LOCUS       NM_014795               9265 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens zinc finger E-box binding homeobox 2 (ZEB2),
            transcript variant 1, mRNA.
ACCESSION   NM_014795 XM_001723541 XM_001723999 XM_001724917
VERSION     NM_014795.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9265)
  AUTHORS   Cai,Y., Zhou,J., Xu,A., Huang,J., Zhang,H., Xie,G., Zhong,K.,
            Wu,Y., Ye,P., Wang,H. and Niu,H.
  TITLE     N6-methyladenosine triggers renal fibrosis via enhancing
            translation and stability of ZEB2 mRNA
  JOURNAL   J Biol Chem 300 (9), 107598 (2024)
   PUBMED   39059495
  REMARK    GeneRIF: N6-methyladenosine triggers renal fibrosis via enhancing
            translation and stability of ZEB2 mRNA.
REFERENCE   2  (bases 1 to 9265)
  AUTHORS   Feng,Y., Zhou,C., Zhao,F., Ma,T., Xiao,Y., Peng,K. and Xia,R.
  TITLE     ZEB2 alleviates Hirschsprung's-associated enterocolitis by
            promoting the proliferation and differentiation of enteric neural
            precursor cells via the Notch-1/Jagged-2 pathway
  JOURNAL   Gene 912, 148365 (2024)
   PUBMED   38485033
  REMARK    GeneRIF: ZEB2 alleviates Hirschsprung's-associated enterocolitis by
            promoting the proliferation and differentiation of enteric neural
            precursor cells via the Notch-1/Jagged-2 pathway.
REFERENCE   3  (bases 1 to 9265)
  AUTHORS   Zhang,W., Xiao,P., Liu,B. and Zhang,Y.
  TITLE     Circ-10720 as a ceRNA adsorbs microRNA-1238 and modulates ZEB2 to
            boost NSCLC development by activating EMT
  JOURNAL   Eur J Med Res 29 (1), 226 (2024)
   PUBMED   38610009
  REMARK    GeneRIF: Circ-10720 as a ceRNA adsorbs microRNA-1238 and modulates
            ZEB2 to boost NSCLC development by activating EMT.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9265)
  AUTHORS   Knox,J.J. and Cancro,M.P.
  TITLE     ABCs begin with ZEB2
  JOURNAL   Immunol Cell Biol 102 (4), 229-231 (2024)
   PUBMED   38525813
  REMARK    GeneRIF: ABCs begin with ZEB2.
REFERENCE   5  (bases 1 to 9265)
  AUTHORS   Comijn,J., Berx,G., Vermassen,P., Verschueren,K., van Grunsven,L.,
            Bruyneel,E., Mareel,M., Huylebroeck,D. and van Roy,F.
  TITLE     The two-handed E box binding zinc finger protein SIP1 downregulates
            E-cadherin and induces invasion
  JOURNAL   Mol Cell 7 (6), 1267-1278 (2001)
   PUBMED   11430829
  REMARK    GeneRIF: Conditional expression of SIP1 in E-cadherin-positive
            cells abrogates E-cadherin-mediated intercellular adhesion and
            induces invasion. SIP1 therefore appears to be a promoter of
            invasion in malignant epithelial tumors.
REFERENCE   6  (bases 1 to 9265)
  AUTHORS   Wakamatsu,N., Yamada,Y., Yamada,K., Ono,T., Nomura,N.,
            Taniguchi,H., Kitoh,H., Mutoh,N., Yamanaka,T., Mushiake,K.,
            Kato,K., Sonta,S. and Nagaya,M.
  TITLE     Mutations in SIP1, encoding Smad interacting protein-1, cause a
            form of Hirschsprung disease
  JOURNAL   Nat Genet 27 (4), 369-370 (2001)
   PUBMED   11279515
REFERENCE   7  (bases 1 to 9265)
  AUTHORS   Verschueren,K., Remacle,J.E., Collart,C., Kraft,H., Baker,B.S.,
            Tylzanowski,P., Nelles,L., Wuytens,G., Su,M.T., Bodmer,R.,
            Smith,J.C. and Huylebroeck,D.
  TITLE     SIP1, a novel zinc finger/homeodomain repressor, interacts with
            Smad proteins and binds to 5'-CACCT sequences in candidate target
            genes
  JOURNAL   J Biol Chem 274 (29), 20489-20498 (1999)
   PUBMED   10400677
REFERENCE   8  (bases 1 to 9265)
  AUTHORS   Ueki,N., Oda,T., Kondo,M., Yano,K., Noguchi,T. and Muramatsu,M.
  TITLE     Selection system for genes encoding nuclear-targeted proteins
  JOURNAL   Nat Biotechnol 16 (13), 1338-1342 (1998)
   PUBMED   9853615
REFERENCE   9  (bases 1 to 9265)
  AUTHORS   Parisi,M.A.
  TITLE     Hirschsprung Disease Overview - RETIRED CHAPTER, FOR HISTORICAL
            REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301612
REFERENCE   10 (bases 1 to 9265)
  AUTHORS   Adam,M.P., Conta,J. and Bean,L.J.H.
  TITLE     Mowat-Wilson Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301585
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA305985.1, AB056507.1,
            AC010130.12 and AI341193.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014795.3.
            
            Summary: The protein encoded by this gene is a member of the Zfh1
            family of 2-handed zinc finger/homeodomain proteins. It is located
            in the nucleus and functions as a DNA-binding transcriptional
            repressor that interacts with activated SMADs. Mutations in this
            gene are associated with Hirschsprung disease/Mowat-Wilson
            syndrome. Alternatively spliced transcript variants have been found
            for this gene.[provided by RefSeq, Jan 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB011141.1, SRR1660805.72925.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467148 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000627532.3/ ENSP00000487174.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-359               DA305985.1         231-589
            360-5328            AB056507.1         589-5557
            5329-8485           AC010130.12        81024-84180         c
            8486-8971           AI341193.1         1-486               c
            8972-9265           AC010130.12        80244-80537         c
FEATURES             Location/Qualifiers
     source          1..9265
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q22.3"
     gene            1..9265
                     /gene="ZEB2"
                     /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
                     /note="zinc finger E-box binding homeobox 2"
                     /db_xref="GeneID:9839"
                     /db_xref="HGNC:HGNC:14881"
                     /db_xref="MIM:605802"
     exon            1..181
                     /gene="ZEB2"
                     /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
                     /inference="alignment:Splign:2.1.0"
     exon            182..323
                     /gene="ZEB2"
                     /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..3895
                     /gene="ZEB2"
                     /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger homeobox 1b; Smad-interacting protein 1; SMAD
                     interacting protein 1"
                     /codon_start=1
                     /product="zinc finger E-box-binding homeobox 2 isoform 1"
                     /protein_id="NP_055610.1"
                     /db_xref="CCDS:CCDS2186.1"
                     /db_xref="GeneID:9839"
                     /db_xref="HGNC:HGNC:14881"
                     /db_xref="MIM:605802"
                     /translation="MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKL
                     HIAEDDGIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEI
                     LQASVDGPEEMKEDYDTMGPEATIQTAINNGTVKNANCTSDFEEYFAKRKLEERDGHA
                     VSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDR
                     GYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQG
                     AGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKC
                     IGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKT
                     EPLDFNDYKVLMATHGFSGTSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGF
                     PTMNSNLSEVQKVLQIVDNTVSRQKMDCKAEEISKLKGYHMKDPCSQPEEQGVTSPNI
                     PPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLV
                     TDDKMIENHNISTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNK
                     AGVFVDNKALLLSSVLSEKGMTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIAVG
                     LPQEFVKEWFEQRKVYQYSNSRSPSLERSSKPLAPNSNPPTKDSLLPRSPVKPMDSIT
                     SPSIAELHNSVTNCDPPLRLTKPSHFTNIKPVEKLDHSRSNTPSPLNLSSTSSKNSHS
                     SSYTPNSFSSEELQAEPLDLSLPKQMKEPKSIIATKNKTKASSISLDHNSVSSSSENS
                     DEPLNLTFIKKEFSNSNNLDNKSTNPVFSMNPFSAKPLYTALPPQSAFPPATFMPPVQ
                     TSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQGELLDGAQDY
                     MSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQ
                     ICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEER
                     EAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESMPRDGESEKEHEKEGED
                     GYGKLGRQDGDEEFEEEEEESENKSMDTDPETIRDEEETGDHSMDDSSEDGKMETKSD
                     HEEDNMEDGM"
     exon            324..581
                     /gene="ZEB2"
                     /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
                     /inference="alignment:Splign:2.1.0"
     exon            582..653
                     /gene="ZEB2"
                     /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
                     /inference="alignment:Splign:2.1.0"
     exon            654..842
                     /gene="ZEB2"
                     /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1057
                     /gene="ZEB2"
                     /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1166
                     /gene="ZEB2"
                     /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..3136
                     /gene="ZEB2"
                     /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..3317
                     /gene="ZEB2"
                     /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
                     /inference="alignment:Splign:2.1.0"
     exon            3318..9265
                     /gene="ZEB2"
                     /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5309..5314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZEB2"
                     /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
                     /note="hexamer: AATAAA"
     polyA_site      5330
                     /gene="ZEB2"
                     /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
                     /note="major polyA site"
     regulatory      8654..8659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZEB2"
                     /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
                     /note="hexamer: AGTAAA"
     polyA_site      8677
                     /gene="ZEB2"
                     /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
     regulatory      8826..8831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZEB2"
                     /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
                     /note="hexamer: AATAAA"
     polyA_site      8849
                     /gene="ZEB2"
                     /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
     regulatory      8952..8957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZEB2"
                     /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
                     /note="hexamer: AACAAA"
     regulatory      8962..8967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZEB2"
                     /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
                     /note="hexamer: ATTAAA"
     polyA_site      8976
                     /gene="ZEB2"
                     /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
     polyA_site      8980
                     /gene="ZEB2"
                     /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
     regulatory      9246..9251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZEB2"
                     /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
                     /note="hexamer: ATTAAA"
     polyA_site      9265
                     /gene="ZEB2"
                     /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
ORIGIN      
        1 agttctaacc tgctctgcag gaataacggt cctgcctccc gacactcttg gcgaggtttt
       61 tgtacagttt gctccgggag ctgtttcttc gcttccacct ttttctcccc cacacttcgc
      121 ggcttcttca tgctttttct tctcaccatt tctggccaaa actacaaaca agacttcgca
      181 gatcgagcct gcgtgctgcc gaagcagggc gccgagtcca tgcgaactgc catctgatcc
      241 gctcttatca atgaagcagc cgatcatggc ggatggcccc cggtgcaaga ggcgcaaaca
      301 agccaatccc aggaggaaaa acgtggtgaa ctatgacaat gtagtggaca caggttctga
      361 aacagatgag gaagacaagc ttcatattgc tgaggatgac ggtattgcca accctctgga
      421 ccaggagacg agtccagcta gtgtgcccaa ccatgagtcc tccccacacg tgagccaagc
      481 tctgttgcca agagaggaag aggaagatga aataagggag ggtggagtgg aacacccctg
      541 gcacaacaac gagattctac aagcctctgt agatggtcca gaagaaatga aggaagacta
      601 tgacactatg gggccagaag ccacgatcca gaccgcaatt aacaatggta cagtgaagaa
      661 tgcaaattgc acatcagatt ttgaggaata ctttgccaaa agaaaactgg aggaacgcga
      721 tggtcatgca gtcagcatcg aggagtacct tcagcgcagt gacacagcca ttatttaccc
      781 agaagcccct gaggagctgt ctcgccttgg cacgccagag gccaatgggc aagaagaaaa
      841 tgacctgcca cctggaactc cagatgcttt tgcccaactg ctgacctgcc cctactgcga
      901 ccggggctac aagcgcttga catcactgaa ggagcacatc aagtaccgcc acgagaagaa
      961 tgaagagaac ttttcctgcc ctctctgtag ctacacgttt gcctaccgca cccagctcga
     1021 gcggcatatg gtgacacaca agccagggac agatcagcac caaatgctaa cccaaggagc
     1081 aggtaatcgc aagttcaaat gcacagagtg tggcaaggcc ttcaaatata aacaccatct
     1141 gaaagaacac ctgcgaattc acagtggtga aaaaccttac gagtgcccaa actgcaagaa
     1201 acgtttctcc cattctggtt cctacagttc gcacatcagc agcaagaaat gtattggttt
     1261 aatctctgta aatggccgaa tgagaaacaa tatcaagacg ggttcttccc ctaattctgt
     1321 ttcttcttct cctactaatt cagccattac ccagttaaga aacaagttgg agaatggaaa
     1381 accacttagt atgtctgaac agacaggctt acttaaaatt aaaacagaac cactagactt
     1441 caatgactat aaagttctta tggctacaca cgggtttagt ggcactagtc cctttatgaa
     1501 tggtgggctt ggagccacca gccctttagg agttcatcca tctgctcaga gtccaatgca
     1561 gcacttaggt gtagggatgg aagccccttt acttgggttt cccaccatga atagtaattt
     1621 aagtgaggta caaaaggttc tacagattgt ggacaatact gtttccaggc aaaaaatgga
     1681 ctgcaaggct gaagaaattt caaagttgaa aggttatcac atgaaggatc catgctctca
     1741 acctgaggaa caaggagtta cttctcctaa tattccgcct gtcggtcttc cggtagtgag
     1801 tcataatggt gccactaaaa gtattattga ctatacgttg gaaaaagtca atgaagccaa
     1861 agcttgcctc cagagcttga ctactgactc aaggagacag atcagtaata taaagaaaga
     1921 gaagctacgt actttaatag atttggtcac tgatgacaaa atgattgaga accacaacat
     1981 atccactcca ttttcatgcc agttctgtaa agaaagtttt cctggcccca tccctttgca
     2041 tcagcatgaa cgttaccttt gtaagatgaa tgaagagatc aaggcggtcc tgcagcctca
     2101 tgaaaacata gtccccaaca aagccggagt ttttgttgat aataaagccc tcctcttgtc
     2161 atctgtactt tctgagaaag gaatgacaag ccccatcaac ccatacaagg accacatgtc
     2221 tgtactcaaa gcatactatg ctatgaacat ggagcccaac tccgatgaac tgctgaaaat
     2281 ttccattgct gtgggccttc ctcaggaatt tgtgaaggaa tggtttgaac aacgaaaagt
     2341 ctaccagtac tcaaattcca ggtccccatc cctggaaaga agctccaagc cgttagctcc
     2401 caacagtaac cctcccacaa aagactcttt attacccagg tctcctgtaa aacctatgga
     2461 ctccataaca tcaccatcta tagcagaact ccacaacagt gttacgaatt gtgatcctcc
     2521 tctcaggcta acaaaacctt cccattttac caatattaaa ccagttgaaa aattggacca
     2581 ctccaggagt aatactcctt ctcccttaaa tctttcctcc acatcttcta aaaactccca
     2641 cagtagttca tacactccaa acagcttctc ttctgaggag ctccaggctg agcctttaga
     2701 cttgtcatta ccaaaacaaa tgaaagaacc caaaagtatt atagccacaa agaacaaaac
     2761 aaaagctagt agcatcagtt tagatcataa cagtgtttct tcctcatctg aaaactcaga
     2821 tgagcctctg aacttgactt ttatcaagaa ggaattttca aattcaaata atctggacaa
     2881 caaaagcact aacccagtgt tcagcatgaa cccatttagt gccaaacctt tatacacagc
     2941 tcttccacct caaagcgcat ttccccctgc tactttcatg ccaccagtcc agaccagtat
     3001 tcctgggcta cgaccatacc caggactgga tcagatgagc ttcctaccac atatggccta
     3061 cacctaccca actggagcag ctacttttgc tgatatgcag caaaggagaa agtaccagcg
     3121 gaaacaagga tttcagggag aattgcttga tggagcacaa gactacatgt caggcctaga
     3181 tgatatgaca gactccgact cctgtctgtc tcgcaaaaag atcaagaaga cagagagtgg
     3241 catgtatgca tgtgacttat gtgacaagac attccagaaa agcagttccc ttctgcgaca
     3301 taaatacgaa cacacaggaa aaagaccaca tcagtgtcag atttgtaaga aagcgtttaa
     3361 acacaagcac caccttatcg agcactcaag gcttcactcg ggcgagaagc cctatcagtg
     3421 tgataaatgt ggcaagcgct tctcacactc gggctcgtac tcgcagcaca tgaatcacag
     3481 gtattcctac tgcaagcggg aggcggagga gcgggaagcg gcggagcgcg aggcgcgcga
     3541 gaaagggcac ttggaaccca ccgagctgct gatgaaccgg gcttacttgc agagcattac
     3601 ccctcagggg tactctgact cggaggagag ggagagtatg ccgagggatg gcgagagcga
     3661 gaaggagcac gagaaagaag gcgaggatgg ctacgggaag ctgggcagac aggatggcga
     3721 cgaggagttc gaggaggaag aggaagaaag tgaaaataaa agtatggata cggatcccga
     3781 aacgatacga gatgaagaag agactggaga tcactccatg gacgatagtt cggaggatgg
     3841 gaaaatggaa accaaatcag accacgagga agacaatatg gaagatggca tgtaataaac
     3901 tactgcattt taagcttcct attttttttt ccagtagtat tgttacctgc ttgaaaacac
     3961 tgctgtgtta agctgttcat gcacgtgcct gacgcttcca ggaagctgta gagagggaca
     4021 gaaggggcgg ttcagccaag acagatgtag acggagttgg agctgggtat tgttaaaaac
     4081 tgcattatgc aaaaattttg tacagtgtta aggcctaaaa actgtgtggt tcagagacta
     4141 attcctgtgt ttaatagcat ttatacttta agcacaacta gaaaattgta agaattgcac
     4201 tctacttatg tatcactaca aactttaaaa aactatgtct aatttatatt aatacatttt
     4261 aaaaaggtgc ccgcactacc atacatcagt atttttatta ttattattgt tattcctttt
     4321 taatttaatg tgctcgcact acaatgcatc agtattatga ttcctctgta ctttcctttc
     4381 gctattcatc aatttcccat tttttttttc agcttaagta accacacaat tttaggcctc
     4441 aatttttttt tttttctgtg aaggaacttg aagtgatgca tgtgtgaatt taagataccg
     4501 aagtcttaaa gtgacctgga cgtgaaggaa aaagtaagat gagaaataaa gaaagccttt
     4561 gtaaggtggt tttaaaagcc ttatatgcaa accttttaat ctgtgtttct gcaagtgcca
     4621 tccttgtaca gtgttaagag ggtaacatgg gttacctttg caccagcttc agtgttaagc
     4681 tcaccctgtt ctttgaagca cccatgtcag tattagaaga ataggcagca gttccttagt
     4741 ttacatatgt ttgtgcaatt attttctgta cttttttgtt cattaatttt gtcagtatta
     4801 caccaaactg tttttgcaac aaaaaaattt tttttgcatt catttaattt taggtcaaat
     4861 aacattttat ttatgtggct cattttatat ttcctaattt tatttatttc atactgtagt
     4921 gtacagtatt atagttcttc aatatataga tatattttag taaaaaagga acatgacgtt
     4981 gatcatttgg gcaaatttta cgtaaagaga agagcattta ttgtgttttg gaacattaat
     5041 tgtgagatgg gatttttcaa ttttattatt ttatttttgt ttttttccaa ttactggaaa
     5101 ttccaaattt gggaactttt gatacgatct tgtgaaaaca ctgtattttc gactgaaaat
     5161 tccactttct tcatcttgtt ttttagctaa aaagagggac tgttaaatac aatgtatgat
     5221 accatgacaa aaatctttcc tgaattgtct ttgtaaaagt attattgaat tttcaatttg
     5281 taatttcttt tgaaaatgac catgctcgaa taaaaatgta gccaaactaa gaatgtagtt
     5341 aatgagttct gtacttttag agagttttcc ttcaatgacc attaacatgt aacatgcttt
     5401 atgcttataa taatgctaat tatgtttttt tcatataatt ttagtttagc aataattttg
     5461 actggtacca ataactgttt tttaaaattc catacctatg tacagcaatt ttacagcttt
     5521 tctcaactga tcctgattcc agattgtgta tttttatgtg aggttatatt attcaaattt
     5581 agtctattta ctttacagac atttctactt ttgcattacg agtatttaga gattatgtgt
     5641 taaaaattca cttctctgtc caaggggtct ttgtgattta ttcaaaaaaa agtctaattt
     5701 caaaaagaca gctattattc agtgttattt ataatatgta acctttttta aaggattggg
     5761 atagtttatc tcactttttg aaatgcagac agtagtttac cgtttatctg aaactagaag
     5821 gcgtgggtgg gagaggaaaa gctaaaagca aatgctaaca aaaataaccg tgattttcta
     5881 agacagtttt tcagttttta caagatgacc ctaatattca gaatatgaat gtattcgtag
     5941 gttttacata atgactttta tcaagaaact agattctgct tcttaaatct aattgccaag
     6001 tgaagaataa cagaaaaaac agattacctt atcaaattta cagctcttga atatacagaa
     6061 ctataatata gtagctgtcc atgtattttt tctactttag aatcaaagaa gaaaagcatc
     6121 attttgctat taaatttgct aaaattttga gtatgatatt tccagttggc aagaacaaca
     6181 tatttatatt tattccttag ccataatacc actttcctaa atttcacaaa agtcattctt
     6241 tgcaacttga aactcaatag aaagtgtgta tgtgtgtgtg tgtatatata tatatatata
     6301 cacacacaca catacacaga aaggatgtaa tgaagataca gtaatagttg agcagacctt
     6361 tttagaaaaa catgttttta gctctatctt caaactttct ggcagagggg gtgggggggg
     6421 cagggggagg agtggcatca aaatgctatg cctcctgtta tccacagcct agagttttta
     6481 tatttggaaa gtttagaaaa ttctatcctc gtttctcctt ctttgaatgg cacaaataaa
     6541 tacactacat aaatttttct ggtttgaaag gctctaggcg ataactttat taattcaacc
     6601 tgaaaatatc aagccattaa attttgtccg ggtagaataa atccctgtgg cctcttttaa
     6661 agcaatgtag gtctctgttg cccatggggc atatctgtgt cccaatccac aagagatagg
     6721 accaacaaac aatgaatgtg caacctaact ctttctcctt ggaaagaaga aagtgtgcac
     6781 gaagtagagg agggtgggca gaccctgcct tgcccctcct gttaccccct tctctgtcat
     6841 ttgttcctaa ctccatttca taggcaggct cagaatacct gagtctgaaa atatcaggat
     6901 aacacttgtg aattgtgaca atcactacaa tgtcccatat ctgaggagtt ttttttaatg
     6961 ctatttatcc gctggacacg attgcacatt agggctgcat aatcctctaa ctctagggaa
     7021 aaataaaaac ttttgatttg tcttaagatt cttctccaag gtcgcaaaca agaaattccc
     7081 ctccacaacc aagagatgtg cattttagta acatcagatg tgttcttctg ttttatcaac
     7141 tacttactct tcccacacgc ttagttctaa atctaacctt tcccccctcg aatagggggc
     7201 aggggaggat gaggaaacac tggaacaact gaacacccct gcccattttc tccaagagcc
     7261 ttttgtattc tagcatatct gtgcaatctt ttcttttttc ttcacatgac actgtaagct
     7321 taggcctgaa ataactggga agagagatgc gtatcagaat ttctccgcaa gagctaaaca
     7381 aaacatacat cttccttagc atgaattgga ctgggggcgg agtgggaggg cttggaggaa
     7441 aggggaaaga agggactata tttgaataaa tatgaataaa tgtattagat acttttcaca
     7501 atcagataac ttttaaaaag gtcatttttt atctttctaa taatgtaagc cttaataaaa
     7561 gcaaatctta gtcacaaatt tgaggagact gcccaataat aagtttacat gtatttgaac
     7621 tgaaaaattg ttaaccatgc ttttgctcca agatgtgtga ggccattcag gggctgtagg
     7681 gccctggata tacacacaaa caagtgtgtg tatatctgga gccccacaca ttgtaataaa
     7741 cacagctgca tttatttgac tatgtgatcc catgtacatg taaaaacatt caaacaaaca
     7801 cactcagcgg atttatttat tgtgcaatgg ggcaattatt caaataaaca tgctcaatgc
     7861 aattatttga atctcacatt gcatgttcat caatcatagc actaaaaaaa gagggggaaa
     7921 aaacaccaaa gaattcacat ggggaaaaaa tatatatatg aaaaccacct tattatagat
     7981 tttatagggc agctgaggtt atggctccct tcttaactgt aactcaacta ttctgtattc
     8041 aatgacattt gtttctaatg attaattggt tcactcactt gatcatataa tagcaaactt
     8101 tataaacctg tattgtgtag agatgtgaaa tctctatatt tcaagagcag aagagttctt
     8161 tctagacacc ttacatcaag ggacactggt ccaattatta tcgcttatat aagcactcct
     8221 ataaattctg aaaaatttta tacatgcaac aaaacattcc tacatttgaa gacattaaga
     8281 aaaatcacag gtgactcatc tgatcattct atatattaat aaatattatg acatatatgt
     8341 gaacacatca caaatcatat tggtgtacca agaggcaatt tatgcctctc ttaagtatgt
     8401 actgacataa cctaatatac taaaatggga aggggctttt agtcactgaa atatgcatcg
     8461 tgtaacaaag atgaagaaaa tacatggctt gtgcccatca taaaaaaaga ttcagactga
     8521 aggcttagct ttggtttttt caattaaatt gttaaactgt gcacagtgat ttttttttag
     8581 aacttgagac atttgtgatg ttggctgttt aaatctttgt taccttcgct gtgaattgaa
     8641 attgtacata tttagtaaat catgcagaca aaacaaactt tttagacaat atttttattg
     8701 gagagttttc ttttcctgta tccatgttaa aaaaaaaaaa gacctccttt cccaaaataa
     8761 aaatgtcaat actaaattta aagaagtata aaggaatgat tgcttccttt agagcaaaat
     8821 atttaaataa acatggagat aattggcaac atgttctttt tgggctagta ggctgtgtcc
     8881 aattttttgg gtctgatgtt tcagagggcc tctgtttcag ggttgaagat gatatattaa
     8941 tctcggaatt aaacaaatgc tattaaataa cagaaataaa tccttcagtc ttcatttgta
     9001 tctgaaatgt ggaattagtc agagaaatgg caccgagata atatgatgct gaatatgcca
     9061 caagctaaaa ctttctctat taaacgagtc gcctactacc tataatctag catgacatgt
     9121 taaaatgctc caaaatactg aaaatagaaa atgaacacta ctgttccgat ttggtcttga
     9181 gattaatatg acaaagattc taataatttt agtcaaagaa aatgatgagt aaaaaataca
     9241 tgaagattaa agtgatgaca aatga
//
