LOCUS       NM_013373               5049 bp    mRNA    linear   PRI 06-MAR-2025
DEFINITION  Homo sapiens zDHHC palmitoyltransferase 8 (ZDHHC8), transcript
            variant 2, mRNA.
ACCESSION   NM_013373
VERSION     NM_013373.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5049)
  AUTHORS   Wang,Z., Wang,Y., Shen,N., Liu,Y., Xu,X., Zhu,R., Jiang,H., Wu,X.,
            Wei,Y. and Tang,J.
  TITLE     AMPKalpha1-mediated ZDHHC8 phosphorylation promotes the
            palmitoylation of SLC7A11 to facilitate ferroptosis resistance in
            glioblastoma
  JOURNAL   Cancer Lett 584, 216619 (2024)
   PUBMED   38211651
  REMARK    GeneRIF: AMPKalpha1-mediated ZDHHC8 phosphorylation promotes the
            palmitoylation of SLC7A11 to facilitate ferroptosis resistance in
            glioblastoma.
REFERENCE   2  (bases 1 to 5049)
  AUTHORS   Mesquita,F.S., Abrami,L., Sergeeva,O., Turelli,P., Qing,E.,
            Kunz,B., Raclot,C., Paz Montoya,J., Abriata,L.A., Gallagher,T., Dal
            Peraro,M., Trono,D., D'Angelo,G. and van der Goot,F.G.
  TITLE     S-acylation controls SARS-CoV-2 membrane lipid organization and
            enhances infectivity
  JOURNAL   Dev Cell 56 (20), 2790-2807 (2021)
   PUBMED   34599882
REFERENCE   3  (bases 1 to 5049)
  AUTHORS   Moraes,L.S., Santos,A.C.C., Ferreira-Fernandes,H., Yoshioka,F.K.N.,
            Teixeira,S.S., Guimaraes,A.C., da Rocha,C.A.M., Rey,J.A.,
            Pinto,G.R. and Burbano,R.R.
  TITLE     Lack of association between COMT Val158Met and ZDHHC8 rs175174
            polymorphisms and susceptibility to schizophrenia in a Brazilian
            population
  JOURNAL   Psychiatr Genet 27 (5), 197-198 (2017)
   PUBMED   28562378
  REMARK    GeneRIF: the association between the COMT Val158Met and ZDHHC8
            rs175174 single nucleotide polymorphism and the susceptibility to
            schizophrenia through a case-control study involving a population
            from the North Region of Brazil, was investigated.
REFERENCE   4  (bases 1 to 5049)
  AUTHORS   Moutin,E., Nikonenko,I., Stefanelli,T., Wirth,A., Ponimaskin,E., De
            Roo,M. and Muller,D.
  TITLE     Palmitoylation of cdc42 Promotes Spine Stabilization and Rescues
            Spine Density Deficit in a Mouse Model of 22q11.2 Deletion Syndrome
  JOURNAL   Cereb Cortex 27 (7), 3618-3629 (2017)
   PUBMED   27365300
REFERENCE   5  (bases 1 to 5049)
  AUTHORS   Ivatt,R.M., Sanchez-Martinez,A., Godena,V.K., Brown,S., Ziviani,E.
            and Whitworth,A.J.
  TITLE     Genome-wide RNAi screen identifies the Parkinson disease GWAS risk
            locus SREBF1 as a regulator of mitophagy
  JOURNAL   Proc Natl Acad Sci U S A 111 (23), 8494-8499 (2014)
   PUBMED   24912190
REFERENCE   6  (bases 1 to 5049)
  AUTHORS   Otani,K., Ujike,H., Tanaka,Y., Morita,Y., Kishimoto,M., Morio,A.,
            Uchida,N., Nomura,A. and Kuroda,S.
  TITLE     The ZDHHC8 gene did not associate with bipolar disorder or
            schizophrenia
  JOURNAL   Neurosci Lett 390 (3), 166-170 (2005)
   PUBMED   16150541
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5049)
  AUTHORS   Glaser,B., Schumacher,J., Williams,H.J., Jamra,R.A., Ianakiev,N.,
            Milev,R., Ohlraun,S., Schulze,T.G., Czerski,P.M., Hauser,J.,
            Jonsson,E.G., Sedvall,G.C., Klopp,N., Illig,T., Becker,T.,
            Propping,P., Williams,N.M., Cichon,S., Kirov,G., Rietschel,M.,
            Murphy,K.C., O'Donovan,M.C., Nothen,M.M. and Owen,M.J.
  TITLE     No association between the putative functional ZDHHC8 single
            nucleotide polymorphism rs175174 and schizophrenia in large
            European samples
  JOURNAL   Biol Psychiatry 58 (1), 78-80 (2005)
   PUBMED   15992527
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 5049)
  AUTHORS   Saito,S., Ikeda,M., Iwata,N., Suzuki,T., Kitajima,T.,
            Yamanouchi,Y., Kinoshita,Y., Takahashi,N., Inada,T. and Ozaki,N.
  TITLE     No association was found between a functional SNP in ZDHHC8 and
            schizophrenia in a Japanese case-control population
  JOURNAL   Neurosci Lett 374 (1), 21-24 (2005)
   PUBMED   15631889
  REMARK    GeneRIF: Because our sample size provided quite high power, ZDHHC8
            may not play a major role in Japanese schizophrenia and our results
            did not support the gender-specific effect of this SNP.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 5049)
  AUTHORS   Chen,W.Y., Shi,Y.Y., Zheng,Y.L., Zhao,X.Z., Zhang,G.J., Chen,S.Q.,
            Yang,P.D. and He,L.
  TITLE     Case-control study and transmission disequilibrium test provide
            consistent evidence for association between schizophrenia and
            genetic variation in the 22q11 gene ZDHHC8
  JOURNAL   Hum Mol Genet 13 (23), 2991-2995 (2004)
   PUBMED   15489219
  REMARK    GeneRIF: genotyped three genetic variants within the ZDHHC8 locus
            and conducted association studies in both population- and
            family-based samples of the Han Chinese population
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 5049)
  AUTHORS   Mukai,J., Liu,H., Burt,R.A., Swor,D.E., Lai,W.S., Karayiorgou,M.
            and Gogos,J.A.
  TITLE     Evidence that the gene encoding ZDHHC8 contributes to the risk of
            schizophrenia
  JOURNAL   Nat Genet 36 (7), 725-731 (2004)
   PUBMED   15184899
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006547.9, BC053544.1 and
            AY894890.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_013373.3.
            
            Summary: This gene encodes a four transmembrane protein that is a
            member of the zinc finger DHHC domain-containing protein family.
            The encoded protein may function as a palmitoyltransferase. Defects
            in this gene may be associated with a susceptibility to
            schizophrenia. Alternate splicing of this gene results in multiple
            transcript variants. A pseudogene of this gene is found on
            chromosome 22.[provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region, which results in a frameshift, compared to
            variant 1. It encodes isoform 2, which has a shorter and distinct
            C-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY894890.1, BC053544.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334554.12/ ENSP00000334490.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC006547.9         92835-92871
            38-2490             BC053544.1         1-2453
            2491-2505           AC006547.9         106480-106494
            2506-3493           BC053544.1         2468-3455
            3494-4625           AC006547.9         107483-108614
            4626-5049           AY894890.1         4590-5013
FEATURES             Location/Qualifiers
     source          1..5049
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..5049
                     /gene="ZDHHC8"
                     /gene_synonym="DHHC8; ZDHHCL1; ZNF378"
                     /note="zDHHC palmitoyltransferase 8"
                     /db_xref="GeneID:29801"
                     /db_xref="HGNC:HGNC:18474"
                     /db_xref="MIM:608784"
     exon            1..248
                     /gene="ZDHHC8"
                     /gene_synonym="DHHC8; ZDHHCL1; ZNF378"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..2442
                     /gene="ZDHHC8"
                     /gene_synonym="DHHC8; ZDHHCL1; ZNF378"
                     /EC_number="2.3.1.225"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger, DHHC domain like containing 1; membrane-associated
                     DHHC8 zinc finger protein; zinc finger protein 378; zinc
                     finger DHHC-type containing 8; palmitoyltransferase
                     ZDHHC8; zinc finger DHHC-type palmitoyltransferase 8"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC8 isoform 2"
                     /protein_id="NP_037505.1"
                     /db_xref="CCDS:CCDS13776.1"
                     /db_xref="GeneID:29801"
                     /db_xref="HGNC:HGNC:18474"
                     /db_xref="MIM:608784"
                     /translation="MPRSPGTRLKPAKYIPVATAAALLVGSSTLFFVFTCPWLTRAVS
                     PAVPVYNGIIFLFVLANFSMATFMDPGVFPRADEDEDKEDDFRAPLYKNVDVRGIQVR
                     MKWCATCHFYRPPRCSHCSVCDNCVEDFDHHCPWVNNCIGRRNYRYFFLFLLSLSAHM
                     VGVVAFGLVYVLNHAEGLGAAHTTITMAVMCVAGLFFIPVIGLTGFHVVLVTRGRTTN
                     EQVTGKFRGGVNPFTRGCCGNVEHVLCSPLAPRYVVEPPRLPLAVSLKPPFLRPELLD
                     RAAPLKVKLSDNGLKAGLGRSKSKGSLDRLDEKPLDLGPPLPPKIEAGTFSSDLQTPR
                     PGSAESALSVQRTSPPTPAMYKFRPAFPTGPKVPFCGPGEQVPGPDSLTLGDDSIRSL
                     DFVSEPSLDLPDYGPGGLHAAYPPSPPLSASDAFSGALRSLSLKASSRRGGDHVALQP
                     LRSEGGPPTPHRSIFAPHALPNRNGSLSYDSLLNPGSPGGHACPAHPAVGVAGYHSPY
                     LHPGATGDPPRPLPRSFSPVLGPRPREPSPVRYDNLSRTIMASIQERKDREERERLLR
                     SQADSLFGDSGVYDAPSSYSLQQASVLSEGPRGPALRYGSRDDLVAGPGFGGARNPAL
                     QTSLSSLSSSVSRAPRTSSSSLQADQASSNAPGPRPSSGSHRSPARQGLPSPPGTPHS
                     PSYAGPKAVAFIHTDLPEPPPSLTVQRDHPQLKTPPSKLNGQSPGLARLGPATGPPGP
                     SASPTRHTLVKKVSGVGGTTYEISV"
     exon            249..370
                     /gene="ZDHHC8"
                     /gene_synonym="DHHC8; ZDHHCL1; ZNF378"
                     /inference="alignment:Splign:2.1.0"
     exon            371..528
                     /gene="ZDHHC8"
                     /gene_synonym="DHHC8; ZDHHCL1; ZNF378"
                     /inference="alignment:Splign:2.1.0"
     exon            529..701
                     /gene="ZDHHC8"
                     /gene_synonym="DHHC8; ZDHHCL1; ZNF378"
                     /inference="alignment:Splign:2.1.0"
     exon            702..804
                     /gene="ZDHHC8"
                     /gene_synonym="DHHC8; ZDHHCL1; ZNF378"
                     /inference="alignment:Splign:2.1.0"
     exon            805..896
                     /gene="ZDHHC8"
                     /gene_synonym="DHHC8; ZDHHCL1; ZNF378"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1038
                     /gene="ZDHHC8"
                     /gene_synonym="DHHC8; ZDHHCL1; ZNF378"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1159
                     /gene="ZDHHC8"
                     /gene_synonym="DHHC8; ZDHHCL1; ZNF378"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1269
                     /gene="ZDHHC8"
                     /gene_synonym="DHHC8; ZDHHCL1; ZNF378"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..2270
                     /gene="ZDHHC8"
                     /gene_synonym="DHHC8; ZDHHCL1; ZNF378"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..5049
                     /gene="ZDHHC8"
                     /gene_synonym="DHHC8; ZDHHCL1; ZNF378"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3475..3480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC8"
                     /gene_synonym="DHHC8; ZDHHCL1; ZNF378"
                     /note="hexamer: ATTAAA"
     polyA_site      3493
                     /gene="ZDHHC8"
                     /gene_synonym="DHHC8; ZDHHCL1; ZNF378"
                     /note="major polyA site"
     regulatory      5027..5032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC8"
                     /gene_synonym="DHHC8; ZDHHCL1; ZNF378"
                     /note="hexamer: AATAAA"
     polyA_site      5049
                     /gene="ZDHHC8"
                     /gene_synonym="DHHC8; ZDHHCL1; ZNF378"
ORIGIN      
        1 gtggggtggg atttcctccg ccgccgccgc cgccgccgcc gcgggtcctg cgccgcgtcc
       61 agcccgcccg cccgaccccg gcccgacccc ggccggccct gcccgcccgg ccccggggag
      121 ggatgcggcg gcgcggcgcc caggatgccc cgcagccccg ggacgcgcct caaacccgcc
      181 aagtacatcc cggtggccac ggccgccgcg ctgctggtcg gctccagcac cctcttcttc
      241 gtgttcacgt gcccgtggtt gacacgagct gtgtccccag ctgttcccgt ctacaatggc
      301 atcatcttcc tctttgtcct ggccaacttc agcatggcca ctttcatgga ccctggtgtt
      361 ttcccccgag cggatgagga tgaggacaag gaggacgact tccgggctcc gctgtacaag
      421 aacgtggatg tgcgaggtat ccaggtccgc atgaagtggt gtgccacgtg ccacttctac
      481 cgcccgccgc gctgctccca ctgcagcgtc tgtgacaact gtgtagagga ctttgaccac
      541 cactgcccct gggtcaacaa ctgcatcggg cgtcgaaact atcgctactt cttcctgttc
      601 ctgctgtcac tcagtgcaca catggtgggc gtcgtggcct tcggcctggt ctacgtgctg
      661 aaccacgctg aggggctggg agccgcgcac accaccatca ccatggctgt catgtgtgtg
      721 gccggcctct tcttcatccc tgtcattggc ctcactggct tccatgtggt gctggtcact
      781 cgggggcgca ccaccaacga gcaggtgact gggaagttcc gcgggggtgt gaaccctttc
      841 acccgaggct gctgtgggaa tgtggagcac gtgctgtgta gccccctggc gccccggtac
      901 gtggtggagc caccccggct gccgctcgcg gtgagtttga agccgccttt ccttaggcct
      961 gaactcctgg accgagctgc accgctcaag gtcaagctta gtgacaacgg gctgaaggct
     1021 ggcctgggcc gtagcaagtc caagggcagc ctggaccggc tggatgagaa gccactggac
     1081 ttggggccac cactgccccc caagatagag gctggcacgt tcagcagtga cctgcagacc
     1141 ccgcgcccag gcagtgctga gagtgccctg tcggtgcaga ggaccagccc cccgacacct
     1201 gccatgtaca agtttaggcc ggctttcccc acgggtccca aggtgccctt ctgtggacca
     1261 ggcgagcagg ttccaggccc tgattccctg accctggggg acgacagcat ccgtagcctg
     1321 gactttgtgt ccgagccgag cctggacctc cctgactatg ggccaggggg cctgcatgca
     1381 gcctacccgc catccccacc gctcagcgcc tctgatgcct tctcgggcgc tttgcgctcc
     1441 ctgagcctca aggcctcgag ccggcggggc ggggatcatg tggccctgca gcccctgcgc
     1501 tctgaggggg ggccccccac gccccaccgt agcatttttg ccccccatgc actgcccaac
     1561 cgcaacggca gcctgtccta tgacagcctg ctcaatcctg gctcgcctgg tggccacgcc
     1621 tgccctgccc acccagcagt tggcgtggcc ggataccact caccctacct gcatcctggg
     1681 gcaacgggcg acccgccacg gcccctaccc cgcagcttca gccccgtgct gggcccccgc
     1741 ccccgggagc cctcgcctgt gcgctacgac aacctgtcca ggaccatcat ggcatccatc
     1801 caggagcgca aggacaggga ggagcgtgag cgcctgctgc gctcccaggc cgactcactc
     1861 ttcggcgact caggcgtcta tgacgctccc agctcctaca gcctgcagca ggccagtgtg
     1921 ctgtccgagg gcccccgagg tcccgcgctg cgctatggct ccagagacga ccttgtggct
     1981 gggcccggct tcggtggcgc ccgcaaccct gccctgcaga cgtcactgtc ctcgctgtcc
     2041 agctccgtga gccgtgcacc gcggacgtcg tcctcctccc tgcaggctga tcaggccagc
     2101 agcaacgccc cggggccccg gcccagcagt ggctcacaca ggtcacctgc acgccagggc
     2161 ctgccctccc cgcccggcac tccccactca ccatcctacg cgggccccaa agctgtcgcc
     2221 ttcatccaca cggacctccc agagccaccg ccctcgctga ccgtgcagag ggaccaccct
     2281 cagctgaaga ctcccccaag taagcttaat gggcagtccc cgggcctggc ccggctggga
     2341 cctgccaccg gccccccagg gccctctgcc agccctacac ggcacacgct ggttaagaag
     2401 gtgtccggcg tgggtgggac cacctacgag atctcggtgt gaggactgac tgccacacat
     2461 ccgccatggt gccacgggga ccaggacccc acagcgcacc ccccctcccc accaacttct
     2521 ctgccccagg gacccgaggc caccccagcc tggtgtggac ccatcggcgg gagagagtgc
     2581 cacgcctcca cagcttgccc caagcgctct gcctgcccgt ccactcatct gcccatgggg
     2641 aagtcggctc actgggacaa gggccactgg gctggtctgt gtctgggcct gtcccatggc
     2701 tggggcagtg agggggccca gtcagcctct ttggggcacc ctctctcagc caggcttggc
     2761 ccactgccat cacccagcac cccagatcac cgccaggcca gcccccaatg gtccccttac
     2821 ggacaggtcc cagagatgga cagaggcacc cagggccccc accgtccttc tgacacagcc
     2881 tgtgggctcc cggaccgagt gtcccccgcc aggctactcc taactaacgc gttgcctttc
     2941 acggaccccg ctggaagctt gtagcttggc aaggctgatg cttctgccct ggcctgctct
     3001 gggtggtggt ggataggtgg acagacggcc agccagccag ctgtggccgg gggcccggct
     3061 ccatgtgtcc cgtgtctgtg tgctgtgctg ccgcgccgtg tctgatgtgt cagtgctccg
     3121 gccgccgctg tccctttcat caaagcctta acctttgctt tatgctcttg tgggaggcga
     3181 cgggggggca ggcgggagca ggcacggggg tgatgctgcc acagggggct ggtgacaccc
     3241 agagccccct ccccagccct caggccctcc ctgccaaact ggagaacccc accccaaggc
     3301 atgccacgtc cgcagccccg gcctggctgc ggtgctcgcg ccgtgggaaa gcacactggg
     3361 gaggggtcag tgcttccctt ggtgtcaggg acctgagagt aagcacatga cagcgtctgc
     3421 ttgcgttgtg tctgttttat gtttttatat ctacatctat atatctataa ttttattaaa
     3481 aaaaagaaaa agagttattt tgattctttc cttgggcaag gccagggcta ttgctgcagg
     3541 atcccgagtt aggggagggc aggggccggg ccccagaaga gggagtggct gctgtctggt
     3601 gtgcaggggt cggtgggttc ctcaggggca tttctgccga cttgggctga gtcagaggct
     3661 tgggaagagg gggcggccga tggtctgtgg ctgggaagtg tgagggtctc tcgccttggg
     3721 tctgtgtcag ttctggcagt gacagggtgt ttgggggaaa gacttgggtc tgccgctacc
     3781 cacaggggac tctcaggaac ccgagagctt ggggagatga aatgggggtg cataggggcc
     3841 acctgttggc tcagggccct gtgggggccg ctgaacctgc tggaactctc ctgcctgcca
     3901 catgccaggg gcagggctga gggagtgtga gggatgcaca gctgttcagg gctgagacat
     3961 tctgggctgg ggctgtccca gcgtgggagg cgtgcgggct gtagggcccc gaagctgacc
     4021 tccacctttc tgcttctctc tcacggacgc cgcggcccgc agggggcgga ttggcacctg
     4081 cacccgtgga tgggggcggc gtggccagcc ttgggtgcct cctgggctgc acctgtgcca
     4141 ccttggccgc ccggaggacc gcccaccact gcgggccccc tggagccagg ccgccggggc
     4201 acccccacgc ggggccatgt gccgcctgca cttggctgcc tccagtcttt tccccagcct
     4261 ctcggggccc tagcaggatg acaagtaggc ggctctgggg cccaggacag cccagctggg
     4321 gacccaggag gtcagactgc agtggaccct ggggcagggc tgggggtggg ctgggctctc
     4381 tgctccacca gccacagctt gacagattcc cagcctgcca gggcctgaga ccctgtgtcc
     4441 acatgacctc agggagtccc ccacctgctg cagggggtcc agcaccccac aggggggcag
     4501 tcccagagct gtggggaccg gcacgacctt tgcccagcct ccctacccaa ccaagcactt
     4561 tagactaagc cacttcctcc tcggggagcc caggcctccg tgggttgggc tgggtggggg
     4621 gggggtctca ggttgcccct gaaggtctct gcactcctcc tgcccttccc ctgacacatg
     4681 aacagatgcc ttaacttcct ggagccacca gcctggtgag ccattggcct ctgcctgcca
     4741 ccaaggtcct gtggtcttgg ccagctccgc ctgggcccca ctggggctgc ctgcacccag
     4801 agacgatgcc ggcgggatct cagagggcct gaggcccaag ccctgtgtcc tccagcagtg
     4861 gtacggcctg cggcagggtg gcactccggc cagcccttct ccgtcacagg gtccctgtcc
     4921 ctgggtccac cctgggctgt ggctctacat ctcccatttg gggacgagaa agccacaaaa
     4981 ccattctcta ttgttcttaa gggtacccct gctaattaat tccccaaata aaatttttgg
     5041 tgttgatca
//
