LOCUS       NM_015457               4443 bp    mRNA    linear   PRI 06-MAR-2025
DEFINITION  Homo sapiens zDHHC palmitoyltransferase 5 (ZDHHC5), mRNA.
ACCESSION   NM_015457 XM_290511
VERSION     NM_015457.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4443)
  AUTHORS   Du,G., Healy,L.B., David,L., Walker,C., El-Baba,T.J.,
            Lutomski,C.A., Goh,B., Gu,B., Pi,X., Devant,P., Fontana,P.,
            Dong,Y., Ma,X., Miao,R., Balasubramanian,A., Puthenveetil,R.,
            Banerjee,A., Luo,H.R., Kagan,J.C., Oh,S.F., Robinson,C.V.,
            Lieberman,J. and Wu,H.
  TITLE     ROS-dependent S-palmitoylation activates cleaved and intact
            gasdermin D
  JOURNAL   Nature 630 (8016), 437-446 (2024)
   PUBMED   38599239
REFERENCE   2  (bases 1 to 4443)
  AUTHORS   Balasubramanian,A., Hsu,A.Y., Ghimire,L., Tahir,M., Devant,P.,
            Fontana,P., Du,G., Liu,X., Fabin,D., Kambara,H., Xie,X., Liu,F.,
            Hasegawa,T., Xu,R., Yu,H., Chen,M., Kolakowski,S., Trauger,S.,
            Larsen,M.R., Wei,W., Wu,H., Kagan,J.C., Lieberman,J. and Luo,H.R.
  TITLE     The palmitoylation of gasdermin D directs its membrane
            translocation and pore formation during pyroptosis
  JOURNAL   Sci Immunol 9 (94), eadn1452 (2024)
   PUBMED   38530158
REFERENCE   3  (bases 1 to 4443)
  AUTHORS   Guo,R., Liu,J., Min,X., Zeng,W., Shan,B., Zhang,M., He,Z.,
            Zhang,Y., He,K., Yuan,J. and Xu,D.
  TITLE     Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies
            autophagy decline in aging
  JOURNAL   Nat Struct Mol Biol 31 (2), 232-245 (2024)
   PUBMED   38177673
  REMARK    GeneRIF: Reduction of DHHC5-mediated beclin 1 S-palmitoylation
            underlies autophagy decline in aging.
REFERENCE   4  (bases 1 to 4443)
  AUTHORS   Wang,Y., Shen,N., Yang,Y., Xia,Y., Zhang,W., Lu,Y., Wang,Z.,
            Yang,Z. and Wang,Z.
  TITLE     ZDHHC5-mediated S-palmitoylation of FAK promotes its membrane
            localization and epithelial-mesenchymal transition in glioma
  JOURNAL   Cell Commun Signal 22 (1), 46 (2024)
   PUBMED   38233791
  REMARK    GeneRIF: ZDHHC5-mediated S-palmitoylation of FAK promotes its
            membrane localization and epithelial-mesenchymal transition in
            glioma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4443)
  AUTHORS   Zheng,S., Que,X., Wang,S., Zhou,Q., Xing,X., Chen,L., Hou,C.,
            Ma,J., An,P., Peng,Y., Yao,Y., Song,Q., Li,J., Zhang,P. and Pei,H.
  TITLE     ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7
            interaction and inflammasome activation
  JOURNAL   Mol Cell 83 (24), 4570-4585 (2023)
   PUBMED   38092000
  REMARK    GeneRIF: ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7
            interaction and inflammasome activation.
REFERENCE   6  (bases 1 to 4443)
  AUTHORS   Li,Y., Martin,B.R., Cravatt,B.F. and Hofmann,S.L.
  TITLE     DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on
            induction of neuronal differentiation in cultured cells
  JOURNAL   J Biol Chem 287 (1), 523-530 (2012)
   PUBMED   22081607
REFERENCE   7  (bases 1 to 4443)
  AUTHORS   Kokkola,T., Kruse,C., Roy-Pogodzik,E.M., Pekkinen,J., Bauch,C.,
            Honck,H.H., Hennemann,H. and Kreienkamp,H.J.
  TITLE     Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5
            palmitoyltransferase
  JOURNAL   FEBS Lett 585 (17), 2665-2670 (2011)
   PUBMED   21820437
  REMARK    GeneRIF: ZDHHC5 and SSTR5 are colocalized at the plasma membrane
            and coexpression of ZDHHC5 increased palmitoylation of SSTR5
            whereas knock-down of endogenous ZDHHC5 by siRNAs decreased it.
REFERENCE   8  (bases 1 to 4443)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (bases 1 to 4443)
  AUTHORS   Yang,W., Di Vizio,D., Kirchner,M., Steen,H. and Freeman,M.R.
  TITLE     Proteome scale characterization of human S-acylated proteins in
            lipid raft-enriched and non-raft membranes
  JOURNAL   Mol Cell Proteomics 9 (1), 54-70 (2010)
   PUBMED   19801377
  REMARK    GeneRIF: Data show that palmitoyl acyltransferases DHHC5, DHHC6,
            and DHHC8 appear to be S-acylated on three cysteine residues within
            a novel CCX(7-13)C(S/T) motif downstream of a conserved
            Asp-His-His-Cys cysteine-rich domain.
REFERENCE   10 (bases 1 to 4443)
  AUTHORS   Ohno,Y., Kihara,A., Sano,T. and Igarashi,Y.
  TITLE     Intracellular localization and tissue-specific distribution of
            human and yeast DHHC cysteine-rich domain-containing proteins
  JOURNAL   Biochim Biophys Acta 1761 (4), 474-483 (2006)
   PUBMED   16647879
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB051535.1, AK023130.1 and AL117662.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015457.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY894889.1, AB051535.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287169.8/ ENSP00000287169.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2137              AB051535.1         105-2241
            2138-4441           AK023130.1         1407-3710
            4442-4443           AL117662.1         1777-1778
FEATURES             Location/Qualifiers
     source          1..4443
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..4443
                     /gene="ZDHHC5"
                     /gene_synonym="DHHC5; ZNF375"
                     /note="zDHHC palmitoyltransferase 5"
                     /db_xref="GeneID:25921"
                     /db_xref="HGNC:HGNC:18472"
                     /db_xref="MIM:614586"
     exon            1..74
                     /gene="ZDHHC5"
                     /gene_synonym="DHHC5; ZNF375"
                     /inference="alignment:Splign:2.1.0"
     exon            75..1248
                     /gene="ZDHHC5"
                     /gene_synonym="DHHC5; ZNF375"
                     /inference="alignment:Splign:2.1.0"
     CDS             1145..3292
                     /gene="ZDHHC5"
                     /gene_synonym="DHHC5; ZNF375"
                     /EC_number="2.3.1.225"
                     /note="zinc finger, DHHC domain containing 5; probable
                     palmitoyltransferase ZDHHC5; membrane-associated DHHC5
                     zinc finger protein; DHHC-5; zinc finger protein 375; zinc
                     finger DHHC domain-containing protein 5; zinc finger
                     DHHC-type palmitoyltransferase 5; zinc finger DHHC-type
                     containing 5"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC5"
                     /protein_id="NP_056272.2"
                     /db_xref="CCDS:CCDS7965.1"
                     /db_xref="GeneID:25921"
                     /db_xref="HGNC:HGNC:18472"
                     /db_xref="MIM:614586"
                     /translation="MPAESGKRFKPSKYVPVSAAAIFLVGATTLFFAFTCPGLSLYVS
                     PAVPIYNAIMFLFVLANFSMATFMDPGIFPRAEEDEDKEDDFRAPLYKTVEIKGIQVR
                     MKWCATCRFYRPPRCSHCSVCDNCVEEFDHHCPWVNNCIGRRNYRYFFLFLLSLTAHI
                     MGVFGFGLLYVLYHIEELSGVRTAVTMAVMCVAGLFFIPVAGLTGFHVVLVARGRTTN
                     EQVTGKFRGGVNPFTNGCCNNVSRVLCSSPAPRYLGRPKKEKTIVIRPPFLRPEVSDG
                     QITVKIMDNGIQGELRRTKSKGSLEITESQSADAEPPPPPKPDLSRYTGLRTHLGLAT
                     NEDSSLLAKDSPPTPTMYKYRPGYSSSSTSAAMPHSSSAKLSRGDSLKEPTSIAESSR
                     HPSYRSEPSLEPESFRSPTFGKSFHFDPLSSGSRSSSLKSAQGTGFELGQLQSIRSEG
                     TTSTSYKSLANQTRNGSLSYDSLLTPSDSPDFESVQAGPEPDPPLGYTSPFLSARLAQ
                     QREAERHPRLVPTGPTHREPSPVRYDNLSRHIVASLQEREKLLRQSPPLPGREEEPGL
                     GDSGIQSTPGSGHAPRTSSSSDDSKRSPLGKTPLGRPAVPRFGKPDGLRGRGVGSPEP
                     GPTAPYLGRSMSYSSQKAQPGVSETEEVALQPLLTPKDEVQLKTTYSKSNGQPKSLGS
                     ASPGPGQPPLSSPTRGGVKKVSGVGGTTYEISV"
     exon            1249..1370
                     /gene="ZDHHC5"
                     /gene_synonym="DHHC5; ZNF375"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1528
                     /gene="ZDHHC5"
                     /gene_synonym="DHHC5; ZNF375"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1701
                     /gene="ZDHHC5"
                     /gene_synonym="DHHC5; ZNF375"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1804
                     /gene="ZDHHC5"
                     /gene_synonym="DHHC5; ZNF375"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1896
                     /gene="ZDHHC5"
                     /gene_synonym="DHHC5; ZNF375"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2029
                     /gene="ZDHHC5"
                     /gene_synonym="DHHC5; ZNF375"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2153
                     /gene="ZDHHC5"
                     /gene_synonym="DHHC5; ZNF375"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2266
                     /gene="ZDHHC5"
                     /gene_synonym="DHHC5; ZNF375"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..3126
                     /gene="ZDHHC5"
                     /gene_synonym="DHHC5; ZNF375"
                     /inference="alignment:Splign:2.1.0"
     exon            3127..4443
                     /gene="ZDHHC5"
                     /gene_synonym="DHHC5; ZNF375"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3602..3607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC5"
                     /gene_synonym="DHHC5; ZNF375"
                     /note="hexamer: AATAAT"
     polyA_site      3624
                     /gene="ZDHHC5"
                     /gene_synonym="DHHC5; ZNF375"
     regulatory      4427..4432
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC5"
                     /gene_synonym="DHHC5; ZNF375"
                     /note="hexamer: AAGAAA"
     polyA_site      4443
                     /gene="ZDHHC5"
                     /gene_synonym="DHHC5; ZNF375"
                     /note="major polyA site"
ORIGIN      
        1 ctctgaggca ggacggcact gccgggaggc ggcggtgaca acgacggcgg tggtgacggg
       61 caccgggctc gcgggtgaga cacagtaacc tggttgaact ctgcatctgg aaagctgaag
      121 actgaagaaa gataagagac attgactagt ctggaaacag ggacatcttt ggaacttcgt
      181 tttcatccac agtaaacttt tgaagtgtca tcaattggaa ttgatttctt catcttattc
      241 tgcctattgg gaagaacatg gcttcaagga ttttaagttt ccctttagtt ttacatgaac
      301 tttgtaggaa acagagccct taaagggctt gggaataaca agaagagatt gaagacagag
      361 aagcttgccc tgttttcctt gccccttcaa agaaaaggat ttacagctca aacttagaac
      421 agctgttgtc cagctttagc catcaagaga gaaataaatt aaaccaccat tgccagacta
      481 caagccctgg tgaagtcagg gtgtgggagt ggtggcattg agaagactac ctaaaagaga
      541 caaagactgc agtaaacaaa gctcctcttt aaagttggaa ggggcctcag gttccttctt
      601 ggattgaaat agaaatagaa acacagggca cacctctttt aggtgcagct cacattttat
      661 ggaactgtag tcgtggaggt actatagtat ctcagaagaa tttttctttg cccaaagttt
      721 ttttgccata ccctgatatt ctctccttct tttgaagacc tgcctccatc catgagctgt
      781 atcttgatct gtctgactgt ccatgttttc cacctgcaac catttgcatg tgtacagcct
      841 actgtttgtc tccagttttt aaactgtaca agttgtgttt cttaatcttc ccttctgcct
      901 tgttctgggg aggtggttat tcatcatttg gaatcacctt tccccctccc atgtgctttc
      961 cttcatttga gatcttttga cctttggctt tatttgggag ggggaagggt gataaagttt
     1021 tctgtttccc tggttttctt ttgtactcct ctctgttgct tccctcctcc cattttcttg
     1081 tctgttctgc cgctgtgtgg gcctgggcta tgcggcaggg cagatttccc atcagagctc
     1141 caacatgccc gcagagtctg gaaagagatt caaacccagc aagtatgtcc cggtctctgc
     1201 agccgccatc ttcctagtgg gagctacgac actcttcttt gcctttacgt gtccaggact
     1261 aagcctgtat gtgtcacctg cagtgcccat ctacaatgca attatgtttc tctttgtgtt
     1321 ggccaacttc agcatggcca ccttcatgga cccagggatt ttccctcgag ctgaggagga
     1381 tgaggacaag gaagatgatt tccgagctcc cctttacaaa acagtggaga taaagggcat
     1441 ccaggtgcgc atgaaatggt gtgccacctg ccgcttttac cgtccccctc gatgttccca
     1501 ctgcagtgtc tgtgacaact gtgtggagga atttgatcat cactgcccct gggtgaataa
     1561 ctgtattggt cgccggaact accgttattt tttccttttc ctcctttccc tgacagccca
     1621 cattatgggt gtgtttggct ttggcctcct ttatgtcctc taccacatag aggaactctc
     1681 aggggtccgc acggctgtca caatggcagt aatgtgtgtg gctggcttat tcttcatccc
     1741 tgtagctggc ctcacgggat ttcacgtggt tctggtggcc aggggacgca caaccaatga
     1801 acaggttacg ggtaaattcc ggggaggtgt gaaccccttc accaatggct gctgtaacaa
     1861 tgtcagccgt gttctctgca gttctccagc acccaggtat ttggggagac caaagaaaga
     1921 gaagacaatt gtaatcagac ctcccttcct tcgaccagaa gtttcagatg ggcagataac
     1981 tgtgaagatc atggataatg gcatccaggg agagctgagg agaacaaagt ctaagggaag
     2041 cctggagata acagagagcc agtctgcaga tgctgaacct ccacctcctc ctaagccaga
     2101 cctgagccgt tacacagggt tgcgaacaca cctcggcttg gctactaatg aggatagtag
     2161 cttattggcc aaggacagcc ccccgacacc taccatgtac aagtatcggc cgggttacag
     2221 tagcagcagt acgtcagctg ccatgccgca ttcctccagc gccaagttga gtcgtgggga
     2281 cagcttgaag gagccaacct caattgcaga gagcagccgt caccccagct accgctcaga
     2341 gcccagcttg gaaccagaga gcttccgttc tcctaccttt ggcaaaagtt ttcacttcga
     2401 tccactatcc agtggctcac gctcctccag cctcaagtca gcccagggca caggctttga
     2461 gctgggccag ttgcaatcca ttcgttcaga gggcaccacc tccacctcct ataagagcct
     2521 ggccaaccag acacgcaatg gaagcctatc ttatgacagc ttgctcacac cttcagacag
     2581 ccctgatttt gagtcagtgc aggcagggcc tgagccagac ccacctttag gctatacctc
     2641 tcccttcctg tcagccaggc tggcccagca acgggaagct gagaggcacc cacgtttggt
     2701 gccaactggc ccaacacacc gagagccctc accagtccgt tacgacaatc tgtcgcgcca
     2761 cattgtggcc tctctccagg aacgagagaa gttgctgcgc cagtcacccc cactcccggg
     2821 ccgtgaggaa gaaccaggct tgggggactc aggcattcag tcaacaccag gctcgggcca
     2881 tgcccctcgt actagttcct cctcagatga ttcaaagaga tcacctttgg gcaagactcc
     2941 actgggacgc ccagctgtcc cccgttttgg caagccagat gggctaaggg gccggggagt
     3001 agggtcccct gaaccaggcc caacagcccc atacctgggc cgatcgatgt cttacagcag
     3061 ccaaaaagcc caacctggtg tctctgagac agaagaagtg gccttgcagc cattactgac
     3121 acccaaagat gaagtacagc tgaagaccac ctacagcaaa tccaacgggc agcccaagag
     3181 cttaggctca gcctcccctg gcccaggcca gccacctctc agtagcccca cgaggggagg
     3241 agtcaagaag gtgtcagggg ttggtggtac cacctatgag atttcggtgt gagccttcgg
     3301 cacctcccct ccccaacgcc tctgcgccta caccaaaggg ccccaggtgg ccaccttcct
     3361 tccctcaagg ggctcccctc ccgtgcatgg acatttttta aaccaccgat tccaagagga
     3421 tgaggagtgt tttctaaaat gcagtaggct tggggagtcg gagagttggg gccctgagac
     3481 tggggtagca accccccctt ttatctttta agaccttccc ttccttgatc cctggaccag
     3541 actcagtgga catttgtgca attgctcgcc ctggagggaa ccagatcatt tttaaaccag
     3601 aaataatttt ttttattatt gttacggatt ctattttttt cctcttctgc gttaccaggt
     3661 gtgtgtgtac atataatata tatatatata tattataaat atcaaagaaa ttatatatct
     3721 atcctgggat gggaaaatga gggagggata catatacgga gggggatctt actcttccca
     3781 ttcctcagac cagcaggaaa agaggggaga cgtcagtctt tttcctgtgg ttccctctca
     3841 tttgtcccag ttactaacta cggaaatagc atcctctgct ggtgctaagt gtgattagga
     3901 agaagcctgg ggagaggtga gtctggaatt ttggtcacaa gagggaagga cttggagagg
     3961 agaattagtt ttctaggctc attggcattt agtttcccta ggaaaggggt caaaacttca
     4021 agacactggt ggtggtggga gatcaggaaa ataacttggc ctagctcaaa caatattgga
     4081 taatcccctc cttgggggag agggattaga gtgtgctcct actggcccct tggagcctcc
     4141 cctagcttac acagttaact tgattttaaa atccaaggcc aggagagaag aatccaaaaa
     4201 gcaatatttt tcatcacatg ccaaaaacgg gggatagaga gaaggagtgg caggcctagg
     4261 cccctccgat tgtcccttgg gggttacccc tcagcccacc tcactatggt gctgggtaga
     4321 ggggatacct gggttctaac ctctaaatag gggagatccc agcctccaca aagaggccct
     4381 tttatttttt attctgatta gccattttaa accaacgagg aataaaaaga aatcctgatc
     4441 taa
//
