     /gene="ZER1"
                     /gene_synonym="C9orf60; ZYG; ZYG11BL"
                     /inference="alignment:Splign:2.1.0"
     exon            751..1187
                     /gene="ZER1"
                     /gene_synonym="C9orf60; ZYG; ZYG11BL"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1364
                     /gene="ZER1"
                     /gene_synonym="C9orf60; ZYG; ZYG11BL"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1479
                     /gene="ZER1"
                     /gene_synonym="C9orf60; ZYG; ZYG11BL"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1626
                     /gene="ZER1"
                     /gene_synonym="C9orf60; ZYG; ZYG11BL"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1800
                     /gene="ZER1"
                     /gene_synonym="C9orf60; ZYG; ZYG11BL"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..2016
                     /gene="ZER1"
                     /gene_synonym="C9orf60; ZYG; ZYG11BL"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2058
                     /gene="ZER1"
                     /gene_synonym="C9orf60; ZYG; ZYG11BL"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2178
                     /gene="ZER1"
                     /gene_synonym="C9orf60; ZYG; ZYG11BL"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2294
                     /gene="ZER1"
                     /gene_synonym="C9orf60; ZYG; ZYG11BL"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2483
                     /gene="ZER1"
                     /gene_synonym="C9orf60; ZYG; ZYG11BL"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2581
                     /gene="ZER1"
                     /gene_synonym="C9orf60; ZYG; ZYG11BL"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..2684
                     /gene="ZER1"
                     /gene_synonym="C9orf60; ZYG; ZYG11BL"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..4293
                     /gene="ZER1"
                     /gene_synonym="C9orf60; ZYG; ZYG11BL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4268..4273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZER1"
                     /gene_synonym="C9orf60; ZYG; ZYG11BL"
                     /note="hexamer: AATACA"
     polyA_site      4293
                     /gene="ZER1"
                     /gene_synonym="C9orf60; ZYG; ZYG11BL"
                     /note="major polyA site"
ORIGIN      
        1 gggtttgttg acagcggagg cggcggcggc tgcaggctcc gagccgtagg agccggatcg
       61 ggggaggggc cgggcccagg agcctcagcc ccgccggcag ccctaagggc aaggtaaccg
      121 ccacggggtc cccgtcgcga ccccctccct cccggagctc ccgtccccgg gatcccaagc
      181 tccgccccgc cgacccccgt ctcccctgga ccccggctct agcctgacga gatccccaac
      241 ctcctgaggt gctctggccc cggattctcc cgggctgcat tctctgctcc tcctcgcctg
      301 cgaagcatca cgtccgcttc ccgacgctga gggcagcccc gtccagggca gtggctctgc
      361 caatgatcct gtgagtattc aggaatcact gttgcccctg gggatccttg tcctggagtg
      421 gcccacctgc ttgcccccag catggcgtcc gacactcccg agtcgctgat ggccctctgt
      481 actgacttct gcttgcgcaa cctggatggc accctgggct acctgctgga caaggagacc
      541 ctgcggctac atccggacat cttcttgccc agcgagatct gtgaccggct cgtcaatgag
      601 tatgtggagc tggtgaacgc tgcctgtaac ttcgagccac acgagagctt cttcagcctc
      661 ttttcggacc cccgcagcac ccgcctcacg cggatccacc tccgtgagga cctggtgcag
      721 gaccaggacc tggaggccat ccgcaagcag gacctggtgg agctgtacct gactaactgc
      781 gagaagctgt ccgccaagag cctgcagaca ctgaggagct tcagccacac cctggtgtcc
      841 ttgagcctct tcggctgtac aaacattttc tatgaggagg agaacccagg gggctgtgaa
      901 gatgagtacc tcgtcaaccc cacctgccag gtgctggtta aggatttcac cttcgagggc
      961 ttcagccgcc tccgcttcct caacttgggc cgcatgattg attgggtccc tgtggagtcc
     1021 ctgctgcggc cgcttaactc cctggctgcc ttggacctct caggcattca gacgagcgac
     1081 gccgccttcc tcacccagtg gaaagacagc ctggtgtccc tcgtcctcta caacatggac
     1141 ctgtccgacg accacatccg ggtcatcgtg cagctgcaca agctgcgaca cctggacatc
     1201 tcccgagacc gcctctccag ctactacaag ttcaagctga ctcgggaggt gctgagcctc
     1261 tttgtgcaga agctggggaa cctaatgtcc ctggacatct ctggccacat gatcctagag
     1321 aactgcagca tctccaagat ggaagaggaa gcggggcaga ccagcattga gccttccaag
     1381 agcagcatca tacctttccg ggctctgaag aggccgctgc agttcctcgg gctctttgag
     1441 aactctctgt gccgcctcac gcacattcca gcctacaaag taagtggtga caaaaacgaa
     1501 gagcaggtgc tgaatgccat cgaggcctac acggagcacc ggcctgagat cacctcgcgg
     1561 gccatcaact tgctttttga catcgcccgc atcgagcgtt gcaaccagct gctgcgggcc
     1621 ctgaagctgg tcatcacggc cctcaagtgc cacaaatatg acaggaacat tcaagtgaca
     1681 ggcagcgccg ctctcttcta cctaacaaat tccgagtacc gctcagagca gagtgtgaag
     1741 ctgcgccggc aggttatcca ggtggtgctg aatggcatgg aatcctacca ggaggtgacg
     1801 gtgcagcgga actgctgcct gacgctctgc aacttcagca tccccgagga gctggaattc
     1861 cagtaccgcc gggtcaacga gctcctgctc agcatcctca accccacgcg gcaggacgag
     1921 tctatccagc ggatcgccgt gcacctgtgc aatgccctgg tctgccaggt agacaacgac
     1981 cacaaggagg ccgtgggcaa gatgggcttt gtcgtgacca tgctgaagct gattcagaag
     2041 aagctgctgg acaagacatg tgaccaggtc atggagttct cctggagtgc cctgtggaac
     2101 atcacagatg aaactcctga caactgcgag atgttcctca atttcaacgg catgaagctc
     2161 ttcctggact gcctgaagga attcccagag aagcaggaac tgcataggaa tatgctagga
     2221 cttttgggga atgtggcaga agtgaaggag ctgaggcctc aactaatgac ttcccagttc
     2281 atcagcgtct tcagcaacct gttggagagc aaggccgatg ggatcgaggt ttcctacaat
     2341 gcctgcggcg tcctctccca catcatgttt gatggacccg aggcctgggg cgtctgtgag
     2401 ccccagcgtg aggaggtgga ggaacgcatg tgggctgcca tccagagctg ggacataaac
     2461 tctcggagaa acatcaatta caggtcattt gaaccaattc tccgcctcct tccccaggga
     2521 atctctcctg tcagccagca ctgggcaacc tgggccctgt ataacctcgt gtctgtctac
     2581 ccggacaagt actgccctct gctgatcaaa gaagggggga tgccccttct gagggacata
     2641 attaagatgg cgaccgcacg gcaggagacc aaggaaatgg cccgcaaggt gattgagcac
     2701 tgcagtaact ttaaagagga gaacatggac acgtctagat agaggcctcc gtccccatgg
     2761 ccgccaccgc tctggaccac aggcggggag gaagcatgct caagcagccc agcgggcggg
     2821 ccccttccga gggagcctcc cacggagtga agagacatgg gggacttttg cacaaccgac
     2881 gcttttcctt aatgttagtg agatatatat atattatata tatatatttt ttttttggtt
     2941 aggaagtgtg aagttttgtg tgtatgattt ctgtgcaaaa acaaaagcaa cactcctgag
     3001 tccttgcagc ttccttggcc attctcaaac ccactcagcc ttcatcgctg acacacacac
     3061 tcctacccca accagactaa atgcctataa cgctgtgagt gtccagtcct tgtccaggaa
     3121 actcagatcc cggcctggct tcctttcatg agaggagcag gccttggaca gcgtatcgag
     3181 catcctgacc cactgcccct gcctgagaac gccatctcgg ctcccgggca cagctgatgg
     3241 ggtttgggga ttagaactta ccccactggg tctcccaaaa gccttggtgc tcccggctgt
     3301 gggccatctg gggcaggaaa gtgagccatt cctaggctga ggtccaggca gccctgcccc
     3361 tgaagaccct ctaggagcag ggcacccagt ggccctgctg ctgtccagcc aggcctgcct
     3421 gaggccacgc tgctatggag gctgcctcct agtctcccac caggtcccag gctgtggaaa
     3481 gccccagccc agggatggtc agaactcagg ggcagattcc actgcccctt ctgccaaaca
     3541 catccagaac ctgccctcag ccctggaagc tagcatcttc tggggccagg ggcttgcttc
     3601 ctcgctccat agccctcaac tgcccaggcg ctcccaccag cagaactgag cctgcctcct
     3661 cctcccagcc tgccccgctg cccagaggac cccacgcctc tcagaggcag aggtcccatg
     3721 acagcctttg acccacaacg gccacacagc cgcctccaga ccagcactcg gactgccctg
     3781 cagtggccgc ttgggcctcc ctggcggtcc cgccctgccc taggctttac cttggaagcc
     3841 tgagaggcgc cggctctctt gctcctccat cgatggacac tgcattgctt ctcatcggac
     3901 acttgtggag cgcaggggcc tggggagcag cgctaaccct ggaggcagcc tttgggtgat
     3961 ggctttttct tcccttttcc tcccgcgggc ctgttttcag gtgttcctag catttctgcc
     4021 tccaggcagg acggcagggg tgagcagctt tgggagagac acctggcctt tttctcctgg
     4081 agcctctccc tcccggccct gggaagtggg cgcagccctg tgttccccca gcttggcaga
     4141 tgggctgcat gcggcgctcc cttccttccc acgctcagcg gccccggcca gaccctggca
     4201 gacttcacac ctcattgctt taccccctgg ggcctgggga aatgtctgta ctttgggaag
     4261 tcacagaaat acatttttgt gcaaaatgga aaa
//
