LOCUS       NM_207340               4803 bp    mRNA    linear   PRI 06-MAR-2025
DEFINITION  Homo sapiens zDHHC palmitoyltransferase 24 (ZDHHC24), transcript
            variant 1, mRNA.
ACCESSION   NM_207340
VERSION     NM_207340.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4803)
  AUTHORS   Bu,L., Wang,H., Zhang,S., Zhang,Y., Liu,M., Zhang,Z., Wu,X.,
            Jiang,Q., Wang,L., Xie,W., He,M., Zhou,Z., Cheng,C. and Guo,J.
  TITLE     Targeting APT2 improves MAVS palmitoylation and antiviral innate
            immunity
  JOURNAL   Mol Cell 84 (18), 3513-3529 (2024)
   PUBMED   39255795
REFERENCE   2  (bases 1 to 4803)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358448.1 and AP002748.4.
            
            On Nov 23, 2018 this sequence version replaced NM_207340.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.154336.1,
                                           SRR1660805.75840.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147920, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310442.5/ ENSP00000309429.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1165              AY358448.1         153-1317
            1166-4803           AP002748.4         108788-112425       c
FEATURES             Location/Qualifiers
     source          1..4803
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..4803
                     /gene="ZDHHC24"
                     /note="zDHHC palmitoyltransferase 24"
                     /db_xref="GeneID:254359"
                     /db_xref="HGNC:HGNC:27387"
     exon            1..326
                     /gene="ZDHHC24"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..900
                     /gene="ZDHHC24"
                     /EC_number="2.3.1.225"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger, DHHC domain containing 24; probable
                     palmitoyltransferase ZDHHC24; DHHC-24; zinc finger DHHC
                     domain-containing protein 24; zinc finger DHHC-type
                     containing 24"
                     /codon_start=1
                     /product="probable palmitoyltransferase ZDHHC24 isoform 1"
                     /protein_id="NP_997223.1"
                     /db_xref="CCDS:CCDS8143.1"
                     /db_xref="GeneID:254359"
                     /db_xref="HGNC:HGNC:27387"
                     /translation="MGQPWAAGSTDGAPAQLPLVLTALWAAAVGLELAYVLVLGPGPP
                     PLGPLARALQLALAAFQLLNLLGNVGLFLRSDPSIRGVMLAGRGLGQGWAYCYQCQSQ
                     VPPRSGHCSACRVCILRRDHHCRLLGRCVGFGNYRPFLCLLLHAAGVLLHVSVLLGPA
                     LSALLRAHTPLHMAALLLLPWLMLLTGRVSLAQFALAFVTDTCVAGALLCGAGLLFHG
                     MLLLRGQTTWEWARGQHSYDLGPCHNLQAALGPRWALVWLWPFLASPLPGDGITFQTT
                     ADVGHTAS"
     exon            327..604
                     /gene="ZDHHC24"
                     /inference="alignment:Splign:2.1.0"
     exon            605..4803
                     /gene="ZDHHC24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1147..1152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC24"
                     /note="hexamer: AATAAA"
     polyA_site      1170
                     /gene="ZDHHC24"
                     /note="major polyA site"
     regulatory      1717..1722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC24"
                     /note="hexamer: AATAGA"
     polyA_site      1751
                     /gene="ZDHHC24"
     regulatory      4510..4515
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC24"
                     /note="hexamer: AATACA"
     polyA_site      4531
                     /gene="ZDHHC24"
     regulatory      4776..4781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC24"
                     /note="hexamer: AATAAA"
     polyA_site      4803
                     /gene="ZDHHC24"
ORIGIN      
        1 ggaagcggcc tagtcctccg gctccgacag ctgggtgtcc aggccatggg gcagccctgg
       61 gcggctggga gcacggacgg ggcgcccgcg cagctgcctc tcgtgctcac cgcgctgtgg
      121 gccgcggccg tgggcctgga gctggcttac gtgctggtgc tcggtcccgg gccgccgccg
      181 ctgggacccc tggcccgggc cttgcagctg gcgctggccg ccttccagct gctcaacctg
      241 ctgggcaacg tggggctctt cctgcgctcg gatcccagca tccgtggcgt gatgctggcc
      301 ggccgcggtc tgggccaggg ctgggcttac tgctaccaat gccaaagcca ggtgccgcca
      361 cgcagcggac actgctctgc ctgccgcgtc tgcatcctgc gtcgggacca ccactgccgc
      421 ctgctgggcc gctgcgtggg cttcggcaac taccggccct tcctgtgcct gctgcttcat
      481 gccgccggcg tcctgctcca cgtctctgtg ctgctgggcc ctgcactgtc ggccctgctg
      541 cgagcccaca cgcccctcca catggctgcc ctcctcctgc ttccctggct catgttgctc
      601 acaggcagag tgtctctggc acagtttgcc ttggccttcg tgacggacac gtgcgtggcg
      661 ggtgcgctgc tgtgcggggc tgggctgctc ttccatggga tgctgctgct gcggggccag
      721 accacatggg agtgggctcg gggccagcac tcctatgacc tgggtccctg ccacaacctg
      781 caggcagccc tggggccccg ctgggccctc gtctggctct ggcccttcct ggcctcccca
      841 ttgcctgggg atgggatcac cttccagacc acagcagatg tgggacacac agcctcctga
      901 ctccaggaag agccagagct gtgcagggag gaaggggtga gaggggggcc cccacaccta
      961 gactcagtaa ggaagtcggg ttggacctta acatctgcat tggacaactc caccccttcc
     1021 ttggccttgc ccctgcccgc ctacactcct acgtgtccag ggcttgggcc gtgacttagg
     1081 cagaggagtg cagaggaggg tctggcaggg gctgctcagg ccgcctagct gcccctttgc
     1141 caggttaata aagcactgac ttgtttctca gcctccctcc atctttgcat agtttctggc
     1201 ccctcacttt gttgctgggg ctgtttctgg gaccctctgt agggcctgga aactgcagga
     1261 tgcctgaggg tctcaggggc tggggctcta cctcccctgg cctgggtgag ttgggggtgg
     1321 ggcaccagca cgccaaggca gtgtcctact gatccaggct atgagaatcc aaacattctt
     1381 tcccaggttt ggcattttat agttagaagc atttctgcaa cagcagtttc atggaacctc
     1441 tcttagctaa cctggtccat ggggcagcag ttacgctcta agaatccatg tggtaagatc
     1501 atggtgcggc aaatggaggc agggtccaac ccaggtcttt gtgcttttgc ctttaccctt
     1561 gcacagctgg aggaaatgag taggaaagaa atcaaggtaa agaaatgcgc tggggctgtt
     1621 tgggcatctg tggagggtgg tgctgacagg gctaggcctg cacctctctg gcctcctcaa
     1681 gagctgcttg ttaaatgttt ccgtgtaaat agaatgaata gagaccgcca tttccacatg
     1741 gcaggcctaa acacatgtgt tcgtctcagt tttctcttag gatctctcta agatgatagt
     1801 aaagaaaatc aaaaataata caaagggaaa gaaaacagga gggaagacag tagaacacag
     1861 agcctgacca cattttcttt tttctctctg ttgccggggc tggagtgcag tggcacgatc
     1921 tcggttcact gtaacctcca cctcccgggt tcaagtgatt cggcctcccg agttgctggg
     1981 attacagaca cccgccacta tgcccggctg attttttttt ttttcttttt tgagacggag
     2041 ttttgctctt gttgctcagg caggagtgca atggcgtgat ctcggctcac tgcaacctcc
     2101 gcctcctggg ttcaagcgat tctcctgcct cagcctcccg agtagctggg attacaggtg
     2161 cccgccacca ttcctggcta atttttgtat ttttagtaga gacgggggtt tcaccatgtt
     2221 ggccaggcag gtctcaaact cgtgaccttg tgatccgccc gccttggcct cccgaagtgc
     2281 tggaattaca ggtgtgagcc attgcgcctg gccatgccca gctaattttt ttgtattttt
     2341 agtatagaca gggtttcacc atgttggcca ggctgaactt gaattcctgg cacctgcctc
     2401 cacctccgtc tcccaaagtg ctaggattac aggcgtgagc taccgtgcct ggctgacaat
     2461 tttttattat tttattttat tttattttat tttattttat ttgagacaga ctcttgttct
     2521 gttgccaggc tggagtgcag tggcacgatc tcggctcact gcaagctccg ccttctgggt
     2581 tcacgccatt ctcctgcctc agcctctcaa gtagctggga ctacaggtgc ctgccaccac
     2641 gccaagctaa ttttttgtat ttttagtaga gacgaggttt caccgtgtta gccaggatgg
     2701 tctcgatctc ctgaccttgt gatccacctg cctcggcctc ccaaagtgct gggattacag
     2761 gtgtgagcca ccactcctgg ccggccagga tggtcttgat ctactgacct cgtgatctgc
     2821 ccgccttggc ctcccaaagt gctgggatta caggtgtgag ccaccgtgcc cggccgcctg
     2881 gctgacattt tcaaagatgg aaagtggatg gagaattaag agctgaaatt atgtgttccc
     2941 aaaaggtggg gccaaaaggc aagtggaatt acctgccaga gccccggagg ggctcaggaa
     3001 ctccaccagg accatggagg gtgaggtgag gcttcggcca acaatgggga ccgatggaaa
     3061 gtctatgtaa ggatcagtgg ggtgccgctc ccccacatcc cacccacacc ccacccacat
     3121 catgcagcca gcagctacac ctctgggtgg ggtggtgtga cgtgaggatt atttgaagga
     3181 taaatggaac cagagaagct tcgggtctta ggcgtactgg ggaggggtgg gtgagaggct
     3241 agaccaaaaa atggggttaa gtgaaagtcc atagatactg ctggggggcc tcccatgaaa
     3301 gaacatgctt gacccccaag aaccttcaga gaaacccacc ctctgacagg ctctgcccat
     3361 gcccacaaag atctgagctg cttggctggt tgtttttgta acaggcatgc tctgttgcta
     3421 ttttttaatg acaggaggaa cttggtgtac ctggcacttt gggctgcaca gacgcattag
     3481 cagactcacc ttgtcctgtt tcatccctcg ccctccacaa tttcttattt tctttctttc
     3541 tctttttatt ttttgagaca gagtttcact cttgttaccc aggctggagt gcaatgatgc
     3601 gatcttggtt caccgaaacc tccgcctccc gggttcaagc gattctcctg ctgcagcctc
     3661 tcggtagctg ggattacagg catgtgccac catgcccggc taattgtttt tgtattttta
     3721 gtagagacgg ggtttctcca tgttggtcag gctggtctgg aactcctgac ctcaggtgat
     3781 ccacctgcct cggcctccca aagtgccggg attacaggta tgagccactg cgcccagccc
     3841 acaatatctt attttcatgt ttttttgtgt gttttgtttt atttttcgag atggagtctc
     3901 tctgttgccc aagctggagt gcaatggcgc gatcttggct cacttcctgg gttcaagcga
     3961 ttctcctgcc ttagcctccc aagtaactgg gattgcaggc acccaccatc atgccctgct
     4021 aaattttgta cttttgtaga gatggagttt caccatgttg gtcaggctgg tcttgaactg
     4081 ctgacctcag gtgatctgcc caccttggcc tcccaaagtg ctgggattac aggtgtgagc
     4141 caccatgcct ggactcgttg ttgttgttgt ttttaattag tgaggagcta caagaacaca
     4201 tttataaaaa ttaagaggaa acagccccac tgcatttgag aaggttacca tttccttcga
     4261 agttcctgct gttgcccctt cctggtgggg gagacactgt cctgtttcag tcattccgtt
     4321 gctttgcttt atagttttat taatgtgttt gtgttggctt tgcatgtttt caaatatatg
     4381 aatgaaatca tgcagagttt attcttttac agtttgcctt ttcacttgat tatgttcctg
     4441 agatgtatcc ggattattgt gtgtagctgt atggcattcc ttttccctgc tgcctagtga
     4501 tccattgaaa atacaataat tgatttttct atgtggttcc actggtcatt tttctgcccc
     4561 tgtgcccttt gggaatcatc tcctaaactc tagtctcggc ccttgctctt ccatgtaacc
     4621 ttgagaatca gcttgtcaaa ttccccccaa aaaccccttg agatgtagaa tggaacccag
     4681 ctgaatctat agatcagtct ggataaaatc agcacctgtg taaaattgaa ttttcccatt
     4741 catgagcagg gtttatttct gcactcaatg ttttcaataa agttgtgtac cttttcccat
     4801 aaa
//
