LOCUS       NM_001039617            1308 bp    mRNA    linear   PRI 06-MAR-2025
DEFINITION  Homo sapiens zDHHC palmitoyltransferase 19 (ZDHHC19), transcript
            variant 1, mRNA.
ACCESSION   NM_001039617
VERSION     NM_001039617.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1308)
  AUTHORS   Huang,X., Yao,J., Liu,L., Chen,J., Mei,L., Huangfu,J., Luo,D.,
            Wang,X., Lin,C., Chen,X., Yang,Y., Ouyang,S., Wei,F., Wang,Z.,
            Zhang,S., Xiang,T., Neculai,D., Sun,Q., Kong,E., Tate,E.W. and
            Yang,A.
  TITLE     S-acylation of p62 promotes p62 droplet recruitment into
            autophagosomes in mammalian autophagy
  JOURNAL   Mol Cell 83 (19), 3485-3501 (2023)
   PUBMED   37802024
REFERENCE   2  (bases 1 to 1308)
  AUTHORS   Liang,S., Zhang,X. and Li,J.
  TITLE     Zinc finger Asp-His-His-Cys palmitoyl -acyltransferase 19
            accelerates tumor progression through wnt/beta-catenin pathway and
            is upregulated by miR-940 in osteosarcoma
  JOURNAL   Bioengineered 13 (3), 7367-7379 (2022)
   PUBMED   35297315
  REMARK    GeneRIF: Zinc finger Asp-His-His-Cys palmitoyl -acyltransferase 19
            accelerates tumor progression through wnt/beta-catenin pathway and
            is upregulated by miR-940 in osteosarcoma.
REFERENCE   3  (bases 1 to 1308)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1308)
  AUTHORS   Zhang,N., Zhao,H. and Zhang,L.
  TITLE     Fatty Acid Synthase Promotes the Palmitoylation of Chikungunya
            Virus nsP1
  JOURNAL   J Virol 93 (3), e01747-18 (2019)
   PUBMED   30404808
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1308)
  AUTHORS   Petrovski,S., Fellay,J., Shianna,K.V., Carpenetti,N., Kumwenda,J.,
            Kamanga,G., Kamwendo,D.D., Letvin,N.L., McMichael,A.J.,
            Haynes,B.F., Cohen,M.S. and Goldstein,D.B.
  CONSRTM   Center for HIV/AIDS Vaccine Immunology
  TITLE     Common human genetic variants and HIV-1 susceptibility: a
            genome-wide survey in a homogeneous African population
  JOURNAL   AIDS 25 (4), 513-518 (2011)
   PUBMED   21160409
REFERENCE   6  (bases 1 to 1308)
  AUTHORS   Kamatani,Y., Matsuda,K., Okada,Y., Kubo,M., Hosono,N., Daigo,Y.,
            Nakamura,Y. and Kamatani,N.
  TITLE     Genome-wide association study of hematological and biochemical
            traits in a Japanese population
  JOURNAL   Nat Genet 42 (3), 210-215 (2010)
   PUBMED   20139978
REFERENCE   7  (bases 1 to 1308)
  AUTHORS   Baumgart,F., Corral-Escariz,M., Perez-Gil,J. and
            Rodriguez-Crespo,I.
  TITLE     Palmitoylation of R-Ras by human DHHC19, a palmitoyl transferase
            with a CaaX box
  JOURNAL   Biochim Biophys Acta 1798 (3), 592-604 (2010)
   PUBMED   20074548
  REMARK    GeneRIF: The increased palmitoylation of R-Ras cotransfected with
            DHHC19 is accompanied by an augmented association with membranes as
            well as with rafts/caveolae.
REFERENCE   8  (bases 1 to 1308)
  AUTHORS   Ohno,Y., Kihara,A., Sano,T. and Igarashi,Y.
  TITLE     Intracellular localization and tissue-specific distribution of
            human and yeast DHHC cysteine-rich domain-containing proteins
  JOURNAL   Biochim Biophys Acta 1761 (4), 474-483 (2006)
   PUBMED   16647879
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG721568.1, BC022078.2, BU929650.1 and BC034801.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001039617.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279846.2894.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296326.8/ ENSP00000296326.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-447               BG721568.1         35-481
            448-728             BC022078.2         477-757
            729-1203            BU929650.1         70-544
            1204-1308           BC034801.1         1709-1813
FEATURES             Location/Qualifiers
     source          1..1308
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..1308
                     /gene="ZDHHC19"
                     /gene_synonym="DHHC19"
                     /note="zDHHC palmitoyltransferase 19"
                     /db_xref="GeneID:131540"
                     /db_xref="HGNC:HGNC:20713"
                     /db_xref="MIM:618671"
     exon            1..231
                     /gene="ZDHHC19"
                     /gene_synonym="DHHC19"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1015
                     /gene="ZDHHC19"
                     /gene_synonym="DHHC19"
                     /EC_number="2.3.1.225"
                     /note="zinc finger, DHHC domain containing 19; probable
                     palmitoyltransferase ZDHHC19; DHHC-19; zinc finger DHHC
                     domain-containing protein 19; zinc finger DHHC-type
                     containing 19; zinc finger DHHC-type palmitoyltransferase
                     19"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC19"
                     /protein_id="NP_001034706.1"
                     /db_xref="CCDS:CCDS43190.1"
                     /db_xref="GeneID:131540"
                     /db_xref="HGNC:HGNC:20713"
                     /db_xref="MIM:618671"
                     /translation="MTLLTDATPLVKEPHPLPLVPRPWFLPSLFAAFNVVLLVFFSGL
                     FFAFPCRWLAQNGEWAFPVITGSLFVLTFFSLVSLNFSDPGILHQGSAEQGPLTVHVV
                     WVNHGAFRLQWCPKCCFHRPPRTYHCPWCNICVEDFDHHCKWVNNCIGHRNFRFFMLL
                     VLSLCLYSGAMLVTCLIFLVRTTHLPFSTDKAIAIVVAVSAAGLLVPLSLLLLIQALS
                     VSSADRTYKGKCRHLQGYNPFDQGCASNWYLTICAPLGPKYMAEAVQLQRVVGPDWTS
                     MPNLHPPMSPSALNPPAPTSGSLQSREGTPGAW"
     exon            232..353
                     /gene="ZDHHC19"
                     /gene_synonym="DHHC19"
                     /inference="alignment:Splign:2.1.0"
     exon            354..493
                     /gene="ZDHHC19"
                     /gene_synonym="DHHC19"
                     /inference="alignment:Splign:2.1.0"
     exon            494..666
                     /gene="ZDHHC19"
                     /gene_synonym="DHHC19"
                     /inference="alignment:Splign:2.1.0"
     exon            667..772
                     /gene="ZDHHC19"
                     /gene_synonym="DHHC19"
                     /inference="alignment:Splign:2.1.0"
     exon            773..858
                     /gene="ZDHHC19"
                     /gene_synonym="DHHC19"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1034
                     /gene="ZDHHC19"
                     /gene_synonym="DHHC19"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1308
                     /gene="ZDHHC19"
                     /gene_synonym="DHHC19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1284..1289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC19"
                     /gene_synonym="DHHC19"
                     /note="hexamer: ATTAAA"
     polyA_site      1308
                     /gene="ZDHHC19"
                     /gene_synonym="DHHC19"
                     /note="major polyA site"
ORIGIN      
        1 gccgtggcca tggagctctg gaagctgggc tgggggagga agcctggtgg ctctgacctc
       61 ccctggaggc gaaggaggcc cagccatgac actcttaacg gatgccacgc cgctggtgaa
      121 ggagccccat cccctgcctc tggtcccacg tccctggttc ctccctagcc tctttgctgc
      181 cttcaatgtg gtgctgctgg tctttttcag tggcctcttc ttcgcattcc cttgcaggtg
      241 gctggctcag aacggggagt gggcctttcc tgttatcaca ggctccctct ttgtccttac
      301 cttcttcagt cttgtttcac tcaacttctc agaccctggc atcttacatc aaggctccgc
      361 tgagcagggc cccttgacgg tgcacgtggt gtgggtgaac cacggggcct tccgcctgca
      421 atggtgtcca aagtgctgct tccaccgccc gccccggact taccactgcc cctggtgcaa
      481 catctgtgtg gaggactttg accaccactg caagtgggtc aataactgca tcggtcaccg
      541 caacttccgc ttcttcatgc tgcttgtcct gtccctgtgc ctctactcgg gcgccatgct
      601 ggtcacctgt ctcatcttcc tggtgcgcac aacccacctg cccttctcca ccgacaaggc
      661 catcgccatc gtggtggccg tgtccgccgc gggcctcctg gtgccgctgt ccctcctgct
      721 gctgatccag gcactgtccg tgagctcggc cgaccgcacc tacaagggca agtgcagaca
      781 ccttcaggga tacaacccct tcgaccaggg ctgtgccagc aactggtatt taacaatttg
      841 tgcaccactg ggacccaagt acatggctga agctgtccag ctgcagagag tggtggggcc
      901 tgactggaca tccatgccga atctgcaccc tccaatgtcc ccctctgctc tcaacccccc
      961 agccccaacc tctgggtccc tacaaagcag ggaagggacc cccggggcgt ggtgaggctg
     1021 cagctctcca ggagttccac acgggcccag tgctgcccct gctgctgcag gagcccccag
     1081 gcgaggttcg gccttcctct cgcccctgtg cacccggaga tgcccacagc accagcacct
     1141 gagctcacct ccgaacccgc ctcctgaacc cgcctcctga acctgcctcc ttacctccca
     1201 cttcctgagc cctgagtgga agcctttctg tgccttgccc tttgcccact cccctggtgg
     1261 gactgccaag accctcaatg cccattaaat actcttgcct gcctctta
//
