LOCUS       NM_001135179           12594 bp    mRNA    linear   PRI 06-MAR-2025
DEFINITION  Homo sapiens zDHHC palmitoyltransferase 3 (ZDHHC3), transcript
            variant 1, mRNA.
ACCESSION   NM_001135179
VERSION     NM_001135179.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12594)
  AUTHORS   Zhang,X., Hou,J., Zhou,G., Wang,H. and Wu,Z.
  TITLE     zDHHC3-mediated S-palmitoylation of SLC9A2 regulates apoptosis in
            kidney clear cell carcinoma
  JOURNAL   J Cancer Res Clin Oncol 150 (4), 194 (2024)
   PUBMED   38619631
  REMARK    GeneRIF: zDHHC3-mediated S-palmitoylation of SLC9A2 regulates
            apoptosis in kidney clear cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12594)
  AUTHORS   Ni,H., Wang,Y., Yao,K., Wang,L., Huang,J., Xiao,Y., Chen,H.,
            Liu,B., Yang,C.Y. and Zhao,J.
  TITLE     Cyclical palmitoylation regulates TLR9 signalling and systemic
            autoimmunity in mice
  JOURNAL   Nat Commun 15 (1), 1 (2024)
   PUBMED   38169466
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 12594)
  AUTHORS   Cui,X., Liu,H., Shi,T., Zhao,Q., Li,F., Lv,W., Yu,C., Huang,H.,
            Tang,Q.Q. and Pan,D.
  TITLE     IFI27 Integrates Succinate and Fatty Acid Oxidation to Promote
            Adipocyte Thermogenic Adaption
  JOURNAL   Adv Sci (Weinh) 10 (28), e2301855 (2023)
   PUBMED   37544897
  REMARK    GeneRIF: IFI27 Integrates Succinate and Fatty Acid Oxidation to
            Promote Adipocyte Thermogenic Adaption.
REFERENCE   4  (bases 1 to 12594)
  AUTHORS   Tang,M., Xia,Y., Xiao,T., Cao,R., Cao,Y. and Ouyang,B.
  TITLE     Structural Exploration on Palmitoyltransferase DHHC3 from Homo
            sapiens
  JOURNAL   Polymers (Basel) 14 (15), 3013 (2022)
   PUBMED   35893977
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 12594)
  AUTHORS   Sharma,C., Yang,W., Steen,H., Freeman,M.R. and Hemler,M.E.
  TITLE     Antioxidant functions of DHHC3 suppress anti-cancer drug activities
  JOURNAL   Cell Mol Life Sci 78 (5), 2341-2353 (2021)
   PUBMED   32986127
  REMARK    GeneRIF: Antioxidant functions of DHHC3 suppress anti-cancer drug
            activities.
REFERENCE   6  (bases 1 to 12594)
  AUTHORS   Tsutsumi,R., Fukata,Y., Noritake,J., Iwanaga,T., Perez,F. and
            Fukata,M.
  TITLE     Identification of G protein alpha subunit-palmitoylating enzyme
  JOURNAL   Mol Cell Biol 29 (2), 435-447 (2009)
   PUBMED   19001095
REFERENCE   7  (bases 1 to 12594)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   8  (bases 1 to 12594)
  AUTHORS   Ohno,Y., Kihara,A., Sano,T. and Igarashi,Y.
  TITLE     Intracellular localization and tissue-specific distribution of
            human and yeast DHHC cysteine-rich domain-containing proteins
  JOURNAL   Biochim Biophys Acta 1761 (4), 474-483 (2006)
   PUBMED   16647879
REFERENCE   9  (bases 1 to 12594)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   10 (bases 1 to 12594)
  AUTHORS   Uemura,T., Mori,H. and Mishina,M.
  TITLE     Isolation and characterization of Golgi apparatus-specific GODZ
            with the DHHC zinc finger domain
  JOURNAL   Biochem Biophys Res Commun 296 (2), 492-496 (2002)
   PUBMED   12163046
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB636483.1, BC015467.1, AC104165.2, AC098649.2, AA778122.1 and
            AK000216.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001135179.1.
            
            Transcript Variant: This variant (1), as well as variants 9 and 10,
            encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.23916.1,
                                           SRR1803614.61657.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000424952.7/ ENSP00000395502.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-580               DB636483.1         9-588
            581-1327            BC015467.1         516-1262
            1328-2036           AC104165.2         19660-20368         c
            2037-2662           AC098649.2         203518-204143       c
            2663-3009           AA778122.1         1-347               c
            3010-12487          AC098649.2         193693-203170       c
            12488-12594         AK000216.1         1632-1738
FEATURES             Location/Qualifiers
     source          1..12594
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..12594
                     /gene="ZDHHC3"
                     /gene_synonym="DHHC-3; DHHC3; GODZ; ZNF373"
                     /note="zDHHC palmitoyltransferase 3"
                     /db_xref="GeneID:51304"
                     /db_xref="HGNC:HGNC:18470"
                     /db_xref="MIM:617150"
     exon            1..242
                     /gene="ZDHHC3"
                     /gene_synonym="DHHC-3; DHHC3; GODZ; ZNF373"
                     /inference="alignment:Splign:2.1.0"
     exon            243..572
                     /gene="ZDHHC3"
                     /gene_synonym="DHHC-3; DHHC3; GODZ; ZNF373"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..1166
                     /gene="ZDHHC3"
                     /gene_synonym="DHHC-3; DHHC3; GODZ; ZNF373"
                     /EC_number="2.3.1.225"
                     /note="isoform 1 is encoded by transcript variant 1; Golgi
                     apparatus-specific protein with DHHC zinc finger domain;
                     golgi-specific DHHC Zinc Finger Protein; DHHC1 protein;
                     zinc finger, DHHC domain containing 3;
                     palmitoyltransferase ZDHHC3; zinc finger protein 373; zinc
                     finger DHHC domain-containing protein 3; zinc finger
                     DHHC-type containing 3; zinc finger DHHC-type
                     palmitoyltransferase 3; acyltransferase ZDHHC3"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC3 isoform 1"
                     /protein_id="NP_001128651.1"
                     /db_xref="CCDS:CCDS46811.1"
                     /db_xref="GeneID:51304"
                     /db_xref="HGNC:HGNC:18470"
                     /db_xref="MIM:617150"
                     /translation="MMLIPTHHFRNIERKPEYLQPEKCVPPPYPGPVGTMWFIRDGCG
                     IACAIVTWFLVLYAEFVVLFVMLIPSRDYVYSIINGIVFNLLAFLALASHCRAMLTDP
                     GAVPKGNATKEFIESLQLKPGQVVYKCPKCCSIKPDRAHHCSVCKRCIRKMDHHCPWV
                     NNCVGENNQKYFVLFTMYIALISLHALIMVGFHFLHCFEEDWTKCSSFSPPTTVILLI
                     LLCFEGLLFLIFTSVMFGTQVHSICTDETGIEQLKKEERRWAKKTKWMNMKAVFGHPF
                     SLGWASPFATPDQGKADPYQYVV"
     exon            573..697
                     /gene="ZDHHC3"
                     /gene_synonym="DHHC-3; DHHC3; GODZ; ZNF373"
                     /inference="alignment:Splign:2.1.0"
     exon            698..794
                     /gene="ZDHHC3"
                     /gene_synonym="DHHC-3; DHHC3; GODZ; ZNF373"
                     /inference="alignment:Splign:2.1.0"
     exon            795..876
                     /gene="ZDHHC3"
                     /gene_synonym="DHHC-3; DHHC3; GODZ; ZNF373"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1007
                     /gene="ZDHHC3"
                     /gene_synonym="DHHC-3; DHHC3; GODZ; ZNF373"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..12594
                     /gene="ZDHHC3"
                     /gene_synonym="DHHC-3; DHHC3; GODZ; ZNF373"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2665..2670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC3"
                     /gene_synonym="DHHC-3; DHHC3; GODZ; ZNF373"
                     /note="hexamer: AATAAA"
     polyA_site      2686
                     /gene="ZDHHC3"
                     /gene_synonym="DHHC-3; DHHC3; GODZ; ZNF373"
                     /note="major polyA site"
     regulatory      7856..7861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC3"
                     /gene_synonym="DHHC-3; DHHC3; GODZ; ZNF373"
                     /note="hexamer: ATTAAA"
     polyA_site      7879
                     /gene="ZDHHC3"
                     /gene_synonym="DHHC-3; DHHC3; GODZ; ZNF373"
     regulatory      12569..12574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC3"
                     /gene_synonym="DHHC-3; DHHC3; GODZ; ZNF373"
                     /note="hexamer: AATAAA"
     polyA_site      12594
                     /gene="ZDHHC3"
                     /gene_synonym="DHHC-3; DHHC3; GODZ; ZNF373"
                     /note="major polyA site"
ORIGIN      
        1 aacctgcgcg gcggccgctc ctgcagccgc ggccgccgcc actgccggga gagctcgatg
       61 ggcttctcct gcgcgccgcc cggtgtctgg ccgagtccag agagccgcgg cgcctcgttc
      121 cgaggagcca tcgccgaagc ccgaggccgg gtcccgggtt ggggactgca ggggaaggca
      181 gcggcggcgg cggcgggagc cccaccgggg tctgggactg gggaactgcc tccggcttca
      241 cgatgccagt atggacagaa tagcttatga tgcttatccc cacccaccac ttccgaaaca
      301 ttgagcggaa accagaatac ctccagccag agaagtgtgt cccacccccc taccctggtc
      361 ctgtgggaac catgtggttt atccgtgacg gctgtggcat cgcctgtgcc atcgttacct
      421 ggtttctggt cctctatgcg gagttcgtgg tcctctttgt catgctgatt ccatctcgag
      481 actacgtgta tagcatcatc aacggaattg tgttcaacct gctggccttc ttggccctgg
      541 cctcccactg ccgggccatg ctgacggacc ccggggcagt gcccaaagga aatgccacta
      601 aagaattcat cgagagttta cagttgaagc ctgggcaggt ggtgtacaag tgccccaaat
      661 gctgcagcat caagcccgac cgagcccacc actgcagtgt ttgtaagcgg tgcattcgga
      721 agatggacca ccactgtccc tgggtcaaca actgtgtagg cgagaacaac cagaagtact
      781 tcgtcctgtt tacaatgtac atagctctca tttccttgca cgccctcatc atggtgggat
      841 tccacttcct gcattgcttt gaagaagatt ggacaaagtg cagctccttc tctccaccca
      901 ccacagtgat tctccttatc ctgctgtgct ttgagggcct gctcttcctc attttcacat
      961 cagtgatgtt tgggacccag gtgcactcca tctgcacaga tgagacggga atagaacaat
     1021 tgaaaaagga agagagaaga tgggctaaaa aaacaaaatg gatgaacatg aaagccgttt
     1081 ttggccaccc cttctctcta ggctgggcca gcccctttgc cacgccagac caagggaagg
     1141 cagacccgta ccagtatgtg gtctgaagga ccccgaccgg catggccact cagacacaag
     1201 tccacaccac agcactaccg tcccatccgt tctcatgaat gtttaaatcg aaaaagcaaa
     1261 acaactactc ttaaaacttt ttttatgtct caagtaaaat ggctgagcat tgcagagaaa
     1321 aaaaaaagtc cccacatttt attttttaaa aaccatcctt tcgatttctt ttggtgaccg
     1381 aagctgctct cttttccttt taaaatcact tctctggcct ctggtttctc tctgctgtct
     1441 gtctggcatg actaatgtag agggcgctgt ctcgcgctgt gcccattcta ctaactgagt
     1501 gagacatgac gctgtgcgtg gatggaatag tctggacacc tggtggggga tgcatgggaa
     1561 agccaggagg gccctgacct cccactgccc aggaggcagt ggcgggctcc ccgatgggac
     1621 ataaaacctc accgaagatg gatgcttacc ccttgaggcc tgagaagggc aggatcagaa
     1681 gggaccttgg cacagcgacc tcatccccca agtggacacg gtttgcctgc taactcgcaa
     1741 agcaattgcc tgccttgtac tttatgggct tggggtgtgt agaatgattt tgcgggggag
     1801 tggggagaaa gatgaaagag gtcttatttg tattctgaat cagcaattat attccctgtg
     1861 attatttgga agagtgtgta ggaaagacgt ttttccagtt caaaatgcct tatacaatca
     1921 agaggaaaaa aaattacaca atttcaggca agctacgttt tcctttgttt catctgcttc
     1981 ctctctcacc accccatctc cctctcttcc ccagcaagat gtcaattaag cagtgtgaat
     2041 tctgactgca ataggcacca gtgcccaaca catacagccc caccatcatc cccttctcat
     2101 tttataaacc tcaaagtgga ttcactttct gatagttaac ccccataaat gtgcacgtac
     2161 ctgtgtctta tctatatttt aacctgggag actgttgtcc tggcatggag atgaccatga
     2221 tgctggggtt acctcacagt ccccaccctt tcaaagttga catatggcca tcccattggc
     2281 cagaatccac agacacacct aagcctgtgg cactgggaca gaatagattt tccatttgag
     2341 aggcacttcc tgtgtcagtc ttgtttgaag gaggtggtga tggtggatag aggtgaagga
     2401 ggtagggagt gccctccaag tgcaaaaata acaaatatga ttattgacca tcggggaatt
     2461 ctcacacatt gatttgtttt ttaagcaatt gccagaaacc ccctttttta gcttttgctt
     2521 ggggtggggg taggagttaa ggtttattca atcctgtcct gggtagggcg aaagttaatc
     2581 tagccatgtg atttttcaga aaagtaagtg gaacatgctg ccacttttca attctgtcag
     2641 tgcttccaca tggaaacaaa atgcaataaa atttttccaa aacctgttct gatttagctc
     2701 tctcttgagg tgttaccctt agtgggaggc cgactatcca caatctactt gagttttctc
     2761 tggttgggtg tttgtttcat tgctctgtct cttgaatgag gatactttat tttttttgtt
     2821 ttaaaatgca tttatggtcc ctctcttgaa ccagcttgcc ccaccaggcc tctttccttt
     2881 gctttctgca gcctgaatca attcctttgt gctgatgggc tctcctaaga gctttcctga
     2941 gtcagttaac tttacctcgt gtctacggtg ctattcatgc gatacgggcg aggctgagat
     3001 gctaagatta aaaagaaaag aatgctgttt tagatcaagt tgatagcatt tgttttccat
     3061 atgctttttt aaaatttttt cataacatac agctcagtta ggtgtatgaa agaagtgtta
     3121 ttgtattaaa taactagagc agggctacag ctctggccct cccctagggg gaagagattg
     3181 gtaatactcc atcttccagg gcatttttta aagtgagcca ggttagctct tttcccctgg
     3241 catttctcag gaatgcagta gatagtgctg aagatgcact gacttttttt tagtcctaaa
     3301 aatagaaact cctcctttaa agctgtgcat actatgctta tctttccaat agagtggggt
     3361 tccttcagat atcctatagg attctgcctc tggttttgta taggccttgg ctagaaagag
     3421 tcaatgtttc tgagctctca aaccagttgc tctcagaaga taggaatacc ccaaggttcc
     3481 tggcattttt cctatttcat ttttgttcag actgatattt tgccaagagc acaatgactg
     3541 aggaatgtag ccatcatttg cagggtagtg attggttccc agcctggctt ccacacagga
     3601 caggaaggga aagcatccct gagctctcct cagtatttcc ggatgtaatg aaagaggaca
     3661 tctttctaca caaagtcagc cccaactttt ggcttggtca caggagttct gatagtactg
     3721 tttggtgcac tcatgggaaa ttgaaccagt cgtagccaca gtctttcaga gcctgggctc
     3781 tggggagtgg aagtgaaaaa taaagatgtg gcttgttgga ttgtgatccc cagcttgctt
     3841 tccttctgtc aactctgtca ggtttgtgtt catagcaact agactgaata tgcaaaaggc
     3901 ttagatccaa gcaaatctat aatctatgca tatttgcatg ggcttggtaa tatcatgtac
     3961 acaaaacaca tttgggtaga agtgcatgtg ctaaatctcc ttttagtccc accattttgt
     4021 cttcttcata ctgtacttcc tcttttttgt ttgagacaag gtcttgctct gtcacccagg
     4081 ctggaatgca gtggcacaat tagagctcac tgcagccttg aactcctggg ctcaagtgat
     4141 tcttgtgcct tggcctcctg aatatccagg gctacaggca cgtactacca tgcctggcta
     4201 atttttttgt tttttaatag agtcagggtc tcactgtgtt gccctagcta gtctcaaatg
     4261 cccggcctcc agcaattttc ctgccttagc ctcccaaagt cctgggatta caggcgtgag
     4321 ccactgggcc cagccctgta cttcttgaaa aagccccaag tattagcttt tgctcatctg
     4381 gctaggccac ttaaatagtt agaatccacc gtcccctaat gcagaaaccg tttaggtgag
     4441 gtaaattaac aaacatttta agccgggcgc ggacacttct cactgtggac atccctcacg
     4501 cctgtaatcc cagcactttg ggaggccgag gcgggcagat cacgaggtca agagatcgag
     4561 atcatcctgg ctaacacggt gaaaccctgt ctctactaaa aatataaaaa aattagctgg
     4621 gcgtggtggc aggcgtctgt agtcccagct acttgggagg ctgaggcagg agaatggcgt
     4681 gaacccggga agtggagctt gcagtgagcc aagatcgcac cactgcactc cagcctgggc
     4741 gacagagtga gactccgtct caaaaaaaaa aaacaaacat tttaaacatg tatgtgaggt
     4801 tggcattaca cagaaactcc tctccgggtg ggctgggatg ggctttctca gccaggctaa
     4861 tgggttttaa atttctctct tttcaagact tgcagtgcat cagcttaaag ggtgagccag
     4921 ccagtagagg ggaaggcgcc ccacctagaa ggtgccctta gatatcaaag aaatgtgaaa
     4981 agagaaagat tttgctagaa tcctcctcaa aggtgttctt gaggttgcca gaccagcaac
     5041 gtcaacatca gcatcacctg agaacttgtt agaaatgcac attctcggtc cccaccccag
     5101 gctaccgaac cagaaaccga gcggggccca gcagcccgtg tcttaacagc cctccaggtg
     5161 attctgacta tcaagtttga gaatccagtt ggggctagca ggagtccccc ctcaggtggt
     5221 ccctgatgcc tgctggtgat atgggtcttg tgtgctgctg ggctcagcat agtgcagttg
     5281 gggtgtgctg attgtgagac aggcacgtgt tccctccgcg gagaagccac tgagactgcc
     5341 ttccctcata agctgcggcc tccccaacaa acaactgcca agacatcaaa gaaagtctgt
     5401 atgaagcaga tccaaattat tagcctgccc accactcctt gtgcatctca tcagtggaac
     5461 ccatctctag accaagggcc ctttgggtga agaagcagcc cggaagggaa agagaaaaga
     5521 gtagaaccaa gggacctcca gatgggagcg gcggccggtg agtagtctag agccaggggc
     5581 attgtagcag cctggataca tgacctgaac acgtcttgac ctttgctttc tacgtgtggg
     5641 tttcaacacc catgtggctt tttcttgtat tctttaaata tgtatctggc ttaggatcac
     5701 ctcatagaag agaaagaatt cacagtgaag cagaaacaag ccactgacca gcgtactccc
     5761 aacctgaacc ttctttttct caccctctcc ctcaagtaaa catcttgctg acttgagcag
     5821 tgtgattgcc gtagcaaagc agagtggccc ccagggatcc cgctctgttg ggcccacagg
     5881 aggagccgat gaagctgatc caaggagtga ggacaagcgc tgcagaggga cgttcgctaa
     5941 aagccttcta ggggccgcac atgctctaac acggacataa ggatgccctg aatttctgca
     6001 gctgaggcca tatagtctgg tgaccaagta tttgggtcct ggcttcagtc tttggttgaa
     6061 atgtctgctt ggctacttat taccgcacct actaccaaaa tatgaccttg agcagtaact
     6121 tctttaagcc tcagtttttt catctgaaaa cgggaatgat aatctaaatc acaaagttaa
     6181 tggaaggatt aaatgagggt gatgaatagg aatgtatagc gtctggccct ggtatggctt
     6241 tataaatgtt agctgtgttg gagctgtgct tttcaaacca ttggtcacag ccattcatgg
     6301 tttgcaacca gcatgttttt caagaaaaat gtttaatgca ttacatattg caggataagt
     6361 attgttttat gaagcttagg gagttgtgtg tatatgtgtt ctggaatgca acagaaaaat
     6421 gtttcctctt gtgggttaca atatagaggt atgaaatctc tgatgaggag agacagtgtt
     6481 atctggcccg ctatgaagag acacatttgc ataggctgct ccctgaggct ctggctttct
     6541 acatctgatg atacagggag cagggaacag cctgttctcg ttctgtgggg ctcagctgag
     6601 tctgttctgc acagactctt ccttcctcgg gagccttagt cctaatacat tcattttgga
     6661 gtgttggtga gtttgttcac agatcacagc tcatgtgtca cccagactga cctgggccaa
     6721 aaggcccatc acacaccctg caagagcttc tggtgtcgac tatgaccccc ttaccaggca
     6781 tcaaccattt ttgttcgttc tcttgagcct gaagctacta ttactgctcc tctgcaaacc
     6841 tcaagcttaa gaactttgcc tgcaggatcc ctttaaatcc acacaaaact caaaattgag
     6901 tcctaccagg aaaaagcagc cctcagccca tttttataca tcggatttgt ttgcaatatt
     6961 ttctttctag actcaaaagt caacactccc tgaaagtttg tcgactttac tgctgaagac
     7021 ctctggtaga caggccaggc tctgtctgga atactttatg aggttggtga ggaggttgag
     7081 tataatccaa gagtgcctat ctgggagcat gccacatgaa tggcaaataa tcatcctgtg
     7141 ggctcttggc ttcattcccc ttctctctga ctgagctcag cctgggcaca gtggtgattt
     7201 gcagtagaac tggaaacctg ttgggcagaa aaaaagacac tagttctggt tccagttctg
     7261 atacataaca agctagatga gccttggcca ccgtcatggc ctcttggaac ttctgtttct
     7321 tccccatctg ccaatcatca atactcatac ccacctcctc acaaggaggc cataaaaacc
     7381 tatggtcatg gctttgagtc caagtcagtg tggatgcagc cagtctgtca tttttgggtg
     7441 tttcctctgt agccgggtct gccatatggt gatgtcccag ctctcgtgct atgaagttaa
     7501 agcctctttc tcaacaggct gcagatgatc acccaggaag agaatgcaga atgcccaaag
     7561 caaaccatct cagctggtca ctgcttctgt gccaagaagg gaggcctggc gaggggccag
     7621 tcaggaagca gcatggcatc acatgctcat gacccacatg aaggtccctt tagacttgtg
     7681 tcaacaagat ccattttctg aaacaactat ttttgttctg attataaaag taacattggc
     7741 tcattggtaa aacttggatt gtgtgagaag tctacagaaa taaatacaaa tcctctagaa
     7801 ttccatcccc aaaagtaacc actcagacaa atgttctaat gtcatgtaaa accatattaa
     7861 accatctttt ctagctgcat agtgttatag aatcatttgc ttaaccatca ttattgggca
     7921 tttctcattt ccagctttgc attattataa ttcagtgttc aagtttgtat tgcataaatc
     7981 tttgtctcag attattgatt atttttaaac tttttgtgaa atcagactta caaaaatgtg
     8041 acaaaaacag tacaaagagt tcccatgtac ctttcagtca gtctcaccaa aggtaaacat
     8101 tttatacaac cataatacaa atataaaacc ctggacattg gcaacaccat acccttaact
     8161 aatgtatgta ccttattcac atttctccag ttgtcccatt aacacccttt tctgttccag
     8221 gatcccacac tgcatcattt gcgatgtctc cttagtctcc tccagtttgt gacagttcct
     8281 cagtcttcct ttgtctttca tgaccttgac cctttttaaa aatcgaggtg aaattcctgt
     8341 aacacaaaat tagccatttt aaagtgtaca tttaatgcat tcacaatgtt ttgtaaccac
     8401 caggtctgtc tggttccaaa atcttttcat caatctttga cccttttgaa gattgtaggg
     8461 caggtattct gtaggctgtc cttcagattg tgtttttgat gtttttctca tgattagatt
     8521 gaggttaggc atttggggca ggagcactgc tgaagcaatg tgtcctcgtt gcaccgtatc
     8581 aggaggcata tggtgttgat acgtttcatt attgtgatgt taactttgat cattgggtga
     8641 aggtggtacg tgcaatgttt cttccctgct attaaggtac tgtttttccc tttgtaattg
     8701 ataagtatct tatgaggata tacttttgag atccaatttt tttaacttag aatttattca
     8761 aaagtcaaga atcttaaatc tctgaaatgg cgtgggaaga aaaagtgcta gatacacaga
     8821 gatctttctt gagtcatgtg aaggagcagt gcccaagccc agcaaaccca cagcaaattc
     8881 ccttggcttc cagaagagat ggagaaagca gtgcccccag tggagggtca aaggcctctg
     8941 tgcagggtgt tgtgggcctg gagagctggc ctggccatgt ctttacctcc tctgggcatc
     9001 tccccacccc aacacccttt ctgtggcctg gtggctgagt tgcagccgac acccagaggc
     9061 aggtgagttg acagcttgga agaggctgca gggtggatct gctgcatgag caggcctgag
     9121 cccagcctta cctccccaca gtggtcctgt gtgccctccg gctgcctaat gcatgttggc
     9181 acttgctgta cgagcacccg cttcttcacc tcgcatgctg tttgtgtcct gcactccttc
     9241 cttaacccca tcgtccttct gctgtgtttg cagcccctat ctaccctggt gggagtggcc
     9301 aaaaatattt aggaggggat caccagtttg tagtggcctc agaggatgtg tggtccccct
     9361 tatgcctcag ccactcatca gcctagcccc tgcccatcat ctggcattgc acttgtggaa
     9421 ggaaagaagg ggagggctgg gtggtgggtg gagaacacgt cagtccacca ggcgggccct
     9481 gcttgctgtg ttcctccacg ctgctgtcca cccacacccc agcagtcctc tgagggacct
     9541 cccgggggtg acctgggcca caacagactg cccactcaga ccccatctta cccatgccgt
     9601 ggacaccccg cccccccccc cgccactgct atgctatagc tgggggtgtc tatgtgagct
     9661 gtacagccca gcaccacgct gacgatgttc ttcatcccct tctccctgca gggcatcgag
     9721 cgcctcaaac gaaagaacca gcccagggag cacatgggga gctggcagtc agtaaaggag
     9781 acctttggtg gggacttctc cctgaactgg ttcaacccct tctccagacc gtgtcagcca
     9841 gagatcccca gtgacaaaga catggtgcgg caggtgacat cgctgtcaga caccgaaaca
     9901 atggaggatc catcagagga gacaaaggac gaggactctg tggaggtgac agatgaatag
     9961 atgctgctgt ggggagagaa gcaaacacta aaaagtgctg tcaaccttca tcctggggtt
    10021 ttggctaaag gggcttatgg gcatggtgcg ctcccagcac ccccagtgct tcccttagcc
    10081 actcgcttgg ccttgccatt tcccctcctt cttctctcca tgttgggcca ggtctggggg
    10141 tcgggagtag gctggggaca tcagaggagg atgggggctt tctcagagtt catctaagaa
    10201 gagtctgcac tgagacggct catcaagaac cgttctccaa gactgggtgg ctttcacatt
    10261 ctccgcccag caaagggagc ttttgaacag ggcatcccag gggcagaaaa gagcttgcct
    10321 ttggctttcc ccaggatttc tgtcttctct tgggaaggct gggcccctgg ctcctggctt
    10381 tgagaagtaa ggttgtgaca gaaggaccgg gcagggcttg ccttggggac ctgggttggg
    10441 acactgacat caggggagac tagcctggaa agactgcaga gctgccagct actccctgga
    10501 aagggcttcc ccatgctgcc tgccgaaatt aggaggtaga ggtggctgcc acatctacct
    10561 gcaagggcca ggcatggttc aaagaggacc ctgcattaag ctctacacac acatgtgcag
    10621 gacatgtcca gcatggacag agccagagtt aagacagtag caccgaaaat gagcccccat
    10681 tccacagaca ctggagtctt cactgagcga gacagctggg agctgtcctg cctgtggcta
    10741 catatctagc cattcacaga tgtggatatg ggaaggacct ctttggagct actggggact
    10801 ccctaaccac tcgcatgaga acttaattga atgttacctc ttggagggag tctaataaca
    10861 catgtaggta gaactgacca taaaccctgc ctgtgtgttt gaaaaggcca gttctcccaa
    10921 attggtgccc atcttgtctc tgaaaagatg ggtgatggcc agggtctgct gattgatgaa
    10981 tcagatgaat caggaagata gacaaacaca cacacacaca cacacacccc accaggatga
    11041 gtctgccctc tattcacccc atttgaagcc tgtggtgtct gtgaccactg ctgaaggtct
    11101 gagcagcgtt ctggtgctcc taaaccccat tccagtggtt gctgaagcag catcttctgc
    11161 acaaagccca acagaagggt tcttatcccc gtttggtata agaagtggat tcaccaccca
    11221 ctccctccac gtgcctttgt tcctctcttt ggcccatttc cccagcgtct actggcgtca
    11281 ggattggcag gagcacaggc actcagcaga gcatgcccct gcaagacctc agtgttaggg
    11341 ccccccttcc agctccaggc aaaagggcat gagtcctggc cccaaggggc ctgtggctgc
    11401 agttcagagg agaagaaggt cagtgtttgg aggtgcagcc tcaggatgct gagaaaggaa
    11461 actggcgacc gtgagaaaga aaagagccaa gcagcatcct ggttcttgga cagcatcttt
    11521 ggacactctg tgaagggcaa cgatcctgcc agagaccgtc tctctacaac tgatgaccca
    11581 ctagggcctg gggttaattg ctcaaagggc ccagtgttca caaagccacc tctgccctaa
    11641 cccttgccag agctctccaa ctatgaccca cgagaggggt gatggtggga ttctaacatc
    11701 aacagagcaa ccagaaagac attgggcctc ccacactcag gctgcaggcc cactttcttg
    11761 gtccttatca gctttaatat ttattaatga cgacatagga gcccgagtca gctgtaaagg
    11821 ccattaactt gcaatctgga caggaagttg acgctcacca ctttgggtaa gagctgctct
    11881 gactgtaggg ccccctattt gttgtcctaa cccagaagca gctctgggct gccaggatgg
    11941 tggatggaat accagagagt tcacactagg gaggaagcaa tgcctgcccc ctggagtctc
    12001 ctagggggca gcagttagaa taagggaaga ggatttgctg gtcactgttt gctgacatgg
    12061 gtttccatgg tgagttcagg cctgaggaca gcagtgtctg caaaaccaca tggcccttga
    12121 gaaatgtcct tgcacattgg gcttcaaact cctcttctag ggaatccatc ttggcctgaa
    12181 agcagaggta caacaccagc cccaaaggca attctgtttt cagattggtt gctctggaaa
    12241 ggaaggctgg ggtgaggggg cattttactt gcacagaggc tgaccctgcc tcccctcttc
    12301 actgacccca tctccaaggt agacctcagc catgtcagtc cctgttctgg gaggtgctgg
    12361 gctgggccac agccagggtt atgtaggtaa ttaacctgtc caaccctgag cctcgcctcc
    12421 ccacaccagc aacacagtgg tctctctgtg gtgaccattc acagcataac attctgctta
    12481 gcctcagact gaaagcattg caactgatgt caaaaccaga tgagatctta cagggagaga
    12541 gattgggtgc aatttgcctc tttctttgaa taaaaagctc tttgctcacc ctca
//
