LOCUS       NM_174976               3408 bp    mRNA    linear   PRI 06-MAR-2025
DEFINITION  Homo sapiens zDHHC palmitoyltransferase 22 (ZDHHC22), transcript
            variant 1, mRNA.
ACCESSION   NM_174976
VERSION     NM_174976.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3408)
  AUTHORS   Huang,J., Li,J., Tang,J., Wu,Y., Dai,F., Yi,Z., Wang,Y., Li,Y.,
            Wu,Y., Ren,G. and Xiang,T.
  TITLE     ZDHHC22-mediated mTOR palmitoylation restrains breast cancer growth
            and endocrine therapy resistance
  JOURNAL   Int J Biol Sci 18 (7), 2833-2850 (2022)
   PUBMED   35541896
  REMARK    GeneRIF: ZDHHC22-mediated mTOR palmitoylation restrains breast
            cancer growth and endocrine therapy resistance.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3408)
  AUTHORS   Gadalla,M.R., Morrison,E., Serebryakova,M.V., Han,X., Wolff,T.,
            Freund,C., Kordyukova,L. and Veit,M.
  TITLE     NS1-mediated upregulation of ZDHHC22 acyltransferase in influenza a
            virus infected cells
  JOURNAL   Cell Microbiol 23 (6), e13322 (2021)
   PUBMED   33629465
  REMARK    GeneRIF: NS1-mediated upregulation of ZDHHC22 acyltransferase in
            influenza a virus infected cells.
REFERENCE   3  (bases 1 to 3408)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3408)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3408)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   6  (bases 1 to 3408)
  AUTHORS   Kim,Y., Yang,H., Min,J.K., Park,Y.J., Jeong,S.H., Jang,S.W. and
            Shim,S.
  TITLE     CCN3 secretion is regulated by palmitoylation via ZDHHC22
  JOURNAL   Biochem Biophys Res Commun 495 (4), 2573-2578 (2018)
   PUBMED   29287726
  REMARK    GeneRIF: Taken together, our results suggest that palmitoylation by
            ZDHHC22 at C241 in the CCN3 TSP1 domain may be required for the
            secretion of CCN3. Aberrant palmitoylation induces intracellular
            accumulation of CCN3, inhibiting neuronal axon growth.
REFERENCE   7  (bases 1 to 3408)
  AUTHORS   Dichgans,M., Malik,R., Konig,I.R., Rosand,J., Clarke,R.,
            Gretarsdottir,S., Thorleifsson,G., Mitchell,B.D., Assimes,T.L.,
            Levi,C., O'Donnell,C.J., Fornage,M., Thorsteinsdottir,U.,
            Psaty,B.M., Hengstenberg,C., Seshadri,S., Erdmann,J., Bis,J.C.,
            Peters,A., Boncoraglio,G.B., Marz,W., Meschia,J.F., Kathiresan,S.,
            Ikram,M.A., McPherson,R., Stefansson,K., Sudlow,C., Reilly,M.P.,
            Thompson,J.R., Sharma,P., Hopewell,J.C., Chambers,J.C., Watkins,H.,
            Rothwell,P.M., Roberts,R., Markus,H.S., Samani,N.J., Farrall,M. and
            Schunkert,H.
  CONSRTM   METASTROKE Consortium; CARDIoGRAM Consortium; C4D Consortium;
            International Stroke Genetics Consortium
  TITLE     Shared genetic susceptibility to ischemic stroke and coronary
            artery disease: a genome-wide analysis of common variants
  JOURNAL   Stroke 45 (1), 24-36 (2014)
   PUBMED   24262325
  REMARK    Review article
REFERENCE   8  (bases 1 to 3408)
  AUTHORS   Tian,L., McClafferty,H., Knaus,H.G., Ruth,P. and Shipston,M.J.
  TITLE     Distinct acyl protein transferases and thioesterases control
            surface expression of calcium-activated potassium channels
  JOURNAL   J Biol Chem 287 (18), 14718-14725 (2012)
   PUBMED   22399288
REFERENCE   9  (bases 1 to 3408)
  AUTHORS   Ohno,Y., Kihara,A., Sano,T. and Igarashi,Y.
  TITLE     Intracellular localization and tissue-specific distribution of
            human and yeast DHHC cysteine-rich domain-containing proteins
  JOURNAL   Biochim Biophys Acta 1761 (4), 474-483 (2006)
   PUBMED   16647879
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007375.6, DA496626.1 and BC117676.2.
            
            On Apr 12, 2007 this sequence version replaced NM_174976.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.202049.1,
                                           SRR1803613.153243.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319374.4/ ENSP00000318222.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AC007375.6         24471-24588         c
            119-580             DA496626.1         119-580
            581-1636            BC117676.2         406-1461
            1637-3408           AC007375.6         14067-15838         c
FEATURES             Location/Qualifiers
     source          1..3408
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..3408
                     /gene="ZDHHC22"
                     /gene_synonym="C14orf59"
                     /note="zDHHC palmitoyltransferase 22"
                     /db_xref="GeneID:283576"
                     /db_xref="HGNC:HGNC:20106"
     exon            1..189
                     /gene="ZDHHC22"
                     /gene_synonym="C14orf59"
                     /inference="alignment:Splign:2.1.0"
     exon            190..729
                     /gene="ZDHHC22"
                     /gene_synonym="C14orf59"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..995
                     /gene="ZDHHC22"
                     /gene_synonym="C14orf59"
                     /EC_number="2.3.1.225"
                     /note="zinc finger, DHHC domain containing 22; zinc finger
                     DHHC-type palmitoyltransferase 22; putative
                     palmitoyltransferase ZDHHC22; DHHC-22; zinc finger DHHC
                     domain-containing protein 22; zinc finger DHHC-type
                     containing 22"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC22"
                     /protein_id="NP_777636.2"
                     /db_xref="CCDS:CCDS45140.1"
                     /db_xref="GeneID:283576"
                     /db_xref="HGNC:HGNC:20106"
                     /translation="MLALRLLNVVAPAYFLCISLVTFVLQLFLFLPSMREDPAAARLF
                     SPALLHGALFLFLSANALGNYVLVIQNSPDDLGACQGASARKTPCPSPSTHFCRVCAR
                     VTLRHDHHCFFTGNCIGSRNMRNFVLFCLYTSLACLYSMVAGVAYISAVLSISFAHPL
                     AFLTLLPTSISQFFSGAVLGSEMFVILMLYLWFAIGLACAGFCCHQLLLILRGQTRHQ
                     VRKGVAVRARPWRKNLQEVFGKRWLLGLLVPMFNVGSESSKQQDK"
     exon            730..3408
                     /gene="ZDHHC22"
                     /gene_synonym="C14orf59"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3383..3388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC22"
                     /gene_synonym="C14orf59"
                     /note="hexamer: AATAAA"
     polyA_site      3408
                     /gene="ZDHHC22"
                     /gene_synonym="C14orf59"
                     /note="major polyA site"
ORIGIN      
        1 ccttactcgc tggcgcccaa gtgggaagcc agcagctgcc cgctccctcc tccccacatc
       61 cccgctactt gcccagttcc cgaagcgaag cgcaggctgc gagccagccg ggccgagtcc
      121 acaactttgc agcctcgggc agggcgagag ccggcgtccg gggctcctct tgtcggcgac
      181 cagagctcgg aatgtaatcg aggatgctgg ccctgcggct gctcaacgtg gtggcccccg
      241 cctacttctt gtgcatctcc ctggtgacct tcgtgctgca gctcttcctc ttcctgccca
      301 gcatgcgcga ggaccccgcg gccgcccggc tcttctcgcc cgccctgctc cacggggcgc
      361 tcttcctatt cctctcggcc aacgccctgg gcaattacgt ccttgtcatc cagaactccc
      421 cagacgacct gggggcctgc cagggggcct cggccaggaa gactccatgc ccctcaccta
      481 gcacccactt ctgccgagtg tgcgccagag tcaccctgag gcacgaccat cactgtttct
      541 tcaccggcaa ctgcatcggc agcaggaaca tgcgcaactt cgtcctgttc tgcctctaca
      601 cctccctggc ctgcctctac tccatggtgg ccggcgtggc ctacatctcc gctgtccttt
      661 ccatctcctt cgcccacccc ttggccttcc tcacgctcct gcccacctcc atcagccagt
      721 tcttctccgg agctgtcctg ggttctgaaa tgttcgtcat cctcatgctc tacctctggt
      781 tcgccatcgg cctggcctgc gccggcttct gctgccacca gctgctgttg atcctccgcg
      841 ggcagacccg ccaccaggtg cggaaggggg tggcagtgag ggcccggccc tggcgcaaga
      901 acttacaaga ggtcttcgga aagaggtggc tgctgggcct gctggtcccc atgttcaatg
      961 tcggaagtga gagctccaag cagcaggata agtagtagac actcccgtca tttatctctc
     1021 tgtctctgtc ttgactcctc ctgagcataa aaccatggca gccttgtctc cacccatgac
     1081 tcactacaac cttgtgctgg taaggtccta gcatcttccc ctcaccttcc acccatgaga
     1141 acagcgtgag ctggtggatc atgacaagga ggaaaaatgt ccccccaggc atttctaggc
     1201 tcctcacgag ccagccaggt ggctgctagc tgttaggctg cctctgcttt ctttccgtcc
     1261 ccttgggatc cctgctttcc ccctcttcct ggctcatcca ttctccaccg tgtctcattc
     1321 atcactgctg tctgctagag cccttcctct cagcccccat gttgggagag gggagtggat
     1381 tcttgctgct ggtatgagac tccctgggac ctagaggctg gcaaatgttt aaaatcacca
     1441 cgtgtaagag gcagccaagt cagctctgcc aactgctagg ggagttggga aagagtgggt
     1501 gtgtgtccgc atcccctctg taggaaaaag aacttagtag cttgctgctc cctcaccacc
     1561 ccccaccagg ttcaagaccc tttttctggg agacagcaat caatggcctg ctttttccaa
     1621 atgttattcc ctgtccaccc tgccccatct ggccggccca gcccagtcca ggacctggct
     1681 ggatgcttcc tgtccctgga actcttccag cctttctact tgatctccag cccccaggtc
     1741 tttgccagat gatgggaagg caaggaagaa gggacaggga aagataatta ctgataaatg
     1801 aaggggatat tcgactgtat aaccatatgg aagtgtgtgt gtgtgtgtgt gtgtgtgtgt
     1861 gagagagaga gagagagaga tgggtggtgg tgagaagtgt tgttagaaac atataggaat
     1921 aatgcctagg ggaaagggag aagtgagagg gacaattggg ttcatttatg ccctatacaa
     1981 agggcattcc agcagctgaa actcttcaat gtttgaatgg ctgcctgtga aggtagtgag
     2041 tgccccatca ctggaggtat tccagcagag tctaggcagt cgtctgccag gcatgctgtg
     2101 gaagggattt ctgtacaggg tcattctagg tgagcttaca cattccttcc aaccccaagg
     2161 ttctgatgtc ctggttgtga ttgctggacc cagaggcaag atctgcagag atgcctgtga
     2221 gatatttgct ttcctagagg ggagtgtggg catgggaggg gtctgaaaat caggacccaa
     2281 cccagccact gaagagagag tctctgcaga gacagggcta cctgggtggt tgaggggact
     2341 gacatttgag gacagggaga tggagcagtg tcattgtcag tggcagggca tggggggcag
     2401 tggtgagcta aggctgagga gtggagatga ccagaatata agggtgcaat tcccagacca
     2461 tccctgcgca tctgactgac tccggtggag gcactgctgt gtgttttctg aaacctagag
     2521 gaccagacct ctggggcata taagggagta gggacaacac aagtgccccc tcctgactgg
     2581 gtcccaaagc caatatgaca tccatgcagg cagcagtgct gaatccatgc cctgcaatgt
     2641 ccaaccgcca actgcagtga cccgctgata gctgcgcaac agcctgggtt cttgagcaga
     2701 gattgggagg actttactgt ggttctgcct tcacaccccc tagagagcta atgtagtatt
     2761 ggctccacct gctcacattt ctccctccca tactcattcc ttcactcatc catcctacgt
     2821 atatttattg agtgccaact acgttcccag cctcttccag gcactggcaa tgcagtgatg
     2881 aacaggatga caagattcat gccatcaggg gcaccttgtc actgccgtct gtgcactgat
     2941 tcacactccc tgcaaaatgg tcactctgcc atcttggtgg ttggtggggc aggtcatttg
     3001 gaaataaaga atgtgataga gatggctgaa gaggggaagc ctaggctgcc tcaatggagg
     3061 agtcgctggg ggcattttca cccacaattc tggccatact taagcaatgg gagggagagg
     3121 gaggagggga agatctgggc aattttggcc ttgactcttt cctggctcca gagctcaagc
     3181 ttagaagcca gccctgctat ttccagcctc ctgaaggctc agcacggtga ggcctgacat
     3241 cctggggaag ggcaacaggg agacctacag gatgttggct gcttgcagac tggtcaatgg
     3301 gggatgacgg tggggaggtt gccagatgtg agacttgagt agcatttgta cacatggccc
     3361 tgtattgtcc ttgaagaaca tcaataaaat atatggtttt aaattgga
//
