LOCUS       NM_022494               2170 bp    mRNA    linear   PRI 06-MAR-2025
DEFINITION  Homo sapiens zDHHC palmitoyltransferase 6 (ZDHHC6), transcript
            variant 1, mRNA.
ACCESSION   NM_022494
VERSION     NM_022494.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2170)
  AUTHORS   Marciel,M.P. and Hoffmann,P.R.
  TITLE     Molecular Mechanisms by Which Selenoprotein K Regulates Immunity
            and Cancer
  JOURNAL   Biol Trace Elem Res 192 (1), 60-68 (2019)
   PUBMED   31187393
  REMARK    Review article
REFERENCE   2  (bases 1 to 2170)
  AUTHORS   Kim,Y.C., Lee,S.E., Kim,S.K., Jang,H.D., Hwang,I., Jin,S.,
            Hong,E.B., Jang,K.S. and Kim,H.S.
  TITLE     Toll-like receptor mediated inflammation requires FASN-dependent
            MYD88 palmitoylation
  JOURNAL   Nat Chem Biol 15 (9), 907-916 (2019)
   PUBMED   31427815
REFERENCE   3  (bases 1 to 2170)
  AUTHORS   Abrami,L., Dallavilla,T., Sandoz,P.A., Demir,M., Kunz,B.,
            Savoglidis,G., Hatzimanikatis,V. and van der Goot,F.G.
  TITLE     Identification and dynamics of the human ZDHHC16-ZDHHC6
            palmitoylation cascade
  JOURNAL   Elife 6, e27826 (2017)
   PUBMED   28826475
  REMARK    GeneRIF: human ZDHHC6, which modifies key proteins of the
            endoplasmic reticulum, is controlled by an upstream
            palmitoyltransferase, ZDHHC16, revealing the first palmitoylation
            cascade.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2170)
  AUTHORS   Senyilmaz,D., Virtue,S., Xu,X., Tan,C.Y., Griffin,J.L.,
            Miller,A.K., Vidal-Puig,A. and Teleman,A.A.
  TITLE     Regulation of mitochondrial morphology and function by
            stearoylation of TFR1
  JOURNAL   Nature 525 (7567), 124-128 (2015)
   PUBMED   26214738
REFERENCE   5  (bases 1 to 2170)
  AUTHORS   Fredericks,G.J., Hoffmann,F.W., Rose,A.H., Osterheld,H.J.,
            Hess,F.M., Mercier,F. and Hoffmann,P.R.
  TITLE     Stable expression and function of the inositol 1,4,5-triphosphate
            receptor requires palmitoylation by a DHHC6/selenoprotein K complex
  JOURNAL   Proc Natl Acad Sci U S A 111 (46), 16478-16483 (2014)
   PUBMED   25368151
  REMARK    GeneRIF: DHHC6 knockdown using shRNA in stably transfected cell
            lines led to decreased expression of the IP3R and impaired
            IP3R-dependent Ca(2+) flux.
REFERENCE   6  (bases 1 to 2170)
  AUTHORS   Ohno,Y., Kashio,A., Ogata,R., Ishitomi,A., Yamazaki,Y. and
            Kihara,A.
  TITLE     Analysis of substrate specificity of human DHHC protein
            acyltransferases using a yeast expression system
  JOURNAL   Mol Biol Cell 23 (23), 4543-4551 (2012)
   PUBMED   23034182
REFERENCE   7  (bases 1 to 2170)
  AUTHORS   Fairbank,M., Huang,K., El-Husseini,A. and Nabi,I.R.
  TITLE     RING finger palmitoylation of the endoplasmic reticulum Gp78 E3
            ubiquitin ligase
  JOURNAL   FEBS Lett 586 (16), 2488-2493 (2012)
   PUBMED   22728137
REFERENCE   8  (bases 1 to 2170)
  AUTHORS   Gorleku,O.A., Barns,A.M., Prescott,G.R., Greaves,J. and
            Chamberlain,L.H.
  TITLE     Endoplasmic reticulum localization of DHHC palmitoyltransferases
            mediated by lysine-based sorting signals
  JOURNAL   J Biol Chem 286 (45), 39573-39584 (2011)
   PUBMED   21926431
REFERENCE   9  (bases 1 to 2170)
  AUTHORS   Ohno,Y., Kihara,A., Sano,T. and Igarashi,Y.
  TITLE     Intracellular localization and tissue-specific distribution of
            human and yeast DHHC cysteine-rich domain-containing proteins
  JOURNAL   Biochim Biophys Acta 1761 (4), 474-483 (2006)
   PUBMED   16647879
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA745043.1, AK025605.1, BX647270.1 and AI695150.1.
            
            On Nov 22, 2018 this sequence version replaced NM_022494.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1, 3, 4 and 5 encode the same protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK025605.1, SRR5189652.94379.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369405.7/ ENSP00000358413.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-433               DA745043.1         1-433
            434-1864            AK025605.1         434-1864
            1865-2147           BX647270.1         4354-4636
            2148-2170           AI695150.1         17-39               c
FEATURES             Location/Qualifiers
     source          1..2170
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.2"
     gene            1..2170
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /note="zDHHC palmitoyltransferase 6"
                     /db_xref="GeneID:64429"
                     /db_xref="HGNC:HGNC:19160"
                     /db_xref="MIM:618715"
     exon            1..210
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /inference="alignment:Splign:2.1.0"
     exon            211..691
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..1666
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /EC_number="2.3.1.225"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 376; transmembrane protein H4; zinc finger
                     DHHC domain-containing protein 6; palmitoyltransferase
                     ZDHHC6; zinc finger DHHC-type containing 6;
                     stearoyltransferase ZDHHC6; zinc finger DHHC-type
                     palmitoyltransferase 6"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC6 isoform 1"
                     /protein_id="NP_071939.1"
                     /db_xref="CCDS:CCDS7574.1"
                     /db_xref="GeneID:64429"
                     /db_xref="HGNC:HGNC:19160"
                     /db_xref="MIM:618715"
                     /translation="MGTFCSVIKFENLQELKRLCHWGPIIALGVIAICSTMAMIDSVL
                     WYWPLHTTGGSVNFIMLINWTVMILYNYFNAMFVGPGFVPLGWKPEISQDTMYLQYCK
                     VCQAYKAPRSHHCRKCNRCVMKMDHHCPWINNCCGYQNHASFTLFLLLAPLGCIHAAF
                     IFVMTMYTQLYHRLSFGWNTVKIDMSAARRDPLPIVPFGLAAFATTLFALGLALGTTI
                     AVGMLFFIQMKIILRNKTSIESWIEEKAKDRIQYYQLDEVFVFPYDMGSRWRNFKQVF
                     TWSGVPEGDGLEWPVREGCHQYSLTIEQLKQKADKRVRSVRYKVIEDYSGACCPLNKG
                     IKTFFTSPCTEEPRIQLQKGEFILATRGLRYWLYGDKILDDSFIEGVSRIRGWFPRKC
                     VEKCPCDAETDQAPEGEKKNR"
     exon            692..783
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /inference="alignment:Splign:2.1.0"
     exon            784..943
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1105
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1159
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1327
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1369
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1515
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1562
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..2170
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2143..2148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /note="hexamer: AATAAA"
     polyA_site      2170
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /note="major polyA site"
ORIGIN      
        1 agagtcctgg cgagggcgct ggccgagagg tgctcggctt gtagcaggtc ccgcactcca
       61 gcctctcgct gccagggttt gctctctgct tgtcctgggc tgaggtgtcc atgacggagt
      121 catccaagga ggaaaaaatc tgttccgggt gagcccaggc cgccccggat atgcgatggc
      181 tgaggagcag acaccaggga ccacactgag gttgggtttc agaccaagac actggattct
      241 cctagttaag ataaagagct ttgggtgcct gacagtgaaa atggtgtaat ctgcgttaac
      301 agttcacagc ttgaaggcat gacaattaaa gaacacacat ggacttgtgg cacatggaaa
      361 tgtgcgcaca gaaaaaggaa atctataatt cttttaaagt aggaaggcat tcttccttgc
      421 caaaatgggt acattctgtt cggttatcaa gtttgaaaat ctacaagaat taaagagact
      481 gtgtcactgg ggtcccatca tagcccttgg tgttatagca atatgttcta ccatggccat
      541 gattgactct gtgttgtggt attggccctt acatacaact ggaggaagtg tgaatttcat
      601 catgttgata aattggactg tcatgattct ttataattac ttcaatgcca tgtttgtcgg
      661 tccgggcttt gtccctctgg ggtggaaacc ggaaatttct caggatacca tgtatctcca
      721 gtattgtaaa gtctgccaag catacaaggc accacgttca catcactgca gaaagtgtaa
      781 cagatgtgtg atgaagatgg accatcactg tccttggatc aacaactgtt gtggttacca
      841 aaatcatgct tcgttcacac tgtttctcct tttagcacca ctgggttgta tccatgctgc
      901 tttcattttt gtgatgacta tgtacacaca gctttatcat cggctctcct ttgggtggaa
      961 cacagtgaag atcgacatga gtgcagcccg gagagatcct cttccaattg ttccatttgg
     1021 attagctgca tttgctacca ccttgtttgc cttgggatta gctttaggaa caaccatagc
     1081 tgttgggatg ttgtttttta tccagatgaa aataattctc agaaacaaaa cttctattga
     1141 gtcatggatt gaagagaagg ctaaagatcg aattcagtat tatcaactag atgaagtctt
     1201 tgtttttcca tatgatatgg gaagtagatg gaggaacttt aaacaggtat ttacgtggtc
     1261 aggggtccct gaaggagatg gacttgagtg gccagtaaga gaaggctgtc accaatacag
     1321 cttaacaata gaacagttga aacaaaaagc agataagaga gtcagaagtg ttcgctataa
     1381 agtaatagaa gattatagtg gtgcctgctg ccctctgaat aaaggaatca aaaccttctt
     1441 cacaagtccc tgcaccgaag agcctcgaat acagctgcaa aaaggggaat tcattttagc
     1501 cacaagaggt ttacgatact ggttatatgg agacaaaatt cttgatgatt cctttataga
     1561 aggtgtttca agaataaggg gttggttccc tagaaaatgt gtggaaaagt gtccctgtga
     1621 tgctgaaaca gatcaagccc cagaggggga gaagaaaaat agatagctgc tgttaaaaca
     1681 aaattatcct ttaagtctgc ttaattactt gaaaattgta catattacta aagaattatg
     1741 caatgagcct actctggtta agatgttctt ttcctcaaag gtgccctagt gccatgattt
     1801 aaatattttt attaccattt tgaaatggag aagccattct gcatatgcct ttgaattcct
     1861 gcccctcttt accacctctt cctccccctc aaaggaaaaa catttcatcc aagtaagtta
     1921 acggcatttt ctgtaggatt ttcttatgca ctgcacactc tggacctcac ctgcagatac
     1981 agttcccccc ttgccaggag catctgcatg tggtacttct cttttccctc agttgatatt
     2041 tcttatatga tattctagat actatagaac tcaatttgtc agattcagta taacctcaga
     2101 ttttgttacc tgtcttttaa aaatgcagat tttgtcaaat caaataaaga tcaatggatg
     2161 ttgggtataa
//
