LOCUS       NM_001134389            1706 bp    mRNA    linear   PRI 06-MAR-2025
DEFINITION  Homo sapiens zDHHC palmitoyltransferase 4 (ZDHHC4), transcript
            variant 4, mRNA.
ACCESSION   NM_001134389
VERSION     NM_001134389.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1706)
  AUTHORS   Zhao,C., Yu,H., Fan,X., Niu,W., Fan,J., Sun,S., Gong,M., Zhao,B.,
            Fang,Z. and Chen,X.
  TITLE     GSK3beta palmitoylation mediated by ZDHHC4 promotes tumorigenicity
            of glioblastoma stem cells in temozolomide-resistant glioblastoma
            through the EZH2-STAT3 axis
  JOURNAL   Oncogenesis 11 (1), 28 (2022)
   PUBMED   35606353
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1706)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1706)
  AUTHORS   Wang,J., Hao,J.W., Wang,X., Guo,H., Sun,H.H., Lai,X.Y., Liu,L.Y.,
            Zhu,M., Wang,H.Y., Li,Y.F., Yu,L.Y., Xie,C., Wang,H.R., Mo,W.,
            Zhou,H.M., Chen,S., Liang,G. and Zhao,T.J.
  TITLE     DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and
            Targeting CD36 to the Plasma Membrane
  JOURNAL   Cell Rep 26 (1), 209-221 (2019)
   PUBMED   30605677
REFERENCE   4  (bases 1 to 1706)
  AUTHORS   Ebersole,B., Petko,J., Woll,M., Murakami,S., Sokolina,K., Wong,V.,
            Stagljar,I., Luscher,B. and Levenson,R.
  TITLE     Effect of C-Terminal S-Palmitoylation on D2 Dopamine Receptor
            Trafficking and Stability
  JOURNAL   PLoS One 10 (11), e0140661 (2015)
   PUBMED   26535572
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1706)
  AUTHORS   Gorleku,O.A., Barns,A.M., Prescott,G.R., Greaves,J. and
            Chamberlain,L.H.
  TITLE     Endoplasmic reticulum localization of DHHC palmitoyltransferases
            mediated by lysine-based sorting signals
  JOURNAL   J Biol Chem 286 (45), 39573-39584 (2011)
   PUBMED   21926431
REFERENCE   6  (bases 1 to 1706)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 1706)
  AUTHORS   Ohno,Y., Kihara,A., Sano,T. and Igarashi,Y.
  TITLE     Intracellular localization and tissue-specific distribution of
            human and yeast DHHC cysteine-rich domain-containing proteins
  JOURNAL   Biochim Biophys Acta 1761 (4), 474-483 (2006)
   PUBMED   16647879
REFERENCE   8  (bases 1 to 1706)
  AUTHORS   Grimsby,S., Jaensson,H., Dubrovska,A., Lomnytska,M., Hellman,U. and
            Souchelnytskyi,S.
  TITLE     Proteomics-based identification of proteins interacting with Smad3:
            SREBP-2 forms a complex with Smad3 and inhibits its transcriptional
            activity
  JOURNAL   FEBS Lett 577 (1-2), 93-100 (2004)
   PUBMED   15527767
REFERENCE   9  (bases 1 to 1706)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK001341.1, BQ185277.1 and AC079742.6.
            
            On Jun 2, 2019 this sequence version replaced NM_001134389.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 5. Variants 1-4 and 6-10 all encode the same isoform
            (b).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK001341.1, AL136674.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335965.11/ ENSP00000337475.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1258              AK001341.1         2-1259
            1259-1311           BQ185277.1         18-70               c
            1312-1706           AC079742.6         13449-13843
FEATURES             Location/Qualifiers
     source          1..1706
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.1"
     gene            1..1706
                     /gene="ZDHHC4"
                     /gene_synonym="ZNF374"
                     /note="zDHHC palmitoyltransferase 4"
                     /db_xref="GeneID:55146"
                     /db_xref="HGNC:HGNC:18471"
     exon            1..45
                     /gene="ZDHHC4"
                     /gene_synonym="ZNF374"
                     /inference="alignment:Splign:2.1.0"
     exon            46..200
                     /gene="ZDHHC4"
                     /gene_synonym="ZNF374"
                     /inference="alignment:Splign:2.1.0"
     exon            201..324
                     /gene="ZDHHC4"
                     /gene_synonym="ZNF374"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..1242
                     /gene="ZDHHC4"
                     /gene_synonym="ZNF374"
                     /EC_number="2.3.1.225"
                     /note="isoform b is encoded by transcript variant 4; zinc
                     finger, DHHC domain containing 4; probable
                     palmitoyltransferase ZDHHC4; DHHC-4; zinc finger protein
                     374; zinc finger DHHC domain-containing protein 4; zinc
                     finger DHHC-type containing 4; zinc finger DHHC-type
                     palmitoyltransferase 4"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC4 isoform b"
                     /protein_id="NP_001127861.1"
                     /db_xref="CCDS:CCDS5352.1"
                     /db_xref="GeneID:55146"
                     /db_xref="HGNC:HGNC:18471"
                     /translation="MDFLVLFLFYLASVLMGLVLICVCSKTHSLKGLARGGAQIFSCI
                     IPECLQRAVHGLLHYLFHTRNHTFIVLHLVLQGMVYTEYTWEVFGYCQELELSLHYLL
                     LPYLLLGVNLFFFTLTCGTNPGIITKANELLFLHVYEFDEVMFPKNVRCSTCDLRKPA
                     RSKHCSVCNWCVHRFDHHCVWVNNCIGAWNIRYFLIYVLTLTASAATVAIVSTTFLVH
                     LVVMSDLYQETYIDDLGHLHVMDTVFLIQYLFLTFPRIVFMLGFVVVLSFLLGGYLLF
                     VLYLAATNQTTNEWYRGDWAWCQRCPLVAWPPSAEPQVHRNIHSHGLRSNLQEIFLPA
                     FPCHERKKQE"
     exon            325..398
                     /gene="ZDHHC4"
                     /gene_synonym="ZNF374"
                     /inference="alignment:Splign:2.1.0"
     exon            399..577
                     /gene="ZDHHC4"
                     /gene_synonym="ZNF374"
                     /inference="alignment:Splign:2.1.0"
     exon            578..703
                     /gene="ZDHHC4"
                     /gene_synonym="ZNF374"
                     /inference="alignment:Splign:2.1.0"
     exon            704..948
                     /gene="ZDHHC4"
                     /gene_synonym="ZNF374"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1706
                     /gene="ZDHHC4"
                     /gene_synonym="ZNF374"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1308
                     /gene="ZDHHC4"
                     /gene_synonym="ZNF374"
                     /note="major polyA site"
     polyA_site      1328
                     /gene="ZDHHC4"
                     /gene_synonym="ZNF374"
     regulatory      1342..1347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC4"
                     /gene_synonym="ZNF374"
                     /note="hexamer: TATAAA"
     polyA_site      1368
                     /gene="ZDHHC4"
                     /gene_synonym="ZNF374"
     polyA_site      1398
                     /gene="ZDHHC4"
                     /gene_synonym="ZNF374"
ORIGIN      
        1 agtctcgtat cgcgcccggg aggcgccgga gcccagcggc tggcgccaga tccaggctcc
       61 tggaagaacc atgtccggca gctactggtc atgccaggca cacactgctg cccaagagga
      121 gctgctgttt gaattatctg tgaatgttgg gaagaggaat gccagagctg ccggctgaaa
      181 attacccaac caagagaaat ctgcaggatg gactttctgg tcctcttctt gttctacctg
      241 gcttcggtgc tgatgggtct tgttcttatc tgcgtctgct cgaaaaccca tagcttgaaa
      301 ggcctggcca ggggaggagc acagatattt tcctgtataa ttccagaatg tcttcagaga
      361 gccgtgcatg gattgcttca ttaccttttc catacgagaa accacacctt cattgtcctg
      421 cacctggtct tgcaagggat ggtttatact gagtacacct gggaagtatt tggctactgt
      481 caggagctgg agttgtcctt gcattacctt cttctgccct atctgctgct aggtgtaaac
      541 ctgttttttt tcaccctgac ttgtggaacc aatcctggca ttataacaaa agcaaatgaa
      601 ttattatttc ttcatgttta tgaatttgat gaagtgatgt ttccaaagaa cgtgaggtgc
      661 tctacttgtg atttaaggaa accagctcga tccaagcact gcagtgtgtg taactggtgt
      721 gtgcaccgtt tcgaccatca ctgtgtttgg gtgaacaact gcatcggggc ctggaacatc
      781 aggtacttcc tcatctacgt cttgaccttg acggcctcgg ctgccaccgt cgccattgtg
      841 agcaccactt ttctggtcca cttggtggtg atgtcagatt tataccagga gacttacatc
      901 gatgaccttg gacacctcca tgttatggac acggtctttc ttattcagta cctgttcctg
      961 acttttccac ggattgtctt catgctgggc tttgtcgtgg ttctgagctt cctcctgggt
     1021 ggctacctgt tgtttgtcct gtatctggcg gccaccaacc agactactaa cgagtggtac
     1081 agaggtgact gggcctggtg ccagcgttgt ccccttgtgg cctggcctcc gtcagcagag
     1141 ccccaagtcc accggaacat tcactcccat gggcttcgga gcaaccttca agagatcttt
     1201 ctacctgcct ttccatgtca tgagaggaag aaacaagaat gacaagtgta tgactgcctt
     1261 tgagctgtag ttcccgttta tttacacatg tggatcctcg ttttccaagc atggcttgtt
     1321 tgttttgatt tctgctgtgc ttataaatca ctttcggtgg gcaagggaga gaggggaaaa
     1381 tgggtgttga ctgaggaatc ccccttgctt gtcttctttt gaaaccgggc atctctgaag
     1441 tcctggtgtc aaggggatca agagatgact tctcagaggt tctaggtgat gctgagacct
     1501 tggtgtctct aaactctggg catgtggaca ggaggggctt gcggccgtgt ctctgacctg
     1561 tgtgatgtgc aggagggtct cattgactca gcgcctgcgc gttgtgcctg gctgtgctct
     1621 cttttatgcc ccctctattc tcctctctcc cccaggggat tttcatctca acaacagagt
     1681 gtcctcaccc aggcctgcct tccggc
//
