LOCUS       NM_001351084            2288 bp    mRNA    linear   PRI 06-MAR-2025
DEFINITION  Homo sapiens zDHHC palmitoyltransferase 6 (ZDHHC6), transcript
            variant 5, mRNA.
ACCESSION   NM_001351084 XM_006717948
VERSION     NM_001351084.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2288)
  AUTHORS   Marciel,M.P. and Hoffmann,P.R.
  TITLE     Molecular Mechanisms by Which Selenoprotein K Regulates Immunity
            and Cancer
  JOURNAL   Biol Trace Elem Res 192 (1), 60-68 (2019)
   PUBMED   31187393
  REMARK    Review article
REFERENCE   2  (bases 1 to 2288)
  AUTHORS   Kim,Y.C., Lee,S.E., Kim,S.K., Jang,H.D., Hwang,I., Jin,S.,
            Hong,E.B., Jang,K.S. and Kim,H.S.
  TITLE     Toll-like receptor mediated inflammation requires FASN-dependent
            MYD88 palmitoylation
  JOURNAL   Nat Chem Biol 15 (9), 907-916 (2019)
   PUBMED   31427815
REFERENCE   3  (bases 1 to 2288)
  AUTHORS   Abrami,L., Dallavilla,T., Sandoz,P.A., Demir,M., Kunz,B.,
            Savoglidis,G., Hatzimanikatis,V. and van der Goot,F.G.
  TITLE     Identification and dynamics of the human ZDHHC16-ZDHHC6
            palmitoylation cascade
  JOURNAL   Elife 6, e27826 (2017)
   PUBMED   28826475
  REMARK    GeneRIF: human ZDHHC6, which modifies key proteins of the
            endoplasmic reticulum, is controlled by an upstream
            palmitoyltransferase, ZDHHC16, revealing the first palmitoylation
            cascade.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2288)
  AUTHORS   Senyilmaz,D., Virtue,S., Xu,X., Tan,C.Y., Griffin,J.L.,
            Miller,A.K., Vidal-Puig,A. and Teleman,A.A.
  TITLE     Regulation of mitochondrial morphology and function by
            stearoylation of TFR1
  JOURNAL   Nature 525 (7567), 124-128 (2015)
   PUBMED   26214738
REFERENCE   5  (bases 1 to 2288)
  AUTHORS   Fredericks,G.J., Hoffmann,F.W., Rose,A.H., Osterheld,H.J.,
            Hess,F.M., Mercier,F. and Hoffmann,P.R.
  TITLE     Stable expression and function of the inositol 1,4,5-triphosphate
            receptor requires palmitoylation by a DHHC6/selenoprotein K complex
  JOURNAL   Proc Natl Acad Sci U S A 111 (46), 16478-16483 (2014)
   PUBMED   25368151
  REMARK    GeneRIF: DHHC6 knockdown using shRNA in stably transfected cell
            lines led to decreased expression of the IP3R and impaired
            IP3R-dependent Ca(2+) flux.
REFERENCE   6  (bases 1 to 2288)
  AUTHORS   Ohno,Y., Kashio,A., Ogata,R., Ishitomi,A., Yamazaki,Y. and
            Kihara,A.
  TITLE     Analysis of substrate specificity of human DHHC protein
            acyltransferases using a yeast expression system
  JOURNAL   Mol Biol Cell 23 (23), 4543-4551 (2012)
   PUBMED   23034182
REFERENCE   7  (bases 1 to 2288)
  AUTHORS   Fairbank,M., Huang,K., El-Husseini,A. and Nabi,I.R.
  TITLE     RING finger palmitoylation of the endoplasmic reticulum Gp78 E3
            ubiquitin ligase
  JOURNAL   FEBS Lett 586 (16), 2488-2493 (2012)
   PUBMED   22728137
REFERENCE   8  (bases 1 to 2288)
  AUTHORS   Gorleku,O.A., Barns,A.M., Prescott,G.R., Greaves,J. and
            Chamberlain,L.H.
  TITLE     Endoplasmic reticulum localization of DHHC palmitoyltransferases
            mediated by lysine-based sorting signals
  JOURNAL   J Biol Chem 286 (45), 39573-39584 (2011)
   PUBMED   21926431
REFERENCE   9  (bases 1 to 2288)
  AUTHORS   Ohno,Y., Kihara,A., Sano,T. and Igarashi,Y.
  TITLE     Intracellular localization and tissue-specific distribution of
            human and yeast DHHC cysteine-rich domain-containing proteins
  JOURNAL   Biochim Biophys Acta 1761 (4), 474-483 (2006)
   PUBMED   16647879
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA621943.1, DA936028.1, AK025605.1, BX647270.1 and AI695150.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001351084.1.
            
            Transcript Variant: This variant (5) differs in the 5' UTR compared
            to variant 1. Variants 1, 3, 4 and 5 encode the same protein
            (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.3608680.1,
                                           SRR18074967.513852.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-541               DA621943.1         3-543
            542-762             DA936028.1         389-609
            763-1982            AK025605.1         645-1864
            1983-2265           BX647270.1         4354-4636
            2266-2288           AI695150.1         17-39               c
FEATURES             Location/Qualifiers
     source          1..2288
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.2"
     gene            1..2288
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /note="zDHHC palmitoyltransferase 6"
                     /db_xref="GeneID:64429"
                     /db_xref="HGNC:HGNC:19160"
                     /db_xref="MIM:618715"
     exon            1..328
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /inference="alignment:Splign:2.1.0"
     exon            329..809
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /inference="alignment:Splign:2.1.0"
     CDS             543..1784
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /EC_number="2.3.1.225"
                     /note="isoform 1 is encoded by transcript variant 5; zinc
                     finger protein 376; transmembrane protein H4; zinc finger
                     DHHC domain-containing protein 6; palmitoyltransferase
                     ZDHHC6; zinc finger DHHC-type containing 6;
                     stearoyltransferase ZDHHC6; zinc finger DHHC-type
                     palmitoyltransferase 6"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC6 isoform 1"
                     /protein_id="NP_001338013.1"
                     /db_xref="CCDS:CCDS7574.1"
                     /db_xref="GeneID:64429"
                     /db_xref="HGNC:HGNC:19160"
                     /db_xref="MIM:618715"
                     /translation="MGTFCSVIKFENLQELKRLCHWGPIIALGVIAICSTMAMIDSVL
                     WYWPLHTTGGSVNFIMLINWTVMILYNYFNAMFVGPGFVPLGWKPEISQDTMYLQYCK
                     VCQAYKAPRSHHCRKCNRCVMKMDHHCPWINNCCGYQNHASFTLFLLLAPLGCIHAAF
                     IFVMTMYTQLYHRLSFGWNTVKIDMSAARRDPLPIVPFGLAAFATTLFALGLALGTTI
                     AVGMLFFIQMKIILRNKTSIESWIEEKAKDRIQYYQLDEVFVFPYDMGSRWRNFKQVF
                     TWSGVPEGDGLEWPVREGCHQYSLTIEQLKQKADKRVRSVRYKVIEDYSGACCPLNKG
                     IKTFFTSPCTEEPRIQLQKGEFILATRGLRYWLYGDKILDDSFIEGVSRIRGWFPRKC
                     VEKCPCDAETDQAPEGEKKNR"
     exon            810..901
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1061
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1223
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1277
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1445
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1487
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1633
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1680
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..2288
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2261..2266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /note="hexamer: AATAAA"
     polyA_site      2288
                     /gene="ZDHHC6"
                     /gene_synonym="DHHC-6; DHHC6; ZNF376"
                     /note="major polyA site"
ORIGIN      
        1 agagtcctgg cgagggcgct ggccgagagg tgctcggctt gtagcaggtc ccgcactcca
       61 gcctctcgct gccagggttt gctctctgct tgtcctgggc tgaggtgtcc atgacggagt
      121 catccaagga ggaaaaaatc tgttccgggt gagcccaggc cgccccggat atgcgatggc
      181 tgaggagcag acaccaggga ccacactgag gtgggagtca aggcagggaa tataagcacg
      241 attttggtgg tctttgtccc accagagtgg gagcaggctc tcctgaatgt tgagaccaac
      301 ctggcttacc aggatatttc ttccttgggt tgggtttcag accaagacac tggattctcc
      361 tagttaagat aaagagcttt gggtgcctga cagtgaaaat ggtgtaatct gcgttaacag
      421 ttcacagctt gaaggcatga caattaaaga acacacatgg acttgtggca catggaaatg
      481 tgcgcacaga aaaaggaaat ctataattct tttaaagtag gaaggcattc ttccttgcca
      541 aaatgggtac attctgttcg gttatcaagt ttgaaaatct acaagaatta aagagactgt
      601 gtcactgggg tcccatcata gcccttggtg ttatagcaat atgttctacc atggccatga
      661 ttgactctgt gttgtggtat tggcccttac atacaactgg aggaagtgtg aatttcatca
      721 tgttgataaa ttggactgtc atgattcttt ataattactt caatgccatg tttgtcggtc
      781 cgggctttgt ccctctgggg tggaaaccgg aaatttctca ggataccatg tatctccagt
      841 attgtaaagt ctgccaagca tacaaggcac cacgttcaca tcactgcaga aagtgtaaca
      901 gatgtgtgat gaagatggac catcactgtc cttggatcaa caactgttgt ggttaccaaa
      961 atcatgcttc gttcacactg tttctccttt tagcaccact gggttgtatc catgctgctt
     1021 tcatttttgt gatgactatg tacacacagc tttatcatcg gctctccttt gggtggaaca
     1081 cagtgaagat cgacatgagt gcagcccgga gagatcctct tccaattgtt ccatttggat
     1141 tagctgcatt tgctaccacc ttgtttgcct tgggattagc tttaggaaca accatagctg
     1201 ttgggatgtt gttttttatc cagatgaaaa taattctcag aaacaaaact tctattgagt
     1261 catggattga agagaaggct aaagatcgaa ttcagtatta tcaactagat gaagtctttg
     1321 tttttccata tgatatggga agtagatgga ggaactttaa acaggtattt acgtggtcag
     1381 gggtccctga aggagatgga cttgagtggc cagtaagaga aggctgtcac caatacagct
     1441 taacaataga acagttgaaa caaaaagcag ataagagagt cagaagtgtt cgctataaag
     1501 taatagaaga ttatagtggt gcctgctgcc ctctgaataa aggaatcaaa accttcttca
     1561 caagtccctg caccgaagag cctcgaatac agctgcaaaa aggggaattc attttagcca
     1621 caagaggttt acgatactgg ttatatggag acaaaattct tgatgattcc tttatagaag
     1681 gtgtttcaag aataaggggt tggttcccta gaaaatgtgt ggaaaagtgt ccctgtgatg
     1741 ctgaaacaga tcaagcccca gagggggaga agaaaaatag atagctgctg ttaaaacaaa
     1801 attatccttt aagtctgctt aattacttga aaattgtaca tattactaaa gaattatgca
     1861 atgagcctac tctggttaag atgttctttt cctcaaaggt gccctagtgc catgatttaa
     1921 atatttttat taccattttg aaatggagaa gccattctgc atatgccttt gaattcctgc
     1981 ccctctttac cacctcttcc tccccctcaa aggaaaaaca tttcatccaa gtaagttaac
     2041 ggcattttct gtaggatttt cttatgcact gcacactctg gacctcacct gcagatacag
     2101 ttcccccctt gccaggagca tctgcatgtg gtacttctct tttccctcag ttgatatttc
     2161 ttatatgata ttctagatac tatagaactc aatttgtcag attcagtata acctcagatt
     2221 ttgttacctg tcttttaaaa atgcagattt tgtcaaatca aataaagatc aatggatgtt
     2281 gggtataa
//
