LOCUS       NM_017740               3448 bp    mRNA    linear   PRI 06-MAR-2025
DEFINITION  Homo sapiens zDHHC palmitoyltransferase 7 (ZDHHC7), transcript
            variant 2, mRNA.
ACCESSION   NM_017740
VERSION     NM_017740.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3448)
  AUTHORS   Lin,Z., Agarwal,S., Tan,S., Shi,H., Lu,X., Tao,Z., Dong,X., Wu,X.,
            Zhao,J.C. and Yu,J.
  TITLE     Palmitoyl acyltransferase ZDHHC7 inhibits androgen receptor and
            suppresses prostate cancer
  JOURNAL   Oncogene 42 (26), 2126-2138 (2023)
   PUBMED   37198397
  REMARK    GeneRIF: Palmitoyl acyltransferase ZDHHC7 inhibits androgen
            receptor and suppresses prostate cancer.
REFERENCE   2  (bases 1 to 3448)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3448)
  AUTHORS   Hohoff,C., Zhang,M., Ambree,O., Kravchenko,M., Buschert,J.,
            Kerkenberg,N., Gorinski,N., Abdel Galil,D., Schettler,C., Vom
            Werth,K.L., Wewer,M.F., Schneider,I., Grotegerd,D., Wachsmuth,L.,
            Faber,C., Skryabin,B.V., Brosius,J., Ponimaskin,E. and Zhang,W.
  TITLE     Deficiency of the palmitoyl acyltransferase ZDHHC7 impacts brain
            and behavior of mice in a sex-specific manner
  JOURNAL   Brain Struct Funct 224 (6), 2213-2230 (2019)
   PUBMED   31183559
  REMARK    GeneRIF: demonstrated the importance of Zdhhc7 for assembling
            proper brain structure, function, and behavior on a system level in
            mice in a sex-related manner
REFERENCE   4  (bases 1 to 3448)
  AUTHORS   Tonn Eisinger,K.R., Woolfrey,K.M., Swanson,S.P., Schnell,S.A.,
            Meitzen,J., Dell'Acqua,M. and Mermelstein,P.G.
  TITLE     Palmitoylation of caveolin-1 is regulated by the same DHHC
            acyltransferases that modify steroid hormone receptors
  JOURNAL   J Biol Chem 293 (41), 15901-15911 (2018)
   PUBMED   30158247
REFERENCE   5  (bases 1 to 3448)
  AUTHORS   Aramsangtienchai,P., Spiegelman,N.A., Cao,J. and Lin,H.
  TITLE     S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its
            Tight Junction Localization and Cell Migration
  JOURNAL   J Biol Chem 292 (13), 5325-5334 (2017)
   PUBMED   28196865
  REMARK    GeneRIF: identified DHHC7 as a JAM-C palmitoylating enzyme
REFERENCE   6  (bases 1 to 3448)
  AUTHORS   Pedram,A., Razandi,M., Deschenes,R.J. and Levin,E.R.
  TITLE     DHHC-7 and -21 are palmitoylacyltransferases for sex steroid
            receptors
  JOURNAL   Mol Biol Cell 23 (1), 188-199 (2012)
   PUBMED   22031296
  REMARK    GeneRIF: the DHHC-7 and -21 proteins are novel targets to
            selectively inhibit membrane sex steroid receptor localization and
            function
REFERENCE   7  (bases 1 to 3448)
  AUTHORS   Tsutsumi,R., Fukata,Y., Noritake,J., Iwanaga,T., Perez,F. and
            Fukata,M.
  TITLE     Identification of G protein alpha subunit-palmitoylating enzyme
  JOURNAL   Mol Cell Biol 29 (2), 435-447 (2009)
   PUBMED   19001095
REFERENCE   8  (bases 1 to 3448)
  AUTHORS   Gudbjartsson,D.F., Walters,G.B., Thorleifsson,G., Stefansson,H.,
            Halldorsson,B.V., Zusmanovich,P., Sulem,P., Thorlacius,S.,
            Gylfason,A., Steinberg,S., Helgadottir,A., Ingason,A.,
            Steinthorsdottir,V., Olafsdottir,E.J., Olafsdottir,G.H.,
            Jonsson,T., Borch-Johnsen,K., Hansen,T., Andersen,G., Jorgensen,T.,
            Pedersen,O., Aben,K.K., Witjes,J.A., Swinkels,D.W., den Heijer,M.,
            Franke,B., Verbeek,A.L., Becker,D.M., Yanek,L.R., Becker,L.C.,
            Tryggvadottir,L., Rafnar,T., Gulcher,J., Kiemeney,L.A., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Many sequence variants affecting diversity of adult human height
  JOURNAL   Nat Genet 40 (5), 609-615 (2008)
   PUBMED   18391951
REFERENCE   9  (bases 1 to 3448)
  AUTHORS   Ohno,Y., Kihara,A., Sano,T. and Igarashi,Y.
  TITLE     Intracellular localization and tissue-specific distribution of
            human and yeast DHHC cysteine-rich domain-containing proteins
  JOURNAL   Biochim Biophys Acta 1761 (4), 474-483 (2006)
   PUBMED   16647879
REFERENCE   10 (bases 1 to 3448)
  AUTHORS   Lehner,B., Semple,J.I., Brown,S.E., Counsell,D., Campbell,R.D. and
            Sanderson,C.M.
  TITLE     Analysis of a high-throughput yeast two-hybrid system and its use
            to predict the function of intracellular proteins encoded within
            the human MHC class III region
  JOURNAL   Genomics 83 (1), 153-167 (2004)
   PUBMED   14667819
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA507340.1, AK000286.1, CN427219.1, AC092341.5 and AW235073.1.
            
            On Jun 2, 2019 this sequence version replaced NM_017740.2.
            
            Transcript Variant: This variant (2) lacks a coding exon but
            maintains the reading frame compared to variant 1. The resulting
            isoform (2) is shorter but has the same N- and C-termini compared
            to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000286.1, SRR14038191.3982634.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313732.9/ ENSP00000315604.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               DA507340.1         1-188
            189-416             AK000286.1         189-416
            417-735             CN427219.1         309-627
            736-1258            AK000286.1         736-1258
            1259-2952           AC092341.5         55583-57276
            2953-3163           AW235073.1         6-216               c
            3164-3448           AC092341.5         57488-57772
FEATURES             Location/Qualifiers
     source          1..3448
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.1"
     gene            1..3448
                     /gene="ZDHHC7"
                     /gene_synonym="DHHC7; SERZ-B; SERZ1; ZNF370"
                     /note="zDHHC palmitoyltransferase 7"
                     /db_xref="GeneID:55625"
                     /db_xref="HGNC:HGNC:18459"
                     /db_xref="MIM:614604"
     exon            1..250
                     /gene="ZDHHC7"
                     /gene_synonym="DHHC7; SERZ-B; SERZ1; ZNF370"
                     /inference="alignment:Splign:2.1.0"
     exon            251..336
                     /gene="ZDHHC7"
                     /gene_synonym="DHHC7; SERZ-B; SERZ1; ZNF370"
                     /inference="alignment:Splign:2.1.0"
     exon            337..668
                     /gene="ZDHHC7"
                     /gene_synonym="DHHC7; SERZ-B; SERZ1; ZNF370"
                     /inference="alignment:Splign:2.1.0"
     CDS             354..1280
                     /gene="ZDHHC7"
                     /gene_synonym="DHHC7; SERZ-B; SERZ1; ZNF370"
                     /EC_number="2.3.1.225"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger, DHHC domain containing 7; palmitoyltransferase
                     ZDHHC7; DHHC-7; zinc finger protein 370; zinc finger DHHC
                     domain-containing protein 7; zinc finger DHHC-type
                     containing 7; Sertoli cell gene with zinc finger
                     domain-I(2); Sertoli cell gene with zinc finger
                     domain-beta; acyltransferase ZDHHC7; zinc finger DHHC-type
                     palmitoyltransferase 7"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC7 isoform 2"
                     /protein_id="NP_060210.2"
                     /db_xref="CCDS:CCDS10950.1"
                     /db_xref="GeneID:55625"
                     /db_xref="HGNC:HGNC:18459"
                     /db_xref="MIM:614604"
                     /translation="MQPSGHRLRDVEHHPLLAENDNYDSSSSSSSEADVADRVWFIRD
                     GCGMICAVMTWLLVAYADFVVTFVMLLPSKDFWYSVVNGVIFNCLAVLALSSHLRTML
                     TDPGAVPKGNATKEYMESLQLKPGEVIYKCPKCCCIKPERAHHCSICKRCIRKMDHHC
                     PWVNNCVGEKNQRFFVLFTMYIALSSVHALILCGFQFISCVRGQWTECSDFSPPITVI
                     LLIFLCLEGLLFFTFTAVMFGTQIHSICNDETEIERLKSEKPTWERRLRWEGMKSVFG
                     GPPSLLWMNPFVGFRFRRLPTRPRKGGPEFSV"
     exon            669..793
                     /gene="ZDHHC7"
                     /gene_synonym="DHHC7; SERZ-B; SERZ1; ZNF370"
                     /inference="alignment:Splign:2.1.0"
     exon            794..890
                     /gene="ZDHHC7"
                     /gene_synonym="DHHC7; SERZ-B; SERZ1; ZNF370"
                     /inference="alignment:Splign:2.1.0"
     exon            891..972
                     /gene="ZDHHC7"
                     /gene_synonym="DHHC7; SERZ-B; SERZ1; ZNF370"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1103
                     /gene="ZDHHC7"
                     /gene_synonym="DHHC7; SERZ-B; SERZ1; ZNF370"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..3448
                     /gene="ZDHHC7"
                     /gene_synonym="DHHC7; SERZ-B; SERZ1; ZNF370"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3028..3033
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC7"
                     /gene_synonym="DHHC7; SERZ-B; SERZ1; ZNF370"
                     /note="hexamer: AATAAA"
     polyA_site      3054
                     /gene="ZDHHC7"
                     /gene_synonym="DHHC7; SERZ-B; SERZ1; ZNF370"
     regulatory      3135..3140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC7"
                     /gene_synonym="DHHC7; SERZ-B; SERZ1; ZNF370"
                     /note="hexamer: AATAAA"
     polyA_site      3163
                     /gene="ZDHHC7"
                     /gene_synonym="DHHC7; SERZ-B; SERZ1; ZNF370"
                     /note="major polyA site"
     regulatory      3420..3425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC7"
                     /gene_synonym="DHHC7; SERZ-B; SERZ1; ZNF370"
                     /note="hexamer: AATAAA"
     polyA_site      3448
                     /gene="ZDHHC7"
                     /gene_synonym="DHHC7; SERZ-B; SERZ1; ZNF370"
ORIGIN      
        1 acttccggcg ctcgcaccgc cccgctctcc agccaaggct ccgggctgag gcatttgctt
       61 ggctgcagcc tccttccgac ctgcccggcg ggacccaggg gaccaagccg agccgagccg
      121 cggggcccgc tccagcccgg ccatgagcgc ggccgcatga tgcgtccctg cctcggccgc
      181 tgcagtcgcc gccgccgccg ccgcaggccg ggaggagccg cagcgccggg cgaccccgcc
      241 cgggcctcgg atccgatcac ataggacagt atgcacctta agatcctgaa gaaacggcac
      301 aaaatgttca agtgatgttt agaaataact tgtgagggtg cgtcagggaa atcatgcagc
      361 catcaggaca caggctccgg gacgtcgagc atcatcctct cctggctgaa aatgacaact
      421 atgactcttc atcgtcctcc tcctccgagg ctgacgtggc tgaccgggtc tggttcatcc
      481 gtgacggctg cggcatgatc tgtgctgtca tgacgtggct tctggtcgcc tatgcagact
      541 tcgtggtgac tttcgtcatg ctgctgcctt ccaaagactt ctggtactct gtggtcaacg
      601 gggtcatctt taactgcttg gccgtgcttg ccctgtcatc ccacctgaga accatgctca
      661 ccgaccctgg ggcagtaccc aaaggaaacg ctacgaaaga atacatggag agcttgcagc
      721 tgaagcccgg ggaagtcatc tacaagtgcc ccaagtgctg ctgtattaaa cccgagcgcg
      781 cccaccactg cagtatttgc aaaagatgta ttcggaaaat ggatcatcac tgcccgtggg
      841 tgaacaattg tgtaggagaa aagaatcaaa gattttttgt gctcttcact atgtatatag
      901 ctctgtcttc agtccatgct ctgatccttt gtggatttca gttcatctcc tgtgtccgag
      961 ggcagtggac tgaatgcagt gatttttcac ctccgataac tgtaatcctg ttgatcttcc
     1021 tgtgccttga gggtcttctg tttttcactt tcactgcagt tatgtttggc acccaaatcc
     1081 actccatatg caacgacgag acggagatcg agcgattgaa aagtgagaag cccacatggg
     1141 agcggaggct gcgatgggaa gggatgaagt ccgtctttgg ggggcccccc tcactcctct
     1201 ggatgaatcc ctttgtgggc ttccgattta ggcgactgcc cacgagaccc agaaaaggtg
     1261 gcccggagtt ctcagtgtga ggcgtggctc atcagactga aacttgctca cagacttcca
     1321 gttatttatt tggggtctga aggatatcaa cagctcatct gtgaccaaca gggcaactgg
     1381 aacctacaca aaccaattgc ttgcagcaag cagagtttta tatatttata gtcacagatg
     1441 gcagaggaag aggctctcag tccccacctg tacaacaacg gaaaggtgtg tggccacacg
     1501 aagaagccaa acgccgtggc ctcctgcaga gctggggctt ctgtggagaa tacttcgggt
     1561 tattacatgg gttattcaaa tcctgggtcc tgagctgctg tttccaatca tgaagaaaaa
     1621 cagtgaatcc agtgaacagg gattctccaa gcagtcattt cagggggctc ctgctgaccc
     1681 cgccactcag cagtgcactc cccggatcac agcagggcgt ttacatagaa agacgttttg
     1741 gtctcgatta gctccgatgc tttgcactga agttgcaaaa gatctgtgca ctgaacagtg
     1801 aaggtggctt ccggcacact ccccgctgcc ccggaagaga catcctttga ccctctcagc
     1861 aagtctgtgt gtgtgcgtgt ctgtgcgtgt gcgcgcgtgt gtgcatgtgt gtcaaaattg
     1921 ccagtgttgt ttaggcaatg taacatttac cggctgtgta cagcaaacaa gctatttttt
     1981 agaaaccgac gtttcaggga agaggggaga gagccgcggg gtcctgcccg tggttactat
     2041 gaatgtattg ctgttggagg acatctcgat ccaaagaaca gccgttcctg tgcggccctt
     2101 cgttgccctc ctgctttcat tttttaaaga aatcttgagt gcttgagggc cttggaactg
     2161 attttttttt tttgttccag ccaaattagc agtgtataaa tggcacctag gtaagagcag
     2221 agctgcggct cggtgacttg atacttgggg cagcccgatg ctgtgtgtgg ggcaggggag
     2281 gcatccttac tggagaggca gggcccagcc attgggcacc tctgggaagg ggaggggacc
     2341 atgaggcagc cagcccctgg caggggcgac tgtgccaccg caggcagcgc tccagtcggg
     2401 aatggccagg atggcgccct cttgttggag tttttggtta gcttttacgt tttcttctcc
     2461 acccacggca caggtgataa aataggatcc ttggtgcgga gcttaaaatt atgccagaaa
     2521 gccaacagct cccctcgtgg ggccttgcct taaacttgcc tggtttgtac attttttgcc
     2581 ggacgcatca agaagcaatc tgtgacaaag tctgagggtc ttcctttatg cttgccctcc
     2641 acactaagag aagttggcgt ctccctcctg ggaattgttt tgcctttctg ttcatctgtg
     2701 aactgttttt tgtttttaat tactctgtac cccatccgaa tcagggcttc taccactgct
     2761 gatgcaaaac cacaaaggga cctacctgag ccaccgtcct agccaagcga gcaaacctgc
     2821 agggggtttg gaagtggact tggtcaccgc agaagcgtgt gcgccgttgg gggaagagct
     2881 gcgtcacagc cagagggaca aagtgtgggt gatcctggag acgccagttt ccgagattgt
     2941 tctgcatatt catttgcaca ttgttgtctg ggttggacat gcgtgtgggc ttcagtgtga
     3001 ggcttttaat atgtatatcc tgttatcaat aaaacaatta tccaagtggt tgaatcctgt
     3061 gagacttggc aagtgtgtgc aaatcaagta tacttgactt ttcaacctct tctttcaatg
     3121 taacttttat atgaaataaa gtaatcaatt aacagttctc aaatggcttc caaagcgccc
     3181 gttcttcctg gatggtggtg ttttcagggg gtgcctttcc gtgcttcgtg ggcccagccc
     3241 caggctgtta aggtcactcc caaacagttt ccagaaactc taaatgcttt tgtgcccatg
     3301 acaagtgacc tgggcactca agcgcgactc acaaatgttg cccagtgagt actgttgctt
     3361 gttgaatgtt taattcgact cccatcgttt tacttagtcc tttttttagt gcacgttgaa
     3421 ataaaaacaa tgtttcaaaa tctccaca
//
