LOCUS       NM_016353               5924 bp    mRNA    linear   PRI 06-MAR-2025
DEFINITION  Homo sapiens zDHHC palmitoyltransferase 2 (ZDHHC2), transcript
            variant 1, mRNA.
ACCESSION   NM_016353
VERSION     NM_016353.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5924)
  AUTHORS   Zhou,B., Yang,W., Li,W., He,L., Lu,L., Zhang,L., Liu,Z., Wang,Y.,
            Chao,T., Huang,R., Gu,Y., Jia,T., Liu,Q., Tian,S., Pierre,P.,
            Maeda,T., Liang,Y. and Kong,E.
  TITLE     Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated
            Inflammatory Response in Psoriasis
  JOURNAL   Front Immunol 11, 607442 (2021)
   PUBMED   33488612
  REMARK    GeneRIF: Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells
            Mediated Inflammatory Response in Psoriasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5924)
  AUTHORS   Zhang,H., Li,X., Ma,C., Wang,K., Zhou,J., Chen,J., Wang,Y. and
            Shi,Y.
  TITLE     Fine-mapping of ZDHHC2 identifies risk variants for schizophrenia
            in the Han Chinese population
  JOURNAL   Mol Genet Genomic Med 8 (7), e1190 (2020)
   PUBMED   32180374
  REMARK    GeneRIF: Fine-mapping of ZDHHC2 identifies risk variants for
            schizophrenia in the Han Chinese population.
REFERENCE   3  (bases 1 to 5924)
  AUTHORS   Woolfrey,K.M., Sanderson,J.L. and Dell'Acqua,M.L.
  TITLE     The palmitoyl acyltransferase DHHC2 regulates recycling endosome
            exocytosis and synaptic potentiation through palmitoylation of
            AKAP79/150
  JOURNAL   J Neurosci 35 (2), 442-456 (2015)
   PUBMED   25589740
REFERENCE   4  (bases 1 to 5924)
  AUTHORS   Peng,C., Zhang,Z., Wu,J., Lv,Z., Tang,J., Xie,H., Zhou,L. and
            Zheng,S.
  TITLE     A critical role for ZDHHC2 in metastasis and recurrence in human
            hepatocellular carcinoma
  JOURNAL   Biomed Res Int 2014, 832712 (2014)
   PUBMED   24995331
  REMARK    GeneRIF: These results suggest an important role for ZDHHC2 as a
            tumor suppressor in metastasis and recurrence of HCC.
REFERENCE   5  (bases 1 to 5924)
  AUTHORS   Lai,J. and Linder,M.E.
  TITLE     Oligomerization of DHHC protein S-acyltransferases
  JOURNAL   J Biol Chem 288 (31), 22862-22870 (2013)
   PUBMED   23793055
REFERENCE   6  (bases 1 to 5924)
  AUTHORS   Sharma,C., Yang,X.H. and Hemler,M.E.
  TITLE     DHHC2 affects palmitoylation, stability, and functions of
            tetraspanins CD9 and CD151
  JOURNAL   Mol Biol Cell 19 (8), 3415-3425 (2008)
   PUBMED   18508921
  REMARK    GeneRIF: DHHC2 affects palmitoylation, stability, and functions of
            tetraspanins CD9 and CD151
REFERENCE   7  (bases 1 to 5924)
  AUTHORS   Zhang,J., Planey,S.L., Ceballos,C., Stevens,S.M. Jr., Keay,S.K. and
            Zacharias,D.A.
  TITLE     Identification of CKAP4/p63 as a major substrate of the palmitoyl
            acyltransferase DHHC2, a putative tumor suppressor, using a novel
            proteomics method
  JOURNAL   Mol Cell Proteomics 7 (7), 1378-1388 (2008)
   PUBMED   18296695
  REMARK    GeneRIF: Identification of CKAP4/p63 as a substrate of DHHC2, a
            putative tumor suppressor.
REFERENCE   8  (bases 1 to 5924)
  AUTHORS   Ohno,Y., Kihara,A., Sano,T. and Igarashi,Y.
  TITLE     Intracellular localization and tissue-specific distribution of
            human and yeast DHHC cysteine-rich domain-containing proteins
  JOURNAL   Biochim Biophys Acta 1761 (4), 474-483 (2006)
   PUBMED   16647879
REFERENCE   9  (bases 1 to 5924)
  AUTHORS   Li,B., Cong,F., Tan,C.P., Wang,S.X. and Goff,S.P.
  TITLE     Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has
            pro-apoptotic activity
  JOURNAL   J Biol Chem 277 (32), 28870-28876 (2002)
   PUBMED   12021275
REFERENCE   10 (bases 1 to 5924)
  AUTHORS   Oyama,T., Miyoshi,Y., Koyama,K., Nakagawa,H., Yamori,T., Ito,T.,
            Matsuda,H., Arakawa,H. and Nakamura,Y.
  TITLE     Isolation of a novel gene on 8p21.3-22 whose expression is reduced
            significantly in human colorectal cancers with liver metastasis
  JOURNAL   Genes Chromosomes Cancer 29 (1), 9-15 (2000)
   PUBMED   10918388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB023584.1 and AC091050.3.
            
            On Nov 22, 2018 this sequence version replaced NM_016353.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039253.1, HM005679.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262096.13/ ENSP00000262096.8
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1743              AB023584.1         156-1898
            1744-3857           AC091050.3         29269-31382         c
            3858-5924           AC091050.3         27202-29268         c
FEATURES             Location/Qualifiers
     source          1..5924
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p22"
     gene            1..5924
                     /gene="ZDHHC2"
                     /gene_synonym="DHHC2; ZNF372"
                     /note="zDHHC palmitoyltransferase 2"
                     /db_xref="GeneID:51201"
                     /db_xref="HGNC:HGNC:18469"
                     /db_xref="MIM:618621"
     exon            1..372
                     /gene="ZDHHC2"
                     /gene_synonym="DHHC2; ZNF372"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1346
                     /gene="ZDHHC2"
                     /gene_synonym="DHHC2; ZNF372"
                     /EC_number="2.3.1.225"
                     /note="isoform 1 is encoded by transcript variant 1; rec;
                     zinc finger, DHHC domain containing 2;
                     palmitoyltransferase ZDHHC2; ream; DHHC-2; zinc finger
                     protein 372; reduced expression in cancer protein; zinc
                     finger DHHC domain-containing protein 2; zinc finger
                     DHHC-type containing 2; reduced expression associated with
                     metastasis protein; testis tissue sperm-binding protein Li
                     56e; zinc finger DHHC-type palmitoyltransferase 2;
                     acyltransferase ZDHHC2"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC2 isoform 1"
                     /protein_id="NP_057437.1"
                     /db_xref="CCDS:CCDS47810.1"
                     /db_xref="GeneID:51201"
                     /db_xref="HGNC:HGNC:18469"
                     /db_xref="MIM:618621"
                     /translation="MAPSGPGSSARRRCRRVLYWIPVVFITLLLGWSYYAYAIQLCIV
                     SMENTGEQVVCLMAYHLLFAMFVWSYWKTIFTLPMNPSKEFHLSYAEKDLLEREPRGE
                     AHQEVLRRAAKDLPIYTRTMSGAIRYCDRCQLIKPDRCHHCSVCDKCILKMDHHCPWV
                     NNCVGFSNYKFFLLFLAYSLLYCLFIAATDLQYFIKFWTNGLPDTQAKFHIMFLFFAA
                     AMFSVSLSSLFGYHCWLVSKNKSTLEAFRSPVFRHGTDKNGFSLGFSKNMRQVFGDEK
                     KYWLLPIFSSLGDGCSFPTCLVNQDPEQASTPAGLNSTAKNLENHQFPAKPLRESQSH
                     LLTDSQSWTESSINPGKCKAGMSNPALTMENET"
     exon            373..399
                     /gene="ZDHHC2"
                     /gene_synonym="DHHC2; ZNF372"
                     /inference="alignment:Splign:2.1.0"
     exon            400..494
                     /gene="ZDHHC2"
                     /gene_synonym="DHHC2; ZNF372"
                     /inference="alignment:Splign:2.1.0"
     exon            495..615
                     /gene="ZDHHC2"
                     /gene_synonym="DHHC2; ZNF372"
                     /inference="alignment:Splign:2.1.0"
     exon            616..685
                     /gene="ZDHHC2"
                     /gene_synonym="DHHC2; ZNF372"
                     /inference="alignment:Splign:2.1.0"
     exon            686..718
                     /gene="ZDHHC2"
                     /gene_synonym="DHHC2; ZNF372"
                     /inference="alignment:Splign:2.1.0"
     exon            719..839
                     /gene="ZDHHC2"
                     /gene_synonym="DHHC2; ZNF372"
                     /inference="alignment:Splign:2.1.0"
     exon            840..972
                     /gene="ZDHHC2"
                     /gene_synonym="DHHC2; ZNF372"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1099
                     /gene="ZDHHC2"
                     /gene_synonym="DHHC2; ZNF372"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1192
                     /gene="ZDHHC2"
                     /gene_synonym="DHHC2; ZNF372"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1305
                     /gene="ZDHHC2"
                     /gene_synonym="DHHC2; ZNF372"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1380
                     /gene="ZDHHC2"
                     /gene_synonym="DHHC2; ZNF372"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..5924
                     /gene="ZDHHC2"
                     /gene_synonym="DHHC2; ZNF372"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1563..1568
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC2"
                     /gene_synonym="DHHC2; ZNF372"
                     /note="hexamer: ATTAAA"
     polyA_site      1579
                     /gene="ZDHHC2"
                     /gene_synonym="DHHC2; ZNF372"
                     /note="major polyA site"
     regulatory      3834..3839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC2"
                     /gene_synonym="DHHC2; ZNF372"
                     /note="hexamer: AATATA"
     regulatory      3844..3849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC2"
                     /gene_synonym="DHHC2; ZNF372"
                     /note="hexamer: AATAAA"
     polyA_site      3857
                     /gene="ZDHHC2"
                     /gene_synonym="DHHC2; ZNF372"
     polyA_site      3866
                     /gene="ZDHHC2"
                     /gene_synonym="DHHC2; ZNF372"
     polyA_site      5788
                     /gene="ZDHHC2"
                     /gene_synonym="DHHC2; ZNF372"
     regulatory      5904..5909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC2"
                     /gene_synonym="DHHC2; ZNF372"
                     /note="hexamer: AATGAA"
     polyA_site      5924
                     /gene="ZDHHC2"
                     /gene_synonym="DHHC2; ZNF372"
ORIGIN      
        1 gcctcctcgg cctccgctcg cagccgccgc ctccgcctcc gccgggctga ggagccggga
       61 gtccgccgcg ccggctcggg gctgcgggat ggggagttag cgccacggcg gcggcagtgg
      121 ccgcagcgca ccccgccgcc gcccaggagc ccgtccagcc aggggtgccg ggcccgccca
      181 gcccgccccg gagccaggcc cgcgggcggc ggcggagctg ggcaggtgga tgcggctgga
      241 agatggcgcc ctcgggcccg ggcagcagcg ccaggcggcg gtgccggcgg gtgctgtact
      301 ggatcccggt ggtgttcatc accctcctgc tcggctggtc ctactacgcc tacgccatcc
      361 agctgtgcat agtgtccatg gaaaacactg gcgaacaagt tgtgtgcctg atggcctatc
      421 atctactttt tgcaatgttt gtctggtcat actggaaaac tatctttaca ttaccaatga
      481 atccttcaaa agaattccat ctctcttatg cagagaaaga tttgttggag agagagccaa
      541 gaggagaagc ccatcaggaa gttcttaggc gagcagccaa ggatcttccc atctatacca
      601 ggaccatgtc tggagccatc cgatactgtg acagatgcca acttataaaa ccagatcgct
      661 gccatcactg ctccgtctgt gataaatgta ttttgaagat ggatcatcat tgtccatggg
      721 tgaacaattg tgttggattt tcaaattata agttctttct ccttttcttg gcttattctc
      781 tgctctactg cctttttatt gcggcaacag atttacagta ttttatcaaa ttttggacaa
      841 atggcctacc tgatactcaa gccaagttcc atattatgtt tttattcttt gctgcagcta
      901 tgttttctgt cagcttgtct tctctgtttg gctatcattg ttggctagtc agcaaaaata
      961 aatctacatt agaggcattc agaagtccag tatttcgaca tggaacagat aagaatggat
     1021 tcagcttggg tttcagtaaa aacatgcgac aagtttttgg tgatgagaag aagtactggt
     1081 tgctacccat tttttcaagt ctaggtgatg gctgctcctt tccaacttgc cttgttaacc
     1141 aggatcctga acaagcatct actcctgcag ggctgaattc cacagctaaa aatctcgaaa
     1201 accatcagtt tcctgcaaag ccattgagag agtcccagag ccaccttctt actgattctc
     1261 agtcttggac ggagagcagc ataaacccag gaaaatgcaa agctggtatg agcaatcctg
     1321 cattaaccat ggaaaatgag acttaactct tcaagcaaga taaattcata ctttataaaa
     1381 gtatcaatgc tgtagatgga tggaagaggc ttcccacagg aaggtgccac cagtcagttg
     1441 tgcctatgtc cctttggctg gaaatgcaga atatgaattg attagttctc tccaagccat
     1501 tgcttaaaat ataacatgtt ttggatccaa tacacacatt gttacaacta acacaaattc
     1561 ctattaaata ttaaaagtag ttctggttta ttaatcaacg gggaaaacat cttctccaaa
     1621 aaacttggaa taaatccaag gaccagtttt tacccaaata tatgggtagc acagtttatc
     1681 acatagaaac tccattaatc atctgatttt ccgaatctga aaattgagac tattaagata
     1741 ttaggatttc agagatttca agtcacatta taatgataag cattattcat aaaacttgtt
     1801 acctttaaga aggtggaagt ggcaaaccat acttcttttt tttcctctga tgtgaatcca
     1861 gcctcagact gagtgaactg taataattat gaattcatta cagagtccag gtggcctgca
     1921 gttgaagatc atcaaccatt tttgcctcac ttaattccag ccttttgttt tctgctggaa
     1981 aataagtgtg gacattgaag cttgagctct caaagcagtt ggctggaata cttttgtcag
     2041 aatacggtac atttctatta catcagaaat atattttcat ctcttcttgt taaattggga
     2101 ggaaatttat gatagcaatt atgaagattg ttttatgaca ttcttttgtc agtttggctt
     2161 tctaaaaatc tctttttaga ttatttctcc tgttgaacat agtaaaacta ttgaatttct
     2221 cttaagaatt cctaataggt caatagattt accctccagt gatatctata ttatttcttt
     2281 ctcgtctcat caaaatgatg acaggtaaac tatatttttc cttaaacacc tattacagtt
     2341 aaattatgca aatcattaaa taaaaatcat acaacttttg gaaagttagt tcaacatgaa
     2401 ctaaaatggc atgctatttg gaaatttagt ttgagataaa ctaaagtgtg ttgatgccag
     2461 aatgttcagc ttcagtaaat ataataagct cttgtgcctt gtatgcacta tttaaaaaaa
     2521 gtttttttta tttgagtcca gtataattca tgtaaatgtt aacaattaga ataatactct
     2581 gtatgctttt ttgatactga ttttgagaat ttaaagcaga ttacctttta aaactggacc
     2641 aactaagtaa ttggtattta atcaaagaga aaatggtaat aaacttttca aaatctttgt
     2701 taaaccaaac attcaacaca aaataaacta gaaggccaga ggataatgga ataaaagatc
     2761 attgcaatta cttatccttc ctaaaaatat agttttatat taattgtgct tatggaagaa
     2821 acaatgtcag ccaagtccat tttatagttt gagtgcaatt ctttgaacaa tagaaatatc
     2881 tgcagtcttt cacagatttg tattatgctg aagagtttca tctgacaatc tgcttcaaga
     2941 aatctcagaa aatatgataa cattttaact ttcattttag agcacgtttt ggtcattttt
     3001 aaaaatacct aaagtgccag accggaacct atagctactg ctagaagtct taaaaaaacc
     3061 aacagcagca caggatgtat taagaattat atgaagtcag gtttgttttt tttttttttt
     3121 ttttttcaaa gcacagtact gttagctgtt tttgtggaca ggattcgatt aagtattccc
     3181 tcttgtcaaa ctggaagcta ggggaaaaag agggattttt atcctttact cttctagagt
     3241 actgttaatg cccctttccc acagtctttt atataattaa atatatgtca atacacatta
     3301 gaatcagatt tgaaaaagtt aaaacaattt cattgttgta attgttccct ttctgttttc
     3361 atatagtgaa taacctttaa agggttgttt tgttttgttt tgaattatag gagttataat
     3421 ctttggagat gattgcatat ctcattagat atgcaatata aatttatctg agtgaacaaa
     3481 gtgctaaata aatagatcta cattttgtac atatttatat aaaatttacc tttaagtatt
     3541 tactttaaaa aatttaatgg cttaactcga acttgaagac acatacttca actgtcctta
     3601 ttgtccatta aactgataat tttgattttt cttgctttta tagattttac tatataggaa
     3661 tcaagattta agaaattttg cattaaaaat agtgtaccaa tgcttcatat acgttagtta
     3721 tttgctatta tgtagggaag aggattgtta tttcaaagat atattaaaga acagttgcat
     3781 ctgaatataa tcatgatgca ttcaatgaag ttcatatcca tgaattcact cctaatatac
     3841 cctaataaag tggttgatca cctacattat ctgtctataa gaaactgcct ttgcactgac
     3901 aatgtaaatt attttaagca taaattttcc taatagttta ttagagctac taatggcaaa
     3961 attcatgtct tcaatgtggc cataacatag gtcttgggag gggtggtgag aaaataaggt
     4021 atttactttg tagtagttaa gtgattctga ggacaattag aaacagacta taaaactcaa
     4081 ctacactgta atcaatagac aactattgga aatatggcat atgttgacaa acacttaact
     4141 agggaaatca aagatataaa tcatgtttat aaaaaattag gcacgcaatc atgtgattca
     4201 tgcttcaaga aaatatatga aaaaagtgtt actccattat gttataaact agcagatttt
     4261 ccctattttg aaatgcatgt aaacgggctc ggctgattct gaaattgtac tgtatcattt
     4321 ggtatttact tatatggtca aatacttgtt tgtaaaagtg atggttctga tacctttgat
     4381 caaacataga tacaaacctc agaaaatggt aaatgcaaag cagtttacgt tgtaaatcat
     4441 gatggtgtcc tccagcacaa ccatcccacc cacacaccta gactacagat tctgatctgt
     4501 gaatattttc accaaagtga catttaaaca agtggatttt tcacaaataa cacgtgttta
     4561 atatctttct gcagaaacgt gttcttctaa agcagaaaac cacgtggctt aatcccaaat
     4621 gttttacact tcttttccac atacttagcc agttcagcac cgatttcctc ttatatgtgg
     4681 aaggagacta tgttacatac ctgaagtatt actcttttac aaagatacca ttagaatttt
     4741 ctcactgtct tggtaaaaat tcctagattc tactttttat tgcaagtgtt agcaatatga
     4801 tcttgtaacg ccatgaaaag cattaagtag aagccaacat taacctagat tttacaactg
     4861 agcaatctgt tccccaccag atttccttta gaatttatta ccaaaggatc ttattttgtt
     4921 acagaacaca ggaaattgtt aaaccttata atgttgcaaa ccatgcattt tccttttctc
     4981 ttttccataa gattttttta ttgtagtagt gccctggctt gtaaacagtg gacatcactg
     5041 aaaggatgaa atcaagtagg cttgtttcaa agagactcct gtgaatcaac tatgaatatg
     5101 aagtatctcc cagaacaatg ttgagtgttt caggagactc tgaaacaggg cacccatttt
     5161 ttttttcctt cctcaaaata gtctccttga aatgtgagca aagaactatg atgatgcagt
     5221 ccaggtatct aatagctcaa tcaccaacac cgctgagaat tgttcttata ccagcaaaaa
     5281 gttcaaatac aataacctgg gcaatgccaa cagaagacac ttttaatcat ttgcagacct
     5341 ttcttgttgc aggaaagtga gggcaaaaac aaactggtga aaaatgttca aaaatagatc
     5401 tttttgatgt tcatagccag tattcagtat ttctgtattg tttacaattg ggggaaaatg
     5461 tctgttaagg ctaatcatct gagtgatttg agtagcaatt aaaccaaagg gaaactttta
     5521 ataagttatt ttaagccctg gtttatggct agttcccttt tgctcaggaa aaatagtact
     5581 actttatggt ttatgaaaac ctatgattta tgttgcatct tccggggaag gtttaacagt
     5641 acaaggagct gaatcctacc tgaaattatt aatgcttaat atattgcttc tgtttgattg
     5701 ataaaggtgc ttaatcaatt gaaaaaaaaa cgcataatgc ttcaaggtaa aattccgttg
     5761 attctgaatt taaaaagata ctacagaatg cgtcagttct cctgttgtat ttttctcagt
     5821 tatgagagca aggctatttt gtcagtttag attttgtgtc tttttctgtc agtatgtatg
     5881 gctccctaat tgaaaacatc ttaaatgaac taatcaaaca ctta
//
