LOCUS       NM_015336               4732 bp    mRNA    linear   PRI 06-MAR-2025
DEFINITION  Homo sapiens zDHHC palmitoyltransferase 17 (ZDHHC17), transcript
            variant 1, mRNA.
ACCESSION   NM_015336
VERSION     NM_015336.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4732)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4732)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4732)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4732)
  AUTHORS   Chen,X., Hao,A., Li,X., Ye,K., Zhao,C., Yang,H., Ma,H., Hu,L.,
            Zhao,Z., Hu,L., Ye,F., Sun,Q., Zhang,H., Wang,H., Yao,X. and
            Fang,Z.
  TITLE     Activation of JNK and p38 MAPK Mediated by ZDHHC17 Drives
            Glioblastoma Multiforme Development and Malignant Progression
  JOURNAL   Theranostics 10 (3), 998-1015 (2020)
   PUBMED   31938047
  REMARK    GeneRIF: Activation of JNK and p38 MAPK Mediated by ZDHHC17 Drives
            Glioblastoma Multiforme Development and Malignant Progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4732)
  AUTHORS   Trepte,P., Kruse,S., Kostova,S., Hoffmann,S., Buntru,A.,
            Tempelmeier,A., Secker,C., Diez,L., Schulz,A., Klockmeier,K.,
            Zenkner,M., Golusik,S., Rau,K., Schnoegl,S., Garner,C.C. and
            Wanker,E.E.
  TITLE     LuTHy: a double-readout bioluminescence-based two-hybrid technology
            for quantitative mapping of protein-protein interactions in
            mammalian cells
  JOURNAL   Mol Syst Biol 14 (7), e8071 (2018)
   PUBMED   29997244
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4732)
  AUTHORS   Huang,K., Yanai,A., Kang,R., Arstikaitis,P., Singaraja,R.R.,
            Metzler,M., Mullard,A., Haigh,B., Gauthier-Campbell,C.,
            Gutekunst,C.A., Hayden,M.R. and El-Husseini,A.
  TITLE     Huntingtin-interacting protein HIP14 is a palmitoyl transferase
            involved in palmitoylation and trafficking of multiple neuronal
            proteins
  JOURNAL   Neuron 44 (6), 977-986 (2004)
   PUBMED   15603740
REFERENCE   7  (bases 1 to 4732)
  AUTHORS   Ducker,C.E., Stettler,E.M., French,K.J., Upson,J.J. and Smith,C.D.
  TITLE     Huntingtin interacting protein 14 is an oncogenic human protein:
            palmitoyl acyltransferase
  JOURNAL   Oncogene 23 (57), 9230-9237 (2004)
   PUBMED   15489887
  REMARK    GeneRIF: has the ability to induce colony formation in cell
            culture, anchorage-independent growth, and tumors in mice
            GeneRIF: HIP14 is a protein: palmitoyl acyltransferase
REFERENCE   8  (bases 1 to 4732)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   9  (bases 1 to 4732)
  AUTHORS   Singaraja,R.R., Hadano,S., Metzler,M., Givan,S., Wellington,C.L.,
            Warby,S., Yanai,A., Gutekunst,C.A., Leavitt,B.R., Yi,H.,
            Fichter,K., Gan,L., McCutcheon,K., Chopra,V., Michel,J.,
            Hersch,S.M., Ikeda,J.E. and Hayden,M.R.
  TITLE     HIP14, a novel ankyrin domain-containing protein, links huntingtin
            to intracellular trafficking and endocytosis
  JOURNAL   Hum Mol Genet 11 (23), 2815-2828 (2002)
   PUBMED   12393793
REFERENCE   10 (bases 1 to 4732)
  AUTHORS   Faber,P.W., Barnes,G.T., Srinidhi,J., Chen,J., Gusella,J.F. and
            MacDonald,M.E.
  TITLE     Huntingtin interacts with a family of WW domain proteins
  JOURNAL   Hum Mol Genet 7 (9), 1463-1474 (1998)
   PUBMED   9700202
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093014.11 and AC124784.4.
            
            On Jul 13, 2020 this sequence version replaced NM_015336.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050324.1, AB024494.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000426126.7/ ENSP00000403397.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               AC093014.11        74939-75153         c
            216-319             AC093014.11        41731-41834         c
            320-442             AC093014.11        33829-33951         c
            443-520             AC093014.11        30148-30225         c
            521-665             AC093014.11        29411-29555         c
            666-730             AC093014.11        24058-24122         c
            731-893             AC093014.11        23249-23411         c
            894-1019            AC093014.11        16737-16862         c
            1020-1162           AC093014.11        12218-12360         c
            1163-1263           AC093014.11        10778-10878         c
            1264-1388           AC124784.4         139503-139627       c
            1389-1451           AC124784.4         138628-138690       c
            1452-1545           AC124784.4         135807-135900       c
            1546-1629           AC124784.4         134930-135013       c
            1630-1787           AC124784.4         133219-133376       c
            1788-1882           AC124784.4         132139-132233       c
            1883-4732           AC124784.4         127913-130762       c
FEATURES             Location/Qualifiers
     source          1..4732
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.2"
     gene            1..4732
                     /gene="ZDHHC17"
                     /gene_synonym="DHHC-17; DHHC17; HIP14; HIP3; HSPC294;
                     HYPH"
                     /note="zDHHC palmitoyltransferase 17"
                     /db_xref="GeneID:23390"
                     /db_xref="HGNC:HGNC:18412"
                     /db_xref="MIM:607799"
     exon            1..215
                     /gene="ZDHHC17"
                     /gene_synonym="DHHC-17; DHHC17; HIP14; HIP3; HSPC294;
                     HYPH"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..2021
                     /gene="ZDHHC17"
                     /gene_synonym="DHHC-17; DHHC17; HIP14; HIP3; HSPC294;
                     HYPH"
                     /EC_number="2.3.1.225"
                     /note="isoform 1 is encoded by transcript variant 1;
                     huntingtin interacting protein 3; huntingtin interacting
                     protein 14; palmitoyltransferase ZDHHC17; huntingtin yeast
                     partner H; huntingtin-interacting protein H; putative
                     MAPK-activating protein PM11; putative
                     NF-kappa-B-activating protein 205; acyltransferase ZDHHC7;
                     acyltransferase ZDHHC17; zinc finger DHHC
                     domain-containing protein 17; zinc finger DHHC-type
                     containing 17; DHHC domain-containing cysteine-rich
                     protein 17; zinc finger DHHC-type palmitoyltransferase 17"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC17 isoform 1"
                     /protein_id="NP_056151.2"
                     /db_xref="CCDS:CCDS44946.1"
                     /db_xref="GeneID:23390"
                     /db_xref="HGNC:HGNC:18412"
                     /db_xref="MIM:607799"
                     /translation="MQREEGFNTKMADGPDEYDTEAGCVPLLHPEEIKPQSHYNHGYG
                     EPLGRKTHIDDYSTWDIVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNR
                     IDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSC
                     IHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVN
                     LGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINH
                     LQEARQAKGYDNPSFLRKLKADKEFRQKVMLGTPFLVIWLVGFIADLNIDSWLIKGLM
                     YGGVWATVQFLSKSFFDHSMHSALPLGIYLATKFWMYVTWFFWFWNDLNFLFIHLPFL
                     ANSVALFYNFGKSWKSDPGIIKATEEQKKKTIVELAETGSLDLSIFCSTCLIRKPVRS
                     KHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFLLFMICWMIYGCISYWGLHC
                     ETTYTKDGFWTYITQIATCSPWMFWMFLNSVFHFMWVAVLLMCQMYQISCLGITTNER
                     MNARRYKHFKVTTTSIESPFNHGCVRNIIDFFEFRCCGLFRPVIVDWTRQYTIEYDQI
                     SGSGYQLV"
     exon            216..319
                     /gene="ZDHHC17"
                     /gene_synonym="DHHC-17; DHHC17; HIP14; HIP3; HSPC294;
                     HYPH"
                     /inference="alignment:Splign:2.1.0"
     exon            320..442
                     /gene="ZDHHC17"
                     /gene_synonym="DHHC-17; DHHC17; HIP14; HIP3; HSPC294;
                     HYPH"
                     /inference="alignment:Splign:2.1.0"
     exon            443..520
                     /gene="ZDHHC17"
                     /gene_synonym="DHHC-17; DHHC17; HIP14; HIP3; HSPC294;
                     HYPH"
                     /inference="alignment:Splign:2.1.0"
     exon            521..665
                     /gene="ZDHHC17"
                     /gene_synonym="DHHC-17; DHHC17; HIP14; HIP3; HSPC294;
                     HYPH"
                     /inference="alignment:Splign:2.1.0"
     exon            666..730
                     /gene="ZDHHC17"
                     /gene_synonym="DHHC-17; DHHC17; HIP14; HIP3; HSPC294;
                     HYPH"
                     /inference="alignment:Splign:2.1.0"
     exon            731..893
                     /gene="ZDHHC17"
                     /gene_synonym="DHHC-17; DHHC17; HIP14; HIP3; HSPC294;
                     HYPH"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1019
                     /gene="ZDHHC17"
                     /gene_synonym="DHHC-17; DHHC17; HIP14; HIP3; HSPC294;
                     HYPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1162
                     /gene="ZDHHC17"
                     /gene_synonym="DHHC-17; DHHC17; HIP14; HIP3; HSPC294;
                     HYPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1263
                     /gene="ZDHHC17"
                     /gene_synonym="DHHC-17; DHHC17; HIP14; HIP3; HSPC294;
                     HYPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1388
                     /gene="ZDHHC17"
                     /gene_synonym="DHHC-17; DHHC17; HIP14; HIP3; HSPC294;
                     HYPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1451
                     /gene="ZDHHC17"
                     /gene_synonym="DHHC-17; DHHC17; HIP14; HIP3; HSPC294;
                     HYPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1545
                     /gene="ZDHHC17"
                     /gene_synonym="DHHC-17; DHHC17; HIP14; HIP3; HSPC294;
                     HYPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1629
                     /gene="ZDHHC17"
                     /gene_synonym="DHHC-17; DHHC17; HIP14; HIP3; HSPC294;
                     HYPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1787
                     /gene="ZDHHC17"
                     /gene_synonym="DHHC-17; DHHC17; HIP14; HIP3; HSPC294;
                     HYPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1882
                     /gene="ZDHHC17"
                     /gene_synonym="DHHC-17; DHHC17; HIP14; HIP3; HSPC294;
                     HYPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..4732
                     /gene="ZDHHC17"
                     /gene_synonym="DHHC-17; DHHC17; HIP14; HIP3; HSPC294;
                     HYPH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4714..4719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZDHHC17"
                     /gene_synonym="DHHC-17; DHHC17; HIP14; HIP3; HSPC294;
                     HYPH"
                     /note="hexamer: AATAAA"
     polyA_site      4732
                     /gene="ZDHHC17"
                     /gene_synonym="DHHC-17; DHHC17; HIP14; HIP3; HSPC294;
                     HYPH"
                     /note="major polyA site"
ORIGIN      
        1 gtcacggggg caggagaaga aggaggagga ggcccgcgtc gcctccggcg gggctcgcgc
       61 tcgccccgcg ctcgccctcc gcctcgcccg agccccggga gggtgaaacg ctttctccca
      121 gcatgcagcg ggaggaggga tttaacacca agatggcgga cggcccggat gagtacgata
      181 ccgaagcggg ctgtgtgccc cttctccacc cagaggaaat caaaccccaa agccattata
      241 accatggata tggtgaacct cttggacgga aaactcatat tgatgattac agcacatggg
      301 acatagtcaa ggctacacaa tatggaatat atgaacgctg tcgagaattg gtggaagcag
      361 gttatgatgt acggcaaccg gacaaagaaa atgttaccct cctccattgg gctgccatca
      421 ataacagaat agatttagtc aaatactata tttcgaaagg tgctattgtg gatcaacttg
      481 gaggggacct gaattcaact ccattgcact gggccacaag acaaggccat ctatccatgg
      541 ttgtgcaact aatgaaatat ggtgcagatc cttcattaat tgatggagaa ggatgtagct
      601 gtattcatct ggctgctcag ttcggacata cctcaattgt tgcttatctc atagcaaaag
      661 gacaggatgt agatatgatg gatcagaatg gaatgacgcc tttaatgtgg gcagcatata
      721 gaacacatag tgtggatcca actagattgc ttttaacatt caatgtttca gttaaccttg
      781 gtgacaagta tcacaaaaac actgctctgc attgggcagt gctagcaggg aataccacag
      841 tcattagcct tcttctggaa gctggagcta atgttgatgc ccagaatatc aagggcgaat
      901 cagcgcttga tttggcaaaa cagagaaaaa atgtgtggat gatcaaccac ttacaagagg
      961 caaggcaagc aaaaggatat gacaatccgt ccttccttag aaagctgaaa gctgataagg
     1021 aatttcggca gaaagtaatg ttaggaactc ctttcctagt tatttggctg gttgggttta
     1081 tagcagacct aaatattgat tcttggctca ttaaagggct aatgtatggt ggtgtttggg
     1141 ctacagtaca gtttctttca aaatcctttt tcgatcattc aatgcatagt gcattgcccc
     1201 ttgggatata tttggcaacc aaattctgga tgtatgtgac gtggttcttc tggttttgga
     1261 atgatctcaa ctttttattt atccatcttc cattccttgc caatagtgtt gcacttttct
     1321 acaattttgg aaaatcttgg aaatcagatc cagggattat taaagcaaca gaagagcaaa
     1381 agaaaaagac aatagttgaa cttgcagaga caggaagtct ggacctcagt atattctgca
     1441 gtacctgttt gatacgaaaa ccggtgaggt ccaaacattg tggtgtgtgc aaccgctgta
     1501 tagcaaaatt tgatcatcat tgcccatggg tgggtaactg tgtaggtgca ggcaaccata
     1561 gatattttat gggctaccta ttcttcttgc tttttatgat ctgctggatg atttatggtt
     1621 gtatatctta ctggggactc cactgtgaga ccacttacac caaggatgga ttttggacat
     1681 acattactca gattgccacg tgttcacctt ggatgttttg gatgttcctg aacagtgttt
     1741 tccacttcat gtgggtggct gtattactca tgtgtcagat gtaccagata tcatgtttag
     1801 gtattactac aaatgaaaga atgaatgcca ggagatacaa gcactttaaa gtcacaacaa
     1861 cgtctattga aagcccattc aaccatggat gtgtaagaaa tattatagac ttctttgaat
     1921 ttcgatgctg tggcctcttt cgtcctgtta tcgtggactg gaccaggcag tatacaatag
     1981 aatatgacca aatatcagga tctgggtacc agctggtgta gcgacatctt atcctatgaa
     2041 gcatattgct gagtggtgcc tgaaaattgt gtctgtccgt gtctttctca cactcgaatc
     2101 cacatccttt gaacaagagc atgctatgtg tagggctaat ggtgaatttt acagtctttt
     2161 tttcaacact tttattaaca aaagtaaaca tggacagaac acactgccat ttctgggaag
     2221 agtaaagatg ataaaaaata attttaatgg ttcttaatgt ggaaattcac aacatactca
     2281 acttttgggt tttgttctca cagtattttt cacaaaaaaa gggtaaactt attctattga
     2341 cagacatggt gtactgatca gaaatgttca gttttaacta aaactaaatt tatgttattt
     2401 ggctaaatgt tatgatgcag tctagtacga gtattgcatc taattccagg agcattgttt
     2461 taagttgatt gactagttat tatgtacatt tcagaatgta cacataaata ctgtgatgaa
     2521 aatcatgtga ttgggatcta ctgtgatgtt gtcttcaaag gcaggagaaa ataatgttca
     2581 caataaaatg tgctaacaat gttttgtttc tatcagctgt tgcaatgctg atatatttct
     2641 agttcagtga aataatttgt agtaacctta ctctgaggtt ttacggtctg ataatgaagc
     2701 acttgcatga gtatagtaag tcatgttttt ttgttcaaat ttaaaagccc tgctaattgc
     2761 atgacacacc acatagaatg tatactagca gatactatcc agtgaagcat aaattagaat
     2821 ttaatttgat gttcaaaaac agttccattt ttaagggtta aggtggtatt ttcaagaaaa
     2881 ggcagaacaa ataatgcaaa attctcagta atagtgatac atggatatac ttccttttaa
     2941 attctcagct gcaaaataat tgtagacaaa ataatggcat ttaactaaag atggagcatg
     3001 atctaagtac atagcacatg tgaataaaag aaaagctgac agtatattct ggtttcaata
     3061 aaatgaccta tcagaaagta gaatttcatc cccaagagta tttcagttta tccaatattg
     3121 agtaagttct gaaacagttt tagaaaaaat tttctttttg ttaaatgtga tgcactgatc
     3181 aatttttgtc acagcatttt cataccttca tggtggacta ctagtcactg cttccataaa
     3241 tattgtttac agggtgagat ttggtttatt catcttaagt gctgtagcaa actgtggttc
     3301 gagcaacctg tgggaaatct gtgagaggga atggggtggg agatgtgggg gaatggtggt
     3361 cagactgatg acagatccta gaccaatgta aagaatgtgt atctgtatat aaataattta
     3421 tcaaatagtt ttctctttgt gtctgtgtta gtgtttttaa agctgctcat ttcattttgt
     3481 ccaaccaaaa agaaaaggga gataactaat gagcttctag tgatgttcaa aattgctgtt
     3541 aataggcatt ataccctgca agttcactgc atgtctgatg cttggtaaaa ctagtcttcc
     3601 ctgtaaaatg cagattacag gtattaaagc aatctagtgg tatacccgcc ccttgcctta
     3661 gtaagaggag cagtgaaatg tatatagttg atgttcagta tttccaagta ccatttttat
     3721 atagtagctt atttgaccat aagtcacaca tcaaaaaaag attaccctta gtgtatgtgt
     3781 tttaatatta gaaaattggc atatgtactt tatttttgaa aagggaagag atgggtgtgg
     3841 ggtggcaata gcattgtgcc attttgtcat agaatgtaaa aattggttaa ctttacaaat
     3901 gtcagctagt tttgactact aattggggga aattttagat aatttttaaa ttcaaagtta
     3961 tttataaaat gctagaattt gttttaattt tttgtatttt gagccacttc acatgaagac
     4021 tcagttgcat ttttatcgaa tacattttta tcaacagtta aagactatgg tggttttttc
     4081 agagtttggc taagaatgtt gttaccatct tctttgtttg tggtacaata ttttcagtgc
     4141 aaaagagatg tcattcagtt aaaaagacaa acctctagat gtgtaattac atggaaaata
     4201 ctagcaatgt gaatgctttt gtagtaacca tcttgtagta cctgtgaaat ctataactca
     4261 gaaatggtca gatggtcagg agccagctat gcagcagtat accatctgtt taattatttt
     4321 gtaggtcctg tgtgtggaac caactataaa cccagttcta aagttgtgta tgatggtgaa
     4381 cctttgggaa tagttcttat caacttaatt ggatactttt agcaaatagg aacttaattc
     4441 tcagcactga acatgaatta cttccttgga gttttttttc attcatattt ttgttgtttc
     4501 caggaattta tttgatatta atgggcgtaa aacagcatca ttgtacttaa gctatggatg
     4561 tttttatttt atattttctt tatttataac tgtgccaagt attattttgc tacttaccgt
     4621 gttattctgt ggaaagaaaa acctgtaaag tgtttaataa attagccctc cttacataaa
     4681 ttaaatgtca aaattttgta aaatattaat cagaataaat actgactctt aa
//
