LOCUS       NM_001320466            6346 bp    mRNA    linear   PRI 06-MAR-2025
DEFINITION  Homo sapiens zDHHC palmitoyltransferase 23 (ZDHHC23), transcript
            variant 1, mRNA.
ACCESSION   NM_001320466 XM_005247265
VERSION     NM_001320466.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6346)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6346)
  AUTHORS   Tian,L., McClafferty,H., Knaus,H.G., Ruth,P. and Shipston,M.J.
  TITLE     Distinct acyl protein transferases and thioesterases control
            surface expression of calcium-activated potassium channels
  JOURNAL   J Biol Chem 287 (18), 14718-14725 (2012)
   PUBMED   22399288
REFERENCE   3  (bases 1 to 6346)
  AUTHORS   Ellinghaus,D., Ellinghaus,E., Nair,R.P., Stuart,P.E., Esko,T.,
            Metspalu,A., Debrus,S., Raelson,J.V., Tejasvi,T., Belouchi,M.,
            West,S.L., Barker,J.N., Koks,S., Kingo,K., Balschun,T.,
            Palmieri,O., Annese,V., Gieger,C., Wichmann,H.E., Kabesch,M.,
            Trembath,R.C., Mathew,C.G., Abecasis,G.R., Weidinger,S.,
            Nikolaus,S., Schreiber,S., Elder,J.T., Weichenthal,M., Nothnagel,M.
            and Franke,A.
  TITLE     Combined analysis of genome-wide association studies for Crohn
            disease and psoriasis identifies seven shared susceptibility loci
  JOURNAL   Am J Hum Genet 90 (4), 636-647 (2012)
   PUBMED   22482804
REFERENCE   4  (bases 1 to 6346)
  AUTHORS   Saitoh,F., Tian,Q.B., Okano,A., Sakagami,H., Kondo,H. and Suzuki,T.
  TITLE     NIDD, a novel DHHC-containing protein, targets neuronal
            nitric-oxide synthase (nNOS) to the synaptic membrane through a
            PDZ-dependent interaction and regulates nNOS activity
  JOURNAL   J Biol Chem 279 (28), 29461-29468 (2004)
   PUBMED   15105416
REFERENCE   5  (bases 1 to 6346)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC128687.10.
            
            On Jun 2, 2019 this sequence version replaced NM_001320466.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). Variants 1 and 2
            encode the same isoform.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.177433.1,
                                           SRR1803616.61572.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000638807.2/ ENSP00000492287.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AC128687.10        58374-58551         c
            179-456             AC128687.10        57601-57878         c
            457-1167            AC128687.10        52154-52864         c
            1168-1335           AC128687.10        50058-50225         c
            1336-6346           AC128687.10        43191-48201         c
FEATURES             Location/Qualifiers
     source          1..6346
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.31"
     gene            1..6346
                     /gene="ZDHHC23"
                     /gene_synonym="DHHC-23; NIDD"
                     /note="zDHHC palmitoyltransferase 23"
                     /db_xref="GeneID:254887"
                     /db_xref="HGNC:HGNC:28654"
                     /db_xref="MIM:617334"
     exon            1..178
                     /gene="ZDHHC23"
                     /gene_synonym="DHHC-23; NIDD"
                     /inference="alignment:Splign:2.1.0"
     exon            179..456
                     /gene="ZDHHC23"
                     /gene_synonym="DHHC-23; NIDD"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..1603
                     /gene="ZDHHC23"
                     /gene_synonym="DHHC-23; NIDD"
                     /EC_number="2.3.1.225"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger DHHC domain-containing protein 23;
                     palmitoyltransferase ZDHHC23; zinc finger DHHC-type
                     containing 23; zinc finger DHHC-type palmitoyltransferase
                     23"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC23 isoform a"
                     /protein_id="NP_001307395.1"
                     /db_xref="CCDS:CCDS93341.1"
                     /db_xref="GeneID:254887"
                     /db_xref="HGNC:HGNC:28654"
                     /db_xref="MIM:617334"
                     /translation="MTQKGSMKPVKKKKTEEPELEPLCCCEYIDRNGEKNHVATCLCD
                     CQDLDEGCDRWITCKSLQPETCERIMDTISDRLRIPWLRGAKKVNISIIPPLVLLPVF
                     LHVASWHFLLGVVVLTSLPVLALWYYYLTHRRKEQTLFFLSLGLFSLGYMYYVFLQEV
                     VPKGRVGPVQLAVLTCGLFLILLALHRAKKNPGYLSNPASGDRSLSSSQLECLSRKGQ
                     EKTKGFPGADMSGSLNNRTTKDDPKGSSKMPAGSPTKAKEDWCAKCQLVRPARAWHCR
                     ICGICVRRMDHHCVWINSCVGESNHQAFILALLIFLLTSVYGITLTLDTICRDRSVFT
                     ALFYCPGVYANYSSALSFTCVWYSVIITAGMAYIFLIQLINISYNVTEREVQQALRQK
                     TGRRLLCGLIVDTGQYNRGFLRNWHQFSTLGTRAFHHPAEDIV"
     exon            457..1167
                     /gene="ZDHHC23"
                     /gene_synonym="DHHC-23; NIDD"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1335
                     /gene="ZDHHC23"
                     /gene_synonym="DHHC-23; NIDD"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..6346
                     /gene="ZDHHC23"
                     /gene_synonym="DHHC-23; NIDD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5931..5936
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC23"
                     /gene_synonym="DHHC-23; NIDD"
                     /note="hexamer: AATAAA"
     polyA_site      5955
                     /gene="ZDHHC23"
                     /gene_synonym="DHHC-23; NIDD"
                     /note="major polyA site"
     regulatory      6322..6327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC23"
                     /gene_synonym="DHHC-23; NIDD"
                     /note="hexamer: AATAAA"
     polyA_site      6346
                     /gene="ZDHHC23"
                     /gene_synonym="DHHC-23; NIDD"
ORIGIN      
        1 acaggtgggc ggctgcggcg agggagcggc cgagcggagc ccgggtcccg gagactcctg
       61 ccgtcacgcc cggggctccg cgtagcagag atcgggagac gcgtctgtgc ctccggggaa
      121 gccgacccat ctcccctccg cctctttggc tgcagttgca cctccggcca gagggcaggc
      181 gttggaggtt aagcagagag agagaggcgt ggacctattt acgagatgta agttgtgttc
      241 tttccacctt taccttctga gggcttctta cgcctcatgg tgacaggtgc aaatcatgac
      301 acagaagggc agtatgaagc ctgtgaagaa aaagaaaacc gaagaacctg aattggagcc
      361 cctgtgctgc tgcgagtaca tagatcggaa tggggaaaag aaccacgtgg ctacttgttt
      421 gtgtgattgt caagatctgg atgaagggtg tgatcgatgg attacatgta aatctttaca
      481 gccagagact tgtgaaagaa tcatggatac aatttctgat cgcctccgaa ttccttggct
      541 taggggagcc aaaaaagtga acatcagcat catccctccg cttgtcctgc tgcctgtctt
      601 ccttcatgtg gcttcctggc atttcctcct gggggtggtg gttttgacct cccttcctgt
      661 gctggcactg tggtactact acctcactca cagaaggaaa gaacagaccc tgtttttcct
      721 gagccttgga ctgttctctc tgggctacat gtactatgtg ttcctgcagg aagtggtccc
      781 caaagggcgt gtgggtcccg ttcagctggc ggttcttacc tgcgggttat ttctgatact
      841 cttagccttg cacagagcca agaagaatcc aggctacctc agcaatccag caagcggtga
      901 cagatctcta agcagcagcc agctggagtg cctgagcaga aaagggcagg agaagaccaa
      961 agggttccct ggggcagaca tgtcgggcag tctcaacaat cgcacaacaa aggatgaccc
     1021 caagggctct tccaagatgc cagctggaag ccccaccaaa gcgaaggagg actggtgtgc
     1081 caagtgccag ctggtgcgac cagcccgggc atggcactgc cggatatgtg gcatctgtgt
     1141 gaggagaatg gatcatcatt gtgtctggat aaatagctgc gttggagaat caaatcatca
     1201 agcatttata cttgcccttt tgatcttctt gctcacctcg gtgtatggga tcacactgac
     1261 cttggacacc atttgtagag acagaagtgt cttcacagct cttttctatt gtcctggagt
     1321 ttatgcaaat tacagctcgg ctctgtcctt cacctgcgtg tggtactctg tgatcatcac
     1381 agcaggcatg gcctacatct tcctgatcca gctgatcaac atcagctaca atgtgactga
     1441 gcgggaagtc cagcaggccc tccgacagaa gactgggcgc cggctcctct gcgggctcat
     1501 cgtggacaca ggccagtaca ataggggctt cctgcggaac tggcaccagt tctccaccct
     1561 gggcacacgt gcattccacc accctgccga ggacattgtc tgaagtgcct tctatgtggc
     1621 tctctgaggg atgatggctc ctccttccgt ctcccttcca ttttacactt cagtgtccat
     1681 ttctatcccc agtttcttaa aggcattata gggccatgct caggtttaga gactggagtg
     1741 ggaagaagtt aatttttctg acgccacaac ttaagagact tttatactga ggcagtaaaa
     1801 gtagagccat tcctttccag tcaccttttt aattgactca gttgcctgaa cttgagaagg
     1861 atgtggattg ctaatgcaca aattgataga agcaattccc atccattagt atggaggaaa
     1921 gagtgttgga ttaggatagt ttctagtccc tctttcgatt cttaatagcc atgtgacccc
     1981 tagctgagtc actttcccaa gtctcagggt catctgcaaa gtggggtact gatgcctgcc
     2041 ctggctacct cacagagccg tcatgagggt cacgtgaggg aagatggatg tggaaagcac
     2101 taaaaaacaa ctcaagagcc atggaaatac aaagtattag gaaaatatta tgatggaaga
     2161 aaaacgttta tagtctagaa tattgaagcc aatattatta gggtaatcag ttttcagcat
     2221 ataccttgtt gtacagttat gagaatttct ccttcttatt agacatgaac tactcaaaca
     2281 gagaagatga ccagatggat tgatgctaag ttgtctcatc ttgaaaagac agttgacaac
     2341 agttataaag ataattattg ctagtgtaat gtagtgtggc catgagttta ggtgatgagt
     2401 tcttctattt atattttata aattctgctt gggtttctta taaataactc caacaggcat
     2461 tcatgtgttt ttcctcttcc catgtttcac caggtaaggt gctagcacac ttgtgactgt
     2521 ggctggaaga ggagaacaga cactcctgtg gggatgcttt actctctttt ctggtaggaa
     2581 ggctgagtaa catcacgggc tcgattattt tcttcatgta tttcaaatgc tgtcagttat
     2641 agcactaaat tgtgaaaatc agccttctgg cattcacatt attctggtat gaactttgag
     2701 gagttgagtg acatcttccc acttaacttg cacattaatt ctcaattacc cctccctaaa
     2761 taacagtatc tcactaagag agaagaaaca gggtatatgt ggtttccact attaatggat
     2821 tactgttctt ccctggctct tccgacaata acaagttgtt tctttaatca tatcttaaaa
     2881 ccgaaaatgt ataaaagatt aaatatttat gtacaatggg ttgttctact atagaattaa
     2941 gatgagggaa tttcagatga ggaaaatacc cttttgaaat gttagttttg aacatgtact
     3001 gttgtgcaat cccaaagata attcatgact ccttaaattt gccttggctt atagcttaat
     3061 atagggaaaa tattgccagc gttttcagtc attctgtgca tgctgcttta agcaagagat
     3121 ttatatttgt tgagaggaaa tattgctact tcctgcactt ccaccctctg cagccagcac
     3181 cgtccctact gttgccatta attggagctg tccttaagat ggtcaccata ttcttattca
     3241 ggctgttgtc attttcccca gagatggttt gtttaacgaa tgataggctc tgtgcctggg
     3301 gatgttagca gactctgggg tttgtacagt gatgccttct ccctggccca gagctgaata
     3361 ttcatctaga attaaagttg gatttgatat aacaaatttc tttctataca ggttttacat
     3421 aagagagaca gtaataatgt caaggatagc ctgtgtgggc agaaattggt agtcgtgctt
     3481 ttgaatgtca gctgtagagc caactctgat tatctagcca ttgatcatac aaattgatag
     3541 aaacattagt cagtaatttt agcttcttgc caaattgttc acaacatcta aatgtaatgt
     3601 gatgtgatga agataagtag tacaaagaga ccaaaataat ttgggagaat taggaatgat
     3661 gacaattttt tttaacaact tacctctaat agggttactt ggatgagcca actccgcttc
     3721 cttcccatgg ataggaaggg actctgtgta ttattcaggt ttattggcac gaagatactt
     3781 gttttaagtt ccttgagaac ccatgatgga cagttgacag aatgcttaaa cctgtcaaaa
     3841 gatgagtgat cttgtgtggg aaaagccttc ccaggcgtct gtaccgaaag gagcagcaaa
     3901 caaggggcta atccatgagc agtgttctgt aggctctgtg acatctttgg tttataggat
     3961 tttggagcct tttatgatct ggaactattt gaggggtttc attataggcc ttggttctct
     4021 ccaggggcca gatgagttta ttgtggaatc tttgaaagga caaggcctct gtgaatgaat
     4081 cagtcccagg gaagcatttg gtggtggcgg cagtggagga ttgcccggtg aacctataaa
     4141 tcagcagtct cttgggcaga ggagcaagcc cctcgaacat gatttcaaac aagcaggtcc
     4201 tcttctctca tctcacgtcc ttagtctctg ttaatgaaca tactggatgt ggagtttaat
     4261 aaattaccta ctatcatctg gccacttaga ttattatcac accactgtgg actgttcctg
     4321 gggggagaag aacagaccga tttgaaagat tcaagggaga aagattaagg atcaggattg
     4381 catgaaagaa gaaaatcctt caatatttaa aatgtttctt acaataccca cggagcactt
     4441 ttatggttcc agccgagcgt tcctgaaatg aactgaccat taacagcgcc tctttgatag
     4501 gttaccctga tgctgctaaa gtaaagcctt aagtgtgttt ttgggacaac gtgctgctta
     4561 ttccacctca gccacatatg tgtttgtgtt taggatattg taaatctttg ctaagtagtg
     4621 ttttccttgg tgaatgaagt cattgttgtc ttcaagtgta ccatctgcct agcaaaaaat
     4681 tgctacaaac tttctcttat gcaatagtcc ttggtacttc taatattttt agcaagagac
     4741 aattttctgt actagaatct tccactgcca gaaaacacag tgccagtaag gttctacata
     4801 ccactgacca tctgcttaat agacatgtat ttcctttgag taggacatta gcttttgatt
     4861 ataaagctca actagtataa gcaaaaatat aacatctaga agcacagttt tagccaggat
     4921 gtttaaaaat tacagttttg tgagacttaa gggtcttttt aacctaggta agtttatatg
     4981 acctaactta attgtagcca tattctggta ccttccattt tgaaaagtag aggttgctta
     5041 agcaagcaat ggataataag agacttttcc tgaggcacct gtttggaatc tggttttctc
     5101 agcggcagct tgacatgtgc acccttttgt attaaacact gcaagggtga tgcaggggag
     5161 caggaaagcc atcctaaact cactactgag tacgattcag tatgttcctg tggatgtctg
     5221 ctgtgactaa tataaatttc ttgcagaatc agctacactt aattatgttg ctgatagaca
     5281 agcatccacg cttcagctgg cactaagtgt tttcattgta ggatcagcag caggttaaag
     5341 actgaacggt tagtgaagac aaatgtctta agaggctgcg atgtctaggt tgggcttgtg
     5401 acttcttagt ggcctagcct tcttgatggc accttgaaag tgaacttcta gaaatctaca
     5461 tttaaaaggc aaagctttaa aagcagagct agtctattct agttactgat gcaactaaaa
     5521 ttctgtattt cttaagatgg agccactgac gagatgtcac agtatagagc ctgcagtctc
     5581 aactcattgt gatcctaatg gtctgggtga ttggatggtt tgagttgtta gggattttga
     5641 gtttttcatt ttattgcata tctgggttgg atgttagact aaaggaaacc caggaatatt
     5701 tacctggtgt tacatttaat atttaatgta actggtctag caacattaag ggggatttct
     5761 gaagccaact ccggaggctg tgggctgcac attttgcact gtttttatat acttgtattc
     5821 atatcctctt atcacctcag actcagacac aaggcctttt acatggaaat tttacaaatt
     5881 acttccattt atgtaaaata acgtcctgtg accaagttgt ttaaatggaa aataaagtgc
     5941 tttctttaag gaaaatagct ggtgtttctt ggagtgtctc ctgaagtctt ctgatttctg
     6001 aaaaccctgc attatacctg tgctgcctct gtggctccct caatgtctct atcctgtggc
     6061 cctgtcccta gccctaaact gttatgttcc cggtggcaat ttctccagtt ttgtgggtca
     6121 gggatactgc ttgttggggc attatgttaa cagtaacatt ttgaaacata ctttcatgat
     6181 agtccagcaa aaaacagcat caaaactatt tccattgtat ctctttagaa ggctctgtat
     6241 tcggtaaaaa gtctagctgg cgccattgga atatgggctg ctaaagactc aatttctagt
     6301 tgatgtttga ggtgaggcaa aaataaagct aaggtagaaa acttaa
//
