LOCUS       NM_001323644            5972 bp    mRNA    linear   PRI 22-MAR-2025
DEFINITION  Homo sapiens zinc finger E-box binding homeobox 1 (ZEB1),
            transcript variant 11, mRNA.
ACCESSION   NM_001323644
VERSION     NM_001323644.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5972)
  AUTHORS   Liu,W., Lin,R., Zhu,C., Chen,Y., Gao,Q. and Zhong,J.
  TITLE     CCT2 Regulates ZEB1-Induced EMT Gene Transcription to Promote the
            Metastasis and Tumorigenesis of Papillary Thyroid Carcinoma
  JOURNAL   Discov Med 36 (188), 1819-1830 (2024)
   PUBMED   39327245
  REMARK    GeneRIF: CCT2 Regulates ZEB1-Induced EMT Gene Transcription to
            Promote the Metastasis and Tumorigenesis of Papillary Thyroid
            Carcinoma.
REFERENCE   2  (bases 1 to 5972)
  AUTHORS   Schwab,A., Rao,Z., Zhang,J., Gollowitzer,A., Siebenkas,K.,
            Bindel,N., D'Avanzo,E., van Roey,R., Hajjaj,Y., Ozel,E.,
            Armstark,I., Bereuter,L., Su,F., Grander,J., Bonyadi Rad,E.,
            Groenewoud,A., Engel,F.B., Bell,G.W., Henry,W.S., Angeli,J.P.F.,
            Stemmler,M.P., Brabletz,S., Koeberle,A. and Brabletz,T.
  TITLE     Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in
            cancer cells by regulating lipogenic enzyme expression and
            phospholipid composition
  JOURNAL   Nat Cell Biol 26 (9), 1470-1481 (2024)
   PUBMED   39009641
  REMARK    GeneRIF: Zeb1 mediates EMT/plasticity-associated ferroptosis
            sensitivity in cancer cells by regulating lipogenic enzyme
            expression and phospholipid composition.
REFERENCE   3  (bases 1 to 5972)
  AUTHORS   Zhang,F., Wang,Y., He,Y. and Dong,B.
  TITLE     Correlation of FBXO45 Expression Levels with Cancer Severity by
            ZEB1 Ubiquitin in Non-Small-Cell Lung Cancer
  JOURNAL   J Environ Pathol Toxicol Oncol 43 (4), 13-23 (2024)
   PUBMED   39016138
  REMARK    GeneRIF: Correlation of FBXO45 Expression Levels with Cancer
            Severity by ZEB1 Ubiquitin in Non-Small-Cell Lung Cancer.
REFERENCE   4  (bases 1 to 5972)
  AUTHORS   Mehta,J.S., Vithana,E.N., Tan,D.T., Yong,V.H., Yam,G.H., Law,R.W.,
            Chong,W.G., Pang,C.P. and Aung,T.
  TITLE     Analysis of the posterior polymorphous corneal dystrophy 3 gene,
            TCF8, in late-onset Fuchs endothelial corneal dystrophy
  JOURNAL   Invest Ophthalmol Vis Sci 49 (1), 184-188 (2008)
   PUBMED   18172091
  REMARK    GeneRIF: The identification of a novel missense mutation in only
            one of the patients implied that TCF8 does not play a significant
            role in the pathogenesis of FECD in this Chinese population.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 5972)
  AUTHORS   Manavella,P.A., Roqueiro,G., Darling,D.S. and Cabanillas,A.M.
  TITLE     The ZFHX1A gene is differentially autoregulated by its isoforms
  JOURNAL   Biochem Biophys Res Commun 360 (3), 621-626 (2007)
   PUBMED   17610840
  REMARK    GeneRIF: The Zfhx1a-1 gene is autoregulated in part by negative
            feedback on its own promoter which is, in turn, modified by the
            availability of the negative dominant isoform Zfhx1a-2.
REFERENCE   6  (bases 1 to 5972)
  AUTHORS   Liskova,P., Tuft,S.J., Gwilliam,R., Ebenezer,N.D., Jirsova,K.,
            Prescott,Q., Martincova,R., Pretorius,M., Sinclair,N., Boase,D.L.,
            Jeffrey,M.J., Deloukas,P., Hardcastle,A.J., Filipec,M. and
            Bhattacharya,S.S.
  TITLE     Novel mutations in the ZEB1 gene identified in Czech and British
            patients with posterior polymorphous corneal dystrophy
  JOURNAL   Hum Mutat 28 (6), 638 (2007)
   PUBMED   17437275
  REMARK    GeneRIF: Four novel pathogenic mutations were identified in four
            families; two deletions, one nonsense, and one duplication within
            exon 7 in the ZEB1 gene at 10p11.2. Czech patients were genotyped
            for a founder haplotype and lack of 20p11.2 locus segregation.
REFERENCE   7  (bases 1 to 5972)
  AUTHORS   Franklin,A.J., Jetton,T.L., Shelton,K.D. and Magnuson,M.A.
  TITLE     BZP, a novel serum-responsive zinc finger protein that inhibits
            gene transcription
  JOURNAL   Mol Cell Biol 14 (10), 6773-6788 (1994)
   PUBMED   7935395
REFERENCE   8  (bases 1 to 5972)
  AUTHORS   Watanabe,Y., Kawakami,K., Hirayama,Y. and Nagano,K.
  TITLE     Transcription factors positively and negatively regulating the
            Na,K-ATPase alpha 1 subunit gene
  JOURNAL   J Biochem 114 (6), 849-855 (1993)
   PUBMED   8138542
REFERENCE   9  (bases 1 to 5972)
  AUTHORS   Williams,T.M., Montoya,G., Wu,Y., Eddy,R.L., Byers,M.G. and
            Shows,T.B.
  TITLE     The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on
            human chromosome 10p11.2
  JOURNAL   Genomics 14 (1), 194-196 (1992)
   PUBMED   1427828
REFERENCE   10 (bases 1 to 5972)
  AUTHORS   Williams,T.M., Moolten,D., Burlein,J., Romano,J., Bhaerman,R.,
            Godillot,A., Mellon,M., Rauscher,F.J. 3rd and Kant,J.A.
  TITLE     Identification of a zinc finger protein that inhibits IL-2 gene
            expression
  JOURNAL   Science 254 (5039), 1791-1794 (1991)
   PUBMED   1840704
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL117340.3, AL158080.21,
            AL355148.9 and AL161935.10.
            
            On Jun 2, 2019 this sequence version replaced NM_001323644.1.
            
            Summary: This gene encodes a zinc finger transcription factor. The
            encoded protein likely plays a role in transcriptional repression
            of interleukin 2. Mutations in this gene have been associated with
            posterior polymorphous corneal dystrophy-3 and late-onset Fuchs
            endothelial corneal dystrophy. Alternatively spliced transcript
            variants encoding different isoforms have been described.[provided
            by RefSeq, Mar 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.117620.1,
                                           SRR1803613.207095.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145313 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-316               AL117340.3         73419-73734
            317-376             AL158080.21        62963-63022
            377-538             AL355148.9         5496-5657
            539-741             AL355148.9         13821-14023
            742-847             AL355148.9         17751-17856
            848-1216            AL355148.9         23274-23642
            1217-2658           AL161935.10        101-1542
            2659-2839           AL161935.10        3539-3719
            2840-5972           AL161935.10        6278-9410
FEATURES             Location/Qualifiers
     source          1..5972
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p11.22"
     gene            1..5972
                     /gene="ZEB1"
                     /gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
                     TCF8; ZFHEP; ZFHX1A"
                     /note="zinc finger E-box binding homeobox 1"
                     /db_xref="GeneID:6935"
                     /db_xref="HGNC:HGNC:11642"
                     /db_xref="MIM:189909"
     exon            1..316
                     /gene="ZEB1"
                     /gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
                     TCF8; ZFHEP; ZFHX1A"
                     /inference="alignment:Splign:2.1.0"
     exon            317..376
                     /gene="ZEB1"
                     /gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
                     TCF8; ZFHEP; ZFHX1A"
                     /inference="alignment:Splign:2.1.0"
     exon            377..538
                     /gene="ZEB1"
                     /gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
                     TCF8; ZFHEP; ZFHX1A"
                     /inference="alignment:Splign:2.1.0"
     exon            539..741
                     /gene="ZEB1"
                     /gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
                     TCF8; ZFHEP; ZFHX1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             712..3432
                     /gene="ZEB1"
                     /gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
                     TCF8; ZFHEP; ZFHX1A"
                     /note="isoform g is encoded by transcript variant 11; zinc
                     finger homeodomain enhancer-binding protein; posterior
                     polymorphous corneal dystrophy 3; delta-crystallin
                     enhancer binding factor 1; transcription factor 8
                     (represses interleukin 2 expression); negative regulator
                     of IL2"
                     /codon_start=1
                     /product="zinc finger E-box-binding homeobox 1 isoform g"
                     /protein_id="NP_001310573.1"
                     /db_xref="GeneID:6935"
                     /db_xref="HGNC:HGNC:11642"
                     /db_xref="MIM:189909"
                     /translation="MTSHKSGRDQRHVTQSGCNRKFKCTECGKAFKYKHHLKEHLRIH
                     SGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVNGRPRTGLKTSQCSSPSLSASP
                     GSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVVASGINCSTPLQNGVFTGG
                     GPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAVDGNVIRQVLENNQANL
                     ASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYSLEQPSQLQVVPQNLKK
                     ENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGDINALPELKHYDL
                     KQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYYALNAQPSAEE
                     LSKIADSVNLPLDVVKKWFEKMQAGQISVQSSEPSSPEPGKVNIPAKNNDQPQSANAN
                     EPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYLYTAEGA
                     QEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKDSCVT
                     DSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIPQVA
                     YTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTE
                     NGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEK
                     PYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQEEAGPEILSNEHVGARAS
                     PSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEE
                     EEVEEAENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTNEA"
     exon            742..847
                     /gene="ZEB1"
                     /gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
                     TCF8; ZFHEP; ZFHX1A"
                     /inference="alignment:Splign:2.1.0"
     exon            848..2658
                     /gene="ZEB1"
                     /gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
                     TCF8; ZFHEP; ZFHX1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2839
                     /gene="ZEB1"
                     /gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
                     TCF8; ZFHEP; ZFHX1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..5972
                     /gene="ZEB1"
                     /gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
                     TCF8; ZFHEP; ZFHX1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5346..5351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZEB1"
                     /gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
                     TCF8; ZFHEP; ZFHX1A"
                     /note="hexamer: AATAAA"
     polyA_site      5370
                     /gene="ZEB1"
                     /gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
                     TCF8; ZFHEP; ZFHX1A"
                     /note="major polyA site"
     regulatory      5926..5931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZEB1"
                     /gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
                     TCF8; ZFHEP; ZFHX1A"
                     /note="hexamer: ATTAAA"
     regulatory      5951..5956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZEB1"
                     /gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
                     TCF8; ZFHEP; ZFHX1A"
                     /note="hexamer: AATAAA"
     polyA_site      5956
                     /gene="ZEB1"
                     /gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
                     TCF8; ZFHEP; ZFHX1A"
     polyA_site      5972
                     /gene="ZEB1"
                     /gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
                     TCF8; ZFHEP; ZFHX1A"
ORIGIN      
        1 agatccctcc ctgccccggg cagccgcggc gggtgtggcc agcgcggagg caggacgccg
       61 ccgagcctcc aactttacct ttccaactcc gacagcccgt cgcctttctg accgcgtccc
      121 tacggtttcc cggcatccgc ctccctctcc ccaccacacc tgaggaaaac ttttccctcg
      181 cccctcaatt caaattcagc agtgcccacg gttgccgcaa accgcccggt ccctagcaac
      241 aaggttccgg ccgtagagcg agagcctcta ggtgtaagga aggtgatgtc gtaaagccgg
      301 gagtgtcgta aaccaggaaa ggaagggcaa gaaatcctgg ggcctgaagc tcaggcagat
      361 gaagcaggat gtacagtaaa agatgatgaa tgcgagtcag atgcagaaaa tgagcaaaac
      421 catgatccta atgttgaaga gtttctacaa caacaagaca ctgctgtcat ttttcctgag
      481 gcacctgaag aggaccagag gcagggcaca ccagaagcca gtggtcatga tgaaaatgga
      541 acaccagatg cattttcaca attactcacc tgtccatatt gtgatagagg ctataaacgc
      601 tttacctctc tgaaagaaca cattaaatat cgtcatgaaa agaatgaaga taactttagt
      661 tgctccctgt gcagttacac ctttgcatac agaacccaac ttgaacgtca catgacatca
      721 cataaatcag gaagagatca aagacatgtg acgcagtctg ggtgtaatcg taaattcaaa
      781 tgcactgagt gtggaaaagc tttcaaatac aaacatcacc taaaagagca cttaagaatt
      841 cacagtggag agaagccata tgaatgccca aactgcaaga aacgcttttc ccattctggc
      901 tcctatagct cacacataag cagtaagaaa tgtatcagct tgatacctgt gaatgggcga
      961 ccaagaacag gactcaagac atctcagtgt tcttcaccgt ctctttcagc atcaccaggc
     1021 agtcccacac gaccacagat acggcaaaag atagagaata aaccccttca agaacaactt
     1081 tctgttaacc aaattaaaac tgaacctgtg gattatgaat tcaaacccat agtggttgct
     1141 tcaggaatca actgttcaac ccctttacaa aatggggttt tcactggtgg tggcccatta
     1201 caggcaacca gttctcctca gggcatggtg caagctgttg ttctgccaac agttggtttg
     1261 gtgtctccca taagtatcaa tttaagtgat attcagaatg tacttaaagt ggcggtagat
     1321 ggtaatgtaa taaggcaagt gttggagaat aatcaagcca atcttgcatc caaagaacaa
     1381 gaaacaatca atgcttcacc catacaacaa ggtggccatt ctgttatttc agccatcagt
     1441 cttcctttgg ttgatcaaga tggaacaacc aaaattatca tcaactacag tcttgagcag
     1501 cctagccaac ttcaagttgt tcctcaaaat ttaaaaaaag aaaatccagt cgctacaaac
     1561 agttgtaaaa gtgaaaagtt accagaagat cttactgtta agtctgagaa ggacaaaagc
     1621 tttgaagggg gggtgaatga tagcacttgt cttctgtgtg atgattgtcc aggagatatt
     1681 aatgcacttc cagaattaaa gcactatgac ctaaagcagc ctactcagcc tcctccactc
     1741 cctgcagcag aagctgagaa gcctgagtcc tctgtttcat cagctactgg agatggcaat
     1801 ttgtctccta gtcagccacc tttaaagaac ctcttgtctc tcctaaaagc atattatgct
     1861 ttgaatgcac aaccaagtgc agaagagctc tcaaaaattg ctgattcagt aaacctacca
     1921 ctggatgtag taaaaaagtg gtttgaaaag atgcaagctg gacagatttc agtgcagtct
     1981 tctgaaccat cttctcctga accaggcaaa gtaaatatcc ctgccaagaa caatgatcag
     2041 cctcaatctg caaatgcaaa tgaaccccag gacagcacag taaatctaca aagtcctttg
     2101 aagatgacta actccccagt tttaccagtg ggatcaacca ccaatggttc cagaagtagt
     2161 acaccatccc catcacctct aaacctttcc tcatccagaa atacacaggg ttacttgtac
     2221 acagctgagg gtgcacaaga agagccacaa gtagaacctc ttgatctttc actaccaaag
     2281 caacagggag aattattaga aaggtcaact atcactagtg tttaccagaa cagtgtttat
     2341 tctgtccagg aagaaccctt gaacttgtct tgcgcaaaaa aggagccaca aaaggacagt
     2401 tgtgttacag actcagaacc agttgtaaat gtaatcccac caagtgccaa ccccataaat
     2461 atcgctatac ctacagtcac tgcccagtta cccacaatcg tggccattgc tgaccagaac
     2521 agtgttccat gcttaagagc gctagctgcc aataagcaaa cgattctgat tccccaggtg
     2581 gcatacacct actcaactac ggtcagccct gcagtccaag aaccaccctt gaaagtgatc
     2641 cagccaaatg gaaatcagga tgaaagacaa gatactagct cagaaggagt atcaaatgta
     2701 gaggatcaga atgactctga ttctacaccg cccaaaaaga aaatgcggaa gacagaaaat
     2761 ggaatgtatg cttgtgattt gtgtgacaag atattccaaa agagtagttc attattgaga
     2821 cataaatatg aacacacagg taaaagacct catgagtgtg gaatctgtaa aaaggcattt
     2881 aaacacaaac atcatttgat tgaacacatg cgattacatt ctggagaaaa gccctatcaa
     2941 tgtgacaaat gtggaaagcg cttctcacac tctgggtctt attctcaaca catgaatcat
     3001 cgctactcct actgtaagag agaagcggaa gaacgtgaca gcacagagca ggaagaggca
     3061 gggcctgaaa tcctctcgaa tgagcacgtg ggtgccaggg cgtctccctc acagggcgac
     3121 tcggacgaga gagagagttt gacaagggaa gaggatgaag acagtgaaaa agaggaagag
     3181 gaggaggata aagagatgga agaattgcag gaagaaaaag aatgtgaaaa accacaaggg
     3241 gatgaggaag aggaggagga ggaggaagaa gtggaagaag aagaggtaga agaggcagag
     3301 aatgagggag aagaagcaaa aactgaaggt ctgatgaagg atgacagggc tgaaagtcaa
     3361 gcaagcagct taggacaaaa agtaggcgag agtagtgagc aagtgtctga agaaaagaca
     3421 aatgaagcct aatcgttttt ctagaaggaa aataaattct aattgataat gaatttcgtt
     3481 caatattatc cttgcttttc atggaaacac agtaacctgt atgctgtgat tcctgttcac
     3541 tactgtgtaa agtaaaaact aaaaaaatac aaaatacaaa acacacacac acacacacac
     3601 acacacacac acacacacac aaaataaatc cgggtgtgcc tgaacctcag acctagtaat
     3661 ttttcatgca gttttcaaag ttaggaacaa gtttgtaaca tgcagcagat tagaaaacct
     3721 taatgactca gagagcaaca atacaagagg ttaaaggaag ctgattaatt agatatgcat
     3781 ctggcattgt tttatcttat cagtattatc actcttatgt tggtttattc ttaagctgta
     3841 caattgggag aaattttata attttttatt ggtaaacata tgctaaatcc gcttcagtat
     3901 tttattatgt tttttaaaat gtgagaactt ctgcactaca aaattccctt cacagagaag
     3961 tataatgtag ttccaacccg tgctaactac cttttataaa ttcagtctag aaggtagtaa
     4021 tttctaatat ttagatgtct tagtagagcg tattatcatt taaagtgtat tgttagcctt
     4081 aagaaagcag ctgatagaag aactgaagtt tcttactcac gtggtttaaa atggagttca
     4141 aaagattgcc attgagttct gattgcaggg actaacaatg ttaatctgat aaggacagca
     4201 aaatcatcag aatcagtgtt tgtgattgtg tttgaatatg tggtaacata tgaaggatat
     4261 gacatgaagc tttgtatctc ctttggcctt aagcaagacc tgtgtgctgt aagtgccatt
     4321 tctcagtatt ttcaaggctc taacccgcct tcatccaatg tgtggcctac aataactagc
     4381 atttgttgat ttgtctcttg tatcaaaatt cccaaataaa acttaaaacc actgactctg
     4441 tcagagaaac tgaaacactg ggacatttca tccttcaatt cctcggtatt gattttatgt
     4501 tgattgattt tcagaatttc tctacagaaa cgaaagggaa attttctaat ctgctttatc
     4561 catgtacttg catttcagac atggacatgc tattgttatt tggctcataa ctgtttccaa
     4621 atgttagtta ttatggaccc aatttattaa caacattagc tgatttttac ctatcagtat
     4681 tattttattt cttttagttt atagatctgt gcaacatttt tgtactgtat gtcttcaaac
     4741 ctggcagtat taataccctt cttactgaca tatgtacttt tagttttaga aaacttttat
     4801 atttatgtgt cttattttta tatttcttta tttattacac agtgtagtgt ataatactgt
     4861 agtttgtatt aatacaataa tatattttag tatgaaaatt tggaaagttg ataagattta
     4921 aagtagagat gcaattggtt ctcctgcatt gagatttgat ttaacagtgt tatgttaaca
     4981 tttatacttg ccttggactg tagaacagaa cttaaatggg aatgtattag ttttacaact
     5041 acaatcaagt cattttacct ttacccagtt tttaatataa aacttaaatt ttgaaattca
     5101 ctgtgtgact aatagcatga tgctctgcag ttttattaag aaatcagcct aaccatacaa
     5161 ctctcatttc cttagtaagc caaattagga ttaacttcta taaacagtgt tgggaacaat
     5221 gtttaacatt ttgtgccaat ttgttcctgt attcatgtat gtaagttaca gatctgactc
     5281 ttcattttta agttccttgt tacatcatgg tcattttcta gttttttacc agactcccat
     5341 ctcacaataa aatgcatcaa caagcctgaa ctgctgtcat tcttttcatc attatcagta
     5401 ttttctttgg aaaactgtga aatggggtac attgtcatcc tgcatttgat tcatcttgag
     5461 ctgaatttgg gtaacactaa atgttttaga cattctccac taaattatgg attttcttgt
     5521 ggctaaatgt ttctggagag gtcagagttg acaaaacctc ttcacaggtt gctccttctt
     5581 cctgaaatcc ttaatcctcc gcatttcatg cttcaggtca tttcagggaa gcctgggttt
     5641 agatgccttt ctgactctca gctcctgcac ttctgtcatc atacctctga tactattatt
     5701 tatattcctt ccccactagg aacaggaacc acatttgtca tagtcactct cacattcctc
     5761 actgcctaac agggtgcctg gcataagttg ggacaacaga tatttgttga ataaaaatat
     5821 aatttgcatg tttatggagc tcagctatgt tctcactttt tttgcttcta attccagaat
     5881 atatgttaaa tgatctaata atttgattat tttcttataa gtcttattaa acactagtca
     5941 taatagacac aataaattat gccttctttt tc
//
