LOCUS       NM_032283               5045 bp    mRNA    linear   PRI 06-MAR-2025
DEFINITION  Homo sapiens zDHHC palmitoyltransferase 18 (ZDHHC18), mRNA.
ACCESSION   NM_032283 XM_046911
VERSION     NM_032283.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5045)
  AUTHORS   Shi,C., Yang,X., Liu,Y., Li,H., Chu,H., Li,G. and Yin,H.
  TITLE     ZDHHC18 negatively regulates cGAS-mediated innate immunity through
            palmitoylation
  JOURNAL   EMBO J 41 (11), e109272 (2022)
   PUBMED   35438208
REFERENCE   2  (bases 1 to 5045)
  AUTHORS   Adachi,N., Hess,D.T., McLaughlin,P. and Stamler,J.S.
  TITLE     S-Palmitoylation of a Novel Site in the beta2-Adrenergic Receptor
            Associated with a Novel Intracellular Itinerary
  JOURNAL   J Biol Chem 291 (38), 20232-20246 (2016)
   PUBMED   27481942
REFERENCE   3  (bases 1 to 5045)
  AUTHORS   Ohno,Y., Kashio,A., Ogata,R., Ishitomi,A., Yamazaki,Y. and
            Kihara,A.
  TITLE     Analysis of substrate specificity of human DHHC protein
            acyltransferases using a yeast expression system
  JOURNAL   Mol Biol Cell 23 (23), 4543-4551 (2012)
   PUBMED   23034182
REFERENCE   4  (bases 1 to 5045)
  AUTHORS   Ohno,Y., Kihara,A., Sano,T. and Igarashi,Y.
  TITLE     Intracellular localization and tissue-specific distribution of
            human and yeast DHHC cysteine-rich domain-containing proteins
  JOURNAL   Biochim Biophys Acta 1761 (4), 474-483 (2006)
   PUBMED   16647879
REFERENCE   5  (bases 1 to 5045)
  AUTHORS   Fukata,M., Fukata,Y., Adesnik,H., Nicoll,R.A. and Bredt,D.S.
  TITLE     Identification of PSD-95 palmitoylating enzymes
  JOURNAL   Neuron 44 (6), 987-996 (2004)
   PUBMED   15603741
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL034380.26, BC066776.1 and AL512765.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032283.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066776.1, AK056427.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374142.9/ ENSP00000363257.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AL034380.26        69523-69544         c
            23-1778             BC066776.1         1-1756
            1779-3161           AL512765.1         1362-2744
            3162-5045           AL034380.26        38628-40511         c
FEATURES             Location/Qualifiers
     source          1..5045
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..5045
                     /gene="ZDHHC18"
                     /gene_synonym="DHHC-18; DHHC18"
                     /note="zDHHC palmitoyltransferase 18"
                     /db_xref="GeneID:84243"
                     /db_xref="HGNC:HGNC:20712"
                     /db_xref="MIM:620963"
     exon            1..452
                     /gene="ZDHHC18"
                     /gene_synonym="DHHC-18; DHHC18"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1284
                     /gene="ZDHHC18"
                     /gene_synonym="DHHC-18; DHHC18"
                     /EC_number="2.3.1.225"
                     /note="zinc finger, DHHC domain containing 18; zinc finger
                     DHHC domain-containing protein 18; zinc finger DHHC-type
                     containing 18; DHHC domain-containing cysteine-rich
                     protein 18; zinc finger DHHC-type palmitoyltransferase 18"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC18"
                     /protein_id="NP_115659.1"
                     /db_xref="CCDS:CCDS30650.1"
                     /db_xref="GeneID:84243"
                     /db_xref="HGNC:HGNC:20712"
                     /db_xref="MIM:620963"
                     /translation="MKDCEYQQISPGAAPLPASPGARRPGPAASPTPGPGPAPPAAPA
                     PPRWSSSGSGSGSGSGSLGRRPRRKWEVFPGRNRFYCGGRLMLAGHGGVFALTLLLIL
                     TTTGLFFVFDCPYLARKLTLAIPIIAAILFFFVMSCLLQTSFTDPGILPRATVCEAAA
                     LEKQIDNTGSSTYRPPPRTREVLINGQMVKLKYCFTCKMFRPPRTSHCSVCDNCVERF
                     DHHCPWVGNCVGRRNYRFFYAFILSLSFLTAFIFACVVTHLTLRAQGSNFLSTLKETP
                     ASVLELVICFFSIWSILGLSGFHTYLVASNLTTNEDIKGSWSSKRGGEASVNPYSHKS
                     IITNCCAVLCGPLPPSLIDRRGFVQSDTVLPSPIRSDEPACRAKPDASMVGGHP"
     exon            453..613
                     /gene="ZDHHC18"
                     /gene_synonym="DHHC-18; DHHC18"
                     /inference="alignment:Splign:2.1.0"
     exon            614..763
                     /gene="ZDHHC18"
                     /gene_synonym="DHHC-18; DHHC18"
                     /inference="alignment:Splign:2.1.0"
     exon            764..901
                     /gene="ZDHHC18"
                     /gene_synonym="DHHC-18; DHHC18"
                     /inference="alignment:Splign:2.1.0"
     exon            902..950
                     /gene="ZDHHC18"
                     /gene_synonym="DHHC-18; DHHC18"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1053
                     /gene="ZDHHC18"
                     /gene_synonym="DHHC-18; DHHC18"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1166
                     /gene="ZDHHC18"
                     /gene_synonym="DHHC-18; DHHC18"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..5045
                     /gene="ZDHHC18"
                     /gene_synonym="DHHC-18; DHHC18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3137..3142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC18"
                     /gene_synonym="DHHC-18; DHHC18"
                     /note="hexamer: AATAAA"
     polyA_site      3158
                     /gene="ZDHHC18"
                     /gene_synonym="DHHC-18; DHHC18"
                     /note="major polyA site"
     regulatory      5016..5021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC18"
                     /gene_synonym="DHHC-18; DHHC18"
                     /note="hexamer: AATAAA"
     polyA_site      5045
                     /gene="ZDHHC18"
                     /gene_synonym="DHHC-18; DHHC18"
ORIGIN      
        1 agtgagtgag cgagcgagcg ccgcgcgcgc cgccgctgcc acctccgctg ctcggcccgg
       61 tcccggagtg gcccggccgg cccgcggggc gcggagccga ggcccgcggc tggctgcatg
      121 aaggactgcg agtaccagca gatcagcccc ggggccgccc cgctgcccgc ctccccgggg
      181 gcgcgccgtc ccggccccgc cgcgtccccg actccgggcc ccgggcccgc gccgcccgcc
      241 gcccccgccc cgccgcgctg gagcagcagc ggcagcggca gcggcagcgg gagcgggagc
      301 ctcggccgcc gcccacggcg caagtgggag gtgttcccgg gtcgcaatcg cttctactgc
      361 ggcggccgcc tcatgctggc cggccacggc ggcgtcttcg cgctcacgct gctgctcatc
      421 ctcaccacca ccggcctctt cttcgtcttt gactgtccct acctggctcg caagctgacc
      481 cttgccatcc ccatcatcgc tgccatcctc ttcttcttcg tcatgagctg cctgctgcag
      541 acaagcttca ccgaccctgg gatcctgccc cgggccactg tctgtgaagc agccgccctg
      601 gagaaacaga tcgacaacac aggcagttct acataccggc caccccctcg gacccgggag
      661 gtgctgatca acgggcagat ggtgaagctg aagtactgct tcacctgcaa gatgttccgg
      721 ccaccccgaa cctcacactg cagtgtctgc gacaactgtg tggaacgatt tgaccatcac
      781 tgcccctggg tgggcaactg tgtggggaga cggaactatc gcttcttcta cgcgtttatt
      841 ctctccctct cattcctgac ggccttcatc ttcgcctgtg tggtcaccca cctgacgttg
      901 cgcgctcagg gaagcaactt cctctccact ctgaaggaga caccagcaag cgtgctggag
      961 ttggtgatct gcttcttctc catctggtcc attctgggcc tctcagggtt tcacacgtac
     1021 ctcgtcgcct ccaacctgac tactaatgaa gacatcaaag gctcgtggtc cagcaagagg
     1081 ggcggtgagg cctctgtcaa cccctacagc cataaaagta ttatcaccaa ctgctgtgct
     1141 gtgctctgtg gccccctacc tcccagccta attgaccgga ggggatttgt gcagtccgac
     1201 accgtgttgc cctcacccat cagaagcgat gagccagcct gcagagccaa gcctgatgcc
     1261 agcatggtag gaggccaccc ctgaccacgg ctcagtactt gccacctgct ggcctgtctg
     1321 accctccgca ctcacctgcc gggaccctcc ctattccatc caagggaagc agaactgcca
     1381 aagactcaag tcttttcata tttatttccc atcctgcgtg gctttccctg aactgttccg
     1441 tggctgtgcc ctctgctccc caaacccagg ttcccacagc cttgggccct aggtacccca
     1501 gctgatcagt gccaggagag accagagcct ctggaggcta cccaggggac cacaccaagt
     1561 ccttgcctgt gccgggcgag ccctgtgtga gtgaggctgt gaactgagcg tgaggcctcc
     1621 caggtggggg aactgcttgg gccttgctga gccagggtcc tcagggtgaa gcaggactga
     1681 ggagtggcca gctctggata gctggctgtg gagaggaagc ctccatgggc tgctttggtc
     1741 tgtgggctcc ttcattccct tggtgataat ttccctttat tctgtgggat ttttggtggg
     1801 gttttccccc cttttttatg gagttggcca ataggattga gttggggctc cagtagagaa
     1861 ggcagggttg gtggtgggtg ggggcagcct gtatcagaca aaggtaaatc agccagccag
     1921 gcacccacag cctcagctcc tgtgcagttc ctgggcagca cagtggaagt gggagcctgg
     1981 tccttcccct gcccatggag agctctttaa gggatcccag cctgcccctc cacttctctc
     2041 ccaagccagg tcccggcatg ggtgggttat gctcatgctg gcaatacttg aaacgggttt
     2101 attaatgctg ggtattttgc acaattttat agacctcttt tctacatagt cttttttaaa
     2161 tggaaggaga aaatgtcagc cacattactg tctgtgtagt gccaggtgaa gggttatcag
     2221 aaggctggtt ggttttaata agtttattcc aagagacctt ctggctggaa tgagtgagag
     2281 tgtgtgtgca tgtgtgtgtg tgttcatgtg tgccctgtat gaatgtggct ggctcccata
     2341 tcccctgggc tgccccctgc cccatcccct ttgagtgtca gaagcactct gagccaaggg
     2401 gacagggggc acgtgcactg gtcacgagaa aaccctgggc tcccactggg gctcagccca
     2461 gcctcctatc tttccttctt ctatggactt cagacagcca gtgtctgggg actctgccac
     2521 tctaccccca gccctaccca ccagccccca ggtgaggctt ccagctggga cctgcccaga
     2581 caggctgagc ctgggcgtgg tgggtggggt gatggctctg gggagcggct gccatcctac
     2641 aagccacacc ccctcctctg agctctgaat atgggaccca gtgccaggag ctggaagaca
     2701 aggtgtttct gccaaacggg gacctccatc cagagaaaag gaagaaggtg cagggtgggc
     2761 caagaggcaa gtgaaggttg gcctgagtct gggccggaaa ctcagaggat gtttctcctc
     2821 tgctgggagc tgtagtttct tatcaaaata gatattgttc caccatcccc ctccttggcc
     2881 cttcaagtgg gctgaagccc ttggaaagtg acataggaag tccccagatc ttgcccttct
     2941 cactccagag gctagtggtc acagacagct gggaatggca gccacagagg gtcccctctg
     3001 ggagaaacag cttcacccca gcctcagggc cctgggccat cactgcagtg gccctgggag
     3061 gtgaggaaga agctggctag aggagggggc tcccacctac cttttattta agccagtatt
     3121 ctttgttcct gcttgtaata aaacttcagt ttataagagt tgctttgctt tggtttggtt
     3181 tttgtttgct tttcctttgc tgaggcccca actgggagcc ctctgttctt tcagacaaat
     3241 ttggttcttt cctggggaga ctgtgagaag gcaggcagcc cagtgatctg gctacatttt
     3301 ccctcacctg gctggagctc tgtccgctgg aggaagagca gagagggctg cggctgagcc
     3361 cccatgggca cgtgaaaaga ggccatcctg tcccctcttt gtcccctcca ccttcccctg
     3421 cctcaggggc ttggagaccc ccaaattctt cttccctact gcctttccac tccgatcccc
     3481 aatgagtgcc cagctaagaa aatgtttgag acagtagatt ccagtttgag agccggagct
     3541 tccctggcta ccacctccaa cctgggcacc agggcccagc cagacaactc ataacactgg
     3601 cccacctctc tggtatctcc ctcaggagga cacctgtcag gattttgcca tctcctgcac
     3661 agcctgaggg gagctaacag gcctctttgc agagggttag ctggtaagac cgtttcttcc
     3721 ctgtcggcca gcactgcccg ctcccctcac acaccatctc atcctcatcg catgcctcgc
     3781 caaccccatg gagcccgtcc atctgtctgg tgtgtggtgc ggtgtgtgtg ctggtggtgg
     3841 tagggtctcc agggactccc cgctaagcag aaggatcggg atatagggca aggctaaaag
     3901 cccagcccca ttgtggactg aggaagtagc ttctcgcaga gcagctctcc agctggaaga
     3961 ggaggtggag ggtgaggctg gggagaggat ggcgaacctg ccctgaggtg cttgggtctg
     4021 tgctggtggg gtcctggtat gcaggggcca ccggtcacta acactcttat gtcctggctt
     4081 tctgtccccg ctgagctttc tctcacccgc ccgttttctc tcctgcttca ttgcctgctg
     4141 cctaagcctt ggcccttctc tcgggcagag gcaggtgctg tggcagcacc tctccccacc
     4201 accggggccc ctgcaggccg cctccctcct cccaggcctg ctaaccctct ctcttctcct
     4261 tctttgctgt cctgccgggg atctccagtg tgtgcggggg cttaaggacc tcctgaggac
     4321 cgctgctctc tgcctctcca ggaatggcct ggggggagcc aggcacccgg cacctccacc
     4381 tgcctaacct gtggcccatc tgccaccatc tgtgcctaca gggtctgccc cccagcctgc
     4441 ccggcctgtg tgctctctag gacccccata gggggcaggg gctggcctct ttgccccatt
     4501 cccgctccat gccggccaga gtgtagaaag ccataacgca gccatcagca caataatgtg
     4561 actctacgct gatatgctcc ctctctcctc cactgacttc cccttcccgg atttgtgagg
     4621 tgtcaagact aggaatctgg ccttagagcc tgcccctcca ccccctcaga tcaggcatag
     4681 ccatagtcaa gcccagcagg tttcctcagg agctgtctgg ggtgttgatg gtggatgacg
     4741 ctgctgaaca agtttggtga ctgttctaag cacaactggc ttgatactgt tcccacggcc
     4801 tgtccacctc ccacccccaa ccctccacca gagtaggtag gatgtaggga gggtgcgtgc
     4861 ctcctttgct ctaggcactg agggaccaag ctagccgtgc acagccccat acacttcagg
     4921 ggactaaagg aaagagctga gccaaggaaa atcagctgag cccagggctg ggggctgctt
     4981 gtctgctatc ctgtaccttt ttttttttta accaaaataa agattcccct cttcttgcca
     5041 tacca
//
