LOCUS       NM_016032               4571 bp    mRNA    linear   PRI 06-MAR-2025
DEFINITION  Homo sapiens zDHHC palmitoyltransferase 9 (ZDHHC9), transcript
            variant 1, mRNA.
ACCESSION   NM_016032
VERSION     NM_016032.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4571)
  AUTHORS   Du,G., Healy,L.B., David,L., Walker,C., El-Baba,T.J.,
            Lutomski,C.A., Goh,B., Gu,B., Pi,X., Devant,P., Fontana,P.,
            Dong,Y., Ma,X., Miao,R., Balasubramanian,A., Puthenveetil,R.,
            Banerjee,A., Luo,H.R., Kagan,J.C., Oh,S.F., Robinson,C.V.,
            Lieberman,J. and Wu,H.
  TITLE     ROS-dependent S-palmitoylation activates cleaved and intact
            gasdermin D
  JOURNAL   Nature 630 (8016), 437-446 (2024)
   PUBMED   38599239
REFERENCE   2  (bases 1 to 4571)
  AUTHORS   Balasubramanian,A., Hsu,A.Y., Ghimire,L., Tahir,M., Devant,P.,
            Fontana,P., Du,G., Liu,X., Fabin,D., Kambara,H., Xie,X., Liu,F.,
            Hasegawa,T., Xu,R., Yu,H., Chen,M., Kolakowski,S., Trauger,S.,
            Larsen,M.R., Wei,W., Wu,H., Kagan,J.C., Lieberman,J. and Luo,H.R.
  TITLE     The palmitoylation of gasdermin D directs its membrane
            translocation and pore formation during pyroptosis
  JOURNAL   Sci Immunol 9 (94), eadn1452 (2024)
   PUBMED   38530158
REFERENCE   3  (bases 1 to 4571)
  AUTHORS   Fan,Y., Gao,Y., Nie,L., Hou,T., Dan,W., Wang,Z., Liu,T., Wei,Y.,
            Wang,Y., Liu,B., Que,T., Lei,Y., Zeng,J., Ma,J., Wei,W. and Li,L.
  TITLE     Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the
            response to anti-tumor immunotherapy
  JOURNAL   Mol Cell 83 (19), 3520-3532 (2023)
   PUBMED   37802025
REFERENCE   4  (bases 1 to 4571)
  AUTHORS   Li,Z., Jiang,D., Liu,F. and Li,Y.
  TITLE     Involvement of ZDHHC9 in lung adenocarcinoma: regulation of PD-L1
            stability via palmitoylation
  JOURNAL   In Vitro Cell Dev Biol Anim 59 (3), 193-203 (2023)
   PUBMED   37002491
  REMARK    GeneRIF: Involvement of ZDHHC9 in lung adenocarcinoma: regulation
            of PD-L1 stability via palmitoylation.
REFERENCE   5  (bases 1 to 4571)
  AUTHORS   Greaves,J. and Chamberlain,L.H.
  TITLE     DHHC palmitoyl transferases: substrate interactions and
            (patho)physiology
  JOURNAL   Trends Biochem Sci 36 (5), 245-253 (2011)
   PUBMED   21388813
  REMARK    GeneRIF: Studies indicate that mutations in DHHC9 were associated
            with X-linked mental retardation.
            Review article
REFERENCE   6  (bases 1 to 4571)
  AUTHORS   Jennings,B.C., Nadolski,M.J., Ling,Y., Baker,M.B., Harrison,M.L.,
            Deschenes,R.J. and Linder,M.E.
  TITLE     2-Bromopalmitate and
            2-(2-hydroxy-5-nitro-benzylidene)-benzo[b]thiophen-3-one inhibit
            DHHC-mediated palmitoylation in vitro
  JOURNAL   J Lipid Res 50 (2), 233-242 (2009)
   PUBMED   18827284
REFERENCE   7  (bases 1 to 4571)
  AUTHORS   Mansilla,F., Birkenkamp-Demtroder,K., Kruhoffer,M., Sorensen,F.B.,
            Andersen,C.L., Laiho,P., Aaltonen,L.A., Verspaget,H.W. and
            Orntoft,T.F.
  TITLE     Differential expression of DHHC9 in microsatellite stable and
            instable human colorectal cancer subgroups
  JOURNAL   Br J Cancer 96 (12), 1896-1903 (2007)
   PUBMED   17519897
  REMARK    GeneRIF: DHHC9 is a gastrointestinal-related protein highly
            expressed in microsatellite stable colorectal cancers.
REFERENCE   8  (bases 1 to 4571)
  AUTHORS   Raymond,F.L., Tarpey,P.S., Edkins,S., Tofts,C., O'Meara,S.,
            Teague,J., Butler,A., Stevens,C., Barthorpe,S., Buck,G., Cole,J.,
            Dicks,E., Gray,K., Halliday,K., Hills,K., Hinton,J., Jones,D.,
            Menzies,A., Perry,J., Raine,K., Shepherd,R., Small,A., Varian,J.,
            Widaa,S., Mallya,U., Moon,J., Luo,Y., Shaw,M., Boyle,J., Kerr,B.,
            Turner,G., Quarrell,O., Cole,T., Easton,D.F., Wooster,R.,
            Bobrow,M., Schwartz,C.E., Gecz,J., Stratton,M.R. and Futreal,P.A.
  TITLE     Mutations in ZDHHC9, which encodes a palmitoyltransferase of NRAS
            and HRAS, cause X-linked mental retardation associated with a
            Marfanoid habitus
  JOURNAL   Am J Hum Genet 80 (5), 982-987 (2007)
   PUBMED   17436253
REFERENCE   9  (bases 1 to 4571)
  AUTHORS   Ohno,Y., Kihara,A., Sano,T. and Igarashi,Y.
  TITLE     Intracellular localization and tissue-specific distribution of
            human and yeast DHHC cysteine-rich domain-containing proteins
  JOURNAL   Biochim Biophys Acta 1761 (4), 474-483 (2006)
   PUBMED   16647879
REFERENCE   10 (bases 1 to 4571)
  AUTHORS   Swarthout,J.T., Lobo,S., Farh,L., Croke,M.R., Greentree,W.K.,
            Deschenes,R.J. and Linder,M.E.
  TITLE     DHHC9 and GCP16 constitute a human protein fatty acyltransferase
            with specificity for H- and N-Ras
  JOURNAL   J Biol Chem 280 (35), 31141-31148 (2005)
   PUBMED   16000296
  REMARK    GeneRIF: Data show that H- and N-Ras are palmitoylated by a human
            protein palmitoyltransferase encoded by the ZDHHC9 and GCP16 genes.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA493628.1, BC003128.1 and
            AL359542.13.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_016032.3.
            
            Summary: This gene encodes an integral membrane protein that is a
            member of the zinc finger DHHC domain-containing protein family.
            The encoded protein forms a complex with golgin subfamily A member
            7 and functions as a palmitoyltransferase. This protein
            specifically palmitoylates HRAS and NRAS. Mutations in this gene
            are associated with X-linked cognitive disability. Alternate
            splicing results in multiple transcript variants that encode the
            same protein.[provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (1) is the longer transcript and
            both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853562.33890.1,
                                           SRR11853563.35554.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357166.11/ ENSP00000349689.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DA493628.1         49-62
            15-2530             BC003128.1         1-2516
            2531-4571           AL359542.13        2037-4077           c
FEATURES             Location/Qualifiers
     source          1..4571
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.1"
     gene            1..4571
                     /gene="ZDHHC9"
                     /gene_synonym="CGI89; CXorf11; DHHC9; MMSA1; MRXSR; MRXSZ;
                     ZDHHC10; ZNF379; ZNF380"
                     /note="zDHHC palmitoyltransferase 9"
                     /db_xref="GeneID:51114"
                     /db_xref="HGNC:HGNC:18475"
                     /db_xref="MIM:300646"
     exon            1..191
                     /gene="ZDHHC9"
                     /gene_synonym="CGI89; CXorf11; DHHC9; MMSA1; MRXSR; MRXSZ;
                     ZDHHC10; ZNF379; ZNF380"
                     /inference="alignment:Splign:2.1.0"
     exon            192..259
                     /gene="ZDHHC9"
                     /gene_synonym="CGI89; CXorf11; DHHC9; MMSA1; MRXSR; MRXSZ;
                     ZDHHC10; ZNF379; ZNF380"
                     /inference="alignment:Splign:2.1.0"
     exon            260..561
                     /gene="ZDHHC9"
                     /gene_synonym="CGI89; CXorf11; DHHC9; MMSA1; MRXSR; MRXSZ;
                     ZDHHC10; ZNF379; ZNF380"
                     /inference="alignment:Splign:2.1.0"
     CDS             395..1489
                     /gene="ZDHHC9"
                     /gene_synonym="CGI89; CXorf11; DHHC9; MMSA1; MRXSR; MRXSZ;
                     ZDHHC10; ZNF379; ZNF380"
                     /EC_number="2.3.1.225"
                     /note="Asp-His-His-Cys domain containing protein 9; zinc
                     finger, DHHC domain containing 10; antigen MMSA-1; zinc
                     finger protein 379; zinc finger protein 380; zinc finger
                     DHHC-type containing 9; zinc finger DHHC-type
                     palmitoyltransferase 9"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC9"
                     /protein_id="NP_057116.2"
                     /db_xref="CCDS:CCDS35395.1"
                     /db_xref="GeneID:51114"
                     /db_xref="HGNC:HGNC:18475"
                     /db_xref="MIM:300646"
                     /translation="MSVMVVRKKVTRKWEKLPGRNTFCCDGRVMMARQKGIFYLTLFL
                     ILGTCTLFFAFECRYLAVQLSPAIPVFAAMLFLFSMATLLRTSFSDPGVIPRALPDEA
                     AFIEMEIEATNGAVPQGQRPPPRIKNFQINNQIVKLKYCYTCKIFRPPRASHCSICDN
                     CVERFDHHCPWVGNCVGKRNYRYFYLFILSLSLLTIYVFAFNIVYVALKSLKIGFLET
                     LKETPGTVLEVLICFFTLWSVVGLTGFHTFLVALNQTTNEDIKGSWTGKNRVQNPYSH
                     GNIVKNCCEVLCGPLPPSVLDRRGILPLEESGSRPPSTQETSSSLLPQSPAPTEHLNS
                     NEMPEDSSTPEEMPPPEPPEPPQEAAEAEK"
     exon            562..722
                     /gene="ZDHHC9"
                     /gene_synonym="CGI89; CXorf11; DHHC9; MMSA1; MRXSR; MRXSZ;
                     ZDHHC10; ZNF379; ZNF380"
                     /inference="alignment:Splign:2.1.0"
     exon            723..881
                     /gene="ZDHHC9"
                     /gene_synonym="CGI89; CXorf11; DHHC9; MMSA1; MRXSR; MRXSZ;
                     ZDHHC10; ZNF379; ZNF380"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1019
                     /gene="ZDHHC9"
                     /gene_synonym="CGI89; CXorf11; DHHC9; MMSA1; MRXSR; MRXSZ;
                     ZDHHC10; ZNF379; ZNF380"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1068
                     /gene="ZDHHC9"
                     /gene_synonym="CGI89; CXorf11; DHHC9; MMSA1; MRXSR; MRXSZ;
                     ZDHHC10; ZNF379; ZNF380"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1171
                     /gene="ZDHHC9"
                     /gene_synonym="CGI89; CXorf11; DHHC9; MMSA1; MRXSR; MRXSZ;
                     ZDHHC10; ZNF379; ZNF380"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1275
                     /gene="ZDHHC9"
                     /gene_synonym="CGI89; CXorf11; DHHC9; MMSA1; MRXSR; MRXSZ;
                     ZDHHC10; ZNF379; ZNF380"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1372
                     /gene="ZDHHC9"
                     /gene_synonym="CGI89; CXorf11; DHHC9; MMSA1; MRXSR; MRXSZ;
                     ZDHHC10; ZNF379; ZNF380"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..4571
                     /gene="ZDHHC9"
                     /gene_synonym="CGI89; CXorf11; DHHC9; MMSA1; MRXSR; MRXSZ;
                     ZDHHC10; ZNF379; ZNF380"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2902..2907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC9"
                     /gene_synonym="CGI89; CXorf11; DHHC9; MMSA1; MRXSR; MRXSZ;
                     ZDHHC10; ZNF379; ZNF380"
                     /note="hexamer: ATTAAA"
     polyA_site      2923
                     /gene="ZDHHC9"
                     /gene_synonym="CGI89; CXorf11; DHHC9; MMSA1; MRXSR; MRXSZ;
                     ZDHHC10; ZNF379; ZNF380"
                     /note="major polyA site"
     regulatory      4488..4493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC9"
                     /gene_synonym="CGI89; CXorf11; DHHC9; MMSA1; MRXSR; MRXSZ;
                     ZDHHC10; ZNF379; ZNF380"
                     /note="hexamer: AAGAAA"
     polyA_site      4520
                     /gene="ZDHHC9"
                     /gene_synonym="CGI89; CXorf11; DHHC9; MMSA1; MRXSR; MRXSZ;
                     ZDHHC10; ZNF379; ZNF380"
     regulatory      4546..4551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC9"
                     /gene_synonym="CGI89; CXorf11; DHHC9; MMSA1; MRXSR; MRXSZ;
                     ZDHHC10; ZNF379; ZNF380"
                     /note="hexamer: AATACA"
     polyA_site      4571
                     /gene="ZDHHC9"
                     /gene_synonym="CGI89; CXorf11; DHHC9; MMSA1; MRXSR; MRXSZ;
                     ZDHHC10; ZNF379; ZNF380"
ORIGIN      
        1 ccatttggcc agtggtgggc ggttgccaca gctggtttag ggccccgacc actggggccc
       61 cttgtcagga ggagacagcc tcccggcccg gggaggacaa gtcgctgcca cctttggctg
      121 ccgacgtgat tccctgggac ggtccgtttc ctgccgtcag ctgccggccg agttgggtct
      181 ccgtggttca ggccggctcc cccttcctgg tctcccttct cccgctgggc cggtttatcg
      241 ggaggagatt gtcttccagg gctagcaatt ggacttttga tgatgtttga cccagcggca
      301 ggaatagcag gcaacgtgat ttcaaagctg ggctcagcct ctgtttcttc tctcgtgtaa
      361 tcgcaaaacc cattttggag caggaattcc aatcatgtct gtgatggtgg tgagaaagaa
      421 ggtgacacgg aaatgggaga aactcccagg caggaacacc ttttgctgtg atggccgcgt
      481 catgatggcc cggcaaaagg gcattttcta cctgaccctt ttcctcatcc tggggacatg
      541 tacactcttc ttcgcctttg agtgccgcta cctggctgtt cagctgtctc ctgccatccc
      601 tgtatttgct gccatgctct tccttttctc catggctaca ctgttgagga ccagcttcag
      661 tgaccctgga gtgattcctc gggcgctacc agatgaagca gctttcatag aaatggagat
      721 agaagctacc aatggtgcgg tgccccaggg ccagcgacca ccgcctcgta tcaagaattt
      781 ccagataaac aaccagattg tgaaactgaa atactgttac acatgcaaga tcttccggcc
      841 tccccgggcc tcccattgca gcatctgtga caactgtgtg gagcgcttcg accatcactg
      901 cccctgggtg gggaattgtg ttggaaagag gaactaccgc tacttctacc tcttcatcct
      961 ttctctctcc ctcctcacaa tctatgtctt cgccttcaac atcgtctatg tggccctcaa
     1021 atctttgaaa attggcttct tggagacatt gaaagaaact cctggaactg ttctagaagt
     1081 cctcatttgc ttctttacac tctggtccgt cgtgggactg actggatttc atactttcct
     1141 cgtggctctc aaccagacaa ccaatgaaga catcaaagga tcatggacag ggaagaatcg
     1201 cgtccagaat ccctacagcc atggcaatat tgtgaagaac tgctgtgaag tgctgtgtgg
     1261 ccccttgccc cccagtgtgc tggatcgaag gggtattttg ccactggagg aaagtggaag
     1321 tcgacctccc agtactcaag agaccagtag cagcctcttg ccacagagcc cagcccccac
     1381 agaacacctg aactcaaatg agatgccgga ggacagcagc actcccgaag agatgccacc
     1441 tccagagccc ccagagccac cacaggaggc agctgaagct gagaagtagc ctatctatgg
     1501 aagagacttt tgtttgtgtt taattagggc tatgagagat ttcaggtgag aagttaaacc
     1561 tgagacagag agcaagtaag ctgtcccttt taactgtttt tctttggtct ttagtcaccc
     1621 agttgcacac tggcattttc ttgctgcaag cttttttaaa tttctgaact caaggcagtg
     1681 gcagaagatg tcagtcacct ctgataactg gaaaaatggg tctcttgggc cctggcactg
     1741 gttctccatg gcctcagcca cagggtcccc ttggaccccc tctcttccct ccagatccca
     1801 gccctcctgc ttggggtcac tggtctcatt ctggggctaa aagtttttga gactggctca
     1861 aatcctccca agctgctgca cgtgctgagt ccagaggcag tcacagagac ctctggccag
     1921 gggatcctaa ctgggttctt ggggtcttca ggactgaaga ggagggagag tggggtcaga
     1981 agattctcct ggccaccaag tgccagcatt gcccacaaat ccttttagga atgggacagg
     2041 taccttccac ttgttgtatt tattagtgta gcttctcctt tgtctcccat ccactctgac
     2101 acctaagccc cactcttttc ccattagata tatgtaagta gttgtagtag agataataat
     2161 tgacatttct cgtagactac ccagaaactt ttttaatacc tgtgccattc tcaataagaa
     2221 tttatgagat gccagcggca tagcccttca cactctctgt ctcatctctc ctcctttctc
     2281 attagcccct tttaatttgt ttttcctttt gactcctgct cccattagga gcaggaatgg
     2341 cagtaataaa agtctgcact ttggtcattt cttttcctca gaggaagcct gagtgctcac
     2401 ttaaacacta tcccctcaga ctccctgtgt gaggcctgca gaggccctga atgcacaaat
     2461 gggaaaccaa ggcacagaga ggctctcctc tcctctcctc tcccccgatg taccctcaaa
     2521 aaaaaaaaaa tgctaaccag ttcttccatt aagcctcggc tgagtgaggg aaagcccagc
     2581 actgctgccc tctcgggtaa ctcaccctaa ggcctcggcc cacctctggc tatggtaacc
     2641 acactggggg cttcctccaa gccccgctct tccagcactt ccaccggcag agtcccagag
     2701 ccacttcacc ctgggggtgg gctgtggccc ccagtcagct ctgctcagga cctgctctat
     2761 ttcagggaag aagatttatg tattatatgt ggctatattt cctagagcac ctgtgttttc
     2821 ctctttctaa gccagggtcc tgtctggatg acttatgcgg tgggggagtg taaaccagaa
     2881 cttttcatct atttgaaggc gattaaactg tgtctaatgc aaacttcctg cctcctcctt
     2941 cccccttcca tttcaagaat atgtttgtgt gtagggtggg ggtgggggtt ggaaggggtt
     3001 gcttgttact ccccaaactt ccattaacca gggcaccctt gggttggaga ggtagttcca
     3061 aactctccat tgatctatac tacattctgg gctgaaggtt ttcttattct ggactatgaa
     3121 gaaaggactt tcaaggagat atagtgtgaa caggatcagg aaggtagagg gattatattt
     3181 acttaagaga acaagctcta tattaggata ttgttttgaa gcagatggat gccgttaatt
     3241 gctaataagt cttagttatt aacgcaggct catcagggcc cccccttgga aatatttgat
     3301 cagtggtctt ttacaagtga tggtatatat ttctttctag gtggtgtata atcaagactc
     3361 cctatcaatt cccatctcat acttcccagt taattggaat taatgaaatt tggctgctcc
     3421 cagacctttt tccatgtctt cctttttcct tttaacagga tttaagttga gcattcttga
     3481 gagagagaga gagagagaga ttggaagaga gatggggaga gactgactca gatccctctc
     3541 ctgtctgctt ctttttctgg ttctctcagt tttttttctt gaagttataa agccaaacct
     3601 ggagaatttg taagttgtta ggtttcccca ggtaacttgg cactcatatg aaccccattt
     3661 taataagtac tcagcccatc tcctctcctg ggctcagatg gctctctctc ctccctcacc
     3721 ttacctcaag tgttctcctg aggaccctta ggtcagacag agaagctttc tctttctgat
     3781 gggaagggtc aaagtggaaa tctcttatct ctagtgtgaa atgattttct gctttttcat
     3841 actccctgcc ctctttcttt tccttaataa atcttccatg tttaagatgt tggcctgaag
     3901 atctgtccca ttcataccat gcaccagctg ggactgtccc tatctgatca gaggggagat
     3961 taaagaatca atgttcccag gggaaaaggg ccttaaattg tttggtcttt tcaatggctg
     4021 acactgtctc caactctccc cttcctcctt cttcctcaag cttcctatgc accctacttt
     4081 cccaggccag gatggttggc actgatccca aacctctggg ggcaggtgga aattggctgt
     4141 ggtgagccat ttcttcatgt ccattcagct ctgaggcctt cctggcccta gctgagatca
     4201 tcatctcctc ctttgctttt accccaggag tgaggttggg ttagaggtgg attctgattc
     4261 cgtagcagct aaattccatt ctccctgtcc tgaccatcct gcctttaccc ataaagcacc
     4321 cgttcctact gaccaaatct ctttactttg ttggagaaaa aaagtatttt gtttttaaat
     4381 ctattttcta atttaaatgc aatttaatat gtaaatctct gcacttttgt gtgagcctac
     4441 aaatgtgtat gtgttggggg tttttcactc tctggtattt cttaataaag aaatctttct
     4501 tttgggggga agccaattaa tgaaggagcc ttgaatggtt ttagaaatac agggctgtct
     4561 gtttctttgt g
//
